Cells mitigate the detrimental consequences of DNA damage on genome stability by attempting high fidelity repair. Homologous recombination templates DNA double‐strand break (DSB) repair on an identical or near identical donor sequence in a process that can in principle access the entire genome. Other physiological processes, such as homolog recognition and pairing during meiosis, also harness the HR machinery using programmed DSBs to physically link homologs and generate crossovers. A consequence of the homology search process by a long nucleoprotein filament (...) is the formation of multi‐invasions (MI), a joint molecule in which the damaged ssDNA has invaded more than one donor molecule. Processing of MI joint molecules can compromise the integrity of both donor sites and lead to their rearrangement. Here, two mechanisms for the generation of rearrangements as a pathological consequence of MI processing are detailed and the potential relevance for non‐allelic homologous recombination discussed. Finally, it is proposed that MI‐induced crossover formation may be a feature of physiological recombination. (shrink)

You reach for the bowl with ‘sugar’ written on it only to discover, from the bad taste of your coffee, that it contained salt. Mundane experiences like these show that epistemic justification does not necessarily hold stable across possible changes of information. One can be justified in believing a proposition at a certain time (that the bowl contains sugar) and cease to be justified at a later time, as one enlarges one’s epistemic perspective (as one drinks a salty coffee). When (...) this happens, one’s justification has been defeated. An epistemic defeater, broadly speaking, is that in terms of which the defeat of justification proceeds. The notion of an epistemic defeater is mostly associated with J. Pollock’s work on reasoning and inference. Pollock has provided the canonical definition of an epistemic defeater and proposed an influential taxonomy in terms of the way different types of defeaters induce their characteristic effects. The notion of an epistemic defeater has acquired a broader meaning in current epistemology, and several distinctions have been introduced that have contributed to a more nuanced understanding of the phenomenon of defeat as well as to complement Pollock’s original taxonomy. The correlated notion of a propositional defeater, defined in terms of would-be defeat of justification, is appealed to by the proponents of the defeasibility theory in the parallel debate about knowledge to explain what prevents a justified true belief from constituting knowledge in Gettier cases. (shrink)

First aim of this paper is to show that Evidentialism, when paired with a Psychologistic ontology of evidence, is unable to account for ordinary cases of inferential justification. As many epistemologists have maintained, however, when it is paired with a Propositionalist ontology of evidence, Evidentialism is unable to explain in a satisfactory way ordinary cases of perceptual justification. So, the Evidentialist is faced with a dilemma. Second aim of this paper is to give an argument in favour of Propositionalism about (...) evidence, and so to motivate the conclusion that perceptual justification must be accounted for in non-evidentialist terms. By this I do not mean to defend a strongly Non-Evidentialist epistemology, according to which there are doxastic attitudes which are unsupported by any justifier. More modestly, I aim to motivate the weakly Non-Evidentialist epistemology according to which a subject’s perceptual beliefs may be justified by non-evidential justifiers. I conclude the paper by explaining why I believe that Pryor's dogmatism supplies a model for the way in which an internalist who is persuaded by my argument might want to detail her weakly Non-Evidentialist account of perceptual justification. (shrink)

This article provides the first extensive study of Emanuel Swedenborg’s (1688–1772) views on Africans and slavery. Although significant scholarship has been devoted to Swedenborg’s influence on the British abolitionist movement in the 1780s-1790s, comparably little has been written on the ideas and context which inspired this influence in the first place. This article explores Swedenborg’s ties to networks and debates about African evangelization, colonization, and slavery during the neglected period of the Swedish Age of Liberty (1719–1772). It shows that Swedenborg (...) was the first Swede to condemn slavery, as early as 1741, explains why he regarded slavery as a divine punishment in the afterlife for European missionaries, and why he presented sub-Saharan Africans as superior, in contrast to the dominant dismissive views of Linnaeus, Bäck, Kant, or Buffon. Like most Lutherans of his time, Swedenborg did not advocate the abolition of slavery, yet within a generation his provocative views about African superiority and spiritual emancipation were used by his followers to articulate their abolitionist agenda. Swedenborg’s millenarian doctrines more broadly re-harnessed biblical traditions about Africa and tropes about the bon sauvage, in a counter-example to narratives about the trope’s decline in the second half of the eighteenth century. (shrink)

Aurel Codoban, Filosofia ca gen literar (Philosophy as a literary genre) Ed. Idea Design&Print, Cluj- Napoca, 2006.

