Histone acetylation is an important regulatory mechanism that controls transcription and diverse nuclear processes. While great progress has been made in understanding how localized acetylation and deacetylation control promoter activity, virtually nothing is known about the consequences of acetylation throughout entire chromosomal regions. An increasing number of genes have been found to reside in large chromatin domains that are controlled by regulatory elements many kilobases away. Recent studies have shown that broad histone acetylation patterns are hallmarks of chromatin domains. The (...) purpose of this review is to discuss how such patterns are established and their implications for regulating gene expression. BioEssays 23:820–830, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This is a review of H. Duméry’s volume Imagination et religion. Éléments de judaïsme, éléments de christianisme. The author studies biblical religion and the origins of the Christian religion, classifying and recording the imaginative element that feeds the narratives of piety: hence the rehabilitation of the myths that frame the functioning of religious representations. The author suggests that the imagination, in its deepest resources, forges the human social, has the power to invent all social roles, and causes the emergence of (...) attitudes of devotion or renunciation which are a human prerogative. (shrink)

Emery, Lucilius A. Concerning Justice. New Haven: Yale University Press, 1914. vii, 170 pp. Reprinted 2002 by The Lawbook Exchange, Ltd. ISBN 1-58477-234-4. Cloth. $60. * This volume reprints the Storrs lectures delivered by Emery [1840-1920] at Yale University in 1914. Emery's profound knowledge of constitutional law and keen interest in philosophy and history are clearly evident here. Beginning with conceptions of justice in Antiquity and in the Judeo-Christian tradition, Emery develops a general theory of rights, (...) and uses it as a basis for his definition of justice. His other lectures deal with the securing of justice. Influenced perhaps by the outbreak of hostilities in Europe, Emery asserts that the United States has created the finest system yet for its preservation. "It is most emphatically a book which, once read, is kept on hand for a re-reading." H.W.C. Yale L.J. 24: 263 as cited in Marke, A Catalogue of the Law Collection at New York University (1953) 191. Dictionary of American Biography 144-145. (shrink)

