To determine the knowledge, attitudes and practices regarding organ donation in a selected adult population in Pakistan.

Slang is one of the important components of spoken discourse. It is integrated in our everyday language to such an extent that we cannot ignore its significance while analyzing the discourse specifically of the younger generation. This paper investigates the nature of Urdu and English slang used among different age groups; children, teenagers and adolescents in particular, living in Karachi. It also discusses the attitudes of elders, which includes parents and teachers, towards the use of slang words nowadays. Simultaneous cross (...) sectional design is adopted to compare the age groups which helped in examining their discourse and exploring different categories in it, which emerged while observing the language of the age groups selected. The result shows that adolescents also incorporate slang in everyday life, as much as teenagers do but there are different categories that distinguish the vocabulary of the two age groups. Moreover informal discussions also helped elicit the responses of parents and teachers towards the excessive use of slang by the youngsters in our society. (shrink)

Objective: There is lack of information on the presentation of eating disorders (EDs) in Saudi Arabia using gold standard clinical tools. The present study aimed to provide data on the presentation of EDs in Saudi Arabia using clinically validated measures.Method: Hundred and thirty-three individuals (33 male) with a mean age of 22 years (2.63) completed three measures: the Eating Disorder Examination (EDE), a semi-structured interview, the Eating Disorder Examination Questionnaire (EDE-Q), a self-report measure, and the Depression Anxiety and Stress Scale (...) (DASS-21) to measure comorbid symptoms.Results: Individuals in Saudi Arabia reported higher levels of restraint, eating concern and shape concern and a higher global score, but lower levels of weight concern on the EDE-Q compared to the EDE. Female participants reported a higher global score, alongside significantly higher scores on the restraint, shape concern and weight concern subscales than males. The most common ED subtype was other specific feeding or ED. Compared with Western community samples, symptom severity in this purposive sample obtained from community settings was significantly higher in this sample.Discussion: Individuals with eating, weight and shape concerns in Saudi Arabia may feel more comfortable expressing their symptoms on a self-report tool compared with a face to face interview. However, it is possible that a self-report measure may over-estimate the severity of symptoms. The data suggest that clinicians in Saudi Arabia should regularly screen for EDs in all genders. It is also important to note that ED symptoms are a cause for concern in young people in Saudi Arabia. (shrink)

Journals have been described as “duty bearers” of upholding fundamental ethical principles that are essential for maintaining the ethical integrity of newly generated and disseminated knowledge. To play our part, we evaluated diversity and inclusion in the leadership and management of global and international health journals. We developed Journal Diversity Index (JDI) to measure three parameters of diversity and representation (gender, geographic, socioeconomic status). Relevant information regarding editorial board members of systematically screened journals was sequentially extracted and job titles were (...) categorized into five editorial roles. Chi-squared test was utilized to study associations between gender and geographic distribution of editors along with the Medline indexing of the journal and its impact factor. Out of 43 journals included, 62.7% were published from two high-income countries. Women comprised 44% of the total editors. Among all the editorial board members, we did not find any information suggesting the representation of non-binary and transgender individuals. Furthermore, 68.2% of editors were based in high-income countries with 67.3% of the editors belonging to the Global North. This disparity in geographic region and socioeconomic level was observed across all five editorial roles. Among all women editors, more than 70% worked in non-Medline and non-impact factor journals. Only two journals scored “excellent” on JDI. Despite the continuous evolution of the definition of global health ethics, marginalized individuals, and their perspectives remain underrepresented in this field. Thus, we call for swift action regarding the decentralization and redistribution of global and international health journal editorial boards. (shrink)

A comparison of nineteen taxa of teleost fishes suggests the gradual acquisition of systems of upper jaw protrusion in the course of fish evolution. However, in view of the loss of protrusion in several groups of advanced teleosts the biomechanicsof protrusile jaws are analysed based on the hydrodynamics of suction feeding. Calculations show that protrusion may reduce the energy otherwise spent in a feeding act to get the predator's mouth as near to the prey in the same time with about (...) 80%. Other generalized advantages and disadvantages of upper jaw protrusion are explained. Detailed ecological data to calculate the balance between pros and cons of jaw protrusion of a particular species in its habitat are still lacking. There is no incompatibility between presence and disappearance of protrusile jaws in fish and current neo-darwinistic theories of evolution. (shrink)

