Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data. To foster organized, cross-disciplinary, information-driven collaborations in the pathological imaging field, we propose to develop an ontology to represent imaging data and methods used in pathological imaging and analysis, and call it Quantitative Histopathological Imaging Ontology – QHIO. We apply QHIO to breast cancer hot-spot detection with (...) the goal of enhancing reliability of detection by promoting the sharing of data between image analysts. (shrink)

Public health agencies regularly survey randomly selected anonymous students to track drug use, sexual activities, and other risk behaviors. Students are unidentifiable, but a recent project that i...

Meiotic recombination occurs preferentially at certain regions called hot spots and is important for generating genetic diversity and proper segregation of chromosomes during meiosis. Hot spots have been characterized most extensively in yeast, mice and humans. The development of methods based on sperm typing and population genetics has facilitated rapid and high‐resolution mapping of hot spots in mice and humans in recent years. With increasing information becoming available on meiotic recombination in different species, it is now possible (...) to compare several molecular features associated with hot‐spot loci. Further, there have been advances in our knowledge of the factors influencing hot‐spot activity and the role that they play in structuring the genome into haplotype blocks. We review the molecular features associated with hot spots in terms of their properties and mechanisms underlying their function and distribution. A large number of these features seem to be shared among hot spots from different species suggesting common mechanisms for their formation and function. BioEssays 28:45–56, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

This paper aims to identify several interpretive problems posed by the final part of DA II.11, where Aristotle intertwines the thesis that a sense is like a ‘mean’ and an explanation for the existence of a ‘blind spot’ related to the sense of touch, adding the further contention that we are capable of discriminating because the mean ‘becomes the other opposite’ in relation to the perceptible property being perceived. To solve those problems, the paper explores a novel interpretation of Aristotle’s (...) claims, arguing that they describe a homeostatic physiological reaction by which the sensory apparatus responds to perceptible stimuli. According to the proposed interpretation, such homeostatic reaction constitutes a necessary condition for perceiving what Aristotle refers to as ‘proper’ perceptible features, which include properties like ‘hot’ and ‘cold’ as well as colors and sounds. (shrink)

Hot spot policing is an established concept that is proven to reduce crime. It is mostly done through foot patrol or car patrols. In the present study it is tested whether helicopters can produce a deterrent policing effect to reduce the amount of vehicle arsons in Sweden on larger hot areas. Sweden tends to have elevated levels of vehicle arsons in August, with about 20% of police districts responsible for 50% of the cases. The risk narrative revolves around youth congregating (...) in public places in deprived neighborhoods to generate disturbances, and the disruption of the risk narrative tested here is based on providing deterrence through helicopter police presence. During 6 weeks in August and September of 2019 police helicopters patrolled four police districts in Sweden to attempt to prevent vehicle arsons. Our data comprise police reports of vehicle arson, and time stamped satellite data over the location for police helicopters. The evaluation considers whether there is an intention to treat effect from this project, in addition to whether there is an effect of actual helicopter presence. The study finds no significant effect of intention to treat, nor of actual dosage. (shrink)

A 10 kHz pulsed X-ray generator utilising a hot-cathode triode in conjunction with a new type of grid control device for controlling X-ray duration is described. The energy-storage condenser was charged up to 70 kV by a power supply, and the electric charges in the condenser were discharged to the X-ray tube repetitively by the grid control device. The maximum values of the grid voltage, the tube voltage, and the tube current were −1.5 kV, 70 kV, and 0.4 A, respectively. (...) The duration of the flash X-ray pulse was primarily determined by the time constant of the grid control device and the cut-off voltage of thermoelectrons. The X-ray duration was controlled within a region of less than 1 ms; the X-ray intensity with a pulse width of 0.27 ms, a charged voltage of 70 kV, and a peak tube current of 0.4 A was 0.92 μC kg −1 at 0.5 m per pulse. The maximum repetition rate was about 10 kHz, and the size of the focal spot was about 3.5×3.5 mm. (shrink)

Dissertação: FARIA, Thiago Hot Pereira de. Mishná e Belo Horizonte: A influência da cultura oral na comunidade judaica belo-horizontina. 2014. Dissertação – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

Many Turkish people migrated to Germany between 1955 and 1975. This study was carried out in Göttingen, Germany. Fifty Turkish people (described as patients) were asked about the care they had received from German health care personnel, and 50 German nurses and 50 German physiotherapists were questioned about care they had given to Turkish patients. Significant findings were the needs of the Turkish patients for good communication, physical contact and understanding of their culture-based expressions of illness. The German nurses and (...) physiotherapists expressed the need for language barriers to be minimized and for education in the specific culture of Turkish patients. Our findings are discussed from an ethical viewpoint. The International Council of Nurses’ code of ethics is used to guide the ethical debate about the findings within the context of transcultural and multicultural care. Suggestions for better transcultural health care paradigms are made for relating to patients from different cultures when patients and care providers have little understanding of each other’s needs and expectations. (shrink)

Previous work showed that the beginning of a sound is more important for the perception of loudness than later parts. When a short silent gap of sufficient duration is inserted into a sound, this primacy effect reoccurs in the second sound part after the gap. The present study investigates whether this temporal weighting occurs independently for different frequency bands. Sounds consisting of two bandpass noises were presented in four different conditions: a simultaneous gap in both bands, a gap in only (...) the lower frequency band, a gap in only the higher frequency band, or no gap. In all conditions, the temporal loudness weights showed a primacy effect at sound onset. For the frequency bands without a gap, the temporal weights decreased gradually across time, regardless of whether the other frequency band did or did not contain a gap. When a frequency band contained a gap, the weight at the onset of this band after the gap was increased. This reoccurrence of the primacy effect following the gap was again largely independent of whether or not the other band contained a gap. Thus, the results indicate that the temporal loudness weights are frequency specific. (shrink)

A growing body of evidence suggests that emotional states under which individuals perform decision-making tasks modulate performance. Studies have mainly reported that negative emotions can differe...

