One widespread argument against the efficacy of subjective well-being as a measure of well-being is the adaptation problem as formulated by Sen and Nussbaum: the phenomenon that people may adapt to deprivation and find satisfaction or happiness in objectively bad circumstances. It is not generally noticed that there are two distinct arguments for why the phenomenon of adaptation is a problem for subjective well-being as a measure of well-being. The Axiological Adaptation Argument is a counter-example to theories of well-being that (...) rely on mental states. The Epistemic Adaptation Argument illustrates that levels of happiness or satisfaction cannot be measured well when people have adapted. I argue that the most serious threat to subjective well-being measures is not the Axiological Argument, but the Epistemic Argument. I reflect on the implications the epistemic problem has for the empirical literature in general, and for research on the phenomenon of adaptation in particular. (shrink)

We develop an approach to automatically identify the most probable multiword constructions used in children’s utterances, given syntactically annotated utterances from the Brown corpus of CHILDES. The found constructions cover many interesting linguistic phenomena from the language acquisition literature and show a progression from very concrete toward abstract constructions. We show quantitatively that for all children of the Brown corpus grammatical abstraction, defined as the relative number of variable slots in the productive units of their grammar, increases globally with age.

Philosophers have long agreed that moral responsibility might not only have a freedom condition, but also an epistemic condition. Moral responsibility and knowledge interact, but the question is exactly how. Ignorance might constitute an excuse, but the question is exactly when. Surprisingly enough, the epistemic condition has only recently attracted the attention of scholars, and it is high time for a full volume on the topic. The chapters in this volume address the following central questions. Does the epistemic condition require (...) akrasia? Why does blameless ignorance excuse? Does moral ignorance sustained by one’s culture excuse? Does the epistemic condition involve knowledge of the wrongness or wrongmaking features of one’s action? Is the epistemic condition an independent condition, or is it derivative from one’s quality of will or intentions? Is the epistemic condition sensitive to degrees of difficulty? Are there different kinds of moral responsibility and thus multiple epistemic conditions? Is the epistemic condition revisionary? What is the basic structure of the epistemic condition? (shrink)

Additionally, the text shows how to develop computationally feasible methods to mesh with this framework.

Throughout more than two millennia philosophers adhered massively to ideal standards of scientific rationality going back ultimately to Aristotle’s Analytica posteriora . These standards got progressively shaped by and adapted to new scientific needs and tendencies. Nevertheless, a core of conditions capturing the fundamentals of what a proper science should look like remained remarkably constant all along. Call this cluster of conditions the Classical Model of Science . In this paper we will do two things. First of all, we will (...) propose a general and systematized account of the Classical Model of Science. Secondly, we will offer an analysis of the philosophical significance of this model at different historical junctures by giving an overview of the connections it has had with a number of important topics. The latter include the analytic-synthetic distinction, the axiomatic method, the hierarchical order of sciences and the status of logic as a science. Our claim is that particularly fruitful insights are gained by seeing themes such as these against the background of the Classical Model of Science. In an appendix we deal with the historiographical background of this model by considering the systematizations of Aristotle’s theory of science offered by Heinrich Scholz, and in his footsteps by Evert W. Beth. (shrink)

The pivotal problem of comorbidity research lies in the psychometric foundation it rests on, that is, latent variable theory, in which a mental disorder is viewed as a latent variable that causes a constellation of symptoms. From this perspective, comorbidity is a (bi)directional relationship between multiple latent variables. We argue that such a latent variable perspective encounters serious problems in the study of comorbidity, and offer a radically different conceptualization in terms of a network approach, where comorbidity is hypothesized to (...) arise from direct relations between symptoms of multiple disorders. We propose a method to visualize comorbidity networks and, based on an empirical network for major depression and generalized anxiety, we argue that this approach generates realistic hypotheses about pathways to comorbidity, overlapping symptoms, and diagnostic boundaries, that are not naturally accommodated by latent variable models: Some pathways to comorbidity through the symptom space are more likely than others; those pathways generally have the same direction (i.e., from symptoms of one disorder to symptoms of the other); overlapping symptoms play an important role in comorbidity; and boundaries between diagnostic categories are necessarily fuzzy. (shrink)

