New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Dans cet ouvrage de 430 pages – dont neuf consacrées à un index des auteurs anciens et modernes – Geneviève Clerico, Bernard Colombat et Jean Soubiran ont réuni 22 textes écrits par Françoise Desbordes de 1981 à 2000 et généralement publiés antérieurement dans des revues scientifiques ou actes de colloques. Ces études ne concernent pas la rhétorique, domaine privilégié de l’activité scientifique de F.D., ni les analyses textuelles, les contributions de F.D. à ces disciplines ayant fait l’obje..

Dans cet ouvrage de 430 pages – dont neuf consacrées à un index des auteurs anciens et modernes – Geneviève Clerico, Bernard Colombat et Jean Soubiran ont réuni 22 textes écrits par Françoise Desbordes de 1981 à 2000 et généralement publiés antérieurement dans des revues scientifiques ou actes de colloques. Ces études ne concernent pas la rhétorique, domaine privilégié de l’activité scientifique de F.D., ni les analyses textuelles, les contributions de F.D. à ces disciplines ayant fait l’obje...

With a new foreword by Jonathan Lear 'Remarkably lively and enjoyable…It is a very rich book, containing excellent descriptions of a variety of moral theories, and innumerable and often witty observations on topics encountered on the way.' -_ Times Literary Supplement_ Bernard Williams was one of the greatest philosophers of his generation. Ethics and the Limits of Philosophy is not only widely acknowledged to be his most important book, but also hailed a contemporary classic of moral philosophy. Drawing on (...) the ideas of the Greek philosophers, Williams reorients ethics away from a preoccupation with universal moral theories towards ‘truth, truthfulness and the meaning of an individual life’. He explores and reflects upon the most difficult problems in contemporary philosophy and identifies new ideas about central issues such as relativism, objectivity and the possibility of ethical knowledge. This edition also includes a commentary on the text by A.W.Moore. At the time of his death in 2003, Bernard Williams was hailed by the Times as 'the outstanding moral philosopher of his age.' He taught at the Universities of Cambridge, Berkeley and Oxford and is the author of many influential books, including _Morality; Descartes: The Project of Pure Enquiry_ and _Truth and Truthfulness_. (shrink)

This book is a philosophically sophisticated and scientifically well-informed discussion of the moral and social issues raised by genetically engineering animals, a powerful technology which has major implications for society. Unlike other books on this emotionally charged subject, the author attempts to inform, not inflame, the reader about the real problems society must address in order to manage this technology. Bernard Rollin is both a professor of philosophy, and physiology and biophysics, and writes from a uniquely well-informed perspective on (...) this topic. The style is non-technical and anecdotal and will ensure that the book can be used on a wide range of courses on bioethics, biotechnology, veterinary medicine and public policy. The book could also appeal to a general, non-academic reader with a serious interest in genetic engineering. (shrink)

We tend to suppose that the ancient Greeks had primitive ideas of the self, of responsibility, freedom, and shame, and that now humanity has advanced from these to a more refined moral consciousness. Bernard Williams's original and radical book questions this picture of Western history. While we are in many ways different from the Greeks, Williams claims that the differences are not to be traced to a shift in these basic conceptions of ethical life. We are more like the (...) ancients than we are prepared to acknowledge, and only when this is understood can we properly grasp our most important differences from them, such as our rejection of slavery. The author is a philosopher, but much of his book is directed to writers such as Homer and the tragedians, whom he discusses as poets and not just as materials for philosophy. At the center of his study is the question of how we can understand Greek tragedy at all, when its world is so far from ours. Williams explains how it is that when the ancients speak, they do not merely tell us about themselves, but about ourselves. _Shame and Necessity_ gives a new account of our relations to the Greeks, and helps us to see what ethical ideas we need in order to live in the modern world. (shrink)