The article is based on reports and discussions held during three online events organized by the Russian Research Center for the Internet of Things together with the Department of Philosophy and Sociology of South-West State University during 2021: an open discussion with the famous transhumanist philosopher David Pearce dedicated to the birthday of Jeremiah Bentham on February 15, a round table dedicated to the World Internet of Things Day on April 9, and a session within the first IoT Hot (...) class='Hi'>Spots conference on June 16. The main topics for discussion this year were the consideration of the following philosophical and socio-cultural problems and concepts in the light of the development of cyberphysical systems: anthropological differences between the «posthuman» and «metahuman» projects, epistemological aspects of bio- and cybersemiotics in modern hybrid techno-social networks, the cultural dimension of remote proximity in the digital age, the ontology of the quantum complexity of the digital multiverse, the ethical dimensions of the digital economy in the post-covid period, the aesthetics of metamodernism in the smart city, the anthropocene effects of silicon addiction and the race of computing, socio-philosophical problems of management in situations of high uncertainty, political strategies for sustainable development. (shrink)

"This is an exceedingly long short book, stretching at least fifty thousand years into the past and who knows how many into the future." So begins Visions of the Future, the prophetic new book by eminent economist Robert Heilbroner. Heilbroner's basic premise is stunning in its elegant simplicity. He contends that throughout all of human history, despite the huge gulf in social organization, technological development, and cultural achievement that divides us from the earliest known traces of homo sapiens, there have (...) really only been three distinct ways of looking at the future. During a period Heilbroner refers to simply as the Distant Past, stretching from prehistory to the appearance of modern nation-states in seventeenth century Europe, there was no notion of a future measurably and materially different from the present or the past. From the Stone Age to the Bronze, Mesopotamia and Egypt to Greece and Rome, and throughout the Middle Ages, a continuum of cultures and civilizations shared one defining expectation--the absence of any expectation of material progress for the great masses of people. Heilbroner maintains that it was not until the first stirrings of the period he refers to as Yesterday, spanning from roughly 1700 to 1950, that the future entered into human consciousness as a great beckoning force. Capitalism, continually reinvigorated by the seemingly endless forward march of science and an evolving sense of democracy, appeared to promise all levels of society some expectation of a future at least somewhat better than the past. It was this unwavering faith in the superiority of the future that separated Yesterday from the age we have now entered, that of Today. While we are still driven towards tomorrow by the same forces that determined the recent past, the lessons of Hiroshima and Chernobyl, the chaos in the former Soviet Union, the stagnation of the West, and the anarchic rage unleashed in our inner cities and in hot spots around the globe have brought on a palpable anxiety that is quite apart from both the resignation of the Distant Past or the bright optimism of Yesterday. In a brilliant conclusion drawing together the threat of nuclear blackmail, global warming and the growing commodification of life represented by video games, voice mail, and VCRs, Visions of the Future issues a call to face the challenges of the twenty-first century with a new resolve strengthened by the inspiration of our collective past. (shrink)

Early modern humans developed mental capabilities that were immeasurably greater than those of nonhuman primates. We see this in the rapid innovation in tool making, the development of complex language, and the creation of sophisticated art forms, none of which we find in our closest relatives. While we can readily observe the results of this high-order cognitive capacity, it is difficult to see how it could have developed. We take up the topic of cave art and archeoacoustics, particularly the discovery (...) that cave art is often closely connected to the acoustic properties of the cave chambers in which it is found. Apparently, early modern humans were able to detect the way sound reverberated in these chambers, and they painted artwork on surfaces that were acoustic “hot spots,” i.e., suitable for generating echoes. We argue that cave art is a form of cross-modality information transfer, in which acoustic signals are transformed into symbolic visual representations. This form of information transfer across modalities is an instance of how the symbolic mind of early modern humans was taking shape into concrete, externalized language. We also suggest that the earliest rock art found in Africa may constitute one of the first fossilized proxies for the expression of full-fledged human linguistic behavior. (shrink)

Molinism is named after Luis de Molina (1535–1600). Molina and his fellow Jesuits became entangled in a fierce debate over issues involving the doctrine of divine providence, which is a picture of how God runs the world. Molinism reemerged in the 1970s after Alvin Plantinga unwittingly assumed it in his Free Will Defense against the ‘Logical’ Argument from Evil. Molinism has been the subject of vigorous debate in analytic philosophy of religion ever since. The main aim of this essay is (...) to survey the main contours of this debate. We will visit some ‘old’ battlefields and current hot spots in the ongoing Molinism Wars. (shrink)

