The dynamic developmental theory (DDT) has benefited from the insights of the commentators, particularly in terms of the implications for the proposed steepened delay gradients in attention-deficit/hyperactivity disorder (ADHD). The introduction of modified memory processes as a basis for the delay gradients improved the links to aspects of ADHD. However, it remains unclear whether the hyperactive-impulsive and inattentive subtypes are separate subgroups or may be explained as different outcomes of the same genetic factors and thus explicable by the same principles. (...) The DDT suggests that altered reinforcement and extinction processes define an endophenotype in ADHD that can be related dimensionally to inattention, hyperactivity, and impulsivity. The relation between the suggested endophenotype, characterized by changes in basic learning mechanisms, and other endophenotypes characterized by delay aversion or response disinhibition, needs to be tested in future studies. (shrink)

Attention-deficit/hyperactivity disorder (ADHD) is currently defined as a cognitive/behavioral developmental disorder where all clinical criteria are behavioral. Inattentiveness, overactivity, and impulsiveness are presently regarded as the main clinical symptoms. The dynamic developmental behavioral theory is based on the hypothesis that altered dopaminergic function plays a pivotal role by failing to modulate nondopaminergic (primarily glutamate and GABA) signal transmission appropriately. A hypofunctioning mesolimbic dopamine branch produces altered reinforcement of behavior and deficient extinction of previously reinforced behavior. This gives rise to delay (...) aversion, development of hyperactivity in novel situations, impulsiveness, deficient sustained attention, increased behavioral variability, and failure to “inhibit” responses (“disinhibition”). A hypofunctioning mesocortical dopamine branch will cause attention response deficiencies (deficient orienting responses, impaired saccadic eye movements, and poorer attention responses toward a target) and poor behavioral planning (poor executive functions). A hypofunctioning nigrostriatal dopamine branch will cause impaired modulation of motor functions and deficient nondeclarative habit learning and memory. These impairments will give rise to apparent developmental delay, clumsiness, neurological “soft signs,” and a “failure to inhibit” responses when quick reactions are required. Hypofunctioning dopamine branches represent the main individual predispositions in the present theory. The theory predicts that behavior and symptoms in ADHD result from the interplay between individual predispositions and the surroundings. The exact ADHD symptoms at a particular time in life will vary and be influenced by factors having positive or negative effects on symptom development. Altered or deficient learning and motor functions will produce special needs for optimal parenting and societal styles. Medication will to some degree normalize the underlying dopamine dysfunction and reduce the special needs of these children. The theory describes how individual predispositions interact with these conditions to produce behavioral, emotional, and cognitive effects that can turn into relatively stable behavioral patterns. Key Words: catecholamine; clumsiness; dopamine; hyperkinesis; hyperkinetic disorder; impulsivity; monoamine; neuromodulator; overactivity; pollutants; reinforcement; reward; verbally governed behavior; soft signs; variability. (shrink)