It is difficult to give a precise definition of hypertext since, in addition to its use as a technical tool, there is the conceptual dimension of a space for organizing memory and mapping connections. People often confuse the hypertext system, which makes it possible, through the digital medium, to link objects of different types, with the products (compositions?) created by means of this technique. Hypertext cannot be limited to either of these aspects. Like ink and paper, it is a medium (...) for composition and expression and should also be seen as such. Whatever its purpose, and even if it involves collecting together pages on the Web in an ad hoc manner, hypertext delineates areas of knowledge and thus helps to produce a dual temporality, one that belongs to documents, the other characterized by instant actualization (which coincides with the eradication of any distance of space or time between the items of information). (shrink)

This paper focuses on extant approaches to counteract the consumption of fake news online. Proponents of structural approaches suggest that our proneness to consuming fake news could only be reduced by reshaping the architecture of online environments. Proponents of educational approaches suggest that fake news consumers should be empowered to improve their epistemic agency. In this paper, we address a question that is relevant to this debate: namely, whether fake news consumers commit mistakes for which they can be criticized and (...) that they could easily avoid by reforming their doxastic conduct. Proponents of structural approaches, like R. Rini and B. Millar, have defended in different ways a negative answer to this question. In this paper, we criticize their views and suggest that individual users could improve on their epistemic practice by widening their information diet. (shrink)

According to Hartry Field, the mathematical Platonist is hostage of a dilemma. Faced with the request of explaining the mathematicians’ reliability, one option could be to maintain that the mathematicians are reliably responsive to a realm populated with mathematical entities; alternatively, one might try to contend that the mathematical realm conceptually depends on, and for this reason is reliably reflected by, the mathematicians’ (best) opinions; however, both alternatives are actually unavailable to the Platonist: the first one because it is in (...) tension with the idea that mathematical entities are causally ineffective, the second one because it is in tension with the suggestion that mathematical entities are mind-independent. John Divers and Alexander Miller have tried to reject the conclusion of this argument—according to which Platonism is inconsistent with a satisfactory epistemology for arithmetic—by redescribing the second horn of the dilemma in light of Crispin Wright’s notion of judgment-dependent truth; in particular they have contended that once arithmetical truth is conceived in this way the Platonist can have a substantial epistemology which does not conflict with the idea that the mathematical entities exist mind-independently. In this paper I analyze Wright’s notion of judgment-dependent truth, and reject Divers and Miller’s argument for the conclusion that arithmetical truth can be so characterized. In the final part, I address the worry that my argument generalizes very quickly to the conclusion that no area of discourse could be characterized as judgment-dependent. As against this conclusion, I indicate under what conditions—notably not satisfied in Divers and Miller’s case, but possibly satisfied in others—a discourse’s judgment-dependency can be successfully vindicated. (shrink)

Why, however, should it be necessarily wrong to discuss the nebulous in a businesslike manner?

In this paper we focus on transmission and failure of transmission of warrant. We identify three individually necessary and jointly sufficient conditions for transmission of warrant, and we show that their satisfaction grounds a number of interesting epistemic phenomena that have not been sufficiently appreciated in the literature. We then scrutinise Wright’s analysis of transmission failure and improve on extant readings of it. Nonetheless, we present a Bayesian counterexample that shows that Wright’s analysis is partially incoherent with our analysis of (...) warrant transmission and prima facie defective. We conclude exploring three alternative lines of reply: developing a more satisfactory account of transmission failure, which we outline; dismissing the Bayesian counterexample by rejecting some of its assumptions; reinterpreting Wright’s analysis to make it immune to the counterexample. (shrink)

The Meditations of Marcus Aurelius are treasured today--as they have been over the centuries--as an inexhaustible source of wisdom. And as one of the three most important expressions of Stoicism, this is an essential text for everyone interested in ancient religion and philosophy. Yet the clarity and ease of the work's style are deceptive. Pierre Hadot, eminent historian of ancient thought, uncovers new levels of meaning and expands our understanding of its underlying philosophy. Written by the Roman emperor for his (...) own private guidance and self-admonition, the Meditations set forth principles for living a good and just life. Hadot probes Marcus Aurelius's guidelines and convictions and discerns the hitherto unperceived conceptual system that grounds them. Abundantly quoting the Meditations to illustrate his analysis, the author allows Marcus Aurelius to speak directly to the reader. And Hadot unfolds for us the philosophical context of the Meditations, commenting on the philosophers Marcus Aurelius read and giving special attention to the teachings of Epictetus, whose disciple he was. The soul, the guiding principle within us, is in Marcus Aurelius's Stoic philosophy an inviolable stronghold of freedom, the "inner citadel." This spirited and engaging study of his thought offers a fresh picture of the fascinating philosopher-emperor, a fuller understanding of the tradition and doctrines of Stoicism, and rich insight on the culture of the Roman empire in the second century. Pierre Hadot has been working on Marcus Aurelius for more than twenty years; in this book he distills his analysis and conclusions with extraordinary lucidity for the general reader. (shrink)