We present a conservative extension of a Bayesian account of confirmation that can deal with the problem of old evidence and new theories. So-called open-minded Bayesianism challenges the assumption—implicit in standard Bayesianism—that the correct empirical hypothesis is among the ones currently under consideration. It requires the inclusion of a catch-all hypothesis, which is characterized by means of sets of probability assignments. Upon the introduction of a new theory, the former catch-all is decomposed into a new empirical hypothesis and a new (...) catch-all. As will be seen, this motivates a second update rule, besides Bayes’ rule, for updating probabilities in light of a new theory. This rule conserves probability ratios among the old hypotheses. This framework allows for old evidence to confirm a new hypothesis due to a shift in the theoretical context. The result is a version of Bayesianism that, in the words of Earman, “keep[s] an open mind, but not so open that your brain falls out”. (shrink)

According to an influential view by Elizabeth Harman, moral ignorance, as opposed to factual ignorance, never excuses one from blame. In defense of this view, Harman appeals to the following considerations: that moral ignorance always implies a lack of good will, and that moral truth is always accessible. In this paper, I clearly distinguish these considerations, and present challenges to both. If my arguments are successful, sometimes moral ignorance excuses.

Michelle Moody-Adams suggests that “the main obstacle to moral progress in social practices is the tendency to widespread affected ignorance of what can and should already be known.” This explanation is promising, though to understand it we need to know what willful (affected, motivated, strategic) ignorance actually is. This paper presents a novel analysis of this concept, which builds upon Moody-Adams (1994) and is contrasted with a recent account by Lynch (2016).

Strategic ignorance is a widespread phenomenon. In a laboratory setting, many participants avoid learning information about the consequences of their behaviour in order to act egoistically. In real life, many consumers avoid information about their purchases or the working conditions in which they were produced in order to retain their lifestyle. The question is whether agents are blameworthy for such strategically ignorant behaviour. In this paper, I explore quality of will resources, according to which agents are blameworthy, roughly, depending on (...) their moral concern. The account I will propose—the Maximal Account—has three innovative features: it utilizes a suitable concept of maximal moral concern, it offers an accountability version of the account which significantly differs from the more familiar attributability variant, and it maintains that agents without maximal concern are blameworthy. (shrink)

Two decades of research on euthanasia in the Netherlands have resulted into clear insights in the frequency and characteristics of euthanasia and other medical end-of-life decisions in the Netherlands. These empirical studies have contributed to the quality of the public debate, and to the regulating and public control of euthanasia and physician-assisted suicide. No slippery slope seems to have occurred. Physicians seem to adhere to the criteria for due care in the large majority of cases. Further, it has been shown (...) that the majority of physicians think that the euthanasia Act has improved their legal certainty and contributes to the carefulness of life-terminating acts. In 2005, eighty percent of the euthanasia cases were reported to the review committees. Thus, the transparency envisaged by the Act still does not extend to all cases. Unreported cases almost all involve the use of opioids, and are not considered to be euthanasia by physicians. More education and debate is needed to disentangle in these situations which acts should be regarded as euthanasia and which should not. Medical end-of-life decision-making is a crucial part of end-of-life care. It should therefore be given continuous attention in health care policy and medical training. Systematic periodic research is crucial for enhancing our understanding of end-of-life care in modern medicine, in which the pursuit of a good quality of dying is nowadays widely recognized as an important goal, in addition to the traditional goals such as curing diseases and prolonging life. (shrink)

According to Vallicella's 'Relations, Monism, and the Vindication of Bradley's Regress' (2002), if relations are to relate their relata, some special operator must do the relating. No other options will do. In this paper we reject Vallicella's conclusion by considering an important option that becomes visible only if we hold onto a precise distinction between the following three feature-pairs of relations: internality/externality, universality/particularity, relata-specificity/relata-unspecificity. The conclusion we reach is that if external relations are to relate their relata, they must be (...) relata-specific (and no special operator is needed). As it eschews unmereological complexes, this outcome is of relevance to defenders of the extensionality of composition. (shrink)

