The precise orchestration of two opposing protein complexes – one in the cytoplasm (β‐catenin destruction complex) and the other at the plasma membrane (LRP6 signaling complex) – is critical for controlling levels of the transcriptional co‐factor β‐catenin, and subsequent activation of the Wnt/β‐catenin signal transduction pathway. The Wnt pathway component Axin acts as an essential scaffold for the assembly of both complexes. How the β‐catenin destruction and LRP6 signaling complexes are modulated following Wnt stimulation remains controversial. A recent study in (...) Science by He and coworkers reveals an underlying logic for Wnt pathway control in which Axin phosphorylation toggles a switch between the active and inactive states. This mini‐review focuses on this and two other recent studies that provide insight into the initial signaling events triggered by Wnt exposure. We emphasize regulation of the β‐catenin destruction and LRP6 signaling complexes and propose a framework for future work in this area. (shrink)

For synchronization of a class of chaotic systems in the presence of nonvanishing uncertainties, a novel time-varying gain observer-based sliding mode control is proposed. First, a novel time-varying gain disturbance observer is developed to estimate the uncertainties. Then, by using the output of TVGDO to modify sliding mode control, a new TVGDO-based SMC scheme is developed. Although the observation and control precision of conventional fixed gain disturbance observer-based control for chaotic systems can be guaranteed by a high observer gain, the (...) undesirable spike problem may be caused by the high gain if the initial values of estimate and true states are not equal. The most attractive feature of this work is that the newly proposed TVGDO can eliminate the spike problem by developing a time-varying gain scheme. Finally, the effectiveness of the proposed method is demonstrated by the numerical simulation. (shrink)

Standard animalists are committed to a stringent form of restricted composition, thereby denying the existence of brains, hands, and other proper parts of an organism . One reason for positing this near-nihilistic ontology comes from various challenges to animalism such as the Thinking Parts Argument, the Unity Argument, and the Argument from the Problem of the Many. In this paper, I show that these putatively distinct arguments are all instances of a more general problem, which I call the ‘Too Many (...) Candidates Problem’ . Given my formulation of the problem, it is evident that standard animalists are mistaken in believing that restricting composition is the only solution. I show that there is another option for solving the TMC. The advantage of such a position, which I call ‘unrestricted animalism’, is that it is compatible with unrestricted composition and the existence of brains and other proper parts of an organism. I conclude by sketching several strategies one can take regarding this latter solution to the TMC. (shrink)

In trying to establish the view that there are no non-living macrophysical objects, Trenton Merricks has produced an influential argument—the Overdetermination Argument—against the causal efficacy of composite objects. A serious problem for the Overdetermination Argument is the ambiguity in the notion of overdetermination that is being employed, which is due to the fact that Merricks does not provide any theory of causation to support his claims. Once we adopt a plausible theory of causation, viz. interventionism, problems with the Overdetermination will (...) become evident. After laying out the Overdetermination Argument and examining one extant objection to it, I will explicate the relevant aspects of an interventionist theory of causation and provide a characterization of overdetermination that follows from such an account. From this, I will argue that the Causal Principle that undergirds the Overdetermination Argument is false and hence the argument is invalid; and I claim that the only other available characterization of overdetermination would render a key premise in the argument false. Thus, the Overdetermination Argument fails to provide us with any reason to deny the causal efficacy of macrophysical objects, and therefore provides no reason to doubt their existence. (shrink)

At the crossroads of poetry and philosophy: Francis Ponge and Maurice Merleau-Ponty The aim of the present article is to clarify the place of the sensitive dictionary in the work of Francis Ponge and to show how it denotes human's relationship to nature. To achieve that, we will use the body question as a measure of the human–nature relationship and apply the phenomenological method that Ponge took over from Merleau-Ponty. It should be noted that Merleau-Ponty rarely makes reference to Ponge's (...) poems, except for a few incisions in his Causeries. As for Ponge, he uses explicitly only the notion of phenomenological reduction to explain his project of sensitive dictionary. However, we will argue that there are many similarities of thought between the philosopher and the poet, which are still unexplored. (shrink)

This paper first shows that some versions of the logic R of Relevance do not satisfy the relevance principle introduced by Anderson and Belnap, the principle of which is generally accepted as the principle for relevance. After considering several possible (but defective) improvements of the relevance principle, this paper presents a new relevance principle for (three versions of) R, and explains why this principle is better than the original and others.