In 1944 Horkheimer and Adorno warned that industrial society turns reason into rationalization, and Polanyi warned of the dangers of the self-regulating market, but today, argues Stiegler, this regression of reason has led to societies dominated by unreason, stupidity and madness. However, philosophy in the second half of the twentieth century abandoned the critique of political economy, and poststructuralism left its heirs helpless and disarmed in face of the reign of stupidity and an economic crisis of global proportions. New theories (...) and concepts are required today to think through these issues. The thinkers of poststructuralism Lyotard, Deleuze, Derrida must be re-read, as must the sources of their thought, Hegel and Marx. But we must also take account of Naomi Klein’s critique of Milton Friedman and the Chicago School and her account of the ‘shock doctrine’. In fact, argues Stiegler, a permanent ‘state of shock’ has prevailed since the beginning of the industrial revolution, intensified by the creative destruction brought about by the consumerist model. The result has been a capitalism that destroys desire and reason and in which every institution is undermined, above all those institutions that are the products par excellence of the Enlightenment the education system and universities. Through a powerful critique of thinkers from Marx to Derrida, Stiegler develops new conceptual weapons to fight this destruction. He argues that schools and universities must themselves be transformed: new educational institutions must be developed both to take account of the dangers of digitization and the internet and to enable us to take advantage of the new opportunities they make available. (shrink)

Tractatus, 5.62 famously says: ‘… what the solipsist means is quite correct; only it cannot be said but makes itself manifest. The world is my world: this is manifest in the fact that the limits of language mean the limits of my world.’ The later part of this repeats what was said in summary at 5.6: ‘the limits of my language mean the limits of my world’. And the key to the problem ‘how much truth there is in solipsism’ has (...) been provided by the reflections of TLP, 5.61. (shrink)

This review demonstrates that an individualist view of emotion and regulation is untenable. First, I question the plausibility of a developmental shift away from social interdependency in emotion regulation. Second, I show that there are multiple reasons for emotional experiences in adults to elicit a process of social sharing of emotion, and I review the supporting evidence. Third, I look at effects that emotion sharing entails at the interpersonal and at the collective levels. Fourth, I examine the contribution of emotional (...) sharing to emotion regulation together with the relevant empirical evidence. Finally, the various functions that the social sharing of emotion fulfills are reviewed and the relevance of the social sharing of emotion for emotion scientists is discussed. (shrink)

How I became a philosopher -- To love, to love me, to love us.

From the beginning the French philosopher Claude Lefort has set himself the task of interpreting the political life of modern society-and over time he has succeeded in elaborating a distinctive conception of modern democracy that is linked to both historical analysis and a novel form of philosophical reflection. This book, the first full-scale study of Lefort to appear in English, offers a clear and compelling account of Lefort's accomplishment-its unique merits, its relation to political philosophy within the Continental tradition, and (...) its great relevance today. Much of what passes for political philosophy in our day is merely politicized philosophical concepts, a distinction author Bernard Flynn underscores as he describes the development of Lefort's truly political philosophy-its ideas formed in response to his own political experience and to the work of certain major figures within the tradition of political thought. Beginning with Lefort's most important single work, his book on Machiavelli, Flynn presents the philosopher's conceptions of politics, modernity, and interpretation in the context within which they took shape. He then draws on a wide variety of Lefort's works to explicate his notions of premodern and modern democracy in which totalitarianism, in Lefort's singular and highly influential theory, is identified as a permanent problem of modernity. A valuable exposition of one of the most important Continental philosophers of the post-World War II period, Flynn's book is itself a noteworthy work of interpretive philosophy, pursuing the ideas and issues addressed by Lefort to a point of unparalleled clarity and depth. (shrink)

Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia, bipolar disorder, and major depression) represent two major suites of disorders of human cognition, affect, and behavior that involve altered development and function of the social brain. We describe evidence that a large set of phenotypic traits exhibit diametrically opposite phenotypes in autistic-spectrum versus psychotic-spectrum conditions, with a focus on schizophrenia. This suite of traits is inter-correlated, in that autism involves a general pattern of constrained overgrowth, whereas schizophrenia involves undergrowth. These disorders also (...) exhibit diametric patterns for traits related to social brain development, including aspects of gaze, agency, social cognition, local versus global processing, language, and behavior. Social cognition is thus underdeveloped in autistic-spectrum conditions and hyper-developed on the psychotic spectrum.;>We propose and evaluate a novel hypothesis that may help to explain these diametric phenotypes: that the development of these two sets of conditions is mediated in part by alterations of genomic imprinting. Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions. (shrink)

