The precise orchestration of two opposing protein complexes – one in the cytoplasm (β‐catenin destruction complex) and the other at the plasma membrane (LRP6 signaling complex) – is critical for controlling levels of the transcriptional co‐factor β‐catenin, and subsequent activation of the Wnt/β‐catenin signal transduction pathway. The Wnt pathway component Axin acts as an essential scaffold for the assembly of both complexes. How the β‐catenin destruction and LRP6 signaling complexes are modulated following Wnt stimulation remains controversial. A recent study in (...) Science by He and coworkers reveals an underlying logic for Wnt pathway control in which Axin phosphorylation toggles a switch between the active and inactive states. This mini‐review focuses on this and two other recent studies that provide insight into the initial signaling events triggered by Wnt exposure. We emphasize regulation of the β‐catenin destruction and LRP6 signaling complexes and propose a framework for future work in this area. (shrink)

How to communicate with "the other" who is culturally different from oneself is one of the greatest challenges facing North-South relations. This paper builds on existential-phenomenological and poststructuralist concepts of alterity and difference to strengthen the position of Latina and other subaltern speakers in North-South dialogue. It defends a postcolonial approach to feminist theory as a basis for negotiating culturally differentiated feminist positions in this age of accelerated globalization, migration, and displacement.

The distinction between heterosexuality and homosexuality does not allow for sufficient attention to be given to the question of non-normative heterosexualities. This paper develops a feminist critique of normative sexuality, focusing on alternative readings of sex and/or gender offered by Beauvoir and Irigaray. Despite their differences, both accounts contribute significantly to dismantling the lure of normative sexuality in heterosexual relations-a dismantling necessary to the construction of a feminist social and political order.

El presente artículo se enfoca en el abordaje de la problemática socioambiental y sus diferentes aristas recrudecidas en el contexto pandémico, enfatizando en su relación con la dimensión temporal en que transcurre su desarrollo. El eje argumentativo se concentra en aquellos elementos del sistema que, desde la perspectiva de esta investigación, se vislumbran cómo impedimentos para mitigar su profundización, a pesar de las evidencias científicas de sus posibles consecuencias, anticipadas desde mitad del siglo XX. Lo cual podría considerarse como “la (...) crónica de una crisis anunciada”. Para dar cuenta de ello, el trabajo se organiza en torno al análisis de las principales contradicciones y dimensiones que dan cuenta del contexto de emergencia de la ruptura ambiental y la definición de algunas de sus posibles disyuntivas, delineadas en los márgenes de un futuro de configuración incierta. (shrink)

Ofelia Schutte holds that these conflicting assessments result from a failure to distinguish between two paradigms of power found in Nietzsche's work: power as ...

This chapter contains sections titled: Latin American Subaltern Studies Post‐Occidentalism and Border Gnosis Cultural Criticism Concluding Thoughts References.

Environmental theory and practice can benefit greatly from Emmanuel Levinas’ non-ontological philosophy of the Other in order to address the current global environmental crisis. From this viewpoint, this article focuses on 2 major positions within deep ecology. We discuss the significance of transitioning from one of them, which represents biocentric responsibility, to the other, which seeks to achieve environmental justice by challenging the hegemony of institutionalised environmentalism. In Levinasian terms, this is represented by moving from the anarchic realm of ethics (...) (face-to-face) to the totalising realm of politics (humanity), where the naked face of the Other becomes visible in the presence of a Third, and decision-making and concrete disputes resolution becomes necessary. Within this framework, historical and current inequalities compel the global North to degrow in order to allow the Others to weather the consequences of resource overconsumption and inequality. (shrink)

At the beginning of the sixteenth century, in the lands that are now the United States (the forty-eight contiguous states, Alaska and Hawaii), there must have been many hundreds of distinct languages. Fewer than two hundred remain, and the future of these is decidedly insecure, even where the remoteness of the location (in the case of Inuit in Northern Alaska) or the large size of the speech community (in the case of Navajo in the Southwest) might seem to protect the (...) community from language loss. Yet even this vastly reduced reservoir of linguistic diversity constitutes one of the great treasures of humanity, an enormous storehouse of expressive power and profound understandings of the universe. The loss of the hundreds of languages that have already passed into history is an intellectual catastrophe in every way comparable in magnitude to the ecological catastrophe we face today as the earth's tropical forests are swept by fire. Each language still spoken is fundamental to the personal, social and - a key term in the discourse of indigenous peoples - spiritual identity of its speakers. They know that without these languages they would be less than they are, and they are engaged in the most urgent struggles to protect their linguistic heritage. The goal of this paper is to review the contexts and practices of this struggle, in the hope that people everywhere will support it. (shrink)