Quantum B-algebras, the partially ordered implicational algebras arising as subreducts of quantales, are introduced axiomatically. It is shown that they provide a unified semantic for non-commutative algebraic logic. Specifically, they cover the vast majority of implicational algebras like BCK-algebras, residuated lattices, partially ordered groups, BL- and MV-algebras, effect algebras, and their non-commutative extensions. The opposite of the category of quantum B-algebras is shown to be equivalent to the category of logical quantales, in the way that every quantum B-algebra admits a (...) natural embedding into a logical quantale, the enveloping quantale. Partially defined products of algebras related to effect algebras are handled efficiently in this way. The unit group of the enveloping quantale of a quantum B-algebra X is shown to be always contained in X, which gives a functorial subgroup X× of X. Similar subfunctors are obtained for the non-commutative extensions of BCK-algebras and effect algebras. The results of Galatos, Jónsson, and Tsinakis on the splitting of generalized BL-algebras into a semidirect product of a partially ordered group operating on an integral residuated poset are extended to a characterization of twisted semidirect products of a po-group by a quantum B-algebra. (shrink)

Social Trinitarianism is a family of views that bear some resemblance to each other in a way that distinguishes them from other Trinitarian accounts. In this paper, we address recent objections by Carl Mosser against ST, objections which have not received much attention by defenders of ST. Mosser claims that proponents of ST offer a narrative that is historically inaccurate, employs concepts of personhood and perichoresis that are incompatible, upholds dubious hermeneutical assumptions, and is unable to preclude Mormon theology within (...) its fold. We argue that all four criticisms fail, especially for a specific version of ST: Perichoretic Monotheism. (shrink)

PurposeAsian Americans comprise 21% of matriculating medical students in the United States but little is known about their mental health. With the growing focus on addressing the mental health of medical students, this systematic, nationwide survey assesses the relationship between anxiety and depression symptoms and coping skills among Asian American medical students.Materials and methodsA survey tool comprised of Patient Health Questionnaire-9, General Anxiety Disorder-7, and questions related to coping were emailed to members of the Asian Pacific American Medical Students Association (...) enrolled in a United States medical school during the 2016–2017 academic year. We evaluated associations between anxiety and coping as well as depression and coping.ResultsA total of 511 Asian American medical students completed the survey. Anxiety symptoms were positively correlated with an increase in negative coping skills. Depressive symptoms were not correlated with an increase in negative coping skills.ConclusionProfessionals and medical schools that aim to improve the mental health of medical students should be aware of the needs of specific populations. Asian American students who experience anxiety were more likely to utilize avoidant or negative coping strategies. In addition, Asian American students who experience depressive symptoms were not more likely to utilize these negative coping strategies. Further research must be done to evaluate the factors that influence the use of negative coping strategies to better address anxiety within the Asian American medical student population. (shrink)

It can be a great challenge for second language learners to comprehend meanings that are implied in utterances rather than the surface meaning of what was said. Moreover, L2 learners’ attitudes toward pragmatic learning are unknown. This mixed-methods study investigates L2 learners’ ability to comprehend conversational implicatures. It also explores their beliefs about and intentions to develop this ability using Ajzen’s theory of planned behavior. A total of 498 freshmen from a public university in China participated in the study. Data (...) were collected using a web-based test, stimulated recall tasks and semi-structured interviews. Results show that the participants differed in recognizing the intended meanings. Complicated factors account for the variations. In addition to the types of implicature, learners’ beliefs about developing pragmatic comprehension also influence their learning intention, and subsequent performance. These beliefs include learners’ multi-layered, complex attitudes toward the outcomes of pragmatic learning, perceived self-efficacy beliefs regarding language proficiency and L2 cultural knowledge, actual behavioral control over opportunities and resources for pragmatic learning, and perceptions of less social pressure on pragmatic learning. The use of TPB may help language teachers and test designers to understand learners’ beliefs about L2 pragmatic learning in the English as a foreign language context. Understanding the factors influencing learners’ intention will help design more effective teaching curricula that may integrate pragmatic instruction and testing in the future. (shrink)

