Understanding the mechanisms and the time and spatial evolution of penumbra following an ischemic stroke is crucially important for developing therapeutics aimed at preventing this area from evolving towards infarction. To help in integrating the available data, we decided to build a formal model. We first collected and categorised the major available evidence from animal models and human observations and summarized this knowledge in a flow-chart with the potential key components of an evolving stroke. Components were grouped in ten sub-models (...) that could be modelled and tested independently: the sub-models of tissue reactions, ionic movements, oedema development, glutamate excitotoxicity, spreading depression, NO synthesis, inflammation, necrosis, apoptosis, and reperfusion. Then, we figured out markers, identified mediators and chose the level of complexity to model these sub-models. We first applied this integrative approach to build a model based on cytotoxic oedema development following a stroke. Although this model includes only three sub-models and would need to integrate more mechanisms in each of these sub-models, the characteristics and the time and spatial evolution of penumbra obtained by simulation are qualitatively and, to some extent, quantitatively consistent with those observed using medical imaging after a permanent occlusion or after an occlusion followed by a reperfusion. (shrink)

We explore the contribution made by oscillatory, synchronous neural activity to representation in the brain. We closely examine six prominent examples of brain function in which neural oscillations play a central role, and identify two levels of involvement that these oscillations take in the emergence of representations: enabling (when oscillations help to establish a communication channel between sender and receiver, or are causally involved in triggering a representation) and properly representational (when oscillations are a constitutive part of the representation). We (...) show that even an idealized informational sender–receiver account of representation makes the representational status of oscillations a non-trivial matter, which depends on rather minute empirical details. (shrink)

John Rawls's work (1971) has greatly contributed to rehabilitating equality as a basic social value, after decades of utilitarian hegemony,particularly in normative economics, but Rawls also emphasized that full equality of welfare is not an adequate goal either. This thesis was echoed in Dworkin's famous twin papers on equality (Dworkin 1981a,b), and it is now widely accepted that egalitarianism must be selective. The bulk of the debate on ‘Equality of What?’ thus deals with what variables ought to be submitted for (...) selection and how this selection ought to be carried out. (shrink)

Logical puzzles like the doctrinal paradox raise the problem of how to aggregate individual judgements into a collective judgement, or alternatively, how to merge collectively inconsistent knowledge bases. In this paper, we view judgement aggregation as a function on propositional logic valuations, and we investigate how logic constrains judgement aggregation. In particular, we show that there is no non-dictatorial decision method for aggregating sets of judgements in a logically consistent way if the decision method is local, i.e., only depends on (...) the individual judgements on the proposition under consideration. (shrink)

The definition and measurement of social welfare have been a vexed issue for the past century. This book makes a constructive, easily applicable proposal and suggests how to evaluate the economic situation of a society in a way that gives priority to the worse-off and that respects each individual's preferences over his or her own consumption, work, leisure and so on. This approach resonates with the current concern to go 'beyond the GDP' in the measurement of social progress. Compared to (...) technical studies in welfare economics, this book emphasizes constructive results rather than paradoxes and impossibilities, and shows how one can start from basic principles of efficiency and fairness and end up with concrete evaluations of policies. Compared to more philosophical treatments of social justice, this book is more precise about the definition of social welfare and reaches conclusions about concrete policies and institutions only after a rigorous derivation from clearly stated principles. (shrink)

We shall focus on moral theories that are solely concerned with promoting the benefits (e.g., wellbeing) of individuals and explore the possibility of such theories ascribing some priority to benefits to those who are worse off—without this priority being absolute. Utilitarianism (which evaluates alternatives on the basis of total or average benefits) ascribes no priority to the worse off, and leximin (which evaluates alternatives by giving lexical priority to the worst off, and then the second worst off, and so on) (...) ascribes absolute priority to the worse off (i.e., favors even a very small benefit to a worse off person over very large benefits to large numbers of better off people). Neither extreme view, we assume, is plausible. (shrink)

This paper explains how the current architecture of the pharmaceutical markets has created a misalignment of financial incentives and public health that is a central cause of harmful practices. It explores three possible solutions to address that misalignment: taxes, increased financial penalties, and drug pricing based on value. Each proposal could help to partly realign financial incentives and public health. However, because of the limits of each proposal, there is no easy solution to fixing the problem of financial incentives.