Ecrire en philosophie consiste à rechercher "le problème d'une oeuvre", affirme Deleuze après Bergson. En s'inspirant de cette recommandation, l'auteur cherche à construire le problème de l'oeuvre du "premier" Deleuze, d'Empirisme et subjectivité à Différence et répétition. Le problème central est celui de la définition de la pensée : que signifie penser et s'orienter dans la pensée? Comment commencer sans présupposés? Ce volume examine le point de départ de la pensée de Deleuze qui consiste dans la critique de l'image de (...) la pensée comme représentation. Il restitue fidèlement sa pensée sans simplification ni jargon. (shrink)

À la manière de Sartre, qui renonce à la question de l'essence de la littérature et lui préfère celle de son utilité, Deleuze interroge, non l'essence de l'art, mais son usage pour le philosophe. Selon Deleuze, l'art est nécessaire au philosophe pour penser sa propre condition. En effet, pour échapper à la représentation qui dénature et assujettit la pensée, la philosophie exige un détour par l'art qui transforme à la fois l'exercice de la pensée et les conditions de l'expérience. L'usage (...) de l'art, c'est ce que fait l'art. L'art capte des forces (il rend visibles des forces invisibles) et transforme, à la fois, l'artiste et le corps social (il bouleverse les manières de sentir et de penser). Cette nouvelle manière de penser et d'user de l'art déborde le cadre habituel des études esthétiques. Il s'agit ici d'établir une périodisation de la question de l'art dans l'oeuvre de Deleuze, en fonction des problèmes qu'il pose. On retiendra trois périodes qui sont trois philosophies de l'art : la première accorde la priorité à la littérature ; la deuxième opère le passage du littéraire au sémiotique, en mettant en lumière le rôle politique de l'art ; et la troisième élabore une sémiotique de l'image, à partir de la peinture et du cinéma. (shrink)

Abstract:This essay presents and discusses how James Rennel (1742–1830), a royal cartographer in eighteenth-century Bengal and father of British Modern Geography, presented and discussed the biblical concept of "exile" as a "practice" for the benefit of the empire. Following Rennell's readings in Biblical and Classical texts, this essay shows how Rennell intervened in contemporary European debates about Jews and trade.

"El libro tiene dos grandes temas: la identidad cultural, sobre la que se expresan opiniones balanceadas entre los extremos posibles, y la 'liberacion social', entendida en general como liberacion con respecto a estructuras opresivas. El itinerario de e.

In this paper I want to pursue some variations on Hegelian philosophy, some responses and elaborations of aspects of Hegel’s thought, which have appeared in Latin America, and which contribute to a new understanding of the philosophical experience as it has taken place in Latin America.

Se realizó un estudio cuantitativo-cualitativo con un diseño descriptivo, analítico e interpretativo, en el que se indagó si la investigación ocupa un espacio relevante en los treinta y cinco planes curriculares de las carreras profesionales de una universidad pública del Perú. Se constató, además, si se programaron competencias investigativas digitales. Finalmente, se analizó si la investigación formativa se encuentra inserta en los currículos. La muestra fue censal y como instrumento se aplicó una matriz de análisis de contenidos para recoger información (...) sobre las categorías establecidas previamente. Los resultados reflejaron diversidad en los contenidos de los planes curriculares estudiados. (shrink)

What is sovereignty? Often taken for granted or seen as the ideology of European states vying for supremacy and conquest, the concept of sovereignty remains underexamined both in the history of its practices and in its aesthetic and intellectual underpinnings. Using global intellectual history as a bridge between approaches, periods, and areas, The Scaffolding of Sovereignty deploys a comparative and theoretically rich conception of sovereignty to reconsider the different schemes on which it has been based or renewed, the public stages (...) on which it is erected or destroyed, and the images and ideas on which it rests. The essays in The Scaffolding of Sovereignty reveal that sovereignty has always been supported, complemented, and enforced by a complex aesthetic and intellectual scaffolding. This collection takes a multidisciplinary approach to investigating the concept on a global scale, ranging from an account of a Manchu emperor building a mosque to a discussion of the continuing power of Lenin’s corpse, from an analysis of the death of kings in classical Greek tragedy to an exploration of the imagery of “the people” in the Age of Revolutions. Across seventeen chapters that closely study specific historical regimes and conflicts, the book’s contributors examine intersections of authority, power, theatricality, science and medicine, jurisdiction, rulership, human rights, scholarship, religious and popular ideas, and international legal thought that support or undermine different instances of sovereign power and its representations. (shrink)