The present study investigated the crossover effects of employee perceptions of servant leadership and job social support on the family satisfaction and quality of family life experienced by the employees’ spouses. These effects were explored through a focus on the mediating role of employee organization-based self-esteem. Results from a three-wave field survey of 199 employee–spouse dyads in the People’s Republic of China support our hypotheses, indicating that OBSE fully mediates the positive effects of servant leadership and job social support on (...) family satisfaction and quality of family life. These findings provide new theoretical directions for work–family research. (shrink)

A new venture barely makes a profit in its initial stage, and its success depends on innovation. Innovation is related to the work environment, and the innovation behavior of employees is of great significance to the performance improvement of new venture. Based on the previous research, in this study, hypotheses on the correlation between work environment, employee innovation behavior, and corporate performance are put forward first. Then, with team cooperation, organizational incentive, leadership support, sufficient resources, and work pressure as the (...) factors of the work environment, the bosses, middle and senior managers involved in entrepreneurship, and the main members of the entrepreneurial team of 202 newly established enterprises in developed regions are surveyed online or in scene. Multivariate hierarchical regression analysis is performed to analyze the data collected from the questionnaire. The results show that the effective recovery rate of the questionnaire is 86.4%; the number of traditional enterprises is 108, and that of R&D enterprises is 68 ; teamwork, leadership support, and work pressure are all correlated with employees’ innovative behavior ; employee innovation behavior is positively correlated with enterprise performance ; the working environment and employee innovation behavior promote enterprise performance ; and the working environment affects the relationship between employee innovation behavior and enterprise performance. The study theoretically enriches the research on the relationship between innovation behavior, work environment, and enterprise performance of new ventures. In practice, it is suggested that start-up enterprises provide good working environment for employees and attach importance to innovation activities at the individual level of employees, which provides useful guidance and reference for the development of Chinese start-up enterprises. (shrink)

This essay aims to explore Xunzi’s 荀子 problem, which was originally proposed by David S. Nivison. The problem revolves around a tension in Xunzi’s writings about human nature. In his chapter “Human Nature is Bad (Xing’e 性惡),” Xunzi states that humans have inborn selfish desires and natural feelings, and if they do not control or regulate these desires and feelings, there will certainly be chaos. However, in the chapter “The Regulations of a Sage King (Wangzhi 王制),” Xunzi argues that human (...) beings possess yi 義, which is an important feature distinguishing them from other creatures. I try to analyze how yi should be understood in the Xunzi by focusing on the relationship of yi with fen 分 (division) and li 禮 (ritual). In the process, I also consider Hall and Ames’s understanding of yi as “meaning-bestowing,” and pay attention to Xunzi’s mention that yi is something that enables human beings to jump from natural to social divisions. (shrink)

As more organizations adopt telecommuting or working from home, the work-connected behavior of their employees during non-working hours increases, weakening the boundary between work and family. However, no study has clearly identified whether and how work connectivity behavior after-hours affects employees’ work and family status. Therefore, using role theory, we explored the mechanisms by which WCBA affects employees’ thriving at work and family through work–family enrichment and work–family conflict, and compared the impact of different levels of support for family members (...) on work–family enrichment and conflict, using the Johnson–Neyman method. Our analysis of two-wave data from 257 employees led to the following findings. WCBA had a positive impact on thriving at work, but not on family. There is a ‘double-edged sword’ effect on the impact of WCBA on thriving at work, meaning that work–family enrichment can positively influence thriving at work and negatively influence work–family conflict. There is a double-edged sword effect on the impact of WCBA on thriving at family, meaning that work–family enrichment can positively influence thriving at family and negatively influence work–family conflict. The support of family members moderates the double-edged sword effect between WCBA and thriving at work, in that it can strengthen the positive effects of work–family enrichment and weaken the negative effects of work–family conflicts. Support from family members reinforces the positive impact of work–family enrichment on thriving at family. Thus our study reveals the mechanisms by which WCBA affects the thriving at work and family of employees, and identifies potential methods for managing different levels of work–family enrichment and work–family conflict from the perspective of family member support. (shrink)