In this paper, I aim to show that agency-based accounts of moral status are more plausible than many have previously thought. I do this by developing a novel account of moral status that takes agency, understood as the capacity for intentional action, to be the necessary and sufficient condition for the possession of moral status. This account also suggests that the capacities required for sentience entail the possession of agency, and the capacities required for agency, entail the possession of sentience. (...) Thus on this account sentient beings possess agency and agents possess sentience. If this is correct, it will show that an Agency Account of moral status can offer a plausible defence of the moral status of all sentient beings, something that previous Agency Accounts have not succeeded in doing. What is more, this account could establish that all sentient animals are not just moral status holders per se, but that they are owed pro tanto obligations regarding continued existence and liberty, similar in kind, though not always in strength, to those owed to humans. (shrink)

When considering the social valuation of a life-year, there is a conflict between two basic intuitions: on the one hand, the intuition of universality, according to which the value of an additional life-year should be universal, and, as such, should be invariant to the context considered; on the other hand, the intuition of complementarity, according to which the value of a life-year should depend on what this extra-life-year allows for, and, hence, on the quality of that life-year, because the quantity (...) of life and the quality of life are complement to each other. This paper proposes three distinct accounts of the intuition of universality, and shows that those accounts either conflict with a basic monotonicity property, or lead to indifference with respect to how life-years are distributed within the population. Those results support the abandon of the intuition of universality. But abandoning the intuition of universality does not prevent a social evaluator from giving priority, when allocating life-years, to individuals with the lowest quality of life. (shrink)

A prominent version of mathematical structuralism holds that mathematical objects are at bottom nothing but "positions in structures," purely relational entities without any sort of nature independent of the structure to which they belong. Such an ontology is often presented as a response to Benacerraf's "multiple reductions" problem, or motivated on hermeneutic grounds, as a faithful representation of the discourse and practice of mathematics. In this paper I argue that there are serious difficulties with this kind of view: its proponents (...) rely on a distinction between "essential" and "nonessential" features of mathematical objects, and there's no good way to articulate this distinction which is compatible with basic structuralist commitments. But all is not lost. For I further argue that the insights motivating structuralism (or at least those worth preserving) can be preserved without formulating the view in ontologically committal terms. (shrink)

Whilst Bayesian epistemology is widely regarded nowadays as our best theory of knowledge, there are still a relatively large number of incompatible and competing approaches falling under that umbrella. Very recently, Wallmann and Williamson wrote an interesting article that aims at showing that a subjective Bayesian who accepts the principal principle and uses a known physical chance as her degree of belief for an event A could end up having incoherent or very implausible beliefs if she subjectively chooses the probability (...) of an event F for which she has much poorer evidence. They also argued that their own version of objective Bayesianism is completely immune to that challenge. In this article, after having presented the strongest version of Wallmann’s and Williamson’s argument, I will show that if successful, it has far-reaching consequences and would not only invalidate moderate subjective Bayesianism and imprecise probalism but also a form of objective Bayesianism that relies on conditionalisation, the principal principle, reference classes, and the principle of indifference applied to the most basic partitions. I then argue that their argument can be defeated by adding the rule that it is always irrational to choose a probability that can be computed from the known probabilities associated to one’s other beliefs. I finally argue that the authors’ main intuition that probabilities have different degrees of reliability favours imprecise Bayesianism over precise Bayesianism. (shrink)

If a potential person would have a good life if he were to come into existence, can we coherently regard his coming into existence as better for him than his never coming into existence? And can we regard the situation in which he never comes into existence as worse for him? In this paper, we argue that both questions should be answered affirmatively. We also explain where prominent arguments to differing conclusions go wrong. Finally, we explore the relevance of our (...) answers to issues in population ethics. (shrink)