This is a review of H. Duméry’s volume Imagination et religion. Éléments de judaïsme, éléments de christianisme. The author studies biblical religion and the origins of the Christian religion, classifying and recording the imaginative element that feeds the narratives of piety: hence the rehabilitation of the myths that frame the functioning of religious representations. The author suggests that the imagination, in its deepest resources, forges the human social, has the power to invent all social roles, and causes the emergence of (...) attitudes of devotion or renunciation which are a human prerogative. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:AN IMPORTANT NEW STUDY OF THOMAS AQUINAS: JEAN-PIERRE TORRELL'S INITIATION A SAINT THOMAS D'AQUIN WALTER H. PRINCIPE, C.S.B. Pontifical Institute of Mediaeval Studies Toronto, Canada BEFORE BECOMING professor of theology at the Universite de Fribourg, Jean-Pierre Torrell, O.P., was a member of the Leonine Commission. This editorial experience, together with his continuing association with members of the commission, enables him in his new work, Initiation a saint Thomas d'Aquin: (...) Sa personne et son oeuvre, to clarify and frequently modify previous research conclusions about the life and work of Thomas Aquinas.1 Thus other recent studies in this area, e.g., those of James A. Weisheipl and Simon Tugwell, will have to be reassessed in the light of Torrell's findings in this important volume.2 Torrell, however, does more than examine the dates and places of Thomas's career and writing: as the book's subtitle and introduction make clear, his aim is to present the person of Thomas Aquinas in his context. This he does in a warm but measured fashion, situating Aquinas in his times, following Thomas's journeys about France and Italy on his intellectual apostolatea true ministry in the Dominican tradition-portraying him as 1 In the series Vestigia: Pensee antique et medievale 13 (Fribourg Suisse: Editions Universitaires; Paris: Cerf, 1993), pp. xviii, 592. 2 See Weisheipl, Friar Thomas d'Aquino: His Life, Thought, and Works, 2nd ed. (Washington, D.C.: Catholic University of America Press, 1983), and Tugwell, trans., ed., introd., Albert & Thomas: Selected Writings, The Classics of Western Spirituality (New York-Mahwah: Paulist Press, 1988), introd. [to Thomas Aquinas], pp. 201-351. 489 490 WALTER H. PRINCIPE, C.S.B. often nearly overwhelmed by the duties of this apostolate, yet vigorous and lively in defense of the faith and of the legitimate role of reason, a warm friend to many con,freres and others, a loyal and sometimes deeply involved member of his family. Torrell is especially adept at linking Thomas's apostolic activity with his profound and distinctive spirituality; this augurs well for Torrell 's promised companion volume, which will deal far more thoroughly with Thomas's spirituality than was possible within the editorial constraints of his earlier article in the Dictionnaire de spiritualite.3 New conclusions about the place and dating of Thomas's works Here, first, will be given a summary, with occasional comment, of this study's significant new conclusions about the place and dating of Thomas's works. Torrell accepts Weisheipl's view that Aquinas did his initial biblical commentary at Cologne before coming to Paris in 1252 and spent the years 1252-1256 working on the Scriptum super Sententiis. The "bref catalogue" at the end, prepared by G. Emery, O.P., states that this work is the "fruit of his teaching as bachelor of the Sentences at the begin;.. ning of his first stay in Paris ( 1252-54) ; its redaction had not yet been completed when he began his activity as Master ( 1256)" (485; emphasis mine). Weisheipl, with whom Torrell agrees as to Thomas's having done his cursory teaching of the Bible at Cologne, holds that Thomas lectured on the Senten:ces for the four years, 1252-1256 (71, 358); Tugwell seems to hold the same position when he speaks of Thomas "writing [his lectures on the Sentences] up for publication as he went" (211). Torrell's limitation of the teaching of the Sentences to 1252-1254 is based on the university statutes prescribing that this teaching be completed in two years (66), after which the candidate for the mastership would be a " formed bachelor " (baccalaureus formatus) whose main task would be to assist the master of 3 See his "Thomas d'Aquin," Dictionnaire de Spiritualite 15 (1991), cols. 718-73. INITIATION A SAINT THOMAS D1 AQUIN 491 theology with his disputed questions (58). This would mean that Thomas spent two whole years, 1254-1256, carrying out this rather minimal duty, redacting the Sentences (a task not completed until the beginning of his period as a master of theology), and composing two small works, the De ente et essentia and the De principiis naturae. Although the Scriptum is a... (shrink)