Motivation has an effect on the rate and success of second language (L2) learning. However, little is known about its role in students’ levels of L2 pragmatic awareness. This study investigated whether and to what extent students’ L2 motivation influences their pragmatic awareness. A total of 498 Chinese university students completed a two-part web-based survey (an appropriateness judgement task and a motivation questionnaire), of whom 12 were subsequently interviewed. The quantitative results show that pragmatic awareness correlates positively with attitudes towards (...) the L2 community and the intended learning efforts. Moreover, a model combining the intended learning efforts, attitudes towards the L2 community and attitudes towards learning English can significantly predict pragmatic awareness. The analysis of semi-structured interviews reveals a mismatch between students’ immediate needs when learning English and outcomes of pragmatic acquisition, which may contribute to the absent correlation between overall levels of L2 motivation and pragmatic awareness. (shrink)

This article investigates Kripke-style semantics for two sorts of logics: pseudo-Boolean and weak-Boolean logics. As examples of the first, we introduce G3 and S53pB.G3 is the three-valued Dummett–Gödel logic; S53pB is the modal logic S5 but with its orthonegation replaced by a pB negation. Examples of wB logic are G3wB and S53wB.G3wB is G3 with a wB negation in place of its pB negation; S53wB is S5 with a wB negation replacing its orthonegation. For each system, we provide a three-valued (...) Kripke-style semantics with and without star operation . We prove soundness and completeness theorems in each case. Note that wB logics may be equivalent to logics with Baaz’s projection Δ. We finally introduce the G3 and the S53pB both with Δ and show that they are equivalent to G3wB and S53wB, respectively. (shrink)

Exemplary Figures (sometimes translated as Model Sayings) is an unabridged, annotated translation of Fayan, one of three major works by the Chinese court poet-philosopher Yang Xiong (53 BCE-18 CE). Yang sought to "renew the old" by patterning these works on earlier classics, drawing inspiration from the Confucian Analects for Exemplary Figures. In this philosophical masterwork, constructed as a dialogue, Yang poses and then answers questions on philosophical, political, ethical, and literary matters. Michael Nylan's rendering of this text, (...) which is laden with word play and is extraordinarily difficult to translate, is a joy to read-at turns wise, cautionary, and playful. (shrink)

No one denies the importance of applying knowledge to actions. But claiming identity (unity) of knowledge and action is quite another thing. There seem to be two problems with the claim: (1) the identity claim implies that the sole cause for one to fail to act on what one judges to be right is ignorance, but it is obviously false that the sole cause of failure in moral actions is ignorance. (2) The identity statement implies non-separation of knowledge and action. (...) But knowledge does not necessarily lead to action. However, the identity of knowledge and action is what a famous Ming Confucian scholar, W ang Yang-ming, proposed and the concept became the central doctrine of his teaching. Though there are several major interpretations of Wang’s doctrine in contemporary literature, it is not clear to me how they deal with the above mentioned difficulties. In this article, I will discuss these interpretations of the doctrine and propose a new interpretation. My purpose is to give an interpretation of Wang’s doctrine that has the capacity of dealing with these challenges to the doctrine and also captures the essence of his teaching. (shrink)

This study aims to investigate the effect of coronavirus disease 2019 on the Chinese public’s mental health during its early stage. We collected the data through an online questionnaire survey. Specifically, we adopted the impact of event scale-revised and state-trait anxiety inventory to assess symptomatic responses to exposure to traumatic life events and public anxiety, respectively, in the COVID-19 pandemic outbreak. Then, we evaluated the differences in the scores among various socio-demographic groups using Kruskal-Wakkis H tests and t-tests and analyzed (...) the IES-R, state anxiety score, and trait anxiety score using the Pearson correlation analysis. Finally, we conducted a path analysis to determine the mediating role of post-traumatic stress disorder symptoms in the relationship between TA and SA. The results show that the average of the SA and TA scores were 48.0 ± 10.4 and 38.0 ± 8.2, respectively; the respondents who suffered from mild, moderate, and severe psychological impacts because of the health crisis accounted for 21.9, 5.2, and 13.1%, respectively; farmers have the highest IES-R score than others; people with the highest income have the lowest SA level; a significant positive correlation existed between the IES-R and STAI scores; and TA produces both direct and indirect effects on SA. Overall, the general Chinese public exhibited much higher anxiety levels than normal in the early days of the pandemic outbreak. Accordingly, we strongly recommend psychological counseling and intervention support to mitigate the adverse psychological impacts of such an event. (shrink)