The routinization of prenatal diagnosis is the source of bioethical and policy debates regarding choice, autonomy, access, and protection. To understand these debates in the context of cultural diversity and moral pluralism, we compare Israel and Germany, focusing on two recent repro-genetic “hot spots” of such policy-making at the beginning of life: pre-implantation genetic diagnosis and non-invasive prenatal genetic testing, two cutting-edge repro-genetic technologies that are regulated and viewed very differently in Germany and Israel, reflecting different medicolegal policies as (...) well as public and bioethical considerations. First, we compare policy-making in the context of PGD for HLA typing, used to create sibling donors, approved in Israel under specific conditions while prohibited in Germany. Second, we compare policy-making in the context of NIPT, which came under fire in Germany, while in Israel there has been little public debate about it. Both countries justify their contrasting policies as reflecting a concern for the well-being and care of the embryo/child, thus highlighting different concepts of embryo/child protection, autonomy, family relations, and the impact of religion and history on the promotion/protection of life. We use the juxtaposition of PGD and NIPT to highlight some inconsistencies in policies concerning the protection of extra- and intra-corporeal embryos. We conclude by drawing on the comparison to show how national variations exist alongside co-evolution. (shrink)

Introduction: Motor evoked potentials (MEPs) to transcranial magnetic stimulation are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods: A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the (...) “hot spot” of the first dorsal interosseous and tibialis anterior muscles, bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results: After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and peripheral motor conduction time at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusions: Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex. (shrink)

The article is based on reports and discussions held during three online events organized by the Russian Research Center for the Internet of Things together with the Department of Philosophy and Sociology of South-West State University during 2021: an open discussion with the famous transhumanist philosopher David Pearce dedicated to the birthday of Jeremiah Bentham on February 15, a round table dedicated to the World Internet of Things Day on April 9, and a session within the first IoT Hot (...) class='Hi'>Spots conference on June 16. The main topics for discussion this year were the consideration of the following philosophical and socio-cultural problems and concepts in the light of the development of cyberphysical systems: anthropological differences between the «posthuman» and «metahuman» projects, epistemological aspects of bio- and cybersemiotics in modern hybrid techno-social networks, the cultural dimension of remote proximity in the digital age, the ontology of the quantum complexity of the digital multiverse, the ethical dimensions of the digital economy in the post-covid period, the aesthetics of metamodernism in the smart city, the anthropocene effects of silicon addiction and the race of computing, socio-philosophical problems of management in situations of high uncertainty, political strategies for sustainable development. (shrink)

Introduction -- Fraud in research : frequency patterns -- An organizational approach to research fraud -- Fraud, lies, deceptions, fabrications, and falsifications -- Deviance in scientific research : norms, hot spots, control -- Concluding discussion.

BackgroundUp-to-date information about the trends of age-related hearing loss and how this varies between countries is essential to plan for an adequate health-system response. Therefore, this study aimed to assess the research hotpots and trends in ARHL and to provide the basis and direction for future research.Materials and methodsThe Web of Science Core Collection database was searched and screened according to the inclusion criteria during 2002–2021. Bibliometric analyses were conducted by CiteSpace software and VOSviewer software.ResultsThe query identified 1,496 publications, which (...) showed a growth trend of this filed. These publications were from 62 countries, the United States of America showed its tremendous impact on this field in publication outputs, total citations, and international collaborations, China following in second. The Journal of Hearing Research was the most productive journal. Weijia Kong published the most papers, and the most productive institution was Washington University. The keyword “presbycusis” ranked first in research frontiers and appeared earlier, and the keywords “age-related hearing loss,” “risk,” “dementia,” “auditory cortex,” “association,” and “decline” began to appear in recent years.ConclusionThe annual number of publications has grown rapidly in the past two decades and will continue to grow. Epidemiological investigation and laboratory research are lasting hot spots, besides future research will focus on the association between ARHL and cognitive decline, dementia, and Alzheimer’s disease. (shrink)

The jaw mechanism of cichlid fishes is an intricate apparatus with complex force transmission from muscles to environment. The proportions of this apparatus change considerably during growth mainly due to scale effects. In adult fishes, the proportions differ, corresponding with the type of preferred food. In such a complex mechanism, it is very hard to gain insight into the functional meaning of the differences in proportions, unless a biomechanical model is constructed, describing kinematics and force equilibria of the apparatus.Such a (...) model has been constructed and by means of perturbation analysis anatomical points could be selected of which the positions are very important for the function of biting. These hot spots need only small displacements in order to obtain an increase in biting force. By means of a newly developed mathematical technique, it was possible to move the anatomical points in very small steps towards more favourable positions for the function of biting. (shrink)

The complex bursting oscillation and bifurcation mechanisms in coupling systems of different scales have been a hot spot domestically and overseas. In this paper, we analyze the bursting oscillation of a generalized Duffing–Van der Pol system with periodic excitation. Regarding this periodic excitation as a slow-varying parameter, the system can possess two time scales and the equilibrium curves and bifurcation analysis of the fast subsystem with slow-varying parameters are given. Through numerical simulations, we obtain four kinds of typical bursting oscillations, (...) namely, symmetric fold/fold bursting, symmetric fold/supHopf bursting, symmetric subHopf/fold cycle bursting, and symmetric subHopf/subHopf bursting. It is found that these four kinds of bursting oscillations are symmetric. Combining the transformed phase portrait with bifurcation analysis, we can observe bursting oscillations obviously and further reveal bifurcation mechanisms of these four kinds of bursting oscillations. (shrink)