This article defends the principle of giving a fresh start to individuals who come to consider that they have mismanaged their share of resources at an earlier stage of their life. The first part challenges the ethical intuition that it would be unfair to tax the steadfast frugal in order to help the regretful spendthrift and argues that the possibility of changing one’s mind is an important freedom. The second part examines the disincentives induced by fresh-start policies. It shows that (...) even when individuals can strategically misrepresent their preferences, there remains a significant difference between unforgiving and forgiving policies. It shows that the optimal policy does not only redistribute funds, but also puts protective constraints on early individual decisions (for example, compulsory saving through social security taxes). Key Words: fairness • freedom • fresh start • incentives • preference changes • regret. (shrink)

This paper proposes an account of why proof is the only way to acquire knowledge of some mathematical proposition’s truth. Admittedly, non-deductive arguments for mathematical propositions can be strong and play important roles in mathematics. But this paper proposes a necessary condition for knowledge that can be satisfied by putative proofs (and proof sketches), as well as by non-deductive arguments in science, but not by non-deductive arguments from mathematical evidence. The necessary condition concerns whether we can justly expect that if (...) the mathematical proposition is actually false, despite the evidence for its truth, then this fact has an explanation. (shrink)

As the ubiquity of technology-mediated communication grows, so does the number of questions about the costs and benefits of replacing in-person interactions with technology-mediated ones. In the present study, we used a daily diary design to examine how people’s emotional experiences vary across in-person, video-, phone-, and text-mediated interactions in day-to-day life. We hypothesised that individuals would report less positive affect and more negative affect after less life-like interactions (where in-person is defined as the most life-like and text-mediated as the (...) least life-like). In line with this hypothesis, the analysis of 527 unique interactions reported by 102 individuals (mean age = 19.3; 85.6% female) over the course of 7 days reveals that people feel lonelier, sadder, less affectionate, less supported, and less happy following less life-like interactions. Additional analyses show that the links between life-like communication and momentary experiences are independent of properties of individual interactions such as interaction length and participants’ overall evaluations of interaction quality. These findings provide initial evidence that there may be inherent properties of common technology-mediated communication tools that may lead to momentary changes in affective experiences and make social connection more challenging. (shrink)

Improper dependencies slant policy over a drug's life span, biasing the development of new drugs, the testing and marketing approval for new drugs, and the monitoring of patient safety after drugs are marketed. This article examines five ways in which the public improperly depends on pharmaceutical firms that compromise the integrity of pharmaceutical policy. Today the public relies on pharmaceutical firms: (1) to set priorities on drug research and development; (2) to conduct clinical trials to test whether drugs are safe (...) and effective; (3) to decide what clinical trial data to disclose to the public; (4) to monitor post marketing drug safety; (5) to supply product information to physicians and to finance continuing medical education and other professional activities. The article suggests options to overcome each of these dependencies. (shrink)

The purist/partisan distinction has dominated recent discussions of sport spectatorship and sport aesthetics. The focus of such discussions, however, has been sport in general or, often implicitly, team sports in particular. Here, using mixed martial arts (MMA) as a case study, we argue that specific aspects of the sport in question can significantly affect how the purist/partisan distinction plays out for viewers. MMA’s status as an individual combat sport mitigates, in illuminating ways, the partisanship displayed so prominently among fans of (...) team sports. We also examine the role of external attitudes – in both the betting subculture of MMA and purist attitudes toward individual combat sports and martial arts – in shaping MMA spectatorship. (shrink)

Here I briefly discuss some comparative data on social play behaviour in hope of broadening the array of species in which researchers attempt to study animal morality. I am specifically concerned with the notion of ‘behaving fairly'. In the term ‘behaving fairly’ I use as a working guide the notion that animals often have social expectations when they engage in various sorts of social encounters the violation of which constitutes being treated unfairly because of a lapse in social etiquette. I (...) will cash this out below in my discussion of social play behaviour. (shrink)

If a potential person would have a good life if he were to come into existence, can we regard his coming into existence as better for him than his never coming into existence? And can we regard the situation in which he never comes into existence as worse for him? In this paper, we argue that both questions should be answered affirmatively.