« Comme toute grande philosophie, celle de Deleuze avant Guattari et avec Guattari renouvelle la définition de la pensée. Depuis Différence et répétition, la pensée n’est pour Deleuze ni naturelle ni spontanée, elle est le produit d’une genèse : Deleuze part d’une critique de l’image représentative de la pensée qui lui permet de dégager le vrai commencement de la pensée, ses conditions réelles. Avec cette genèse, grâce à laquelle la pensée se cherche un sol autre que la représentation en renonçant (...) en même temps à tout fondement, Deleuze résout, pour son propre compte, le problème du commencement en philosophie, en faisant surgir une pensée sans image. Par la suite, Deleuze et Guattari construisent ensemble une nouvelle métaphysique qui semble se passer, en apparence seulement, des notions d’image de la pensée et de pensée sans image. En réalité, à l’unique « Image de la pensée » qu’il s’agissait de détruire dans Différence et répétition, Deleuze et Guattari substituent, dès Mille plateaux, une pluralité d’images de la pensée, chacune étant historiquement et singulièrement déterminée. Ils esquissent même dans cet ouvrage l’idée d’une « noologie » qu’ils prendraient pour objet d’étude. Ces images deviendront les plans d’immanence de Qu’est-ce que la philosophie?. Quant à la pensée sans image, nous montrerons que, loin de disparaître, elle prend différentes formes, notamment celle du chaos, dans leur dernier ouvrage. Notre hypothèse est donc que, sous des vocables changeants, ces deux idées, comme leur relation mise à jour par Deleuze, ne disparaissent pas de leur métaphysique commune. ». (shrink)

La saturación ecológica del planeta a la que hemos llegado hace insostenible el actual modo de vida de la humanidad, por lo que es necesario tomar medidas drásticas para reinsertar nuestras prácticas dentro de los límites biofísicos que nos impone. Para ello, es necesario hacer frente a dos tendencias de nuestra sociedad, que en la obra de Jorge Riechmann se desarrollan como: consumo desmedido y humanidad en fuga. Contra éstas, el autor propone la autocontención –una ética de la suficiencia– y (...) el desarrollo de una humanidad fronteriza. El diálogo entre esta teoría y otros autores de la corriente crítica nos permite desentrañar las características de la sociedad actual que causan estas tendencias autodestructivas, como así también los principios filosóficos que sustentan la propuesta del autor. Consideramos que la humanidad fronteriza que propone Riechmann no debe fabricarse desde cero, en cambio, puede encontrarse en los márgenes de la civilización occidental, donde los modos de vida se han desarrollado históricamente dentro de los límites biofísicos que impone su ambiente. Nos referimos a países del sur global, culturas ancestrales y campesinas, que son menospreciadas por el pensamiento dominante de la modernidad tardía, muchas veces bajo el mote de barbarie, y que, no obstante, cumplen con los principios éticos desarrollados en este trabajo. (shrink)

In Speculum of the Other Woman (1974), Luce Irigaray argues that "any theory of the subject has always been appropriated by the masculine." This paper offers an analysis of Irigaray's critique of subjectivity and examines the psychological mechanism referred to as "the phallic economy of castration." A different way of conceiving the relation between subject and object is explored by imagining a new subject of desire.

: This paper responds to comments, queries, and criticisms offered by Alcoff, Bergoffen, and Ferguson at a scholar's session on my work held at the annual meeting of the Society for Phenomenology and Existential Philosophy in October 2001. Responding to Alcoff, I highlight my understanding of liberation in the context of a Nietzschean and a Latin American feminism and the politics of conceptualizing "resistance" in postcolonial theory. Responding to Ferguson, I address, among other issues, the often misunderstood distinction between postcolonialism (...) and postmodernism, as well as related implications regarding some postcolonial feminists' qualified appeals to universals and women's rights. Responding to Bergoffen, I advocate on behalf of cultural formations supportive of the feminist affirmation of life and of radical subjectivities that challenge gender orthodoxies. (shrink)

This comprehensive collection of original essays written by aninternational group of scholars addresses the central themes inLatin American philosophy. Represents the most comprehensive survey of historical andcontemporary Latin American philosophy available today Comprises a specially commissioned collection of essays, manyof them written by Latin American authors Examines the history of Latin American philosophy and itscurrent issues, traces the development of the discipline, andoffers biographical sketches of key Latin American thinkers Showcases the diversity of approaches, issues, and styles thatcharacterize the field.

In Speculum of the Other Woman, Luce Irigaray argues that “any theory of the subject has always been appropriated by the masculine.” This paper offers an analysis of Irigaray's critique of subjectivity and examines the psychological mechanism referred to as “the phallic economy of castration.” A different way of conceiving the relation between subject and object is explored by imagining a new subject of desire.