Event cameras which transmit per-pixel intensity changes have emerged as a promising candidate in applications such as consumer electronics, industrial automation, and autonomous vehicles, owing to their efficiency and robustness. To maintain these inherent advantages, the trade-off between efficiency and accuracy stands as a priority in event-based algorithms. Thanks to the preponderance of deep learning techniques and the compatibility between bio-inspired spiking neural networks and event-based sensors, data-driven approaches have become a hot spot, which along with the dedicated hardware and (...) datasets constitute an emerging field named event-based data-driven technology. Focusing on data-driven technology in event-based vision, this paper first explicates the operating principle, advantages, and intrinsic nature of event cameras, as well as background knowledge in event-based vision, presenting an overview of this research field. Then, we explain why event-based data-driven technology becomes a research focus, including reasons for the rise of event-based vision and the superiority of data-driven approaches over other event-based algorithms. Current status and future trends of event-based data-driven technology are presented successively in terms of hardware, datasets, and algorithms, providing guidance for future research. Generally, this paper reveals the great prospects of event-based data-driven technology and presents a comprehensive overview of this field, aiming at a more efficient and bio-inspired visual system to extract visual features from the external environment. (shrink)

In today’s era of rapid development in science and technology, the development of digital technology has increasingly higher requirements for data processing functions. The matrix signal commonly used in engineering applications also puts forward higher requirements for processing speed. The eigenvalues of the matrix represent many characteristics of the matrix. Its mathematical meaning represents the expansion of the inherent vector, and its physical meaning represents the spectrum of vibration. The eigenvalue of a matrix is the focus of matrix theory. The (...) problem of matrix eigenvalues is widely used in many research fields such as physics, chemistry, and biology. A neural network is a neuron model constructed by imitating biological neural networks. Since it was proposed, the application research of its typical models, such as recurrent neural networks and cellular neural networks, has become a new hot spot. With the emergence of deep neural network theory, scholars continue to combine deep neural networks to calculate matrix eigenvalues. This article aims to study the estimation and application of matrix eigenvalues based on deep neural networks. This article introduces the related methods of matrix eigenvalue estimation based on deep neural networks, and also designs experiments to compare the time of matrix eigenvalue estimation methods based on deep neural networks and traditional algorithms. It was found that under the serial algorithm, the algorithm based on the deep neural network reduced the calculation time by about 7% compared with the traditional algorithm, and under the parallel algorithm, the calculation time was reduced by about 17%. Experiments are also designed to calculate matrix eigenvalues with Obj and recurrent neural networks (RNNS) models, which proves that the Oja algorithm is only suitable for calculating the maximum eigenvalues of non-negative matrices, while RNNS is commonly used in general models. (shrink)

Driven by the desire to fill newspaper pages with sensational images, press photographers shot everything, day and night: automobile accidents, fires, murders, all the cop news that fought for a hot spot on the Front Page. And they covered uncounted numbers of social affairs -- pictures called 'grip-and-grins' in the trade: school events, sports, celebrities, oddities both of nature and humanity. Veteran journalist and mystery writer Larry Millett has unearthed over 200 of the best photos from the archives of the (...) St Paul Pioneer Press and the St Paul Dispatch for 'Strange Days, Dangerous Nights'. Included are the sensational stories behind the photos and biographies of some of the top press photographers of the day. An evocative look at another time, this is a visual history like no other, a feast for fans of photography and photojournalism, crime buffs, and urban historians -- and a testament to the craft of those photographers who documented their era one shot at a time. (shrink)

The goal of this pilot study is to investigate expressions of the collective disquiet of people in the first months of Covid-19 pandemic, and to try to understand how they manage covert risk, especially with religion and magic. Four co-authors living in early hot spots of the pandemic speculate on the roles of science, religion, and magic, in the latest global catastrophe. They delve into the consolidation that should be occurring worldwide because of a common, viral enemy, but find (...) little evidence for it. They draw parallels to biblical works, finding evidence of a connection between plague and “social strife.” They explore changes in the purviews of science, religion, and magic, and how and why they have changed, as three systems of covert risk management. They speculate on the coming wave of grief when the world populations finally decide that too many people have died, and they envision cultural changes on the other side of the pandemic, to lifestyles, travel, reverse urbanization, and living and working in smaller communities. Using an unusual approach named “crowd-sourced ethnography”, they conduct un-traditional ethnography and speculate on management of covert risk in their native countries. (shrink)