This chapter introduces a novel account of fake news and explains how it differs from other definitions on the market. The account locates the fakeness of an alleged news report in two main aspects related to its production, namely that its creators do not think to have sufficient evidence in favor of what they divulge and they fail to display the appropriate attitude towards the truth of the information they share. A key feature of our analysis is that it does (...) not require that fake news must be circulated with the intention to deceive one’s audience. In this way, our account overcomes a potential limitation of the current philosophical discussion about fake news, which appears to individuate the main problem with this phenomenon in the fact that fake news consumers are misled and misinformed. In contrast, the proposed analysis shows that an additional (and perhaps equally fundamental) problem uncovered by the spread of fake news is a widespread pathological relationship with information, one on which we consume information not to satisfy our interest in the truth but to strengthen our social identities and quench our hunger for social recognition. (shrink)

The pandemic seems to have reversed the relationship between Knowledge and Communication: communication prevails and determines the significance and meaning of events, just as it happened in premodern times. Public knowledge is being eroded. Post-modern scientific knowledge, already unfathomably complex and technical, is both evolving and becoming obsolete at such great speed that it unveils, paradoxically, the vulnerability and relativity of the truth it claims to grasp. Alongside truth-correspondence and truth-coherence, the older truth-significance also makes itself known. Amplified by the (...) resonance chamber of new media and social networks, the latter can emerge as the “post-truth” and “fake-news” that transform Public Communication into Public Relations. (shrink)

The book sets out to analyse the notion of a priori justification and of a priori knowledge.

Come pensavano il tempo i Greci di eta arcaica, prima che Platone ed Aristotele ne formulassero una definizione? Nei miti, il tempo della natura, ciclico e rassicurante, non era messo a confronto con quello umano, imprevedibile anche se inesorabilmente determinato. Il ritmo scandito dal sole non era sovrapponibile a quelle della vita umana, l'avvicendarsi delle stagioni non misurava la durata della stirpe. Solo in eta sapienziale (VII-V secolo a.C.) si comincio a pensare il tempo in modo onnicomprensivo e si avverti (...) l'esigenza di misurarne il flusso. In quell'epoca, Eraclito tratteggio una concezione del tempo assolutamente innovativa, capace di ribaltare le visione del mondo trasmessa dai miti. Penso al tempo delle stagioni in analogia con quello interiore e vide nell'inesauribile creativita dell'anima umana lo specchio dell'infinita potenzialita della natura. La concezione offerta da Eraclito, avversata dai filosofi di eta classica e misconosciuta dalla scienza, trasmette ancora oggi, a chi legge con attenzione i frammenti rimasti della sua opera, un fiducioso messaggio di speranza nella capacita umana di vivere creativamente il tempo. (shrink)

AI can identify images, but cannot understand them as man does. The problem of understanding the iconic signs is the analogy, which cannot be clearly operationalized. Nothing guarantees signification by analogy, because it is neither the necessary effect of a cause, as in the indicative signs, nor the obligatory consequence of a rule, as of symbols. But the analogy is also fundamental to the human condition because our Ego implies the presence of Other. Or, just as the images, the understanding (...) of Other implies the analogy: he is a self like me, but another self than myself, that is, an analogous self. That is, you can understand the behavior of the other's activities and actions, even what he communicates as messages because you interpret them as if it were about yourself. Different from the human being who is an existent, in AI the essence precedes existence. Even if the algorithms of the analogy process will be infinitely perfected, that analogy will miss the interpretation that comes from the life of the existing one. AI knows digital, man understands analog; AI understands from knowledge, man knows from understanding. (shrink)

This article analyzes the institutional patterns of eight young democracies in Asia. The analysis originates from Lijphart's majoritarian-consensus framework. It illustrates that neither Lijphart's two-dimensional democracy pattern, nor an alternative pattern exists in Asia. Instead, the review of possible causes for the lack of conformity between Lijphart's patterns of democracy and the reality of the situation in Asia support the criticism in existing research literature regarding some of Lijphart's main assumptions and major conclusions. Furthermore, Asian realities provide only partial support (...) for Lijphart's advice that the consensus option is the more attractive option for countries that designed their first democratic constitutions. (shrink)

