Ageing is a complex phenomenon which remains a major challenge to modern biology. Although the evolutionary biology of ageing is well understood, the mechanisms that limit lifespan are unknown. The isolation and analysis of single‐gene mutations which extend lifespan (Age mutations) is likely to reveal processes which influence ageing. Caenorhabditis elegans is the only metazoan in which Age mutations have been identified. The Age mutations not only prolong life, but also confer a complex array of other phenotypes. Some of these (...) phenotypes provide clues to the evolutionary origins of these genes while others allude to mechanisms of lifespan‐extension. Many of the Age genes interact and share a second common phenotype, that of stress resistance. Rather than invertebrate ageing being determined by a ‘clock mechanism’, a picture is emerging of ageing as a non‐adaptive process determined, in part, by resistance to intrinsic stress mediated by stress‐response genes. (shrink)

Putting forward a new case for ethical intuitionism, Trevor Curnow finds its roots in the wisdom traditions of antiquity, while also drawing on Eastern philosophy and modern psychology.

This paper first argues that we can bring out a tension between the following three popular doctrines: (i) the canonical reduction of metaphysical modality to essence, due to Fine, (ii) contingentism, which says that possibly something could have failed to be something, and (iii) the doctrine that metaphysical modality obeys the modal logic S5. After presenting two such arguments (one from the theorems of S4 and another from the theorems of B), I turn to exploring various conclusions we might draw (...) in light of these results, and argue that none comes cost free. In the course of laying out possible responses to my arguments, we'll have a chance to evaluate various doctrines about the interplay between contingency and essence, as well as develop some alternative reductions of metaphysical modality to essence. I don't decisively come down in favor of one response over the others, though I say some things that point towards the conclusion that essence has no role to play in reducing metaphysical modality. (shrink)

Religious-secular distinctions have been crucial to the way in which modern governments have rationalised their governance and marked out their sovereignty – as crucial as the territorial boundaries that they have drawn around nations. The authors of this volume provide a multi-dimensional picture of how the category of religion has served the ends of modern government. They draw on perspectives from history, anthropology, moral philosophy, theology and religious studies, as well as empirical analysis of India, Japan, Mexico, the United States, (...) Israel-Palestine, France and the United Kingdom. (shrink)

In Pragmatism’s Evolution, Trevor Pearce demonstrates that the philosophical tradition of pragmatism owes an enormous debt to specific biological debates in the late 1800s, especially those concerning the role of the environment in development and evolution. Many are familiar with John Dewey’s 1909 assertion that evolutionary ideas overturned two thousand years of philosophy—but what exactly happened in the fifty years prior to Dewey’s claim? What form did evolutionary ideas take? When and how were they received by American philosophers? Although (...) the various thinkers associated with pragmatism—from Charles Sanders Peirce to Jane Addams and beyond—were towering figures in American intellectual life, few realize the full extent of their engagement with the life sciences. In his analysis, Pearce focuses on a series of debates in biology from 1860 to 1910—from the instincts of honeybees to the inheritance of acquired characteristics—in which the pragmatists were active participants. If we want to understand the pragmatists and their influence, Pearce argues, we need to understand the relationship between pragmatism and biology. (shrink)

The consensus among spacetime substantivalists is to respond to Leibniz's classic shift arguments, and their contemporary incarnation in the form of the hole argument, by pruning the allegedly problematic metaphysical possibilities that generate these arguments. Some substantivalists do so by directly appealing to a modal doctrine akin to anti-haecceitism. Other substantivalists do so by appealing to an underlying hyperintensional doctrine that implies some such modal doctrine. My first aim in this paper is to pose a challenge for all extant forms (...) of this consensus position. My second aim is to show what form substantivalism must take in order to uphold the consensus while addressing this challenge. The result is a novel "plenitudinous" substantivalist view, which predicts that certain modal facts about spacetime are vague or indeterminate. I then argue against this view on independent grounds, concluding that substantivalists should reject the consensus position. The paper also discusses the way forward for substantivalists in light of this conclusion. (shrink)

The hole argument purports to show that all spacetime theories of a certain form are indeterministic, including the General Theory of Relativity. The argument has given rise to an industry of searching for a metaphysics of spacetime that delivers the right modal implications to rescue determinism. In this paper, I first argue that certain prominent extant replies to the hole argument—namely, those that appeal to an essentialist doctrine about spacetime—fail to deliver the requisite modal implications. As part of my argument, (...) I show that threats to determinism of the sort brought out by the hole argument are more general than has heretofore been recognized. I then use these results to propose a novel essentialist doctrine about spacetime that successfully rescues determinism, what I call sufficiency metric essentialism. However, I go on to argue that once we realize what an essentialist doctrine about spacetime must look like in order to address the hole argument, we should reject all such doctrines, because they can't fulfill their ambition of improving on standard modal replies to the argument. I close by suggesting some lessons for future work on spacetime and the metaphysics of physics more broadly, and also drawing some general morals for contemporary metaphysics, in particular about (i) whether essence can be used to articulate a precise structuralist doctrine, and (ii) the relationship between essence and modality. (shrink)

