The Y chromosomes of most Drosophila species are necessary for male fertility but they are not involved in sex determination. They have many puzzling properties that resemble the effects caused by B chromosomes. Classical genetic and molecular studies reveal substantial affinities between Y and B chromosomes and suggest that the Y chromosomes of Drosophila are not degenerated homologues of the X chromosomes, but rather that their Y chromosomes evolved as specialized supernumeraries similar to classical B chromosomes.

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of (...) viral NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

Since P. Thielscher, in Philologus, 1907, pp. 117, 128, supplies us with information about the Manilian MS. Palatinus 1711 , the importance of which he himself does not seem to comprehend, I should like to point out what an interesting MS. this is. ‘It is to be suspected,’ says Thielscher, ‘that it offers interpolated readings.’ It is not a matter of ‘suspicion’ at all. If Thielscher did not know it for himself, he could have learnt from Scaliger , from Bentley, (...) from Jacob, that the readings of P long ago received sufficient publicity to enable scholars to assign it to the ‘ interpolated’ class of MSS. The Variae Lectiones of Junius is mostly occupied with the readings of P, and tells us all about P that we need know, save what Thielscher has himself added. From Thielscher we for the first time learn that P belonged to ‘Johannes Archiepiscopus Strigoniensis,’ and that it contains this subscription: ‘legi et emendaui cum magistro Galeotto 1469.’ Now just as Thielscher seems to know nothing of Junius, so he seems to have no idea who Johannes Strigoniensis is, though the reference to Galeotto and the year 1469 should at once have told him. If he had troubled to look at Schmitt's Archiepiscopi he would have found that, while Schmitth enumerates no less than six archbishops of Gran who bore the name John, yet the only one of them who fits the date 1469 is John IV. And John IV. is a famous person, being none other than that leader of the Hungarian Renaissance whom we commonly call Vitezius. (shrink)

For over thirty years C. A. Campbell has made major contributions to both ethics and metaphysics. Since these do not correspond to the prevailing fashions in philosophy and theology they are in danger of being under-estimated, if not ignored. I hope to summarise and comment on them as impartially as possible. Inevitably I must be selective. In writing for this journal I have, naturally, chosen to stress those elements in Campbell's thought which are directly or indirectly relevant to religion. Even (...) so, there are many points which I have no space to develop. I shall be content if I say enough to indicate the importance of Campbell's writings for the study of the philosophically crucial topics to which they are devoted. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 149 On the other hand, "a history which were only a lofty generalisation would go astray in pure speculation and would deduce its content from principles without making sure that the bulk of facts produced in reality could find its proper place within its frame" (ibid.). Hence, between the anecdotic and fantastic, history asserts its own exigencies, which are authenticity and intelligibility expressed in a true system (...) of human evolution. In the last chapter of Part I, Callot makes interesting observations concerning the problem of prevision or prediction in history. He mentions two types, the long4erm and the shortterm type, which he calls the type of prediction on the basis of history of philosophy, and the type of prediction on a sociological basis, respectively (p. 216). As is well known, Hegel developed his dialectical method in a constructive critique of Kant's doctrine of antinomies. In his Encyclopgdie, he observes that Kant's discovery of the inevitability of antinomies is "one of the most important and profound developments in modern philosophy." This association of ideas invites certainly to a further constructive critique and should be discussed in a book whose main subject is the antinomies in history. Furthermore, Marx's contribution to the development of dialectic and, in particular, his doctrine of "contradictions " as presented in Capital is far too important to be passed over in silence. The connection between Marxian dialectic and the Correspondence principle in physics (Bohr), to which Callot seems to refer on page 264, is so obvious that it should not be neglected in a book which otherwise bears testimony of erudition and intrepidity. I quite agree with Fernand Braudel that the author owes us another volume where the thinking of Marx and his historiographical descendants up to Jean-Paul Sartre's Critique de la raison dialectique is closely scrutinized. By taking such a step, Callot would probably create a still more suitable basis for the discussion of the problems of history of philosophy and science, of which he, in Part II of the book, gives an instructive and lengthy report. JOHANNES WI~-HANSEN University of Copenhagen BOOK NOTES New Editions Pierre Bayle, Oeuvres diverses, I. Avec une introduction par Elisabeth Labrousse. Hildesheim, C~eorge Olms, Verlagsbuchhandlung, 1964. xx -{- 760 pp. Subscription price per volume, DM 118. (Individual volumes, DM 148.) In view of the revival of interest in Pierre Bayle's thought and influence, it is fortunate that this excellent photoreproduction edition of his Oeuvres diverses, which have been so difficult to obtain, will now again be available. The four volumes, published first in 1727, bring together all of Bayle's works other than the Dictionnaire historique et critique, plus many of his letters. The present photoreproduetion edition will include all the works except the letters, since a new edition, including a very large number of those not in the Oeuvres diverses is now being prepared by a group of scholars under the direction of Madame Labrousse for the International Archives of the History of Ideas series. The first volume consists of the issues of the Nouvelles de la Republique des Lettres during Bayle's editorship, from its inception in 1684, until Bayle withdrew because of illness in 1687. Madame Labrousse, in her fine Introduction, discusses the history of this journalistic venture, and its importance in European intellectual history. The flight of so many French refugees to the Netherlands made it possible to set up a journal in Holland, written in French, that would review works in theology, philosophy, natural science, mathematics, history, etc. The capital, the publisher, the printers, the author and most of the readers were all refugees from Louis XIu persecutions. Bayle, while teaching philosophy at the ]~cole illustre of Rotterdam and writing some of his famous works, like the Ce que c'est la France toute catholique and Commentaire philosophique, undertook to review what was going on in the Republic of Letters. His objectivity, erudition, wit, and critical ability made the effort a success, and led to the series of other efforts, such as Jean Le Clerc's Bibliotheque choisie, and Henri Basnage de Beauval's Histoire des ouvrages des Sgavans. Bayle discussed the issues of the day--the... (shrink)