ipamati kistamati pari tumatimis: Luwian and Hittite Studies Presented to J. David Hawkins on the Occasion of His 70th Birthday. Edited by Itamar Singer. Emery and Claire Yass Publications in Archaeology, Monograph Series, vol. 28. Tel Aviv: Tel Aviv University Institute of Archaeology, 2010. Pp. xx + 262, illus. $65.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 525 "an awareness of its perfection in perfect sell-identity" stems from his own theological bias: if God is to be connected with the world, His thinking cannot be merely a thinking about itself; His mind must also contain the Ideas of the sensible world. The inconsistency is quite apparent in the concluding paragraph of the introductory chapter three on "SellKnowledge ": If we study chapters seven and (...) nine of Book Lambda against the background of these texts on the meaning of friendship, it becomes apparent that a fortiori God's thinking must concern his own being and that "the thinking of thinking" is the supreme form of self-knowledge. Far from being an objectless returning to oneself, this knowledge concerns the very being of the First Principle. It would also seem to fot|ow that iust as knowing a friend is a certain degree of self-knowledge because of the ontological kinship between the self and a friend, God, in knowing himself, also knows, to a certain degree, the essential principles of things in so far as he is the first being encompassing within himself the perfections which other beings possess. This would, however, not imply that the first being would know the world as distinct from himself or as dependent on himself (pp. 33-34). How can God (the Unmoved Mover) think only of Himself, and at the same time, to a certain degree (whatever this means) know also the essential principles of things, the perfections which other beings possess? And what textual justification is there for attributing this position to Aristotle? There are a number of errors in the text. Some of them are as follows: (1) On p. 21 Elders quotes from Laws 987b, in spite of the fact that the Laws ends on 969c. The passage referred to would have to be in Epinomis, but at 987b there is nothing of the text he quotes, to wit, vo~g ~v n0ooXQf3o0oa~E~0~tv 6006g 0~tv. (2) On p. 24, note 41, he correctly gives the text at 432a4 as ~ ~oggdSEo~xotg do0n~o~g x6 vo~x6 ~oxt but makes it mean: '~ere are phantasmata in which the intelligible things are contained." Evidently he confuses this with the passage at 431b1--4. (3) On p. 279, p~.~oxr should read p~i~.t~r (4) On p. 5, ~oo~v should read 6.~ao6v. K. W. Hsaa~oroN Emery University In Our Image and Likeness: Humanity and Divinity in Italian Humanist Thought. Two Volumes. By Charles Trinkaus. (Chicago: The University of Chicago Press, 1970. Pp. 985. $22.50) I. Since the appearance of Burckhardt's classic essay more than a century ago, three schools of thought have grown up around the problem of the nature and extent of humanism 's relationship to Christianity. The classic position, represented by Burckhardt, Symends, Dilthey, Gentile, Cassirer, Saitta, and others, has interpreted humanism as an essentiaUy anti-Christian, anti-scholastic, rationatistic, and individualistic phenomenon caught up in an overwhelming concern for attaining to historical greatness in this world. If religion has been considered at all (and it is usually left to take care of itself), it has been so reinterpreted as to become consistent with the interests of emerging secularism, liberalism, and modern science. Opposing the Burckhardtian position, however, is one originally associated with the work of Giuseppe Toffanin and, more recently, Hiram Haydn. Here, Renaissance humanism is seen to be fundamentaUy Catholic, orthodox, and traditional---the two movements joined in perfect harmony by a common concern for antiquity and universaiism, for Latinity, faith, and corporate elitism, and by a common opposition to democratic particularism, heresy, individualism, modernity, and the vernaculars. What makes these two positions extreme, however, is the existence of the largest, most 526 HISTORY OF PHILOSOPHY moderate, and most diversified camp. Originating with Thode, Pastor, Olgiati, and Joachimsen, among a host of others, it has encompassed the general view that humanism and Christianity are separate yet interrelated. For some, medieval Catholicism is not the antithesis but the fountainhead of Renaissance humanism--the religious cause of a secular effect. For others, humanism is a novel intellectual movement, but one yet operating within a still... (shrink)

Process engraver and printer Emery Walker was a pivotal figure in the English, American, and continental European Private Press Movement from the 1880s until his death in 1933. This article looks at his theories for the typography, design, and production of books, and how those theories were developed by key designers and close associates of Walker such as William Morris, T. J. Cobden Sanderson, and Bruce Rogers and through the practical teaching of figures such as J. H. Mason and (...) Edward Johnston. It examines how the theories were then taken up by the exponents of fine printing from the early 20th century through to the 1930s, focusing on the presses of Bernard Newdigate, Harry Kessler, Harold Curwen, and Francis Meynell. From these presses, and also via Stanley Morison and the Monotype Corporation, Walker’s theories are shown to have spread into mainstream book publishing in the first half of the 20th century. The article considers questions of whether the improvement in the readability of books in the early 20th century has had a continuing impact in book publishing, and makes suggestions how to access the incunabula referenced by the designers discussed, as well as collections of private press books and other early 20th-century fine printing. (shrink)

The controversy over the equivalence of continuous sedation until death (CSD) and physician-assisted suicide/euthanasia (PAS/E) provides an opportunity to focus on a significant extended use of CSD. This extension, suggested by the equivalence of PAS/E and CSD, is designed to promote additional patient autonomy at the end-of-life. Samuel LiPuma, in his article, “Continuous Sedation Until Death as Physician-Assisted Suicide/Euthanasia: A Conceptual Analysis” claims equivalence between CSD and death; his paper is seminal in the equivalency debate. Critics contend that sedation follows (...) proportionality protocols for which LiPuma’s thesis does not adequately account. Furthermore, sedation may not eliminate consciousness, and as such LiPuma’s contention that CSD is equivalent to neocortical death is suspect. We not only defend the equivalence thesis, but also expand it to include additional moral considerations. First, we explain the equivalence thesis. This is followed by a defense of the thesis against five criticisms. The third section critiques the current use of CSD. Finally, we offer two proposals that, if adopted, would broaden the use of PAS/E and CSD and thereby expand options at the end-of-life. (shrink)