This article suggests that in the delicate balance between grace and freedom, the opposite of rejecting God’s grace is not acceptance of grace, but rather is non-rejection or the openness to God that is the human person’s obediential potency. Using the insights of Karl Rahner and David Coffey, this article goes on to explain efficacious grace and sufficient grace as the one self-communication of God in the modes of acceptance and rejection. To protect the human freedom, one must emphasize that (...) human persons can reject God’s offer of self, but to protect the gratuity of grace, one must acknowledge that acceptance of God’s grace is always undergirded and empowered by that same grace. The mediating point between these two modes is human openness or obediential potency for grace. One does not have to accept God’s grace to be this openness, but rather one must simply not reject God’s offer of grace, hence the primary categories of human freedom are not rejection and acceptance, but rejection and non-rejection. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Keiji Nishitani and Karl Rahner: A Response to NihilityHeidi Ann RussellIn his essay “Kenosis and Emptiness,” Buddhist scholar Masao Abe states that “the necessity of tackling the Buddhist-Christian dialogue not merely in terms of interfaith dialogue, but also as an inseparable part of the wider sociocultural problem of religion versus irreligion has become more and more pressing in the past few decades.” 1 From Keiji Nishitani’s perspective a culture (...) of self-centeredness has developed out of the inability of many people to move beyond a sense of nihilism in their lives. Furthermore, technological advances and an increased understanding of the laws of nature have allowed humans to manipulate those laws for their own purposes. In this development, Nishitani believes that “the perversion that occurred in the original relationship of man to the laws of nature has taken the shape of a fundamental intertwining of the mechanization of man and his transformation into a subject in pursuit of its desires, at the ground of which nihility has opened up as a sense of the meaninglessness of the whole business.” 2Both Nishitani and Karl Rahner see in the development of science and technology a tendency to manipulate the laws of nature for one’s own benefit in a way that increases the self-centeredness and self-absorption of humankind while at the same time devaluing humanity and engendering an attitude of meaninglessness. In a world today that is confronted with issues such as war and global warming and in which religious communities are trying to make sense out of scientific issues such as stem cell research and cloning, the ability to address a nihilistic standpoint that sees the surrounding world as simply being at human disposal has never been more crucial. So how does one confront this crisis of a nihilistic culture? Abe recommends that both Buddhism and Christianity need “to pursue a fundamental reorganization in characterizing their faith such that the prevailing basic assumptions are drastically changed—for example, a revolutionary reinterpretation of the concept of God in Christianity and the concept of Emptiness in Buddhism—thereby allowing a new paradigm or model of understanding to emerge.” 3 The concept of emptiness or nothingness in Keiji Nishitani’s Religion and Nothingness and the concept of God as incomprehensible mystery in the theology of Karl Rahner 4 could allow for the [End Page 27] emergence of a model of understanding that addresses the problem of irreligion or nihility from an interreligious perspective.5 While in no way negating the very real dissimilarities between the concepts of Nishitani and Rahner or the respective religious traditions of which they are a part, one need not think of their concepts as diametrically opposed to one another in such a way that dialogue is impossible. To that effect, this essay will explore the common ground between Nishitani’s concept of śūnyatā6 (often translated or defined as ku /emptiness or mu /nothingness) and Rahner’s incomprehensible God 7 based on their interpretations of the human experience of meaninglessness and the need for a surrender of the self that manifests itself in one’s loving relationship with others. Common human experience, such as the experience of death or meaninglessness, and the interpretations of that experience found in various religions can provide ground from which to begin interreligious dialogue. One can search for a connection between the religious concepts by looking at the way they make sense out of a common affective experience without requiring an absolute identity between the cognitive religious concepts themselves.8 The important point of comparison is not manufacturing a false identity between the concepts, but the way the concepts work within the living communities to move one to volitive action. In this way the practical or ethical implications of the concepts and how they are lived out in the world become the focus. In the work of Nishitani and Rahner, that common human experience is the meaninglessness encountered in the world today and the call for a selfless love that will transcend such meaninglessness. In their roles as philosopher-theologians, both Nishitani and Rahner have probably had more influence on individuals or leaders within certain Buddhist and Christian... (shrink)

Abstract: Many, if not most philosophers, deny that a sentence like ‘Sherlock Holmes smokes’ could be true. However, this attitude conflicts with the assignment of true to that sentence by natural language speakers. Furthermore, this process of assigning truth values to sentences like ‘Sherlock Holes smokes’ seems indistinguishable from the process that leads speakers to assign true to other sentences, those like ‘Bertrand Russell smokes’. I will explore the idea that when speakers assign the value true to the first (...) sentence, they are not mistaken or confused — that we ought to take these assignments at face value. I show how the most popular alternative to this idea is inadequate for explaining various sentences involving fictional names. In addition, I offer evidence that these truth value assignments to sentences are tracking semantic content rather than pragmatic effects. (shrink)