This paper concentrates on some aspects of the history of the analytic-synthetic distinction from Kant to Bolzano and Frege. This history evinces considerable continuity but also some important discontinuities. The analytic-synthetic distinction has to be seen in the first place in relation to a science, i.e. an ordered system of cognition. Looking especially to the place and role of logic it will be argued that Kant, Bolzano and Frege each developed the analytic-synthetic distinction within the same conception of scientific rationality, (...) that is, within the Classical Model of Science: scientific knowledge as cognitio ex principiis . But as we will see, the way the distinction between analytic and synthetic judgments or propositions functions within this model turns out to differ considerably between them. (shrink)

This introduction provides an overview of the current state of the debate on the epistemic condition of moral responsibility. In sect. 1, we discuss the main concepts ‘ignorance’ and ‘responsibility’. In sect. 2, we ask why agents should inform themselves. In sect. 3, we describe what we take to be the core agreement among main participants in the debate. In sect. 4, we explain how this agreement invites a regress argument with a revisionist implication. In sect. 5, we provide an (...) overview of the main responses to the regress argument. In sect. 6, we address the question why blameless ignorance excuses. In sect. 7, we describe further issues that are addressed in the book. In sect. 8, we conclude with some discussion of future directions the debate might take. (shrink)

Benjamin's famous description of the aura in the `Small History of Photography' starts: `What is aura? A strange texture of space and time...', and ends with: `That means breathing the aura of these mountains and this branch'. Until now, the meaning of `breathing' has hardly been subject to interpretation. In this article it will be shown that Benjamin refers to Goethe's `diastole/systole', and to Hölderlin's concept of the unity of antagonistic dispositions, for example the paradoxical constellation of the sacred/sobriety. To (...) Benjamin `breathing' means the original, prehistorical, situation of harmony and peace. Together with the decline of bourgeois society, parallel to the development of a new technology in photography and film, the aura disappears. In its place we find the dialectical image. Benjamin tries to show that the decline of the aura is not just some aesthetic question, but that it is connected to the traditional philosophical problem of defining the truth and the relation between myth and rationality. Referring to Benjamin's cosmological speculations, as well as to his references to Baudelaire, it can be argued that, notwithstanding his lyrical description of the aura, Benjamin was in favour of the destruction of the aura. Under the conditions of a capitalist economy and a malfunctioning republic, a society which can be defined as `false', the traditional idea of aura, being the `shine' of a true society, cannot be taken for granted. The `dialectical image', showing that antagonistic forces hide behind a `shine' of unity and harmony, enables us to see that the traditional idea of truth is obsolete and to look for a new solution. (shrink)

After more than 15 years of study, the 1/f noise or complex-systems approach to cognitive science has delivered promises of progress, colorful verbiage, and statistical analyses of phenomena whose relevance for cognition remains unclear. What the complex-systems approach has arguably failed to deliver are concrete insights about how people perceive, think, decide, and act. Without formal models that implement the proposed abstract concepts, the complex-systems approach to cognitive science runs the danger of becoming a philosophical exercise in futility. The complex-systems (...) approach can be informative and innovative, but only if it is implemented as a formal model that allows concrete prediction, falsification, and comparison against more traditional approaches. (shrink)

The dialogue between science and theology is no longer confined to discussing theology, physics and biology, but, as these essays make clear, sociology, psychology & neuroscience are now open for discussions between theologians and scientists.

The view that persons are entitled to respect because of their moral agency is commonplace in contemporary moral theory. What exactly this respect entails, however, is far less uncontroversial. In this book, Van der Rijt argues powerfully that this respect for persons’ moral agency must also encompass respect for their subjective moral judgments – even when these judgments can be shown to be fundamentally flawed. Van der Rijt scrutinises the role persons’ subjective moral judgments play within the context of coercion (...) and domination. His fresh, original analysis of Kant’s third formulation of the Categorical Imperative reveals how these judgments are intimately connected to a person’s dignity. The result is an insightful new account of coercion, a novel Kantian reformulation of the republican notion of non-domination and a compelling, innovative argument in favour of retributive justice. "In this admirably clear and insightful work, Van der Rijt develops an original account of coercion and dignity. On the basis of his analysis of the relation between these two concepts, he also provides an intriguing new angle on the nature of republicanism. I recommend this book to anyone interested in freedom and power and their roles in normative political theory." Ian Carter - University of Pavia "In this carefully argued and original study Jan-Willem van der Rijt offers an analysis of coercion, a broadly Kantian argument that coercion is an affront to dignity, and an illuminating contrast with Philip Pettit's republicanism. A most welcome contribution." Thomas E. Hill, Jr. - University of North Carolina at Chapel Hill "Jan-Willem van der Rijt has written a well argued, original book that will prove to be extremely helpful for the philosophical inquiry of the relationship between coercion and human dignity as well as for the assessment of republicanism and its consequences." Ralf Stoecker - University of Potsdam. (shrink)