This study sheds new insight on how historically oppressed and marginalized actors are able to pursue environmental sustainability based on alternative worldviews (e.g., Indigenous worldviews) rather than succumbing to those dominant in the Western society, based on a study of the Syilx (“Okanagan”) people in British Columbia, Canada. We found that the Syilx people enacted the ethical practice of _nʕawqnwixʷ_ (“the reciprocal gentle dropping of thoughts, like water, into everyone’s minds to address the issue at the centre of discussion and (...) to reach collective consensus for action”), anchored in the Syilx worldview, to reconstruct the relationships between humans and nature. Two overlapping processes are involved: developing foundational principles for human–nature relations and carrying out reconstruction work. Ongoing enactment of _nʕawqnwixʷ_ practice provided community-based agency, enabling the Syilx people to shift the conversation around environmental sustainability. From this, we discuss the theoretical potential of community-based agency for the study of environmental sustainability, and the role of Indigenous worldviews for (re)imagining human-nature ethics (and reorienting the theoretical lens of human-animal or human-plant ethics form a firm-centric focus to a community-oriented lens), and important implications for practitioners and policymakers in the field of environmental sustainability. (shrink)

En décembre 2007, Jacqueline Hamesse a fêté son 65ème anniversaire, puis a accédé à l’éméritat en 2008. Nombreux sont les collègues et amis qui ont souhaité marquer ces dates en rendant hommage à son dévouement aux études médiévales, que ce soit dans l’enseignement et la recherche ou pour la création et le développement d’institutions internationales dans ce domaine, sans oublier les efforts déployés pour l’édition de nombreux ouvrages collectifs et l’organisation de diverses rencontres scientifiques. Nous avons donc décidé de lui (...) dédier ce volume d’études intitulé «Florilegium mediaevale». L’ouvrage comprend des études concernant l’un des quatre thèmes suivants: les textes philosophiques dans leur contexte et leur support matériel, les instruments travail ainsi que le vocabulaire des textes philosophiques. En effet, ce sont des domaines qui ont surtout retenu son attention depuis de nombreuses années et dans lesquels elle a apporté des contributions significatives à la recherche. Contributions de: L-J. Bataillon (†) et O. Weijers (Paris / Den Haag), F. Bertelloni (Buenos Aires), Ch. Burnett (London), J. Casteigt (Toulouse), J. Celeyrette et J-L. Solère (Lille / Boston), W. Courtenay (Wisconsin-Madison), G. Dahan (Paris), G. Dinkova-Bruun (Toronto), K. Emery Jr. (Notre Dame), Ch. Erismann (Cambridge), B. Faes de Mottoni (Milano), G. Federici Vescovini (Firenze), B. Fernández de la Cuesta (Madrid), R. Friedman et Ch. Schabel (Leuven / Nicosia), D. Gottschall (Lecce), S. Harvey (Jerusalem), I. Heullant-Donat (Reims), R. Hissette (Köln), M. Hoenen (Freiburg i.B.), J. Meirinhos (Porto), O. Merisalo (Jyväskylä), M. Mulchahey (Toronto), M. J. Muñoz Jiménez (Madrid), M. C. Pacheco (Porto), G. Piaia (Padova), R. H. Pich (Porto Alegre), J. Puig Montada (Madrid), R. Ramón Guerrero (Madrid), C. Sirat et M. Geoffroy (Paris), G. Spinosa (Roma), I. Ventura (Louvain-la-Neuve). (shrink)

A common compatibilist view says that we are free and morally responsible in virtue of the ability to respond aptly to reasons. Many hold a version of this view despite disagreement about whether free will requires the ability to do otherwise. The canonical version of this view is reductive. It reduces the pertinent ability to a set of modal properties that are more obviously compatible with determinism, like dispositions. I argue that this and any reductive view of abilities faces a (...) significant challenge: it cannot adequately explain the freedom-grounding element of this ability. The problem has the form of a dilemma. This leaves reasons-responsive compatibilists with two options: abandon theories of free will grounded in abilities or abandon reductive theories of abilities. (shrink)

This edited volume explores the previously underacknowledged 'pre-history' of mathematical structuralism, showing that structuralism has deep roots in the history of modern mathematics. The contributors explore this history along two distinct but interconnected dimensions. First, they reconsider the methodological contributions of major figures in the history of mathematics. Second, they re-examine a range of philosophical reflections from mathematically-inclinded philosophers like Russell, Carnap, and Quine, whose work led to profound conclusions about logical, epistemological, and metaphysic.