The presented study introduces a new theoretical model of collapse for social, cultural, or political systems. Based on the current form of quantum anthropology conceptualized by Heidi Ann Russell, further development of this field is provided. The new theoretical model is called the spiral model of collapses, and is suggested to provide an analytical framework for collapses in social, cultural, and political systems. The main conclusions of this study are: 1) The individual crises in the period before a (...) collapse of social, cultural, and political systems form the trajectory of a conical helix similar to a vortex. 2) The occurrences of crises in the period before a collapse have the shape of the trajectory on the surface of the circular cone with a convex wall narrowing up to its peak. The shape of this cone is based on the Fibonacci sequence coiled into the three-dimensional space. 3) The constant circular movement along the trajectory of crises can occur in exceptional situations in the development of social, cultural, and political systems; however, such a state is always temporary. In such cases, the trajectory of the crisis does not follow the Fibonacci sequence, but the shape of a regular helix. Remaining on the trajectory of a regular helix in the long-term is highly improbable for social, cultural, and political systems. 4) The creation of new potentialities after the final collapse of a system is explained by the conception of topological inversion, when the heretofore embodied part of the energy-information field returns to the global, wave-particle energy-information potential. 5) The global, wave-particle energy-information potential is a source of energy-information for future embodiments in the sense of the future collapses of wave functions. (shrink)

This anthology is a thorough introduction to classic literature for those who have not yet experienced these literary masterworks. For those who have known and loved these works in the past, this is an invitation to reunite with old friends in a fresh new format. From Shakespeare's finesse to Oscar Wilde's wit, this unique collection brings together works as diverse and influential as The Pilgrim's Progress and Othello. As an anthology that invites readers to immerse themselves in the masterpieces of (...) the literary giants, it is must-have addition to any library. (shrink)

The formulation and proof of Hume’s Law and several related inference barrier theses.

What does it mean to "trust?" What makes us feel secure enough to place our confidence—even at times our welfare—in the hands of other people? Is it possible to "trust" an institution? What exactly do people mean when they claim to "distrust" their governments? As difficult as it may be to define, trust is essential to the formation and maintenance of a civil society. In Trust and Trustworthiness political scientist Russell Hardin addresses the standard theories of trust and articulates (...) his own new and compelling idea: that much of what we call trust can be best described as "encapsulated interest." Research into the roles of trust in our society has offered a broad range of often conflicting theories. Some theorists maintain that trust is a social virtue that cannot be reduced to strategic self-interest; others claim that trusting another person is ultimately a rational calculation based on information about that person and his or her incentives and motivations. Hardin argues that we place our trust in persons whom we believe to have strong reasons to act in our best interests. He claims that we are correct when we assume that the main incentive of those whom we trust is to maintain a relationship with us—whether it be for reasons of economic benefit or for love and friendship. Hardin articulates his theory using examples from a broad array of personal and social relationships, paying particular attention to explanations of the development of trusting relationships. He also examines trustworthiness and seeks to understand why people may behave in ways that violate their own self-interest in order to honor commitments they have made to others. The book also draws important distinctions between vernacular uses of "trust" and "trustworthiness," contrasting, for example, the type of trust (or distrust) we place in individuals with the trust we place in institutions Trust and Trustworthiness represents the culmination of important new research into the roles of trust in our society; it offers a challenging new voice in the current discourse about the origins of cooperative behavior and its consequences for social and civic life. A Volume in the Russell Sage Foundation Series on Trust. (shrink)

In this book, Russell Winslow analyzes contemporary discourses in microbiology and evolutionary inheritance theory to foreground the metaphysical prejudices that unreflectively subtend these discourses, highlight and illuminate an emergent prejudice of an ecological ontology in microbiology, and determine what interpretive possibilities it affords.

In this paper we examine how the use of robots in caring for elders can impact the meaningfulness of elders’ lives. We present a framework for understanding ‘meaningfulness in life’, and then apply that framework in discussing ways in which the use of robots to assist in activities of daily living can preserve, enhance or undermine the meaningfulness of elders’ lives. We conclude with a discussion of if and how having false beliefs about companion robots can affect meaningfulness in the (...) life of the person having those false beliefs. (shrink)