The jaw mechanism of cichlid fishes is an intricate apparatus with complex force transmission from muscles to environment. The proportions of this apparatus change considerably during growth mainly due to scale effects. In adult fishes, the proportions differ, corresponding with the type of preferred food. In such a complex mechanism, it is very hard to gain insight into the functional meaning of the differences in proportions, unless a biomechanical model is constructed, describing kinematics and force equilibria of the apparatus.Such a (...) model has been constructed and by means of perturbation analysis anatomical points could be selected of which the positions are very important for the function of biting. These hot spots need only small displacements in order to obtain an increase in biting force. By means of a newly developed mathematical technique, it was possible to move the anatomical points in very small steps towards more favourable positions for the function of biting. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Into the Jaws of Yama, Lord of Death: Buddhism, Bioethics, and DeathDamien KeownInto the Jaws of Yama, Lord of Death: Buddhism, Bioethics, and Death. By Karma Lekshe Tsomo. Albany: State University of New York Press, 2006. Pp. 270.An anecdote recounted in this work gives an insight into the present state of Buddhist bioethics. The author relates how she asked the spiritual director of a Tibetan centre in Honolulu (...) whether he thought it was a good idea to donate one’s organs at the time of death. He immediately replied in the affirmative. When asked if the removal of the organs would disturb the dying process, he responded that it would be okay since the doctors could “wait for a few days.” On being informed that the organs had to be removed immediately to save the life of the recipient he “expressed alarm” and changed his mind, advising that for an ordinary Buddhist practitioner organ donation might not be advisable after all (p. 160).The fact that Tibetan lamas are giving ethical advice on organ donation without even a layman’s knowledge of the medical procedures involved suggests that Buddhist teachers have a lot to learn about adapting traditional teachings to modern contexts. If the problem were simply that many lack scientific knowledge, this could probably be resolved in the short to medium term. The deeper problem, however, is that Buddhism as a tradition lacks the ethical infrastructure needed to address moral dilemmas, particularly those of the complex kind presented by contemporary scientific and medical developments. Despite their undoubted acumen in certain branches of philosophy (notably metaphysics), Buddhist thinkers of the past have consistently failed to probe the moral foundations of their teachings or to establish a theoretical foundation in terms of which moral dilemmas can be analyzed. Not a single treatise on moral philosophy was produced by any of the classical scholars cited in this volume as authorities. Not surprisingly, the legacy of this neglect is that the voice of Buddhism has been almost completely silent with respect to the kinds of ethical issues addressed in this book.The present work commendably seeks to remedy this absence of information on Buddhist bioethics. This is only the second book ever to attempt such a task, the first being my Buddhism and Bioethics, published over ten years ago in 1996 (reissued by Palgrave in 2002). In the intervening period there have been many scientific [End Page 157] advances, such as cloning and genetic engineering, both of which receive attention in the volume under review. While my own approach sought to build bridges by translating Buddhist concepts into the vocabulary of contemporary bioethics, the present volume holds more tightly to the traditional teachings of Tibetan Buddhism. Accordingly, while the concepts and terminology used will be familiar to those inside the tradition, I am not sure to what extent it will facilitate dialogue with bioethicists and clinicians, for whom the colorful and somewhat medieval facets of these teachings may at times seem esoteric.Before discussing the ethical issues further, it should be pointed out that less than half of the book (chapters 8–11) is devoted directly to bioethics. The first seven chapters are for the most part an account of topics in Mahayana philosophy (such as no-self, dependent origination, and emptiness) and descriptions of the beliefs and practices of Tibetan Buddhism surrounding death. These include meditational practices relating to death and the notion of the post-mortem intermediate state (bardo). Somewhat oddly, chapter 5, titled “Foundations of Buddhist Ethics,” has almost nothing to say about ethics: after a short but potentially interesting section titled “Buddhist Definitions of Life and Death,” it veers off into a lengthy summary of Madhyamaka, Vijnanavada, and Tathagatagarbha doctrines.Tibetan teachings about death have been summarized in numerous popular volumes in recent years, and it is unclear why such an extended treatment of them is presented again here. The opening sentence of chapter 8 suggests this was necessary to “set the stage for an exploration of bioethical issues from Buddhist points of view,” but the bulk of this material has little connection with bioethics. In particular, it is not clear how it is... (shrink)

