Ground s’enfronta al xoc de l’art contemporani plantejant, a manera de reflexió filosòfica, aquelles preguntes «grolleres» que semblaven confinades en la resposta de l’home del carrer o del crític reaccionari: no és una xorrada aquesta pila de rajoles al museu? No obstant això, la seua intenció no és fer-nos prendre partit a favor o en contra de determinades obres d’art del Minimal o del Conceptual. El que batega al fons del llibre de Ground és una defensa de l’art contemporani quan (...) reivindica la seua intel·ligibilitat com un tret centralment constitutiu d’aquest. Una defensa que passa, necessàriament, per mantenir en peus la vigència de la pregunta que dóna títol al llibre, a pesar dels intents recents per anul·lar-la o per relegar-la a una desautorització ingenuista i/o reaccionària de «tot» l’art contemporani. (shrink)

We hypothesise that the sarcolemma of an actively growing myofibre has different properties to the sarcolemma of a mature adult myofibre. Such fundamentally different properties have clinical consequences for the onset, and potential therapeutic targets, of various skeletal muscle diseases that first manifest either during childhood (e.g. Duchenne muscular dystrophy, DMD) or after cessation of the main growth phase (e.g. dysferlinopathies). These characteristics are also relevant to the selection of both tissue culture and in vivo models employed to study such (...) myopathies and the molecular regulation of adult myofibres. During growth, multinucleated myofibres increase enormously in size and volume with dramatic increases in length (up to ∼600 mm). This is in striking contrast with most mononucleated cells such as fibroblasts, that remain at a relatively small size (∼10–20 µm diameter). The consequences of a dynamic, expanding sarcolemma during growth, compared with that of an adult myofibre of a fixed length, are discussed with respect to various aspects of muscle biology. (shrink)

Cora Diamond’s discussions of the ethics of our treatment of animals offer a critique of conceptions of morality which regard our ethical responses as founded on reasons which ought to be reasons for anyone. Diamond takes issue with accounts of our treatment of animals based on their possession of capacities which are shared with us. She offers instead a concept of the moral life, as a form of life—inherited, shared and negotiated—only within which can moral reasons count as reasons at (...) all. Our fellow creatures have some share in this life, but one that must be recognized as partial and problematic.In this discussion, we offer an account which is consistent with Diamond’s general perspective. But one which also offers a more generous account of ways in which the discoveries of the ethological sciences dynamically reshape the place of animals in our shared moral life. (shrink)

El text d’Ian Ground la traducció del qual transcrivim a continuació va ser llegit a l’acte de presentación del seu llibre ¿Arte o chorrada? (València, Publicacions de la Universitat de València / Col•lecció Estètica & Crítica, 2008) el dia 9 de juny de 2008 a l’Aula Magna de l’edifici del Carrer La Nau de la Universitat de València, amb la presència, a més d’Ian Ground, de Romà de la Calle (en qualitat de Director de la col•lecció Estètica & Crítica) i (...) de mi mateix, Salvador Rubio (en qualitat de traductor, editor i autor de la introducció del llibre). El text va ser llegit en anglés pel seu autor, alternat, paràgraf per paràgraf, amb la lectura de la traducció castellana. Hem preferit que el text traduit aparega ací en castellà, exactament igual al que va ser llegit a l’esmentat acte de presentació. La reflexió que ens proposa Ian Ground, en cara que específicament concebuda per a aquest acte, no necessita cap presentació i pot ser llegida perfectament com un text autònom. Tanmateix, em permet precedir-la amb unes quantes observacions que no pretenen sustituir les meues paraules a l’acte (on, naturalment, els agraïments eren els protagonistes) ni tampoc la introducció del llibre ja publicada, i a la qual es pot remetre directament el lector d’aquest article. (shrink)

ED455370 - Lifelong Learning, Equity and Inclusion. Proceedings [of the] UACE Conference (Cambridge, England, March 29-31, 1999).

Must We Mean What We Play? INTRODUCTION It was Sir Thomas Beecham who said,'The English do not care for music-but they love the noise it makes.'Sir Thomas was, of course, given to making acerbic swipes but this one has always seemed to me to have.

This rich, subtle and hugely ambitious book might also have been called “why (and how) metaphysics matters”. Cooper's themes are the tensions implicit in the relation of contingent human beings to the world and the implications of those tensions, and of putative means of their.

On the now dominant Quinean view, metaphysics is about what there is. Metaphysics so conceived is concerned with such questions as whether properties exist, whether meanings exist, and whether numbers exist. I will argue for the revival of a more traditional Aristotelian view, on which metaphysics is about what grounds what. Metaphysics so revived does not bother asking whether properties, meanings, and numbers exist (of course they do!) The question is whether or not they are fundamental.

Extreme loss of skeletal muscle mass (atrophy) occurs in human muscles that are not used. In striking contrast, skeletal muscles do not rapidly waste away in hibernating mammals such as bears, or aestivating frogs, subjected to many months of inactivity and starvation. What factors regulate skeletal muscle mass and what mechanisms protect against muscle atrophy in some species? Severe atrophy also occurs with ageing and there is much clinical interest in reducing such loss of muscle mass and strength (sarcopenia). In (...) the meat industry, a key aim is optimizing the control of skeletal muscle growth and meat quality. The impaired response of muscle to insulin resulting in diabetes, that is a consequence of the metabolic impact of increasing obesity and fat deposition in humans, is also of increasing clinical concern. Intensive research in these fields, combined with mouse models, is reviewed with respect to the molecular control of muscle growth (myogenesis) and atrophy/hypertrophy and fat deposition (adipogenesis) in skeletal muscle, with a focus on IGF‐1/insulin signaling. BioEssays 28: 994–1009, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

身のまわりの卑近な事柄を根本から考え直してみたい。そんな欲求が人々の心をとらえている。看護する自分に、哲学はそのための力を与えてくれるだろうか。知識・科学・心・モラルといった主題にそって看護の主要な問 題をとりあげ、哲学ならではの思索の道筋を示す。「考える看護」の面白さが実感できる「ナースのための哲学入門」。.