Later reprinted by Deborah Charles Publications (and not available from Amazon), this book expounds and comments on the application of Greimasian semiotics to a legal text, as found in the article by Greimas and Landowski in Greimas, Sémiotique et Sciences Sociales (1976), compares this with the semiotic presuppositions of Hart, Dworkin, MacCormick and Kelsen, and offers my own analysis of the implications of such semiotic analysis for legal theory, including some more recent radical non-positivist accounts.

Philosophy should not try to assimilate itself to the aims of the sciences. Scientism stems from the false assumption that a representation of the world minimally based on local perspectives is what best serves self-understanding. Philosophy must concern itself with the history of our conceptions, and we must overcome the need to think that this history should ideally be vindicatory. There is no basic conflict between arguing within the framework of our ideas, reflectively making better sense of them, and understanding (...) their highly contingent history. The third of these activities is an inescapable part of the second. (shrink)

This is the text of The Lindley Lecture for 1985, given by Bernard Williams, a British philosopher.

This new volume of philosophical papers by Bernard Williams is divided into three sections: the first Action, Freedom, Responsibility, the second Philosophy, Evolution and the Human Sciences; in which appears the essay which gives the collection its title; and the third Ethics, which contains essays closely related to his 1983 book Ethics and the Limits of Philosophy. Like the two earlier volumes of Williams's papers published by Cambridge University Press, Problems of the Self and Moral Luck, this volume will (...) be welcomed by all readers with a serious interest in philosophy. It is published alongside a volume of essays on Williams's work, World, Mind, and Ethics: Essays on the Ethical Philosophy of Bernard Williams, edited by J. E. J. Altham and Ross Harrison, which provides a reappraisal of his work by other distinguished thinkers in the field. (shrink)

Most conceptual models of the organization of the cardiovascular system begin with the premise that the nervous system regulates the metabolic and nonmetabolic reflex adjustments of the circulation. These models assume that all the neurally mediated responses of the circulation are reactive, i.e., reflexes elicited by adequate stimuli. This target article suggests that the responses of the circulation are conditional in three senses. First, as Sherrington argued, reflexes are conditional in that they never operate in a vacuum but in a (...) context together with other reflexes. Guided by functional utility, they interact rather than add. Second, as Pavlov argued, stimuli acquire meanings as a result of experience. This notion of stimulus effect plus the Sherringtonian notion of conditionality suggest that association is one of the ways stimuli eliciting cardiovascular reflexes acquire their meanings and thus their relative strengths. Finally, as Skinner and others have argued, operants are responses that act upon the environment to obtain consequences – that is, stimuli. As operants, cardiovascular responses fulfill a major biological need, functioning proactively. The cardiovascular response is an integral component of the animal's behavior regardless of whether it is an elicited reflex or the eliciting stimulus acquired its properties as a result of the genetic inheritance of the animal or through experience, or the cardiovascular response is emitted in anticipation of an environmental consequence. The main theses of this essay are: (1) behavior is an integrated set of responses and the circulation is one of the response systems comprising behavior; (2) behavior is, in part, determined by its functional significance within a context; (3) the contextual factors operative at the time of the behavior have a major role in determining which of the set of possible responses will determine the final act, that is, which behavior will be the effective response and which other behaviors will be concomitants. (shrink)