Aim: The present work proposes the study of the neuromotor activity of the masseter-jaw-tongue articulation during diadochokinetic exercising to establish functional statistical relationships between surface Electromyography, 3D Accelerometry, and acoustic features extracted from the speech signal, with the aim of characterizing Hypokinetic Dysarthria. A database of multi-trait signals of recordings from an age-matched control and PD participants are used in the experimental study. Hypothesis: The main assumption is that information between sEMG and 3D acceleration, and acoustic features may be quantified (...) using linear regression methods. Methods: Recordings from a cohort of eight age-matched control participants and eight PD participants were collected during the utterance of a diadochokinetic exercise. The dynamic and acoustic absolute kinematic velocities produced during the exercises were estimated by acoustic filter inversion and numerical integration and differentiation of the speech signal. The amplitude distributions of the absolute kinematic and acoustic velocities are estimated to allow comparisons in terms of Mutual Information. Results: The regression results show the relationships between sEMG and dynamic and acoustic estimates. The projection methodology may help in understanding the basic neuromotor muscle activity regarding neurodegenerative speech in remote monitoring neuromotor and neurocognitive diseases using speech as the vehicular tool, and in the study of other speech-related disorders. The study also showed strong and significant cross-correlations between articulation kinematics, both for the control and the PD cohorts. The absolute kinematic variables presents an observable difference for the PD participants compared to the control group. Conclusion: Kinematic distributions derived from acoustic analysis may be useful biomarkers toward characterizing HD in neuromotor disorders providing new insights into PD. (shrink)

Reflection on the history of skepticism shows that philosophers have often conjoined as a single doctrine various theses that are best kept apart. Some of these theses are incredible – literally almost impossible to accept – whereas others seem quite plausible, and even verging on the platitudinous. Mixing them together, one arrives at a view – skepticism – that is as a whole indefensible. My aim is to pull these different elements apart, and to focus on one particular strand of (...) skepticism that deserves sustained and respectful attention. The strand I have in mind I will refer to as epistemic defeatism. Roughly, in its most global form, it is the view that, in the final analysis, we have no good evidence for the truth of any proposition. Working through various historical texts, I attempt to untangle epistemic defeatism from neighboring views, and in particular to establish its independence from questions about knowledge. Having thus established the view's autonomy, I turn to the options for self-consciously accepting defeat. One may despair or one may have faith. But I will ultimately propose that the most attractive option – the option that preserves the most of our epistemic integrity – is to have hope. (shrink)

The embryonic vertebrate face is composed of similarly sized buds of neural crest‐derived mesenchyme encased in epithelium. These buds or facial prominences grow and fuse together to give the postnatal morphology characteristic of each species. Here we review the role of neural crest cells and foregut endoderm in differentiating facial features. We relate the developing facial prominences to the skeletal structure of the face and review the signals and genes that have been shown to play an important role in facial (...) morphogenesis. We also examine two experiments one at the genetic level and one at the signal level in which transformation of facial prominences and subsequent change of jaw identity was induced. We propose that signals such as retinoids and BMPs and downstream transcription factors such as Distal‐less related genes specify jaw identity. BioEssays 25:554–568, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This paper investigates the relationship between the 2004 film Iron Jawed Angels and the historic events and figures it purports to represent. As a major film on the national women’s suffrage movement in the US, Iron Jawed Angels had great potential in terms of educating viewers on the lives and accomplishments of America’s suffragists. However, this paper argues that in modifying the character and story of activist Alice Paul to appeal to female, conservative, and American audiences, the movie (...) diminishes Paul’s achievements and assumes that female spectators require the tropes of a “chick flick” to sustain their interest. (shrink)

The mouthparts of anuran tadpoles are highly derived compared to those of caecilians or salamanders. The suprarostral cartilages support the tadpole's upper beak; the infrarostral cartilages support the lower beak. Both supra‐ and infrarostral cartilages are absent in other vertebrates. These differences reflect the evolutionary origin of a derived feeding mode in anuran tadpoles. We suggest that these unique cartilages stem from the evolution of new articulations within preexisting cartilages, rather than novel cartilage condensations. We propose testing this hypothesis through (...) a search for similarities in the development of the suprarostral and infrarostral cartilage articulations and of the primary jaw joint. In Xenopus, the gene zax is expressed in a region corresponding to the infrarostral cartilage. This gene is related to the bapx1‐gene, which regulates jaw joint development. Further investigation of these genes, as well as other genes with joint‐related functions, in anuran craniofacial development may provide a connection between the morphological diversity seen in the vertebrate head and the corresponding diversity in genetic regulatory processes. We believe that the evolution of larval jaws in anurans may shed light on the general evolutionary mechanisms of how new articulations, not only in the jaw region, could have arisen in the vertebrate skull. BioEssays 27: 526–532, 2005. © 2005 Wiley periodicals, Inc. (shrink)

This article deals both with greatly extended finite life and with immortality and uses the term ‘greatly extended life’ to cover both. Except where indicated, it proceeds from some assumptions adapted from Christine Overall. First, people would know the life expectancy in their society or would know that they were immortal. Second, everyone would have the opportunity to choose greatly extended life. Third, greatly extended life would not be mandatory; people would be able to opt out at any point.