This book brings together disparate strands of ToM research, lays out historical roots of the idea, and indicates better alternatives.

Existential claims are widely held to be grounded in their true instances. However, this principle is shown to be problematic by arguments due to Kit Fine. Stephan Krämer has given an especially simple form of such an argument using propositional quantifiers. This note shows that even if a schematic principle of existential grounds for propositional quantifiers has to be restricted, this does not immediately apply to a corresponding non-schematic principle in higher-order logic.

Environment and the Arts: Perspectives on Environ- mental Aesthetics. Edited by ARNOLD BERLEANT . Ashgate. 2002. pp. 192. C ONSISTING of twelve chapters, and an extended introduction, this volume provides a leading-edge anthology of reflections on environmental aesthetics.

This article provides a new argument and a new value-theoretical ground for person-centered care and shared decision making that ascribes to it the role of enabling rational choice in situations involving clinical choice. Rather than referring to good health outcomes and/or ethical grounds such as patient autonomy, it argues that a plausible justification and ground for person-centered care and shared decision making is preservation of rationality in the face of comparative non-determinacy in clinical settings. Often, no alternative treatment will (...) be better than or equal to every other alternative. In the face of such comparative non-determinacy, Ruth Chang has argued that we can make rational decisions by invoking reasons that are created through acts of willing. This article transfers this view to clinical decision making and argues that shared decision making provides a solution to non-determinacy problems in clinical settings. This view of the role of shared decision making provides a new understanding of its nature, and it also allows us to better understand when caregivers should engage in shared decision making and when they should not. (shrink)

Introduction: Natural necessity, being, and becoming -- Accentuate the negative -- Diffracting dialectic -- Opening totality -- Constellating ethics -- Metacritique I : philosophy's primordial failing -- Metacritique II : dialectic and difference -- Conclusion: Natural necessity and the grounds of justice : natural necessity as material meshwork.

Is it merely a matter of taste or convention to consider something right or wrong? Or can we find good reasons for our values and judgements that are independent of culture and tradition? The problem is as old as philosophy itself; and after more than two millennia of scholarly debate, there seems no end to the controversy. But Christian Illies suggests that powerful new forms of transcendental argument (a philosophical tool known since antiquity) may offer a long-sought cornerstone for morality.

"As a distinctive philosophy, religious humanism emphasizes man's place in an unfathomed universe, reason as an instrument for discovering the truth, free inquiry as a condition for discerning meaning and purpose, and happiness as a fundamental value. "Man's uniqueness emerges partly from homo sapiens' capacity to employ symbols effectively. For this reason, Willard's provocative book is not a celebration of controversy but a sophisticated study exploring the grounds of man's knowledge. Drawing upon phenomenologists such as Alfred Schultz, psychologists such (...) as George Kelley, and argumentation philosophers such as Stephen Toulmin, Willard makes a genuine contribution to intellectual inquiry by extending essential consideration about human knowledge. The [author] demonstrates how 'secular sources' provide a fundamental resource in developing religious understanding from argumentative interactions. "Highly insightful and intellectually refreshing... _Argumentation and the Social Grounds of Knowledge_ provides thought-provoking reading for humanists concerned with rational inquiry, communication theory, religious philosophy, and liberal education." _--Religious Humanism_. (shrink)

The current study sought to determine research scientists’ sensitivity to various justifications for engaging in behaviors typically considered to be questionable research practices by asking them to evaluate the appropriateness and ethical defensibility of each. Utilizing a within-subjects design, 107 National Institutes of Health principal investigators responded to an invitation to complete an online survey in which they read a series of research behaviors determined, in prior research, to either be ambiguous or unambiguous in their ethical defensibility. Additionally, each behavior (...) was paired with either an ostensibly sound or unsound reason for the behavior. Consistent with hypotheses, the results indicated that scientists perceived QRPs as more appropriate and defensible when paired with a justifiable motive relative to when paired with a clearly unethical motive, particularly for QRPs that are more ambiguous in their ethicality. In fact, ambiguous QRPs were perceived as categorically defensible when given a justifiable motive. This suggests scientists are sensitive to contextual factors related to QRPs’ appropriateness, which could inform how institutions develop appropriate training modules for research integrity. (shrink)

An argument that in response to sociocultural pressures, human minds develop self-consciousness by activating a complex machinery of self-regulation.

In this chapter, we compare Kant and James’ accounts of freedom. Despite both thinkers’ rejecting compatibilism for the sake of practical reason, there are two striking differences in their stances. The first concerns whether or not freedom requires the possibility of an open future. James holds that morality hinges on the real possibility that the future can be affected by our actions. Kant, on the other hand, seems to maintain that we can still be free in the crucial sense, even (...) if none of our actions can have any effect on the future. The second difference between them is related, and concerns the location of freedom. Kant views experience as determined by natural necessity, and locates freedom outside of it, in things-in-themselves. James, on the other hand, has a richer conception of experience than Kant, and holds that we can locate our freedom within experience alone. In the end, we contend that James has a better account of how freedom relates to our experience, but this comes at a cost. For while Kant's account struggles with the relationship between freedom and experience, it has the advantage of insulating our freedom from potential empirical challenges. (shrink)