BackgroundAn important principle underlying the Dutch Euthanasia Act is physicians' responsibility to alleviate patients' suffering. The Dutch Act states that euthanasia and physician-assisted suicide are not punishable if the attending physician acts in accordance with criteria of due care. These criteria concern the patient's request, the patient's suffering (unbearable and hopeless), the information provided to the patient, the presence of reasonable alternatives, consultation of another physician and the applied method of ending life. To demonstrate their compliance, the Act requires physicians (...) to report euthanasia to a review committee. We studied which arguments Dutch physicians use to substantiate their adherence to the criteria and which aspects attract review committees' attention.MethodsWe examined 158 files of reported euthanasia and physician-assisted suicide cases that were approved by the review committees. We studied the physicians' reports and the verdicts of the review committees by using a checklist.ResultsPhysicians reported that the patient's request had been well-considered because the patient was clear-headed (65%) and/or had repeated the request several times (23%). Unbearable suffering was often substantiated with physical symptoms (62%), function loss (33%), dependency (28%) or deterioration (15%). In 35%, physicians reported that there had been alternatives to relieve patients' suffering which were refused by the majority. The nature of the relationship with the consultant was sometimes unclear: the consultant was reported to have been an unknown colleague (39%), a known colleague (21%), otherwise (25%), or not clearly specified in the report (24%). Review committees relatively often scrutinized the consultation (41%) and the patient's (unbearable) suffering (32%); they had few questions about possible alternatives (1%).ConclusionDutch physicians substantiate their adherence to the criteria in a variable way with an emphasis on physical symptoms. The information they provide is in most cases sufficient to enable adequate review. Review committees' control seems to focus on (unbearable) suffering and on procedural issues. (shrink)

Pyrrhonism is the view that we should suspend all our beliefs in order to be rational and reach peace of mind. One of the main objections against this view is that it makes action impossible. One cannot suspend all beliefs and act normally at once. Yet, the question is: What is it about actions that they require beliefs? This issue has hardly been clarified in the literature. This is a bad situation, for if the objection fails and it turns out (...) that the Pyrrhonists found a way to secure peace of mind, we better know the details. In the following, I take up this systematic query and show how the objection can be made precise. Despite Sextus Empiricus? ingenious appearance/reality distinction, which is to ensure Pyrrhonism in this, I eventually argue that a life by appearances is quite unlike a normal life. (shrink)

Where the possibility of metaphysics as a science is concerned, Kant assigns the exact sciences the function of an exemplar; for these disciplines have long been well established on "the secure path of a science." Accordingly, in the Prolegomena Kant explicitly addresses the question "How is metaphysics possible as a science?" by way of the questions "How is pure mathematics possible?" and "How is pure natural science possible?" Moreover, all these questions arise directly out of the main transcendental question: "How (...) are synthetic judgments a priori possible?" The deplorable situation of the metaphysics of the day would have been entirely attributable to misappraisal of this central transcendental question. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

This article presents a generalization of the Condorcet Jury Theorem. All results to date assume a fixed value for the competence of jurors, or alternatively, a fixed probability distribution over the possible competences of jurors. In this article, we develop the idea that we can learn the competence of the jurors by the jury vote. We assume a uniform prior probability assignment over the competence parameter, and we adapt this assignment in the light of the jury vote. We then compute (...) the posterior probability, conditional on the jury vote, of the hypothesis voted over. We thereby retain the central results of Condorcet, but we also show that the posterior probability depends on the size of the jury as well as on the absolute margin of the majority. (shrink)

Quine's well-known ‘Two Dogmas of Empiricism’ (1951) plays a key role in the debate about the analytic-synthetic distinction. Taking to task the ideas of Carnap in particular, Quine shows that logical positivism works with a concept of scientific rationality that is based dogmatically on, among other things, the opposition analytic-synthetic.