First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

In this article, we present ideas related to three key aspects of mindfulness training: the regulation of attention via noradrenaline, the importance of working memory and its various components (particularly the central executive and episodic buffer), and the relationship of both of these to mind-wandering. These same aspects of mindfulness training are also involved in the preparation and execution of movement and implicated in the pathophysiology of psychosis. We argue that by moving in a mindful way, there may be an (...) additive effect of training as the two elements of the practice (mindfulness and movement) independently, and perhaps synergistically, engage common underlying systems (the default mode network). We discuss how working with mindful movement may be one route to mindfulness training for individuals who would struggle to sit still to complete the more commonly taught mindfulness practices. Drawing on our clinical experience working with individuals with severe and enduring mental health conditions, we show the real world application of these ideas and how they can be used to help those who are suffering and for whom current treatments are still far from adequate. (shrink)

Objective—To explore the opinions of unpaid healthy volunteers on the payment of research subjects.Design—Prospective cohort.Setting—Southern Alberta, Canada.Participants—Medically eligible persons responding to recruiting advertisements for a randomised vaccine trial were invited to take part in a study of informed consent at the point at which they formally consented or refused trial participation. Of 72 invited, 67 returned questionnaires at baseline and 54 at follow-up.Outcome measures—Proportions of persons who agreed or disagreed with three close-ended statements on the payment of research subjects; themes (...) and categories identified by content analysis of responses to an open-ended question.Results—A minority agreed with paying either patient or healthy volunteer participants. Opinions did not change over time. Participants' comments addressed: benefits and drawbacks to research participation; benefits and drawbacks to paying research participants; conditions under which payment of research subjects would be acceptable, and the nature of acceptable recognition. Acceptable conditions were to improve problematic recruitment, to reimburse costs, and to recognise participants, particularly for their time investment. Both non-monetary and monetary recognition of volunteers were thought to be appropriate.Conclusions—Most unpaid volunteers disagreed with paying research participants. The themes arising from their comments are similar to those that have been raised by ethicists and suggest that recognising the time and effort of participants should receive greater emphasis than presently occurs. (shrink)

First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

Despite recent advances in ways to prevent transmission of HIV from a mother to her child during pregnancy, infants continue to be born and become infected with HIV, particularly in southern Africa where HIV prevalence is the highest in the world. In this region, emphasis has shifted from voluntary HIV counselling and testing to routine testing of women during pregnancy. There have also been proposals for mandatory testing. Could mandatory testing ever be an option, even in high-prevalence settings? Many previous (...) examinations of mandatory testing have dealt with it in the context of low HIV prevalence and a well-resourced health care system. In this discussion, different assumptions are made. Within this context, where mandatory testing may be a strategy of last resort, the objections to it are reviewed. Special attention is paid in the discussion to the entrenched vulnerability of women in much of southern Africa and how this contributes to both HIV prevalence and ongoing challenges for preventing HIV transmission during pregnancy. While mandatory testing is ethically plausible, particularly when coupled with guaranteed access to treatment and care, the discussion argues that the moment to employ this strategy has not yet come. Many barriers remain for pregnant women in terms of access to testing, treatment and care, most acutely in the southern African setting, despite the presence of national and international human rights instruments aimed at empowering women and removing such barriers. While this situation persists, mandatory HIV testing during pregnancy cannot be justified. (shrink)

Virtue ethicists sometimes say that a right action is what a virtuous person would do, characteristically, in the circumstances. But some have objected recently that right action cannot be defined as what a virtuous person would do in the circumstances because there are circumstances in which a right action is possible but in which no virtuous person would be found. This objection moves from the premise that a given person ought to do an action that no virtuous person would do, (...) to the conclusion that the action is a right action. I demon‐strate that virtue ethicists distinguish “ought” from “right” and reject the assumption that “ought” implies “right.” I then show how their rejection of that assumption blocks this “right but not virtuous” objection. I conclude by showing how the thesis that “ought” does not imply “right” can clarify a further dispute in virtue ethics regarding whether “ought” implies “can.”. (shrink)

