Some patients who are dependent on extracorporeal membrane oxygenation (ECMO) are alert and retain capacity to participate in decision-making, including decisions regarding whether to continue life...

For many people, open-air preaching is associated with a particularly limited understanding of the nature of the event. In part this is related to the fact that open-air preaching has received relatively little serious academic study. From a variety of sources, however, it is possible to piece together something of a critically analytic sketch of the practice. This sketch demonstrates that not only can open-air preaching claim longevity but that in turn it is a practice with considerable diversity as open-air (...) preachers seek to make meaning through their gathering and encounter with audiences. (shrink)

Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain (...) objections to Salmon's account of causal-mechanical explanation. I conclude by discussing how mechanistic explanations can provide understanding by unification. (shrink)

We assume that acting ethically is a skill. We then use a phenomenological description of five stages of skill acquisition to argue that an ethics based on principles corresponds to a beginner’s reliance on rules and so is developmentally inferior to an ethics based on expert response that claims that, after long experience, the ethical expert learns to respond appropriately to each unique situation. The skills model thus supports an ethics of situated involvement such as that of Aristotle, John Dewey, (...) and Carol Gilligan against the detached, rationalist ethics of Kant, John Rawls, Lawrence Kohlberg, and Jürgen Habermas. (shrink)

On 26 August 1974, Michel Foucault completed work on Discipline and Punish, and on that very same day began writing the first volume of The History of Sexuality. A little under ten years later, on 25 June 1984, shortly after the second and third volumes were published, he was dead. This decade is one of the most fascinating of his career. It begins with the initiation of the sexuality project, and ends with its enforced and premature closure. Yet in 1974 (...) he had something very different in mind for The History of Sexuality than the way things were left in 1984. Foucault originally planned a thematically organised series of six volumes, but wrote little of what he promised and published none of them. Instead over the course of the next decade he took his work in very different directions, studying, lecturing and writing about historical periods stretching back to antiquity. This book offers a detailed intellectual history of both the abandoned thematic project and the more properly historical version left incomplete at his death. It draws on all Foucault’s writings in this period, his courses at the Collège de France and lectures elsewhere, as well as material archived in France and California to provide a comprehensive overview and synthetic account of Foucault’s last decade. (shrink)

Over the past decade, public discussion has focused on the ethics of issuing Do‐Not‐Resuscitate Orders, and the failure of many hospitals to acknowledge their actions openly. Recent efforts on the part of some hospitals to establish formal DNR guidelines that are prudent, fair, and humane, are a helpful beginning, though they cannot account for all the vagaries of illness and human communication. But concerns about DNR should not divert us from looking closely and rigorously at other, more common treatment/nontreatment decisions (...) in the critical care setting. (shrink)

What is it for an individual thing in the natural world—a rock, a mouse, a family or a planet—to be made of other things—crystals, organs, animals, soil, water, or dirt? Rocks, mice, families and planets are composites, but how are we to understand the relation that holds between these composites and their component parts? My aim is to offer a new account of this relation, which I shall call corporeal composition. A central claim of my account is that corporeal composition (...) is grounded in causal relations between components. I will show how this claim, combined with a minimalist approach to causation—that causation is not one thing, but many—entails a position I call compositional minimalism—that composition is not one thing, but many. (shrink)

In the Realm of Criminal Law, Antony Duff seeks to defend the view that we should criminalize conduct only if it is wrongful. Skeptics of legal moralism argue that this occurs all the time in supposedly overinclusive offenses whose definitions capture not only the kind of conduct that constitutes the target wrong, but also a wider class of conduct that is not wrongful prior to prohibition. An example is statutory rape. Duff, in response, contends that such offenses need not violate (...) the requirements of legal moralism. Having exploitative sex with juveniles is obviously wrong even prior to its legal regulation. But having non-exploitative sex with juveniles is also potentially wrong, inasmuch as it involves a violation of a prohibition that society has decided is justified for instrumental reasons. While Duff’s analysis offers an ingenious explanation for why offenses like statutory rape need not violate the bare minimum requirements of legal moralism, it simultaneously exposes separate, largely unacknowledged, problems of fair labeling and proportionality. By combining in a single offense wrongs that are primarily malum in se with ones that are primarily malum prohibitum—a process referred to as “wrongfulness conflation”—we risk treating unlike wrongs alike, imposing disproportionate punishments, and blurring offense labels. And such problems occur not just in the context of statutory rape, but also with respect to a host of other supposedly overinclusive offenses, including various forms of sexual assault. (shrink)

Robustness with respect to climate models is often considered by philosophers of climate science to be a crucial issue in determining whether and to what extent the projections of the Earth’s future climate that models yield should be trusted. Parker (2011) and Lloyd (2009, 2015) have introduced influential accounts of robustness for climate models with seemingly conflicting conclusions. I argue that Parker and Lloyd are characterizing distinct notions of robustness and providing complementary insights. Confidence, if warranted, need be by virtue (...) of causally consistent climate models rather than by agreement upon projections by a diverse range of models. (shrink)

When it was published in 1980, the Diagnostic and Statistical Manual of Mental Disorders, third edition - universally known as DSM-III - embodied a new method for identifying psychiatric illness. The manual's authors and their supporters claimed that DSM-III's development was guided by scientific principles and evidence and that its innovative approach to diagnosis greatly ameliorated the problem of the unreliability of psychiatric diagnoses. In this paper we challenge the conventional wisdom about the research data used to support this claim. (...) Specifically, we argue that the rhetoric of science, more than the scientific data, was used convincingly by the developers of DSM-III to promote their new manual. We offer a re-analysis of the data gathered in the original DSM-III field trials in light of the interpretations that had been offered earlier for the reliability studies of others. We demonstrate how the standards for interpreting reliability were dramatically shifted over time in a direction that made it easier to claim success with DSM-III when, in fact, the data were equivocal. (shrink)