Thomas Hobbes was the first great English political philosopher. His work excited intense controversy among his contemporaries and continues to do so in our own time. In this masterly introduction to his work, Bernard Gert provides the first account of Hobbes’s political and moral philosophy that makes it clear why he is regarded as one of the best philosophers of all time in both of these fields. In a succinct and engaging analysis the book illustrates that the commonly accepted (...) view of Hobbes as holding psychological egoism is not only incompatible with his account of human nature but is also incompatible with the moral and political theories that he puts forward. It also explains why Hobbes’s contemporaries did not accept his explicit claim to be providing a natural law account of morality. Gert shows that for Hobbes, civil society is established by a free-gift of their right of nature by the citizens; it does not involve a mutual contract between citizens and sovereign. As injustice involves breaking a contract, the sovereign cannot be unjust; however, the sovereign can be guilty of ingratitude, which is immoral. This distinction between injustice and immorality is part of a sophisticated and nuanced political theory that is in stark contrast to the reading often incorrectly attributed to Hobbes that “might makes right”. It illustrates how Hobbes’s goal of avoiding civil war provides the key to understanding his moral and political philosophy. _Hobbes: Prince of Peace_ is likely to become the classic introduction to the work of Thomas Hobbes and will be a valuable resource for scholars and students seeking to understand the importance and relevance of his work today. (shrink)

In this paper, the authors briefly summarize how object theory uses definite descriptions to identify the denotations of the individual terms of theoretical mathematics and then further develop their object-theoretic philosophy of mathematics by showing how it has the resources to address some objections recently raised against the theory. Certain ‘canonical’ descriptions of object theory, which are guaranteed to denote, correctly identify mathematical objects for each mathematical theory T, independently of how well someone understands the descriptive condition. And to have (...) a false belief about some particular mathematical object is not to have a true belief about some different mathematical object. (shrink)

Thomas Hobbes was the first great English political philosopher. His work excited intense controversy among his contemporaries and continues to do so in our own time. In this masterly introduction to his work, Bernard Gert provides the first account of Hobbes’s political and moral philosophy that makes it clear why he is regarded as one of the best philosophers of all time in both of these fields. In a succinct and engaging analysis the book illustrates that the commonly accepted (...) view of Hobbes as holding psychological egoism is not only incompatible with his account of human nature but is also incompatible with the moral and political theories that he puts forward. It also explains why Hobbes’s contemporaries did not accept his explicit claim to be providing a natural law account of morality. Gert shows that for Hobbes, civil society is established by a free-gift of their right of nature by the citizens; it does not involve a mutual contract between citizens and sovereign. As injustice involves breaking a contract, the sovereign cannot be unjust; however, the sovereign can be guilty of ingratitude, which is immoral. This distinction between injustice and immorality is part of a sophisticated and nuanced political theory that is in stark contrast to the reading often incorrectly attributed to Hobbes that “might makes right”. It illustrates how Hobbes’s goal of avoiding civil war provides the key to understanding his moral and political philosophy. _Hobbes: Prince of Peace_ is likely to become the classic introduction to the work of Thomas Hobbes and will be a valuable resource for scholars and students seeking to understand the importance and relevance of his work today. (shrink)

I outline some of my work and results on my matter-gravity entanglement hypothesis, according to which the entropy of a closed quantum gravitational system is equal to the system’s matter-gravity entanglement entropy. The main arguments presented are: that this hypothesis is capable of resolving what I call the second-law puzzle, i.e. the puzzle as to how the entropy increase of a closed system can be reconciled with the asssumption of unitary time-evolution; that the black hole information loss puzzle may be (...) regarded as a special case of this second law puzzle and that therefore the same resolution applies to it; that the black hole thermal atmosphere puzzle can be resolved by adopting a radically different-from-usual description of quantum black hole equilibrium states, according to which they are total pure states, entangled between matter and gravity in such a way that the partial states of matter and gravity are each approximately thermal equilibrium states ; that the Susskind–Horowitz–Polchinski string-theoretic understanding of black hole entropy as the logarithm of the degeneracy of a long string cannot be quite correct but should be replaced by a modified understanding according to which it is the entanglement entropy between a long string and its stringy atmosphere, when in a total pure equilibrium state in a suitable box, which ) goes over, at strong-coupling, to a black hole in equilibrium with its thermal atmosphere. The modified understanding in is based on a general result, which I also describe, which concerns the likely state of a quantum system when it is weakly coupled to an energy-bath and the total state is a random pure state with a given energy. This result generalizes Goldstein et al.’s ‘canonical typicality’ result to systems which are not necessarily small. (shrink)