In this chapter, we will take a trip around several hot-spots where Bohmian mechanics and its capacity to describe the microscopic reality, even in the absence of measurements, can be harnessed as computational tools, in order to help in the prediction of phenomenologically accessible information (also useful for the followers of the Copenhagen theory). As a first example, we will see how a Stochastic Schrödinger Equation, when used to compute the reduced density matrix of a non-Markovian open quantum system, (...) necessarily seems to employ the Bohmian concept of a conditional wavefunction. We will see that by dressing these conditional wavefunctions with an interpretation, the Bohmian theory can prove to be a useful tool to build general quantum simulation frameworks, such as a high-frequency electron transport model. As a second example, we will explain how a Copenhagen “observable operator” can be related to numerical properties of the Bohmian trajectories, which within Bohmian mechanics, are well-defined even for an “unmeasured” system. Most importantly in practice, even if these numbers are given no ontological meaning, not only we will be able to simulate (thus, predict and talk about) them, but we will see that they can be operationally determined in a weak value experiment. Therefore, they will be practical numbers to characterize a quantum system irrespective of the followed quantum theory. (shrink)

"The only way not to to make mistakes is to wait until history has passed you by," states Bernard-Henri Lévy. But he doesn't like to wait. And that's why 'BHL', armed with a cell phone and raybans, takes off for political hot spots.""Je t'embrasse." The philosopher ends the phone call and places the tiny Ericsson cell phone on the table next to his Ray Bans. He turns to his interviewers: "Where were we?"For a moment they are lost, distracted by (...) the question of who BHL may have been 'embracing'. His wife? His mistress? Perhaps a student of French picked up casually during his lightning visit to The Netherlands? (shrink)

In order to study the intelligent collection system of moving object trajectory data under cloud computing, information useful to passengers and taxi drivers is collected from massive trajectory data. This paper uses cloud computing technology, through clustering algorithm and density-based DBSCAN algorithm combined with Map Reduce programming model and design trajectory clustering algorithm. The results show that based on the 8-day data of 15,000 taxis in Shenzhen, the characteristic time period is determined. The passenger hot spot area is obtained by (...) clustering the passenger load points in each time period, which verifies the feasibility of the passenger load point recommendation application based on trajectory clustering. Therefore, in the absence of holidays, the number of passenger hotspots tends to be stable. It is reliable to perform cluster analysis. The recommended application has been demonstrated through experiments, and the implementation results show the rationality of the recommended application design and the feasibility of practice. (shrink)

The aim of this paper is to consider the vicissitudes of “area studies” from the Second World War to the present focusing eventually on the normative imperative to develop a new paradigm of “planetary thinking.” First an overview of the history of “area studies” will be given from the start in the U.S. during the Second World War in response to the geostrategic imperative for America to know its new geopolitical responsibilities in a world divided by war. This security imperativemorphed (...) into the postwar requisite to develop a counterhegemonic strategy against soviet communism in the hot spot parts of Asia, Latin American, and later Africa. The latter military‐oriented strategy was added to with research into development and modernization in the third-world through to the boundary displacement of areas studies at the end of the Cold War into the current era of globalization. At this very historical moment of transition a new rationale for area studies emerged in the form of a geoeconomic imperative – both in the U.S. and, with a different gloss, in South Korea in the late 1990s. Second, on the basis of this historical apercu, the argument will be proposed that, given the problem of global warming and the issue‐area of global inequality lurking behind the UnitedNation’s Millennium Development Goals, a pressing contemporary task for philosophy is to make a critical contribution to developing a new planetary perspective for area studies informed by a constitutive philosophical anthropology attendant to the species being of human beings. (shrink)

The aim of this paper is to consider the vicissitudes of “area studies” from the Second World War to the present focusing eventually on the normative imperative to develop a new paradigm of “planetary thinking.” First an overview of the history of “area studies” will be given from the start in the U.S. during the Second World War in response to the geostrategic imperative for America to know its new geopolitical responsibilities in a world divided by war. This security imperativemorphed (...) into the postwar requisite to develop a counterhegemonic strategy against soviet communism in the hot spot parts of Asia, Latin American, and later Africa. The latter military‐oriented strategy was added to with research into development and modernization in the third-world through to the boundary displacement of areas studies at the end of the Cold War into the current era of globalization. At this very historical moment of transition a new rationale for area studies emerged in the form of a geoeconomic imperative – both in the U.S. and, with a different gloss, in South Korea in the late 1990s. Second, on the basis of this historical apercu, the argument will be proposed that, given the problem of global warming and the issue‐area of global inequality lurking behind the UnitedNation’s Millennium Development Goals, a pressing contemporary task for philosophy is to make a critical contribution to developing a new planetary perspective for area studies informed by a constitutive philosophical anthropology attendant to the species being of human beings. (shrink)

The aim of this paper is to consider the vicissitudes of “area studies” from the Second World War to the present focusing eventually on the normative imperative to develop a new paradigm of “planetary thinking.” First an overview of the history of “area studies” will be given from the start in the U.S. during the Second World War in response to the geostrategic imperative for America to know its new geopolitical responsibilities in a world divided by war. This security imperativemorphed (...) into the postwar requisite to develop a counterhegemonic strategy against soviet communism in the hot spot parts of Asia, Latin American, and later Africa. The latter military‐oriented strategy was added to with research into development and modernization in the third-world through to the boundary displacement of areas studies at the end of the Cold War into the current era of globalization. At this very historical moment of transition a new rationale for area studies emerged in the form of a geoeconomic imperative – both in the U.S. and, with a different gloss, in South Korea in the late 1990s. Second, on the basis of this historical apercu, the argument will be proposed that, given the problem of global warming and the issue‐area of global inequality lurking behind the UnitedNation’s Millennium Development Goals, a pressing contemporary task for philosophy is to make a critical contribution to developing a new planetary perspective for area studies informed by a constitutive philosophical anthropology attendant to the species being of human beings. (shrink)