This paper combines two classes of generalized logics, one of which is the class of weakly implicative logics introduced by Cintula and the other of which is the class of gaggle logics introduced by Dunn. For this purpose we introduce implicational tonoid logics. More precisely, we first define implicational tonoid logics in general and examine their relation to weakly implicative logics. We then provide algebraic semantics for implicational tonoid logics. Finally, we consider relational semantics, called Routley–Meyer–style semantics, for finitary those (...) logics. (shrink)

ABSTRACT This article develops a theory of rhetorical impression through a critical genealogy of the term phantasia. The genealogy demonstrates cause for understanding phantasia as impression, not image. I trace phantasia as impression through the work of Plato and Aristotle but ultimately argue that the stoics offer the most productive leads for thinking through impressions, materiality, and sensations together. Specifically, I demonstrate how the stoics' concept of lekton can productively mediate the relationship between rhetoric, materiality, imagination, and idealism. In the (...) closing section, I suggest how a theory of rhetorical impression can address lacunae in existing new materialist approaches. (shrink)

To effectively improve the efficiency of international service design talent training and make it more in line with society's needs, we analyze the current status of international service design talent training and its professional training focus. Based on the above problems, from the perspective of cognitive psychology, artificial intelligence and human–computer interaction technology are used to construct the international service design talent training mode of the HCI intelligent service robot. This mode can be used to solve the existing teaching problems (...) by using novel means to ensure the quality of teaching. Finally, through the actual analysis of teaching cases, the effectiveness of the proposed talent training mode is verified. The HCI system is based on knowledge of cognitive psychology. According to the characteristics and functions of an educational robot, the robot is combined with traditional teaching activities, and the robot-assisted talent training mode is designed. Robot-assisted talent training is a feasible training method that can improve the efficiency of talent training. Students have confidence in their learning skills before the course, and the confidence is further strengthened after the end of the course. After the course, the students have a stronger sense of cooperation. This study can provide theoretical ideas for the research of international service talent training mode. (shrink)

To understand the gaps between current bioethics education and the requirements of practicing nurses, a semistructured questionnaire was used to invite the directors of nursing departments at all 82 teaching hospitals in Taiwan to participate in this survey. The response rate was 64.6%. Through content analysis we obtained information about previous bioethical training, required themes and content, recommended teaching strategies, and difficulties with education and its application. The results suggest that Taiwanese nursing personnel need to be instilled with both self-cultivation (...) of morality and mental cultivation to acquire nursing virtues and the right attitudes toward bioethical issues. Good communication skills to prevent damage to the harmonious relationships between patients, their families and medical team members, policies that support the provision of systematic formal knowledge of ethics, small group training, and clarification of values were also shown to be important in bioethics education. (shrink)

In the long 20th century, modern China experienced perhaps the world’s most radical and systematic secularization process and the decimation of traditional religious and ritual cultures. This article seeks to account for this experience by engaging with postcolonial theory, a body of discourse seldom found relevant to China Studies. The article attempts a two-pronged critique of both state secularization and some aspects of existing Postcolonial Studies/theory. It shows the many ways in which nationalist elites in modern China unwittingly absorbed Western (...) Orientalist discourse even as their words and actions were ostensibly anti-colonial, and much of the article examines the consequences of this native Orientalism upon Chinese religiosities. Finally, the article suggests that one cannot discuss governmentality in modern China without understanding how it is intertwined with a sovereign power that is both archaic and, at the same time, has experienced renewal and expansion in modernity. (shrink)

Recent research has suggested that young children may have primitive knowledge of ratio and proportions. However, it is unclear how precisely young children represent ratio magnitudes and how well...

This article starts with the environmental changes in human cognition, analyzes the virtual as the main feature of visual perception under digital technology, and explores the transition from passive to active human cognitive activities. With the diversified understanding of visual information, human contradiction of memory also began to become prominent. Aiming at the problem that the existing multimodal TV media recognition methods have low recognition rate of unknown application layer protocols, an adaptive clustering method for identifying unknown application layer protocols (...) is proposed. This method clusters application layer protocols based on similarity of the load characteristics of network stream application layer protocol data. The method divides the similarity calculation in the clustering algorithm to improve the clustering efficiency of the algorithm. Experimental results show that the proposed method can efficiently and accurately recognize unknown visual communication. This article proposes that, in the interactive multimodal visual information transmission, human visual perception experience has changed, the diversity of visual information content expression makes the aesthetic subject more personalized and stylized. (shrink)

In _On Human Action and Practical Wisdom_, Yang Guorong offers a description of wisdom and action based on his “concrete metaphysics.” Yang attempts to go beyond the excessively linguistic, logical, and abstract focus found in the American analytic tradition.