This is an attempt to describe and explain so-called timbre-based music as a special system of musicking, communication, and psychological and social usage, which along with its corresponding beliefs constitutes a viable alternative to “frequency-based” music. Unfortunately, the current scientific research into music has been skewed almost entirely in favor of the frequency-based music prevalent in the West. Subsequently, whenever samples of timbre-based music attract the attention of Western researchers, these are usually interpreted as “defective” implementations of frequency-based music. The (...) presence of discrete pitch is often regarded as the structural criterion that distinguishes music from non-music. We would like to present evidence to the contrary—in support of the existence of indigenous music systems based on the discretization and patterning of aspects of timbre, rather than pitch. This evidence comes mainly from extensive ethnographic research systematically conducted in eastern European and Asian parts of Russia from the 1890s. It involved the efforts of thousands of specialists and was coordinated by dozens of research institutions, and it has included not just ethnomusicology but linguistics, philology, organology, archaeology, anthropology, geography, and religious and social studies. Much of the data has not been translated into Western languages. Timbre-based tonal organization (TO) differs from that based on frequency in its personal orientation: musicking here occurs primarily for oneself and/or for close relatives/friends. Collective music-making is rare and exceptional. The foundation of timbre-based music seems to have vocal roots and rests on “personal song”—a system of personal identification through individualized patterns of rhythm, timbre, and pitch contour, utilized like a “human voice”—whose sound enables the recognition of a particular individual. The instrumental counterpart of the personalized singing tradition is the jaw harp tradition. The jaw harp is the principal musical instrument for at least 21 ethnicities in Russia, who occupy over half the territory of the country. The evolution of its TO forms the backbone for the development of timbre-based music art. Here, we provide the acoustic, socio-cultural, geographic, and chronological overview of timbre-based music. (shrink)

The human masticatory system is a complex functional unit characterized by a multitude of skeletal components, muscles, soft tissues, and teeth. Muscle activation dynamics cannot be directly measured on live human subjects due to ethical, safety, and accessibility limitations. Therefore, estimation of muscle activations and their resultant forces is a longstanding and active area of research. Reinforcement learning (RL) is an adaptive learning strategy which is inspired by the behavioral psychology and enables an agent to learn the dynamics of an (...) unknown system via policy-driven explorations. The RL framework is a well-formulated closed-loop system where high capacity neural networks are trained with the feedback mechanism of rewards to learn relatively complex actuation patterns. In this work, we are building on a deep RL algorithm, known as the Soft Actor-Critic, to learn the inverse dynamics of a simulated masticatory system, i.e., learn the activation patterns that drive the jaw to its desired location. The outcome of the proposed training procedure is a parametric neural model which acts as the brain of the biomechanical system. We demonstrate the model’s ability to navigate the feasible three-dimensional (3D) envelope of motion with sub-millimeter accuracies. We also introduce a performance analysis platform consisting of a set of quantitative metrics to assess the functionalities of a given simulated masticatory system. This platform assesses the range of motion, metabolic efficiency, the agility of motion, the symmetry of activations, and the accuracy of reaching the desired target positions. We demonstrate how the model learns more metabolically efficient policies by integrating a force regularization term in the RL reward. We also demonstrate the inverse correlation between the metabolic efficiency of the models and their agility and range of motion. The presented masticatory model and the proposed RL training mechanism are valuable tools for the analysis of mastication and other biomechanical systems. We see this framework’s potential in facilitating the functional analyses aspects of surgical treatment planning and predicting the rehabilitation performance in post-operative subjects. (shrink)