A new science, the science of complexity, is birthing. This science boldly promises to transform the biological and social sciences in the forthcoming century. My own book, Origins of Order: Self Organization and Selection in Evolution, (Kauffman, 1992), is at most one strand in this transformation. I feel deeply honored that Marjorie Grene undertook organizing a session at the Philosophy of Science meeting discussing Origins, and equally glad that Dick Burian, Bob Richardson and Rob Page have undertaken their reading of (...) the manuscript and careful thoughts. In this article I shall characterize the book, but more importantly, set it in the broader context of the emerging sciences of complexity. Although the book is not yet out of Oxford press’s quiet womb, my own thinking has moved beyond that which I had formulated even a half year ago. Meanwhile, in the broader scientific community, the interest in “complexity” is exploding. (shrink)

While some philosophers of history have argued that explanations in human history are of a fundamentally different kind than explanations in the natural sciences, I shall argue that this is not the case. Human beings are part of nature, human history is part of natural history, and human historical explanation is a species of natural historical explanation. In this paper I shall use a case study from the history of the American Civil War to show the variety of close parallels (...) between natural and human historical explanation. In both instances, I shall argue that these explanations involve narrative descriptions of causal mechanisms. I shall show how adopting a mechanistic approach to explanation can provide resources to address some important aspects of human historiographic explanation, including problems concerning event individuation, historical meaning, agency, the role of laws, and the nature of contingency. (shrink)

The overwhelming majority of commentary on fetal pain has looked at the maturation of cortical pathways to decide a lower age limit for fetal pain. This approach assumes pain can be felt directly from neural activation and ignores psychological development. Here we propose that neural activation is a necessary but not a sufficient condition for phenomenological experience, including pain. Isolated neural activation is just one physical fact amongst an infinity of physical facts that requires order or structure to be isolated (...) and experienced. A new theoretical approach is necessary to understand essential phenomenological experience. We conjecture that infant caregiver interaction provides the necessary order or structure so that the infant can isolate fundamental sense experiences delivered by neural activity. Cortical structures provide the necessary neural basis for qualia but qualia are revealed as phenomenological only as the infant becomes a subjective self. (shrink)

From the operation of the universe to DNA, the brain and the economy, natural and social frequently describe their activity as being concerned with discovering mechanisms. Despite this fact, for much of the twentieth century philosophical discussions of the nature of mechanisms remained outside philosophy of science. This is an outstanding reference source to the key topics, problems and debates in this exciting subject and is the first collection of its kind. Comprising over thirty chapters by a team of international (...) contributors the Handbook is divided into four parts: Historical Perspectives on Mechanisms; The Nature of Mechanisms; Mechanisms and the Philosophy of Science; Disciplinary Perspectives. Within these sections central topics and problems are examined, including the rise of mechanical philosophy in the seventeenth century; mechanisms as parts and wholes and their interactive powers; mechanisms and laws and regularities; how mechanisms are discovered and explained; dynamical systems theory; and disciplinary perspectives from physics, chemistry, biology, biomedicine, ecology, neuroscience and the social and political sciences. Essential reading for students and researchers in philosophy of science and philosophy the Handbook will also be of interest to those in related fields, such as metaphysics, philosophy of psychology and history of science. (shrink)

Contemporary evolutionary theory, derived from the intellectual marriage of Darwin's and Mendel's discoveries, leads us to view organisms as successful, but essentially ad hoc, responses to chance and necessity. Biological universals, the code, the pentadactyl limb, are frozen accidents shared by descent. The source of biological order has come to be seen as selection itself. This paper argues that this view is fundamentally inadequate. It ignores those underlying sources of biological order which derive from the generic self-organizing properties of the (...) biological building blocks. Among these generic properties are almost universal aspects of phase resetting responses in biological rhythmic systems, fascinating properties of continuity, symmetry and handedness seen in pattern regeneration across distant phyla; and statistically robust properties expected of eukaryotic gene regulatory systems persistently subject to mutations which "scramble" regulatory interactions. These examples suggest that many properties in organisms reflect a balance between selection, and the rich generic properties which would occur in the absence of selection. Where the balance is "close" to generic, a new pattern of evolutionary inference, and an ahistorical source of biological universals may be found: Those properties reflect, not selection, but the self-organizing features of the building blocks. (shrink)

The study of adhesion plaques in normal and transformed cells provides a series of phenotypic markers by which the process of transformation can be followed. Several proteins which are concentrated in adhesion plaques have now been identified; a few of these can act as targets for tyrosine kinase. In an attempt to characterize the relationship between tyrosine phosphorylation and cell transformation, the reactions of three such proteins – vinculin, talin and integrin – with a range of tyrosine kinase oncogene products (...) have been studied in detail. (shrink)

_Outlines a mystical theology and experience of the sacred founded on the absence of god._.

Finding an appropriate place for STS within the American science and engineering curriculum has never been easy. Convincing science, engineering, and medical students, and their professors, to pay serious attention to the broader context of their respective professions seems to require a sustained dialogue across conventional disciplinary boundaries. Otherwise, STS ends up talking mostly to itself and its critics rather than to its most important audience, students (at all levels) and the general public (especially museum visitors). This essay considers a (...) number of historical and present-day examples to argue that the founding vision of STS as a collaborative enterprise still offers some valuable lessons about how best to reach that audience. (shrink)