Prescribing drugs for uses that the FDA has not approved — off-label drug use — can sometimes be justified but is typically not supported by substantial evidence of effectiveness. At the root of inappropriate off-label drug use lie perverse incentives for pharmaceutical firms and flawed oversight of prescribing physicians. Typical reform proposals such as increased sanctions for manufacturers might reduce the incidence of unjustified off-label use, but they do not remove the source of the problem. Public policy should address the (...) cause and control the practice. To manage inappropriate off-label drug use, off-label prescriptions must be tracked in order to monitor the risks and benefits and the manufacturers’ conduct. Even more important, reimbursement rules should be changed so that manufacturers cannot profit from off-label sales. When off-label sales pass a critical threshold, manufacturers should also be required to pay for independent testing of the safety and effectiveness of off-label drug uses and for the FDA to review the evidence. Manufacturers should also finance, under FDA supervision, programs designed to warn physicians and the public about the risks of off-label drug use. (shrink)

The heart of the matter -- The evolution of the French medicine -- Coping with physicians' conflicts of interest in France -- The rise of a protected medical market : the United States before 1950 -- The commercial transformation : the United States, 1950-1980 -- The logic of medical markets : the United States, 1980 to the present -- Coping with physicians' conflicts of interest in the United States -- The evolution of Japanese medicine -- Coping with physicians' conflicts of (...) interest in Japan -- Reforms -- Professionalism reconsidered. (shrink)

Dad jokes, I argue, are a manifestation of a much older fatherly impulse to tease one’s children. On the surface, dad jokes are puns that are characterized by only violating a pragmatic norm and nothing else, which makes them lame and unfunny. Only violating a pragmatic norm and nothing else, however, is itself a violation of the norms of joke-telling, which makes dad jokes a type of anti-humor. Fathers may in turn seek to embarrass their children by purposively violating the (...) norms of joke-telling in this way, thus weaponizing the lame pun against their children as a type of good-natured teasing. Given their personality profile, it makes sense that fathers should be particularly prone to weap­onize dad jokes teasingly against their children like this, with the phenomenon bearing an illuminating resemblance to the rough-and-tumble play that fathers have engaged their children in since before the dawn of our species. (shrink)

Through the 1960s, many people claimed that drug advertising was educational and physicians often relied on it. Continuing Medical Education (CME) was developed to provide an alternative. However, because CME relied on grants, industry funders chose the subjects offered. Now policymakers worry that drug firms support CME to promote sales and that commercial support biases prescribing and fosters inappropriate drug use. A historical review reveals parallel problems between advertising and industry-funded CME. To preclude industry influence and improve CME, we should (...) ensure independent funding by taxing medical industries, facilities and physicians. Independent public and professional authorities should create CME curricula. An independent agency should allocate all funds to educational institutions for approved curricula. (shrink)

Standardly, epistemic peers regarding a given matter are said to be people of equal competence who share all relevant evidence. Alternatively, one can define epistemic peers regarding a given matter as people who are equally likely to be right about that matter. I argue that a definition in terms of likelihood captures the essence of epistemic peerhood better than the standard definition or any variant of it. What is more, a likelihood definition implies the truth of the central thesis in (...) the debate on peer disagreement, the so-called Equal Weight View, according to which we should give the opinions of our peers the same weight we give our own. Adopting a likelihood definition, however, does not end the debate on peer disagreement, because the alleged theoretical alternatives to the Equal Weight View, reinterpreted in the light of a likelihood definition, can in fact be shown to be compatible with this view—though the reinterpreted versions may appear less plausible than the original ones. (shrink)

This paper examines the exercise of individual or group rights within the game form approach. It focuses in particular on what it means for a strategy or action to be feasible and admissible. Admissibility is best discussed in relation to two basic distinctions among rights, passive and active rights on the one hand and negative and positive rights on the other. It is argued that while there are quite a few cases in which the outcomes of mutual rights exercising are (...) to the fore, there are many situations where the uninhibited exercise of individual or group rights and not particular outcomes are what society is primarily interested in. (shrink)

A commonly neglected feature of the so-called Equal Weight View, according to which we should give our peers’ opinions the same weight we give our own, is its prima facie incompatibility with the common picture of philosophy as an armchair activity: an intellectual effort to seek a priori knowledge. This view seems to imply that our beliefs are more likely to be true if we leave our armchair in order to find out whether there actually are peers who, by disagreeing (...) with us, force us to revise our beliefs. This article argues that the Equal Weight View should be spelled out in such a way that not only actual peer disagreement requires us to revise our beliefs, but also merely possible peer disagreement. This result is not a reductio ad absurdum of the view. Quite the opposite: it shows that the view is, contrary to appearance, compatible with our common way of doing philosophy. (shrink)