Alzheimer’s Disease (AD) provides an excellent case study to investigate emerging conceptions of health, disease, pre-disease, and risk. Two scientific working groups have recently reconceptualized AD and created a new category of asymptomatic biomarker positive persons, who are either said to have preclinical AD, or to be at risk for AD. This article examines how prominent theories of health and disease would classify this condition: healthy or diseased? Next, the notion of being “at risk”—a state somewhere in-between health and disease—is (...) considered from various angles. It is concluded that medical-scientific developments urge us to let go of dichotomous ways of understanding disease, that the notion of “risk,” conceptualized as an increased chance of getting a symptomatic disease, might be a useful addition to our conceptual framework, and that we should pay more attention to the practical usefulness and implications of the ways in which we draw lines and define concepts. (shrink)

A naturalistic theory of intentionality is proposed that differs from previous evolutionary and tracking theories. Full-blown intentionality is constructed through a series of evolvable refinements. A first, minimal version of intentionality originates from a conjectured internal process that estimates an organism’s own fitness and that continually modifies the organism. This process produces the directedness of intentionality. The internal estimator can be parsed into intentional components that point to components of the process that produces fitness. It is argued that such intentional (...) components can point to mistaken or non-existing entities. Different Fregian senses of the same reference correspond to different components that have different roles in the estimator. Intentional components that point to intentional components in other organisms produce directedness towards semi-abstract entities. Finally, adding a general, population-wide means of communication enables intentional components that point to fully abstract entities. Intentionality thus naturalized has all of its expected properties: being directed; potentially making errors; possibly pointing to non-existent, abstract, or rigid entities; capable of pointing many-to-one and one-to-many; distinguishing sense and reference; having perspective and grain; and having determinate content. Several examples, such as ‘swampman’ and ‘brain-in-a-vat’, illustrate how the theory can be applied. (shrink)

While Merleau-Ponty’s political positions evolved over the course of his career, they are grounded in and guided by a remarkably consistent account of historicity. Praxis requires authentic historical engagement; and Merleau-Ponty was critical of inauthentic a-historical approaches throughout his career. I chart a trajectory of Merleau-Ponty’s position from The War Has Taken Place (1945), through some of the newly published material from the mid to late 1940’s Michel Dalissier’s monumental two volume collection of inédits, and the Introduction to Signs (1960). (...) This results in two surprising and admittedly controversial observations that contradict dominant narratives. I argue that: (1) Merleau-Ponty’s account of historicity precludes the claim that he abandoned Marxism altogether with the writing of Adventures of the Dialectic (1955); and (2) Merleau-Ponty’s account of historicity reveals the dominant Western narrative about the war in Ukraine to be inauthentic. (shrink)

My primary aim in this paper is to show that the structure of experience must include a subject (or self). I argue that the subjectless (No-Self) views of our experience must be rejected, primarily because without the consciousness-unifying function of a subject they are unable to account for the unities of consciousness present in our experience. In addition, I contend that such views fail in another respect. They emphasize the streaming of experience, the ever-changing flow of conscious events, but have (...) difficulty identifying what must stand unmoving to provide the contrast needed for the experience of motion. (shrink)

Studies of patient decision‐making use many different measures to evaluate the quality of decisions and the decision‐making process, partly to determine whether the ethical goals of informed consent, patient autonomy, and shared decision‐making have been achieved. We describe these measures, grouped under three main approaches, and review their limitations, leading to three conclusions. First, no measure or combination of measures can provide a complete assessment of decision quality. Second, the quality of a decision is best characterized vaguely, for instance as (...) “good,” “satisfactory,” or “poor,” and these categorizations depend on qualitative judgments that go beyond quantitative measures. Third, bioethicists should focus on identifying and addressing poor or problematic decisions, rather than trying to incrementally increase decision quality, quantified by a measure. Decision‐quality measures can be useful in research and in advancing important goals of bioethics, as long as the challenges of defining and measuring decision quality are recognized. (shrink)