There are many ways that biological theory can inform ethical discussions of genetic engineering and biomedical enhancement. In this essay, we highlight some of these potential contributions, and along the way provide a synthetic overview of the papers that comprise this special issue. We begin by comparing and contrasting genetic engineering with programs of selective breeding that led to the domestication of plants and animals, and we consider how genetic engineering differs from other contemporary biotechnologies such as embryo selection. We (...) go on to consider the implications of genetic engineering for human nature, human evolution, and persistence of the human species. Finally, we question whether genetic interventions warrant the extraordinary ethical scrutiny they are often given, and we show how the misleading “genetic blueprint” metaphor has imposed a faulty structure on the enhancement debate. We conclude by considering the nature of biological development and the sobering limits it places on what genetic engineering can reasonably hope to achieve. (shrink)

In book 3 of his Republic, Plato has Socrates undertake an assessment of the educational curriculum that the city (which is being constructed by him in speech) will implement for its youth. Consequently we see that Socrates assigns to poetry a crucial importance; by their imitation of it, poetry shapes the citizens with an initial formation, casts them within a certain orientation, and places them on a path leading in an already conceived direction, toward some unarticulated good. Thus, in forming (...) this city and the souls of its citizens, Socrates first conducts a censorship of the content of the formative myths of the city in an attempt to orchestrate a certain fail-safe against ambiguity and against falling off .. (shrink)

This article addresses two interrelated questions: Why is it often difficult to create better environmental conditions in the world using traditional political processes and new technological fixes? May science and technology studies analyses of user strategies and micropolitics contribute to societies’ treatment of these difficulties? Focusing on the problems that the electric car has confronted in establishing itself as a viable alternative to the internal combustion car, the authors argue that its failure illustrates the poverty of organized politics, on one (...) hand, and the shortcomings of engineering design practices, on the other. The authors suggest that a thoroughgoing change in the automobility system will take place only if more attention is paid to the actual use of alternative vehicles. By driving differently and viewing automobility differently, electric vehicle owners develop “user scripts” that challenge established political and engineering scripts while contributing to what the authors call a “cultural politics of automobility.”. (shrink)

Despite recent advances in ways to prevent transmission of HIV from a mother to her child during pregnancy, infants continue to be born and become infected with HIV, particularly in southern Africa where HIV prevalence is the highest in the world. In this region, emphasis has shifted from voluntary HIV counselling and testing to routine testing of women during pregnancy. There have also been proposals for mandatory testing. Could mandatory testing ever be an option, even in high‐prevalence settings? Many previous (...) examinations of mandatory testing have dealt with it in the context of low HIV prevalence and a well‐resourced health care system. In this discussion, different assumptions are made. Within this context, where mandatory testing may be a strategy of last resort, the objections to it are reviewed. Special attention is paid in the discussion to the entrenched vulnerability of women in much of southern Africa and how this contributes to both HIV prevalence and ongoing challenges for preventing HIV transmission during pregnancy. While mandatory testing is ethically plausible, particularly when coupled with guaranteed access to treatment and care, the discussion argues that the moment to employ this strategy has not yet come. Many barriers remain for pregnant women in terms of access to testing, treatment and care, most acutely in the southern African setting, despite the presence of national and international human rights instruments aimed at empowering women and removing such barriers. While this situation persists, mandatory HIV testing during pregnancy cannot be justified. (shrink)

Slaman and Wehner have constructed structures which distinguish the computable Turing degree 0 from the noncomputable degrees, in the sense that the spectrum of each structure consists precisely of the noncomputable degrees. Downey has asked if this can be done for an ordinary type of structure such as a linear order. We show that there exists a linear order whose spectrum includes every noncomputable Δ 0 2 degree, but not 0. Since our argument requires the technique of permitting below a (...) Δ 0 2 set, we include a detailed explanation of the mechanics and intuition behind this type of permitting. (shrink)