The aim of this paper is to consider the vicissitudes of “area studies” from the Second World War to the present focusing eventually on the normative imperative to develop a new paradigm of “planetary thinking.” First an overview of the history of “area studies” will be given from the start in the U.S. during the Second World War in response to the geostrategic imperative for America to know its new geopolitical responsibilities in a world divided by war. This security imperative (...) morphed into the postwar requisite to develop a counterhegemonic strategy against soviet communism in the hot spot parts of Asia, Latin American, and later Africa. The latter military-oriented strategy was added to with research into development and modernization in the third-world through to the boundary displacement of areas studies at the end of the Cold War into the current era of globalization. At this very historical moment of transition a new rationale for area studies emerged in the form of a geoeconomic imperative – both in the U.S. and, with a different gloss, in South Korea in the late 1990s. Second, on the basis of this historical apercu, the argument will be proposed that, given the problem of global warming and the issue‐area of global inequality lurking behind the United Nation’s Millennium Development Goals, a pressing contemporary task for philosophy is to make a critical contribution to developing a new planetary perspective for area studies informed by a constitutive philosophical anthropology attendant to the species being of human beings. (shrink)

There is an increasing interest in scanning and assessing the science and technology landscape for emerging technologies - such as those based on genomics knowledge - because innovations are beneficial to businesses and nations, and because of the Collingridge dilemma. The latter concerns the uncertainty and manageability of technology in its early development phases versus the more solidified later stages. In this context, the assessment of upcoming scientific and technological (sub)fields or "hot spots" is of interest. In this paper (...) we focus on methods to identify hot spots in pharmacogenomics and nutrigenomics and how this method can contribute to policy strategies. Moreover, the bibliometric results contribute to our understanding of hot spots within these genomics subfields. We answer the following leading research question: What are the main research fields of emerging pharmacogenomics and nutrigenomics technologies and how do these impact policy strategies? First, this paper introduces a novel method for identifying hot spots in emerging technologies. Following this method, pharmacogenomics and nutrigenomics show an above-average growth in patent applications. Patent search also suggests that for pharmacogenomics, countries such as Italy and France, and subfields such as cancer genomics are highly visible. For nutrigenomics, the Netherlands and Austria are important countries, while the dairy subfield proves to be a hot spot. Second, we discuss implications for policy strategies. We argue that it is difficult for policymakers to follow hot spots when they design their policy, because of the inherent tendency to "nurture" winners instead of "picking" fundamental new winners. Policymakers should be aware of this bias and research should address this issue by, for example, complementing the hot spot analysis with more interactive methods. (shrink)

Advances in Pig Welfare analyses current topical issues in the key areas of pig welfare assessment and improvement. With coverage of both recent developments and reviews of historical welfare issues, the volume provides a comprehensive survey of the field. The book is divided into two sections. Part I opens with an overview of main welfare challenges in commercial pig production systems and then reviews pig welfare hot spots from birth to slaughter. Part II highlights emerging topics in pig welfare, (...) such as pain and health assessment, early socialisation and environmental enrichment, pig-human interactions, breeding for welfare, positive pig welfare and pigs as laboratory animals. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs and poultry. With its expert editor and international team of contributors, Advances in Pig Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of pigs. (shrink)

Emotional labor generally exists in organization members. Emotional labor will not only affect employees’ interpersonal relationships, but also affect employees’ mental health. Affected by many factors such as the economic environment, they often need to bear multiple pressures. The degree of stress is positively correlated with the depth of the development of the times and people’s education. As mental health research has become the frontier and hot spot in the field of psychology, the role of mental health in the process (...) of employee creativity has been paid more and more attention. Therefore, this paper proposes a study on the causes of employees’ psychological stress based on emotional feature clustering. Based on the clustering of emotional characteristics, this paper analyzes the causes of employees’ mental health stress from an economic perspective. For teams with low level of team openness, with the improvement of team heterogeneity, team task performance shows a slight upward trend. It is clear from the experiment that when the number of experiments reaches 100, the task performance of high atmosphere level is 12.14, while the task performance of low atmosphere level is only 9.89. Therefore, the atmosphere of team employees is very important to team task performance. Through the cluster analysis of employees’ mental health characteristics, it not only increases employees’ spare time life, but also reduces employees’ daily contradictions. It eases the work pressure of employees, and becomes a platform for employees to improve their awareness and a promoter of harmonious employee relations. (shrink)

The fifth base in human DNA, 5‐methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the CpG methyl acceptor site and an 80% depletion in its frequency of occurrence in vertebrate DNA. The coding regions of many genes contain CpGs which are methylated in sperm and serve as hot spots for mutation in human genetic diseases. Fully 30–40% of all human germline point mutations are thought to be methylation induced even though the CpG dinucleotide (...) is under‐represented and efficient cellular repair systems exist. Importantly, tumor suppressor genes such as p53 also contain methylated CpGs and these serve as hot spots for mutations in some, but not all, human cancers. Comparison of the spectrum of mutations present in this gene in different human cancers allows for predictions to be made on the molecular mechanisms of tumorigenesis. (shrink)