The impact of digital media and technology on performance arts is evident when digital visual effects (VFX) filming techniques are introduced on a film set. Digital technologies influence the film actor’s approach to be congruent to and authentic within the circumstances of the scene. Actors require an effective skillset and strategies to successfully deliver an embodied performance aligning with the various digital VFX techniques. Focusing on imagination, action and emotion that would facilitate such an embodied performance, we drew on relevant (...) neuroscientific notions such as neuron reactivation, conceptual blending, as-if body states and affordances. Additionally, we incorporated relevant embodied performance concepts from Stanislavski, Laban/Bartenieff Movement Studies, Effector Patterns including the Emotional Body Approach and Lessac Kinesensics to the development of a digital acting programme, advancing the actor’s required skills and providing on-set digital acting strategies to support congruency with digital VFX and authenticity within the diegetic reality. The efficacy of this programme was determined by assessing pre- and post-intervention recordings of both a control and an experimental group of trained actors. Reflection-on-action journals from participants supplemented the assessment. The assessments and journals indicate that the acquired skillset and on-set digital acting strategies effectively improve the actor’s performance with digital VFX filming technology. (shrink)

This article examines the relationship between Jeremy Waldron’s supersession thesis and compensation. Recently, Waldron has argued that claims for material compensation for the original injustice cannot be superseded. He limits supersession to issues of restitution. Waldron’s supersession thesis is frequently cited by opponents of claims based on historical injustice, so his view of compensation warrants close examination. In our article, we explain the details of Waldron’s ‘simple model’ of compensation, offer an internal critique of it, and try to sympathetically reconstruct (...) it. We contend that a crucial claim about this model does not work; his model would result in many more backward-looking compensatory claims than he realizes. Waldron’s allowing for material compensation claims from historical injustice is in tension with, or incompatible with, his long-expressed view that the spirit of the supersession thesis is that justice should be forward-looking and look to present-day costs. We have argued elsewhere that the abstract possibility that restitution claims may be superseded due to changing circumstances (what we call the ‘supersession thesis proper’) is separable from the question of whether justice has a forward-looking or backward-looking orientation. We argue here that Waldron’s model of compensation can best be made sense of through our distinction of ‘full supersession’ and ‘partial supersession.’ This allows us to show that Waldron’s model relies on a more strongly backward-looking orientation than he seems to endorse in his earlier works on restitution and his most recent article discussing compensation. We conclude by offering external criticisms of Waldron’s model of compensation. (shrink)

1993: GE’s NBC News unit issues an on-air apology to General Motors for staging a misleading simulated crash test. NBC agrees to pay GM’s estimated $1 million legal and investigation expenses.February 1994: The Justice Department brought a criminal antitrust case against General Electric, accusing it of conspiring with an arm of the South African DeBeers diamond cartel to fix prices in the $600 million world market for industrial diamonds. General Electric denied wrongdoing...

Background Whether patients' life-style should involve lower priority for treatment is a controversial question in bioethics. Less is known about clinicians' views. Aim To study how clinical doctors' attitudes to questions of patient responsibility and priority vary over time. Method Surveys of doctors in Norway in 2008, 2014, 2021. Questionnaires included statements about patients' lifestyle's significance for priority to care, and vignettes of priority cases (only in 2014). Results Attitudes were fairly stable between 2008 and 2021. 17%/14% agreed that patients' (...) lifestyle should count, while 19%/22% agreed that it should involve lower priority to scarce organs. 42/44% agreed that smokers should have lower priority. Substantially more agreed in 2014. Regression analyses showed that being male, working in hospital, and younger age increased the likelihood of agreeing. Conclusion A substantial minority of doctors agreed that lifestyle should be a priority criterion, possibly contrary to Norwegian legislation and professional ethics. The finding might be explained by the unspecified meaning of priority, increased scarcity-awareness, or socio-cultural trends towards individualism. The 2014 results indicate a framing effect; the vignettes may have primed the respondents towards accepting lifestyle as a criterion. We conclude that attitudes to normative questions are unstable and depend on context. A substantial minority of doctors seems to be positive to deprioritizing patients allegedly responsible for their illness. However, what deprioritization implies in practice is not clear. (shrink)