It is a well-documented phenomenon that individuals stop searching earlier than predicted by the optimal, risk-neutral stopping rule, leading to inefficient searches. Individuals' search behaviors during making investment decisions in financial markets can be easily affected by their peers. In this study, we designed a search game in a simplified experimental stock market in which subjects were required to search for the best sell prices for their stocks. By randomly assigning subjects into pairs and presenting them with real-time information on (...) their peers' searches, we investigated the effects of peers' decisions on search behaviors. The results showed that two subjects in the same group with real-time peer information learned and engaged in similar search behaviors. However, this peer effect did not exist when subjects had access to feedback information on the ex-post best response. In addition, we found that the presence of information about peers' decisions alone had no significant impact on search efficiency, whereas access to both information on peers' decisions and feedback information significantly improved subjects' search efficiency. (shrink)

The current work investigated whether differences in phonological overlap between the past- and present-tense forms of regular and irregular verbs can account for the graded neurophysiological effects of verb regularity observed in past-tense priming designs. Event-related potentials were recorded from 16 healthy participants who performed a lexical-decision task in which past-tense primes immediately preceded present-tense targets. To minimize intra-modal phonological priming effects, cross-modal presentation between auditory primes and visual targets was employed, and results were compared to a companion intra-modal auditory (...) study (Justus, T., Larsen, J., de Mornay Davies, P., Swick, D. (2008). Interpreting dissociations between regular and irregular past-tense morphology: evidence from event-related potentials. Cognitive, Affective, Behavioral Neuroscience, 8, 178–194.). For both regular and irregular verbs, faster response times and reduced N400 components were observed for present-tense forms when primed by the corresponding past-tense forms. Although behavioral facilitation was observed with a pseudopast phonological control condition, neither this condition nor an orthographic-phonological control produced significant N400 priming effects. Instead, these two types of priming were associated with a post-lexical anterior negativity (PLAN). Results are discussed with regard to dual- and single-system theories of inflectional morphology, as well as intra- and cross-modal prelexical priming. (shrink)

It has been suggested that damage to anterior regions of the left hemisphere results in a dissociation in the perception and lexical activation of past-tense forms. Specifically, in a lexical-decision task in which past-tense primes immediately precede present-tense targets, such patients demonstrate significant priming for irregular verbs (spoke–speak), but, unlike control participants, fail to do so for regular verbs (looked–look). Here, this behavioral dissociation was first confirmed in a group of eleven patients with damage to the pars opercularis (BA 44) (...) and pars triangularis (BA 45) of the left inferior frontal gyrus (i.e., Broca's area). Two conditions containing word-onset orthographic–phonological overlap (bead–bee, barge–bar) demonstrated that the disrupted regular-verb priming was accompanied by, and covaried with, disrupted ortho-phonological priming, regardless of whether prime stimuli contained the regular inflectional rhyme pattern. Further, the dissociation between impaired regular-verb and preserved irregular-verb priming was shown to be continuous rather than categorical; priming for weak-irregular verbs (spent–spend) was intermediate in size between that of regular verbs and strong verbs. Such continuous dissociations grounded in ortho-phonological relationships between present- and past-tense forms are predicted by single-system, connectionist approaches to inflectional morphology and not predicted by current dual-system, rule-based models. Event-related potential data demonstrated that N400 priming effects were intact for both regular and irregular verbs, suggesting that the absence of significant regular-verb priming in the response time data did not result from a disruption of lexical access, and may have stemmed instead from post-lexical events such as covert articulation, segmentation strategies, and/or cognitive control. (shrink)

Let [NB]₁ denote the ideal generated by nonbounding c.e. degrees and NCup the ideal of noncuppable c.e. degrees. We show that both [NB]₁ ∪ NCup and the ideal generated by nonbounding and noncuppable degrees are new, in the sense that they are different from M, [NB]₁ and NCup—the only three known definable ideals so far.