Chromosomal rearrangements frequently occur at specific places (“hot spots”) in the genome. These recombination hot spots are usually separated by 50–100 kb regions of DNA that are rarely involved in rearrangements. It is quite likely that there is a correlation between the above‐mentioned distances and the average size of DNA loops fixed at the nuclear matrix. Recent studies have demonstrated that DNA loop anchorage regions can be fairly long and can harbor DNA recombination hot spots. We previously (...) proposed that chromosomal DNA loops may constitute the basic units of genome organization in higher eukaryotes. In this review, we consider recombination between DNA loop anchorage regions as a possible source of genome evolution. (shrink)

The end of the Cold War resulted in a diffusion of the level of threat worldwide and concluded the system of bipolarity in the world. Beside the European continent, where the rivalries were at the highest level, the consequences of the end of the Cold War were especially visible in North-East Asia. A decrease of military activities of Russia and China, and the retreat of the USA from the region, give way for improvement of political and economical relations between the (...) countries of the region. The end of hostilities produced by the Cold War no doubt have relaxed relations between countries in the region and opened ways for a new more peaceful co-existence. However, this does not mean that the region is not vulnerable to some of the hot spots such as North Korea, Spratly Parcels and especially Taiwan Strait. The latter is considered to be the most dangerous potential Asian zone of crisis in the twenty-first century. The East Asian countries such as China, Japan and other Association of Southeast Asian Nations countries are the world’s most growing economies and, at the same time, leaders in military acquisition; therefore, the potential for conflict and crises is current and real. This article examines one of these hot spots, namely the Taiwan Strait dispute, and assesses the possibility of this issue leading to a war between China, the USA and Japan. In order to have a clear view of the dispute the author will reveal some data in the introduction and then will explore relations, conflicts and interests between China, the USA and Japan vis-à-vis Taiwan and assess the risk that these countries might be drawn in potential war over the Taiwan Strait. (shrink)

“Walk on the Sun” is an interactive experience of image as music. As explorers move across images that are data projected onto the floor, their movements are visually tracked and used to select pixels in the images which they immediately hear as musical pitches played by various instruments. The sonification design maps color to one of 9 instruments, brightness to one of 50 pitches, and location in the image to panning position, creating 57,600 differentiable musical events. This high resolution and (...) interactive auditory presentation of pixel data enables the blind to explore images of the Sun from the STEREO space mission, nebula and galactic images from Hubble, as well as art masterpieces. Specifically, the blind can hear when hot spots cross the center of the Sun or the solar winds and corona are changing by sonifying virtual geometric structures, such as lines and circles, to create chords of music reflecting the changing content of the selected pixels within that structure as images are played as movies. Originally funded by a NASA/STSCI Ideas grant, the exhibit has toured to more than 12 cities in the US, visiting blind and science centers in the process and receiving enthusiastic response throughout. Plans for additional work furthering NASA wide image sonification standards are in process. (shrink)

Explanation is a perennially hot topic in philosophy of science. Yet philosophers have exhibited a curious blind spot to the questions of how explanatory projects develop over time, as well as what processes are involved in generating their developmental trajectories. This paper examines these questions using research into the end-Permian mass extinction as a case study. It takes as its jumping-off point the observation that explanations of historical events tend to grow more complex over time, but it goes beyond this (...) observation by scrutinizing the processes responsible for generating this pattern. Surveying several decades of research into the end-Permian extinction, I suggest that the principal “driver” of explanation in geohistory is non-explanatory work: work that is undertaken to increase our descriptive understanding of a phenomenon, not to test a particular explanatory claim. Non-explanatory work drives explanation by imposing or eliminating demands on explanation, and by furnishing new resources for constructing explanatory models. Explanations grow more complex because the demands on explanation tend to increase with ongoing characterization of the target phenomenon, and characterization tends grows the roster of explanatory resources. However, the fact that non-explanatory work sometimes eliminates demands on explanation means that this trend is not irreversible. I suggest that to achieve a more rounded view of the dynamics of explanation, philosophers should ask how research into complex phenomena is organized, as well as how explanatory progress depends upon the coordination of different kinds of material and epistemic resources. (shrink)