This essay asks why Aristotle, certainly no friend to unlimited democracy, seems so much more comfortable with unconstrained rhetoric in political deliberation than current defenders of deliberative democracy. It answers this question by reconstructing and defending a distinctly Aristotelian understanding of political deliberation, one that can be pieced together out of a series of separate arguments made in the Rhetoric, the Politics, and the Nicomachean Ethics.

This book reviews the classical schools of jurisprudence with particular reference to their linguistic presuppositions, and summarises an alternative account based on Paris school semiotics. Detailed ToC available from linked web page. NOT available from Amazon.

Abstract The idea of a purely civic nationalism has attracted Western scholars, most of whom rightly disdain the myths that sustain ethnonationalist theories of political community. Civic nationalism is particularly attractive to many Americans, whose peculiar national heritage encourages the delusion that their mutual association is based solely on consciously chosen principles. But this idea misrepresents political reality as surely as the ethnonationalist myths it is designed to combat. And propagating a new political myth is an especially inappropriate way of (...) defending the legacy of Enlightenment liberalism from the dangers posed by the growth of nationalist political passions. (shrink)

Let $D_{tt} $ denote the set of truth-table degrees. A bijection π: $D_{tt} \to \,D_{tt} $ is an automorphism if for all truth-table degrees x and y we have $ \leqslant _{tt} \,y\, \Leftrightarrow \,\pi (x)\, \leqslant _{tt} \,\pi (y)$ . We say an automorphism π is fixed on a cone if there is a degree b such that for all $x \geqslant _{tt} b$ we have π(x) = x. We first prove that for every 2-generic real X we have (...) X' $X' \le _{tt} \,X\, \oplus \,0'$ . We next prove that for every real $X \ge _{tt} \,0'$ there is a real Y such that $Y \oplus 0{\text{'}}\, \equiv _{tt} \,Y{\text{'}} \equiv _{tt} \,X$ . Finally, we use this to demonstrate that every automorphism of the truth-table degrees is fixed on a cone. (shrink)

In his recent address to the Aristotelian Society, Aurel Kolnai suggests that games exhibit what he calls a “genuine paradoxy.” I do not believe that he has shown this to be the case, even on the most permissive interpretation of what it means to be a paradox. Kolnai has, however, called attention to an aspect of games which invites further investigation, and I should like to advance the following considerations not so much as a criticism of Kolnai as an attempt (...) to take the investigation along a path which Kolnai has indicated, but which he has not himself, in my opinion, followed. It is not that Kolnai does not say many interesting, indeed penetrating, things about games, for he does. That Kolnai's inquiry is an important contribution to the philosophy of games is not in question. What is questionable is whether paradox has very much to do with that contribution. (shrink)

How can literature, which consists of nothing more than the description of imaginary events and situations, offer any insight into the workings of "human reality" or "the human condition"? Can mere words illuminate something that we call "reality"? Bernard Harrison answers these questions in this profoundly original work that seeks to re-enfranchise reality in the realms of art and discourse. In an ambitious account of the relationship between literature and cognition, he seeks to show how literary fiction, by deploying (...) words against a background of imagined circumstances, allows us to focus on the roots, in social practice, of the meanings by which we represent our world and ourselves. Engaging with philosophers and theorists as diverse as Wittgenstein, Sartre, Merleau-Ponty, Foucault, Derrida, F. R. Leavis, Cleanth Brooks, and Stanley Fish, and illustrating his ideas through readings of works by Swift, Woolf, Appelfeld, and Dickens, among others, this book presents a systematic defense of humanism in literary studies, and of the study of the Humanities more generally, by a distinguished scholar. (shrink)