Wilcox proposed an argument against imprecise probabilities and for the principle of indifference based on a thought experiment where he argues that it is very intuitive to feel that one’s confidence in drawing a ball of a given colour out of an unknown urn should decrease while the number of potential colours in the urn increases. In my response to him, I argue that one’s intuitions may be unreliable because it is very hard to truly feel completely ignorant in such (...) a situation. I further argue that Wilcox must also account for the conflicting intuition that it is absurd to have to feel completely convinced that a specific claim about reality is true _in the absence of any evidence_ in order to avoid being irrational. It is dubious that this intuition is considerably less universal and strongly-held than Wilcox’s own intuition. Finally, I point out that even if Wilcox’s intuition were to be universally shared among members of our biological species, it is far from being clear that someone refusing to let that intuition dictate his or her beliefs would be irrational. For all these reasons, I believe that Wilcox was not successful in proving that philosophers and scientists representing uncertainty through imprecise probabilities are violating the principles of rationality. (shrink)

We highlight a new paradox for the social evaluation of risk that bears on the evaluation of individual well-being rather than social welfare, but has serious implications for social evaluation. The paradox consists in a tension between rationality, respect for individual preferences, and a principle of informational parsimony that excludes individual risk attitudes from the assessment of riskless situations. No evaluation criterion can satisfy these three principles. This impossibility result has implications for the evaluation of social welfare under risk, especially (...) when the preferences of some individuals are not known. It generalizes existing impossibility results, while relying on very weak principles of social rationality and respect for individual preferences. We explore the possibilities opened by weakening each of our three principles and discuss the advantages and drawbacks of these different routes. (shrink)

We argue that the economic evaluation of health care (cost–benefit analysis) should respect individual preferences and should incorporate distributional considerations. Relying on individual preferences does not imply subjective welfarism. We propose a particular non-welfarist approach, based on the concept of equivalent income, and show how it helps to define distributional weights. We illustrate the feasibility of our approach with empirical results from a pilot survey.

L’analyse empirique des inégalités porte en général sur les ressources, tandis que les théories philosophiques de la justice se divisent entre celles qui se concentrent sur les ressources et les opportunités, d’un côté, et celles qui se focalisent sur les relations sociales, de l’autre. Cet article propose une représentation de la société qui intègre à la fois les ressources et les relations sociales au sein d’un réseau d’interactions sociales qui déterminent dans quelle mesure les individus s’épanouissent ou non au cours (...) de leur vie. Cette représentation invite à repenser l’analyse des inégalités et de la justice sociale, et suggère qu’il est possible d’identifier des tensions et des synergies entre les différentes composantes du réseau social. (shrink)

L’analyse empirique des inégalités porte en général sur les ressources, tandis que les théories philosophiques de la justice se divisent entre celles qui se concentrent sur les ressources et les opportunités, d’un côté, et celles qui se focalisent sur les relations sociales, de l’autre. Cet article propose une représentation de la société qui intègre à la fois les ressources et les relations sociales au sein d’un réseau d’interactions sociales qui déterminent dans quelle mesure les individus s’épanouissent ou non au cours (...) de leur vie. Cette représentation invite à repenser l’analyse des inégalités et de la justice sociale, et suggère qu’il est possible d’identifier des tensions et des synergies entre les différentes composantes du réseau social. (shrink)

The word “identity,” like too many abstract words, has become a repetitive slogan in contemporary usage, sometimes even a resolute exemption from feeling and thinking. Identity is sacred; it is evident; we can only be for it.We use this little abstract word none too seriously. We rush to build ideological camps on it. However, it conceals abysses that the greatest minds since Plato have sought to explore. We can read in the Timaeus, with respect to being and by opposition to (...) becoming : “It is a solitary and unique circle, but because of its excellence capable of living alone with itself, without needing anyone else, and with respect to relations and friends, it is self-sufficient.”. (shrink)

"The Film Theory Reader brings together a range of key theoretical texts, organized thematically to emphasise the development of specific critical concepts and theoretical models in the field of film theory.