The participation of vulnerable patients in clinical research poses apparent ethical dilemmas. Depending on the nature of the vulnerability, their participation may challenge the ethical principles of autonomy, non-maleficence, or justice. On the other hand, non-participation may preclude the building of a knowledge base that is a prerequisite for defining the optimal clinical management of vulnerable patients. Such clinical uncertainty may also incur substantial economic costs. We present the participation of pre-menopausal women with atrial fibrillation in trials of novel oral (...) anticoagulant drugs as a case study. Due to their non-participation in pivotal trials, it is uncertain whether for them, the risks that are associated with these drugs are outweighed by the advantages compared with conventional treatment. We addressed the question whether research of this new class of drugs in this subgroup would be appropriate from both, an ethical as well an economic perspective. We used the method of specifying norms as a wider framework to resolve the apparent ethical dilemma, while incorporating the question whether research of oral anticoagulants in premenopausal women with atrial fibrillation can be justified on economic grounds. For the latter, the results of a value-of-information analysis were used. Further clinical research on NOACs in premenopausal women with atrial fibrillation can be justified on both, ethical and economic grounds. Addressing apparent ethical dilemmas by invoking a method such as specifying norms can improve the quality of public practical reasoning. As such, the method should also prove valuable to committees that have formally been granted the authority to review trial protocols and proposals for scientific research. (shrink)

People cannot understand intentions behind observed actions by direct simulation, because goal inference is highly context dependent. Context dependency is a major source of computational intractability in traditional information-processing models. An embodied embedded view of cognition may be able to overcome this problem, but then the problem needs recognition and explication within the context of the new, layered cognitive architecture.

Zwischen 1934 und 1939 war die Zeitschrift für Sozialforschung für Walter Benjamin die zuverlässigste Publikationsmöglichkeit. Auch finanziell war Benjamin von der, vom ´Institut für Sozialforschung herausgegebenen, Zeitschrift abhängig. Zwei seiner wichtigsten Essays, L´oeuvre d´art à l´époque de sa reproduction mécanisée , Über einige Motive bei Baudelaire und vier weitere Beiträge erschienen in der Zeitschrift.Um die ersten beiden Texte entwickelten sich zwischen Adorno, der als Sachwalter der Redaktion auftrat, teilweise Horkheimer einerseits und Benjamin anderseits äußerst heftige Kontroversen. Es ging dabei nicht (...) nur darum, inwiefern marxistische Optionen unverhüllt ausgesprochen werden durften, sondern vor allem um systematische Fragen, die zwischen Adorno und Benjamin strittig waren und blieben. Mehr als die veröffentlichten Essays der beiden gibt der Briefwechsel zwischen Adorno und Benjamin überraschende Aufschlüsse über die tiefer liegenden, kontroversen Konzepte von Dialektik und anthropologischem Materialismus. (shrink)

Background The European Union aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury, aiming to inform and stimulate initiatives to improve efficiency. Methods We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury. (...) Documents included detailed information on IRB procedures and the duration from IRB submission until approval. They were translated and analyzed to determine the level of harmonization of IRB procedures within Europe. Results From 18 countries, 66 centers provided the requested documents. The primary IRB review was conducted centrally or locally and primary IRB approval was obtained after one, two or three review rounds with a median duration of respectively 50 and 98 days until primary IRB approval. Additional IRB approval was required in 55% of countries and could increase duration to 535 days. Total duration from submission until required IRB approval was obtained was 114 days and appeared to be shorter after submission to local IRBs compared to central IRBs. Conclusion We found variation in IRB procedures between and within European countries. There were differences in submission and approval requirements, number of review rounds and total duration. Research collaborations could benefit from the implementation of more uniform legislation and regulation while acknowledging local cultural habits and moral values between countries. (shrink)

If an argument can be reconstructed in at least two different ways, then which reconstruction is to be preferred? In this paper I address this problem of argument reconstruction in terms of Ryle’s infinite regress argument against the view that knowledge-how requires knowledge-that. First, I demonstrate that Ryle’s initial statement of the argument does not fix its reconstruction as it admits two, structurally different reconstructions. On the basis of this case and infinite regress arguments generally, I defend a revisionary take (...) on argument reconstruction: argument reconstruction is mainly to be ruled by charity (viz. by general criteria which arguments have to fulfil in order to be good arguments) rather than interpretation. (shrink)