Formal criteria of theoretical equivalence are mathematical mappings between specific sorts of mathematical objects, notably including those objects used in mathematical physics. Proponents of formal criteria claim that results involving these criteria have implications that extend beyond pure mathematics. For instance, they claim that formal criteria bear on the project of using our best mathematical physics as a guide to what the world is like, and also have deflationary implications for various debates in the metaphysics of physics. In this paper, (...) I investigate whether there is a defensible view according to which formal criteria have significant non-mathematical implications, of these sorts or any other, reaching a chiefly negative verdict. Along the way, I discuss various foundational issues concerning how we use mathematical objects to describe the world when doing physics, and how this practice should inform metaphysics. I diagnose the prominence of formal criteria as stemming from contentious views on these foundational issues, and endeavor to motivate some alternative views in their stead. (shrink)

Environmental ethicists have not reached a consensus about whether or not individuals who contribute to climate change have a moral obligation to reduce their personal greenhouse gas emissions. In this paper, I side with those who think that such individuals do have such an obligation by appealing to the concept of integrity. I argue that adopting a political commitment to work toward a collective solution to climate change—a commitment we all ought to share—requires also adopting a personal commitment to reduce (...) one’s emissions. On these grounds, individuals who contribute to climate change have a prima facie moral duty to lower their personal greenhouse gas emissions. After presenting this argument and supporting each of its premises, I defend it from two major lines of objection: skepticism about integrity’s status as a virtue and concerns that the resulting moral duty would be too demanding to be morally required. I then consider the role that an appeal to integrity could play in galvanizing the American public to take personal and political action regarding climate change. (shrink)

This book examines the link between population growth and environmental impact and explores the implications of this connection for the ethics of procreation. In light of climate change, species extinctions, and other looming environmental crises, Trevor Hedberg argues that we have a collective moral duty to halt population growth to prevent environmental harms from escalating. This book assesses a variety of policies that could help us meet this moral duty, confronts the conflict between protecting the welfare of future people (...) and upholding procreative freedom, evaluates the ethical dimensions of individual procreative decisions, and sketches the implications of population growth for issues like abortion and immigration. It is not a book of tidy solutions: Hedberg highlights some scenarios where nothing we can do will enable us to avoid treating some people unjustly. In such scenarios, the overall objective is to determine which of our available options will minimize the injustice that occurs. This book will be of great interest to those studying environmental ethics, environmental policy, climate change, sustainability, and population policy. (shrink)

In my contribution to this symposium on Miriam McCormick's Believing Against the Evidence, I challenge her claim that true beliefs are not valuable for their own sake. I argue that positing that true beliefs have at least some non-instrumental value better explains our attitudes toward the pursuit of truth than her alternative view. McCormick offers a response in the next segment of the symposium.

Making Knowledge presents the work of leading anthropologists who promote pioneering approaches to understanding the nature and social constitution of human knowledge. The book offers a progressive interdisciplinary approach to the subject and covers a rich and diverse ethnography. Presents cutting-edge research and theory in anthropology. Includes many beautiful illustrations throughout. The contributions cover a rich and diverse ethnography. Offers a progressive interdisciplinary approach to the eternal questions concerning 'human knowledge' Contributions by leading scholars in the field who explore a (...) wide range of disciplines through an anthropological perspective"--Provided by publisher. (shrink)

This commentary aims to place Grace de Laguna’s critique of pragmatism in its historical context. It examines her 1904 response to Henry Heath Bawden, her 1909 attack on John Dewey’s immediate empiricism, and her 1910 book Dogmatism and Evolution, focusing on the following question: Why did she describe her approach as an attempt to complete the pragmatists’ Darwinian revolution in logic?

I demonstrate that a set of well-known objections defeat John Stuart Mill’s plural voting proposal, but do not defeat plural voting as such. I adopt the following as a working definition of political equality: a voting system is egalitarian if and only if departures from a baseline of equally weighted votes are normatively permissible. I develop an alternative proposal, called procedural plural voting, which allocates plural votes procedurally, via the free choices of the electorate, rather than according to a substantive (...) standard of competence. The alternative avoids standards objections to Mill’s proposal. Moreover, reflection on the alternative plural voting scheme disrupts our intuitions about what counts as an egalitarian voting system. Undue emphasis on Mill’s version of plural voting obscures three important reasons to reject plural voting in favor of strictly egalitarian voting systems: that certain choices that generate inequalities of political power are morally impermissible; that even... (shrink)