The relation between morality and religion has often been discussed. However, it is not always recognized that the relation varies greatly according to the variety of religions. I shall here be concerned solely with Christian theism in its traditional form. I take the latter to signify, essentially, belief in a morally perfect Creator who exists in the threefold form of Father, Son and Holy Spirit and who, in the person of the Son, became man in Christ for our salvation. I (...) thus exclude from consideration all non-theistic accounts of God or the Absolute. Also I shall consider, not simply bare theism of the kind that Christians share with Jews and Muslims, but also the distinctively Christian form of theism that is generated by distinctively Christian revelation. Many otherwise sound descriptions of the relation between morality and theism are defective because they fail to consider the distinctively Christian contribution to the theistic concept of God and of his relation to the world. (shrink)

Many writers often generalise about mysticism without a sufficiently close analysis of texts. Consequently the generalisations are often invalid. My present aim is to analyse one text and, in the light of this analysis, to offer some observations concerning mysticism in general and Christian mysticism in particular.

Christianity affirms, with Judaism and Islam, that God is the omnipotent Creator of all things. But it diverges from them in also affirming that the Creator assumed a human nature in one figure of history, Jesus of Nazareth. Christ thus differs from other men in kind, not merely in degree; he is absolutely, not just relatively, unique. Admittedly many Christian theologians have held that the difference between Christ and other men is only one of degree. Yet the Church's traditional claim, (...) as expressed in the Chalcedonian Definition, is that Jesus was both creature and Creator, both fully man and fully God. (shrink)

The purpose of this paper is to resolve two paradoxes, which occur in quantum theory, by using the discussion of the theory of measurement presented in two earlier papers by the author [3], [4], [5]. The two paradoxes discussed will be the Schrödinger cat paradox and the Einstein, Podolski, Rosen paradox [2]. An introductory section will be included which summarizes the relevant results from the author's previous papers. Also a discussion will be made regarding the author's interpretation of the density (...) operator. (shrink)

Stable maintenance of genetic information during meiosis and mitosis is dependent on accurate chromosome transmission. The centromere is a key component of the segregational machinery that couples chromosomes with the spindle apparatus. Most of what is known about the structure and function of the centromeres has been derived from studies on yeast cells. In Saccharomyces cerevisiae, the centromere DNA requirements for mitotic centromere function have been defined and some of the proteins required for an active complex have been identified. Centromere (...) DNA and the centromere proteins form a complex that has been studied extensively at the chromatin level. Finally, recent findings suggest that assembly and activation of the centromere are integrated in tethe cell cycle. (shrink)

This handbook with exercises reveals the mathematical beauty of formalisms hitherto mostly used for software and hardware design and verification.

Poverty violates fundamental human values through its impact on individuals and on human environments, and it goes against the core values of democratic societies. Drawing on numerous scientific studies as well as his own experience witnessing the systematic poverty in his home country of South Africa, H. P. P. [Hennie] Lötter presents a holistic profile of poverty and its effects on human lives all the while accounting for the complexity of each individual case. He argues that shared ethical values must (...) guide the planning and distribution of aid and that our society must reevaluate our notions of justice and reimagine the role of the state in order to enable collective human responsibility for poverty’s successful eradication. (shrink)