Climate has a strong influence on urban planning and also plays a fundamental role in soil composition affecting the character of plants and animals. The climate is a combination of different meteorological factors that characterized a specific region over a specific time. The movement of the Sun and Earth inclination toward it is the most important factors which determine the characteristics of the climate. The global movement of the air from equator toward poles and vice versa influences also drastically the (...) climate change. In this section are also included breezes. Also air relative humidity plays an important role shaping the climate. It plays a very important role in cloud formation. The built environment can influence the urban climate of the city through height, form, and applied building materials. Building form and shape, building materials, openings in the façade, and their orientation often are determined by climate parameters. Urban density, directions, and street network and their shape are related to the climate change, apart from topography. Density of urban structures produces important effects on the microclimatic conditions in external spaces. The bioclimatic behavior of each type of outdoor spaces depends on the relationship with its surrounding elements. The city of Tirana is included in Mediterranean climate characterized by hot dry summers and mild cold wet winters with high daily thermal excursions. All of the countries bordering the Mediterranean Sea benefit from the Mediterranean climate. Specifically spotted, Tirana is part of Mediterranean coastal zone (<22 °C in temperature) with an annual temperature of 15.3 °C. In the inner city can be found areas with high pollution, which normally contain a high percentage of business and industry, settlements, and traffic, so-called “sealed” areas. They constitute “hyperthermic areas” or “heat islands”. The term “heat island” describes built-up areas which are hotter than nearby rural areas. Heat islands can affect communities by increasing summertime peak energy demand, air-conditioning costs, air pollution, greenhouse gas emissions, heat-related illness and mortality, and water quality. The aim of the bioclimatic design is also the reduction of the heat-island phenomenon. The use of materials with different energy absorption capabilities and integration of green spaces into urban life is important. The vegetation effects on microclimate and in the built environment are present. Trees are necessary and indispensable to human life. They provide shelter for us, provide food, and their fibers cloth us. Implementation of the green belts in the city is one of the strategies in order to reduce heat-island effect. Vegetation also can provide a deep feeling of attachment to certain places and trees which are part of it. The use of trees avoids monotony and ensures diversification. They play a crucial role creating microclimates which influence the thermal comfort of people reducing heating or cooling loads. Vegetation also creates cooler microclimates around the building through evapotranspiration, reduces wind speed, regulates humidity, and reduces temperature. It is observed that tree species have a greater influence on humidity than on temperature. Trees can also absorb and reduce the reverberation time of the sound, behaving as sound buffers. The benefits of tree plantation in the inner city are enormous and they can’t be neglected. (shrink)

Hot-cold empathy gaps are a pervasive phenomena wherein one’s predictions about others tend to skew ‘in the direction’ of one’s own current visceral states. For instance, when one predicts how hungry someone else is, one’s prediction will tend to reflect one’s own current hunger state. These gaps also obtain intrapersonally, when one attempts to predict what one oneself would do at a different time. In this paper, we do three things: We draw on empirical evidence to argue that so-called hot-cold (...) empathy gaps arise when one projects one’s own current state into a simulation about another. Second, we argue that this process does not typically confer knowledge, even when the predictions it produces happen to be accurate. Third, we suggest that these results can be used to develop a challenge for L.A. Paul's view that authentic action sometimes requires subjective knowledge of one’s own values and how these values relate to relevant outcomes. We then sketch an alternative view of the epistemic grounds of authenticity, one on which authenticity requires a kind of understanding. The relevant form of understanding can be achieved by subjective knowledge but can also be achieved elsewise, such as through testimony from a close friend about what one values. (shrink)

When confronted with an ethical dilemma, most of us like to think we would stand up for our principles. But we are not as ethical as we think we are. In Blind Spots, leading business ethicists Max Bazerman and Ann Tenbrunsel examine the ways we overestimate our ability to do what is right and how we act unethically without meaning to. From the collapse of Enron and corruption in the tobacco industry, to sales of the defective Ford Pinto, the (...) downfall of Bernard Madoff, and the Challenger space shuttle disaster, the authors investigate the nature of ethical failures in the business world and beyond, and illustrate how we can become more ethical, bridging the gap between who we are and who we want to be. Explaining why traditional approaches to ethics don't work, the book considers how blind spots like ethical fading--the removal of ethics from the decision--making process--have led to tragedies and scandals such as the Challenger space shuttle disaster, steroid use in Major League Baseball, the crash in the financial markets, and the energy crisis. The authors demonstrate how ethical standards shift, how we neglect to notice and act on the unethical behavior of others, and how compliance initiatives can actually promote unethical behavior. They argue that scandals will continue to emerge unless such approaches take into account the psychology of individuals faced with ethical dilemmas. Distinguishing our "should self" from our "want self", the authors point out ethical sinkholes that create questionable actions. Suggesting innovative individual and group tactics for improving human judgment, Blind Spots shows us how to secure a place for ethics in our workplaces, institutions, and daily lives. (shrink)

When confronted with an ethical dilemma, most of us like to think we would stand up for our principles. But we are not as ethical as we think we are. In Blind Spots, leading business ethicists Max Bazerman and Ann Tenbrunsel examine the ways we overestimate our ability to do what is right and how we act unethically without meaning to. From the collapse of Enron and corruption in the tobacco industry, to sales of the defective Ford Pinto, the (...) downfall of Bernard Madoff, and the Challenger space shuttle disaster, the authors investigate the nature of ethical failures in the business world and beyond, and illustrate how we can become more ethical, bridging the gap between who we are and who we want to be. Explaining why traditional approaches to ethics don't work, the book considers how blind spots like ethical fading--the removal of ethics from the decision--making process--have led to tragedies and scandals such as the Challenger space shuttle disaster, steroid use in Major League Baseball, the crash in the financial markets, and the energy crisis. The authors demonstrate how ethical standards shift, how we neglect to notice and act on the unethical behavior of others, and how compliance initiatives can actually promote unethical behavior. They argue that scandals will continue to emerge unless such approaches take into account the psychology of individuals faced with ethical dilemmas. Distinguishing our "should self" from our "want self", the authors point out ethical sinkholes that create questionable actions. Suggesting innovative individual and group tactics for improving human judgment, Blind Spots shows us how to secure a place for ethics in our workplaces, institutions, and daily lives. (shrink)