We live in anagewhere"progressive" intellectualspresuppose that true democracy demands the affirmation of "global values" and the drive toward a world government, a"universal and homogenous state." Intellectuals, journalists, and educators bemoan the effects of "globalization" even as they uncritically endorse cosmopolitanism and dismissnational attachments as parochial and outdated. They confuse thoughtful patriotism - and commitment to the self-governing nation - with the narrowest form of nationalism. In a wonderfullylucid and learned essay, Trevor Shelley recovers a humane liberal tradition, from Montesquieu (...) to Manent, that takes the political seriously and does full justice to the legitimate claims of both universality and particularity. Whether discussing Tocqueville's critique of the pantheistic reveries of democratic man or Pierre Manent's erudite defense of the nation, the political form that provides the indispensable framework for democratic self-government, Shelley thoughtfully illumines the place and limits of globalization in a democratic age. --Daniel J. Mahoney, Augustine Chair in Distinguished Scholarship, Assumption College. (shrink)

Scholarship on European imperialism in the Americas has become increasingly prominent in the historiography of early America after a long period when the subject was hardly discussed. Historians have come to see that local experience in the Americas needs to be placed in a wider, comparative Atlantic context. They have realised that what united most peoples’ experiences in the Americas was that they lived as colonial subjects within colonies that were part of imperial polities. This article examines recent writings on (...) European empires in the Americas, relating imperial history to related developments in fields such as Atlantic history. It suggests that renewed attention to imperialism allows historians to discuss in a fruitful fashion the relationship between power and authority in the formation of colonial societies and draws attention to the continuing importance of metropolitan influence in the articulation of colonial identities. (shrink)

This book considers how language can be appropriately theorized as both a natural and cultural phenomenon. In reaching his conclusion, Pateman draws on a wide range of work in linguistics, philosophy, and social theory, and argues in defense of Chomsky and against Wittgenstein, all within the framework of a realist philosophy of science and contemporary social theory.

In this lively series of conversations with writer Michel Treguer, René Girard revisits the major concepts of mimetic theory and explores science, democracy, and the nature of God and freedom. Girard affirms that “our unprecedented present is incomprehensible without Christianity.” Globalization has unified the world, yet civil war and terrorism persist despite free trade and economic growth. Because of mimetic desire and the rivalry it generates, asserts Girard, “whether we’re talking about marriage, friendship, professional relationships, issues with neighbors or matters (...) of national unity, human relations are always under threat.” Literary masters including Marivaux, Dostoevsky, and Joyce understood this, as did archaic religion, which warded off violence with blood sacrifice. Christianity brought a new understanding of sacrifice, giving rise not only to modern rationality and science but also to a fragile system that is, in Girard’s words, “always teetering between a new golden age and a destructive apocalypse.” Treguer, a skeptic of mimetic theory, wonders: “Is what he’s telling me true...or is it just a nice story, a way of looking at things?” In response, Girard makes a compelling case for his theory. (shrink)

Significant challenges arise for clinical care teams when a patient or surrogate decision-maker hopes a miracle will occur. This article answers the question, “How should clinical bioethicists respond when a medical decision-maker uses the hope for a miracle to orient her medical decisions?” We argue the ethicist must first understand the complexity of the miracle-invocation. To this end, we provide a taxonomy of miracle-invocations that assist the ethicist in analyzing the invocator's conceptions of God, community, and self. After the ethicist (...) appreciates how these concepts influence the invocator's worldview, she can begin responding to this hope with specific practices. We discuss these practices in detail and offer concrete recommendations for a justified response to the hope for a miracle. (shrink)

This study examines the use of a modified form of the theory of planned behavior in understanding the decisions of undergraduate students in engineering and humanities to engage in cheating. We surveyed 527 randomly selected students from three academic institutions. Results supported the use of the model in predicting ethical decision-making regarding cheating. In particular, the model demonstrated how certain variables (gender, discipline, high school cheating, education level, international student status, participation in Greek organizations or other clubs) and moral constructs (...) related to intention to cheat, attitudes toward cheating, perceptions of norms with respect to cheating, and ultimately cheating behaviors. Further the relative importance of the theory of planned behavior constructs was consistent regardless of context, whereas the contributions of variables included in the study that were outside the theory varied by context. Of particular note were findings suggesting that the extent of cheating in high school was a strong predictor of cheating in college and that engineering students reported cheating more frequently than students in the humanities, even when controlling for the number of opportunities to do so. (shrink)

Supererogatory acts, those which are praiseworthy but not obligatory, have become a significant topic in contemporary moral philosophy, primarily because morally supererogatory acts have proven difficult to reconcile with other important aspects of normative ethics. However, despite the similarities between ethics and epistemology, epistemic supererogation has received very little attention. In this paper, I aim to further the discussion of supererogation by arguing for the existence of epistemically supererogatory acts and considering the potential implications of their existence. First, I offer (...) a brief account of moral supererogation and how morally supererogatory acts generate a strong intuition that a similar phenomenon should exist in epistemology. Afterward, I argue for the existence of epistemically supererogatory acts by examining five cases where an epistemic activity appears to be epistemically supererogatory. Epistemic supererogation appears to provide the best explanation for our considered judgments about the individuals’ behavior in these different cases. Finally, I consider how epistemic supererogation might impact the contemporary study of epistemology, particularly with regard to how we appraise certain epistemic duties. (shrink)