This article presents an overview of traditional legal and regulatory incentives directed at achieving lawful corporate behavior, together with examples of more recent governmental incentives aimed at encouraging self regulation activities by corporations. These incentives have been differentiated into positive incentives that benefit corporations for actions that encourage or assist lawful behavior, and punitive incentives that only punish corporations for violations of legal or regulatory standards. This analysis indicates that traditional legal and regulatory incentives for lawful corporate behavior are overwhelmingly (...) punitive in their intended effects, while more recent governmental incentives to encourage voluntary corporate self regulation are much more positive in their intended effects.A prototype private compliance system containing typical features specified in governmental incentives for corporate self regulation was then analyzed applying the same positive/punitive analysis that was performed with the governmental incentives. This analysis suggests that corporate compliance programs that are structured to comply with Department of Defense regulations for defense contractors or the new Federal Organizational Sentencing Guidelines will reflect the same overwhelmingly punitive balance of incentives for lawful and ethical employee conduct as do the traditional legal and regulatory incentive systems for lawful corporate behavior. (shrink)

In “On the Life of thinking in Aristotle’s De Anima,” the author offers an interpretation of the tripartite structure of the unified soul in Aristotle’s text. The principleactivity that unities the nutritive, sensuously perceptive and noetically perceptive parts of the soul into a single, continuous entity is shown by our author to be genesis (or the sexual begetting of offspring). After establishing this observation, the paper provides the textual grounds to understand how both sensuous and noetic perception can be understood (...) as a kind of embodied genesis. A further consequence of this argument will be an interpretation of “thinking,” of noetic perception, as a kind of open and passive reception of the primary forms of other beings. As such, Aristotle’s conception of thinking, qua nous, is a refreshing, if strange, contrast to the more common modern vision of “thinking” as the activity of an agent mentally seizing hold of beings in the service of the mastery of nature. (shrink)

This essay pursues an interpretation of epagôgê in Aristotle in order to challenge the current claims in the scholarship that Aristotle’s method of discovery is, on the one hand, empirical or, on the other hand, a priori. In contrast to these claims, this essay offers a reading of the Analytica in conjunction with the Physics in order to propose the following: if we are to think through Aristotle’s method of discovery, we must first unhinge ourselves from the oppositional paradigm of (...) empirical contra conceptual. Through the example of Aristotle’s inquiry into nature, it is shown that Aristotle’s method of discovery is, at once, one intimately betrothed to “conceptual” (or, more properly, “dialogical”) resources, while also subtended by a comportment itself wakeful and perceptive of the being undergoing inquiry. (shrink)

Mistakes and errors happen in most spheres of human life and activity, including in medicine. A mistake can be as simple and benign as the collection of an extra and unnecessary urine sample. Or a mistake can cause serious but reversible harm, such as an overdose of insulin in a patient with diabetes, resulting in hypoglycemia, seizures, and coma. Or a mistake can result in serious and permanent damage for the patient, such as the failure to consider epiglottitis in an (...) initial differential diagnosis, resulting in a chronic vegetative state for a seven-year-old boy. Or a mistake can be an error in judgment that leads to a patient's death. (shrink)

Our target article concerns the direction and growth of enactivism, a framework portrayed as a revolutionary shift in understanding cognition. While enactivism continues to be a lively position, it is unclear how its contributions relate to the cognitive sciences. Despite some empirical successes, enactivism remains somewhat insulated as a theoretical position and as a research program. There exists a discrepancy between enactivist aims and delivery. The basis of this problem, we argue, is that the overall objective of enactive theorising is (...) not clear, which has led to diverging strategies for implementation and integration with the cognitive sciences. We review contributions from different strains of enactivism – autopoietic, sensorimotor and radical – and their research goals, both tacit and explicit. We show that enactivism is productively understood as two projects we term utopian enactivism and scientific enactivism. Utopian enactivism aims to develop a philosophically defensible lens through which cognitive science is to be viewed. Scientific enactivism intervenes in scientific practice by contributing to the implementation of enactive ideas. Once disentangled, the utopian and scientific projects have important but independent tasks. Utopian enactivism is useful for building a coherent and defensible enactive philosophy of nature, while scientific enactivism is free to draw upon and contribute to non-enactive approaches in the cognitive sciences. We aim to motivate discussions that will enhance enactivism’s progress, and our reappraisal also offers a clear and explicit roadmap for renewing advances in enactivist philosophy and cognitive science. (shrink)