Based on narrative, iconographical, and liturgical sources, this is the first systematic study to trace the story of the ritual of royal self-coronations from Ancient Persia to the present. Exposing as myth the idea that Napoleon's act of self-coronation in 1804 was the first extraordinary event to break the secular tradition of kings being crowned by bishops, Jaume Aurell vividly demonstrates that self-coronations were not as transgressive or unconventional as has been imagined. Drawing on numerous examples of royal self-coronations, with (...) a particular focus on European Kings of the Middle Ages, including Frederic II of Germany, Alphonse XI of Castile, Peter IV of Aragon and Charles III of Navarra, Aurell draws on history, anthropology, ritual studies, liturgy and art history to explore royal self-coronations as privileged sites at which the frontiers and limits between the temporal and spiritual, politics and religion, tradition and innovation are encountered. (shrink)

A subject S's belief that Q is well-grounded if and only if it is based on a reason of S that gives S propositional justification for Q. Depending on the nature of S's reason, the process whereby S bases her belief that Q on it can vary. If S's reason is non-doxastic––like an experience that Q or a testimony that Q––S will need to form the belief that Q as a spontaneous and immediate response to that reason. If S's reason (...) is doxastic––like a belief that P––S will need to infer her belief that Q from it. The distinction between these two ways in which S's beliefs can be based on S's reasons is widely presupposed in current epistemology but––we argue in this paper––is not exhaustive. We give examples of quite ordinary situations in which a well-grounded belief of S appears to be based on S's reasons in neither of the ways described above. To accommodate these recalcitrant cases, we introduce the notion of enthymematic inference and defend the thesis that S can base a belief that Q on doxastic reasons P1, P2, …, Pn via inferring enthymematically Q from P1, P2, …, Pn. (shrink)

According to the implicit commitment thesis, once accepting a mathematical formal system S, one is implicitly committed to additional resources not immediately available in S. Traditionally, this thesis has been understood as entailing that, in accepting S, we are bound to accept reflection principles for S and therefore claims in the language of S that are not derivable in S itself. It has recently become clear, however, that such reading of the implicit commitment thesis cannot be compatible with well-established positions (...) in the foundations of mathematics which consider a specific theory S as self-justifying and doubt the legitimacy of any principle that is not derivable in S: examples are Tait’s finitism and the role played in it by Primitive Recursive Arithmetic, Isaacson’s thesis and Peano Arithmetic, Nelson’s ultrafinitism and sub-exponential arithmetical systems. This casts doubts on the very adequacy of the implicit commitment thesis for arithmetical theories. In the paper we show that such foundational standpoints are nonetheless compatible with the implicit commitment thesis. We also show that they can even be compatible with genuine soundness extensions of S with suitable form of reflection. The analysis we propose is as follows: when accepting a system S, we are bound to accept a fixed set of principles extending S and expressing minimal soundness requirements for S, such as the fact that the non-logical axioms of S are true. We call this invariant component the semantic core of implicit commitment. But there is also a variable component of implicit commitment that crucially depends on the justification given for our acceptance of S in which, for instance, may or may not appear reflection principles for S. We claim that the proposed framework regulates in a natural and uniform way our acceptance of different arithmetical theories. (shrink)

Transmission of justification across inference is a valuable and indeed ubiquitous epistemic phenomenon in everyday life and science. It is thanks to the phenomenon of epistemic transmission that inferential reasoning is a means for substantiating predictions of future events and, more generally, for expanding the sphere of our justified beliefs or reinforcing the justification of beliefs that we already entertain. However, transmission of justification is not without exceptions. As a few epistemologists have come to realise, more or less trivial forms (...) of circularity can prevent justification from transmitting from p to q even if one has justification for p and one is aware of the inferential link from p to q. In interesting cases this happens because one can acquire justification for p only if one has independent justification for q. In this case the justification for q cannot depend on the justification for p and the inferential link from p to q, as genuine transmission would require. The phenomenon of transmission failure seems to shed light on philosophical puzzles, such as Moore's proof of a material world and McKinsey's paradox, and it plays a central role in various philosophical debates. For this reason it is being granted continued and increasing attention. (shrink)

Western historiography experienced an important shift in the seventies due to the emergence of the theories associated with the linguistic turn, postmodernism and postestructuralism. Hayden White was one of the historians who led this transformation in the historical discipline. He argued that a historical text could be compared to a literary artifact on the leven of the form, since both use the same instrument —narrative— to representation the truth —whose content is factual events in history and fiction in literature. This (...) idea revolutionized contemporary approaches to the interpretation of historical texts. This paper analyzes White’s theories and its effects on contemporary historical writing. (shrink)