This article considers María Lugones's work in Pilgrimages/Peregrinajes, especially her association of the fragmented self with modernity, in order to understand the existential grounds of what she calls an impure, perceptually aware, mestizaje. It suggests that the impure Latina self validated thereby may be seen retrospectively as the forerunner of the decolonial feminist self who unveils the coloniality of gender analysis. Noting some discrepancies between them, the article questions whether Lugones's use of Quijano's world systems theory leads to an overdetermining (...) historical approach that disables the spirit of inquiry for diversely situated Latinas, even as the theory itself invokes the heterogeneity of their experiences. The dilemma is illustrated by two types of peregrinas: a community-bound peregrina who easily undertakes the decolonial turn, and a diasporic peregrina who may or may not pass its guarded gate. The question remains: what difference does the divergence between these two peregrinas's paths make? (shrink)

It may be that the process of socialization is generally thought to depend upon the development of the slave consciousness. It appears that at present the type of indoctrination a child receives when he or she is socialized by parents and teachers is the general way in which a society makes sure it transmits its values from one generation to the next. If this is so, the analysis of the slave consciousness we have been pursuing would fundamentally call into question (...) the benefits that are to be expected from this most pervasive and fundamental social practice. The development of the heteronomous conscience does not simply guarantee that the citizen will comply with the standards of society; it also guarantees that individuals will develop (some to a greater extent than others) such socially disruptive attitudes as a revengeful sense of justice and a psychological predisposition toward envy. Furthermore, given the massive amounts of social inequality and injustice characterizing many contemporary societies, the combination of economic and psychological factors almost guarantees a tacit or explicit level of frustration which will often erupt into violence. This violence is senseless, repeated, and pervasive because it is nothing but the nourishment needed by the slave consciousness to maintain itself in power. Exploitation, murder, rape, war, the nuclear weapons contest, the polarization of groups against each other, etc., are manifestations of a consciousness that always has to outdo itself vis-à-vis the other. As Nietzsche (1966, p. 140) observed, “Thus the will, the liberator, took to hurting; and on all who can suffer, it wreaks revenge for its inability to go backward [to a condition of autonomy].” With the liberation of imagination and memory, and a combined dedication to fighting all forms of social injustice, however, one can begin to transform society in ways that will confirm rather than deny the human aspiration for harmony and freedom. (shrink)

In Latin America, institutionalized feminist philosophy is a recent phenomenon, dating for the most part since the 1980s. Historically, the gifted writer/philosopher/poet Sor Juana Inés de la Cruz (Mexico, Colonial Period) and the utopian socialist activist Flora Tristán (France and Peru) are especially recognized for their original feminist contributions. The Uruguayan philosopher Carlos Vaz Ferreira wrote the moderately pro‐feminist treatise Sobre feminismo in 1918, during the suffragist phase of the movement. Contemporary feminist philosophy has followed the general theoretical trends established (...) since the 1970s in Western European and Anglo‐American feminist philosophy and theory. Feminist philosophers have challenged traditional androcentric readings of the canon and have pursued alliances with colleagues in Women's Studies programs. As of the mid‐1990s, a firm tradition of feminist studies has been established in several countries. Important feminist journals and publications include Debate feminista (Mexico), Estudos feministas (Brazil), Isis Internacional (Chile), and Feminaria (Argentina); Hiparquía (Argentina) currently publishes feminist and non‐feminist articles by women philosophers. (shrink)

This chapter contains section titled: Defining Postcolonial Feminisms US—based Postcolonial Theory Feminist Postcolonial Criticism What about Latin American Postcolonialism? References Further Reading.

Introduction to the special cluster of feminist philosophy papers from Spain and Latin America.

This chapter contains sections titled: Feminist Philosophy in a Historical Context Feminist Perspectives in Philosophy Feminist Methodologies: Key Issues New Orientations References Further Reading.

This paper articulates a methodological strategy for creating a “conceptual home” whose aim is the enabling and promotion of Latin American feminist philosophy in the context of Latin American feminist theory's concern for the relationship between theory and practice. The author argues that philosophy as a discipline is still too compromised by masculine-dominant, Anglocentric, and Eurocentric ways of representing knowledge such that discursive and ideological impediments make it difficult to conceive and develop ways of feminist theorizing that arise from an (...) interpellation of the philosopher by the Latin American conditions affecting her social and cultural life. The author offers a fourfold approach to grounding knowledge, based on the principles of pursuing a critical approach to knowledge, a concern for the relationship of theory and practice, an orientation toward progressive political projects of freedom and liberation in the context of Latin American history and politics, and a transformative politics of culture. It is argued that through such specific methodological concerns, Latin American feminist philosophy can attain a distinct identity and stop depending for its articulation on paradigms of knowledge whose premises are not necessarily best attuned to understand the issues it must confront in its sociocultural practice. (shrink)