Multiple sensory signals from visual, somatosensory and vestibular systems are used for human postural control. To maintain postural stability, the central nervous system keeps the center of mass (CoM) within the base of support. The influence of the stomatognathic motor system on postural control has been established under static conditions, but it has not yet been investigated during dynamic steady-state balance. The purpose of the study was to investigate the effects of controlled stomatognathic motor activity on the control and stability (...) of the CoM during dynamic steady-state balance. A total of 48 physically active and healthy adults were assigned to three groups with different stomatognathic motor conditions: jaw clenching, tongue pressing and habitual stomatognathic behavior. Dynamic steady-state balance was assessed using an oscillating platform and the kinematic data were collected with a 3D motion capturing system. The path length (PL) of the 3D CoM trajectory was used for quantifying CoM sway. Temporal dynamics of the CoM movement was assessed with a detrended fluctuation analysis (DFA). An uncontrolled manifold (UCM) analysis was applied to assess the stability and control of the CoM with a subject-specific anthropometric 3D model. The statistical analysis revealed that the groups did not differ significantly in PL, DFA scaling exponents or UCM parameters. The results indicated that deliberate jaw clenching or tongue pressing did not seem to affect the sway, control or stability of the CoM on an oscillating platform significantly. Because of the task-specificity of balance, further research investigating the effects of stomatognathic motor activities on dynamic steady-state balance with different movement tasks are needed. Additionally, further analysis by use of muscle synergies or co-contractions may reveal effects on the level of muscles, which were not visible on the level of kinematics. This study can contribute to the understanding of postural control mechanisms, particularly in relation to stomatognathic motor activities and under dynamic conditions. (shrink)

The jaw movements of speech are most probably derived from jaw movements associated with vocalisation. Cyclicity does not argue strongly for derivation from a cyclic pattern, because it arises readily in any system with feedback control. The appearance of regular repetition as a part of ritualisation of a display may have been important.

All surviving jawed vertebrate representatives achieve diversity in immunoglobulin‐based B and T cell receptors for antigen recognition through recombinatorial rearrangement of V(D)J segments. However, the extant jawless vertebrates, lampreys and hagfish, instead generate three types of variable lymphocyte receptors (VLRs) through a template‐mediated combinatorial assembly of different leucine‐rich repeat (LRR) sequences. The clonally diverse VLRB receptors are expressed by B‐like lymphocytes, while the VLRA and VLRC receptors are expressed by lymphocyte lineages that resemble αβ and γδ T lymphocytes, respectively. (...) These findings suggest that three basic types of lymphocytes, one B‐like and two T‐like, are an essential feature of vertebrate adaptive immunity. Around 500 million years ago, a common ancestor of jawed and jawless vertebrates evolved a genetic program for the development of prototypic lymphoid cells as a foundation for an adaptive immune system. This acquisition preceded the convergent evolution of alternative types of clonally diverse receptors for antigens in all vertebrates, as reviewed in this article. (shrink)

I think … we ought to distinguish two sense of “deconstruction.” In one sense the word refers to the philosophical projects of Jacques Derrida. Taken this way, breaking down the distinction between philosophy and literature is essential to deconstruction. Derrida’s initiative in philosophy continues along a line laid down by Friedrich Nietzsche and Martin Heidegger. He rejects, however, Heidegger’s distinctions between “thinkers” and “poets” and between the few thinkers and the many scribblers. So Derrida rejects the sort of philosophical professionalism (...) which Nietzsche despised and which Heidegger recovered. This does indeed lead Derrida in the direction of “a general, undifferentiated textuality.” In his work, the philosophy-literature distinction is, at most, part of a ladder which we can let go of once we have climbed up it.In a second sense of “deconstruction,” however, the term refers to a method of reading texts. Neither this method, nor any other, should be attributed to Derrida—who shares Heidegger’s contempt for the very idea of method.2 But the method exists, and the passage I have quoted from Culler describes one of its essential features. Culler is quite right to say that deconstruction, in the second sense, needs a clear distinction between philosophy and literature. For the kind of reading which has come to be called “deconstructionist” requires two different straight persons: a macho professional philosopher who is insulted by the suggestion that he has submitted to a textual exigency, and a naive producer of literature whose jaw drops when she learns that her work has been supported by philosophical oppositions. The philosopher had thought of himself as speaking a sparse, pure, transparent language. The poetess shyly hoped that her unmediated woodnotes might please. Both reel back in horror when the deconstructionist reveals that each has been making use of complex idioms to which the other has contributed. Both go all to pieces at this news. A wild disorder overtakes their words. Their whimpers lend into interminable androgynous keening. Once again, deconstructionist intervention has produced a splendidly diffuse irresolution. Richard Rorty is Kenan Professor of Humanities at the University of Virginia. He is the author of Consequences of Pragmatism and is currently writing a book on Martin Heidegger. (shrink)

Once upon a time, the planet was tyrannized by a giant dragon. The dragon stood taller than the largest cathedral, and it was covered with thick black scales. Its red eyes glowed with hate, and from its terrible jaws flowed an incessant stream of evil-smelling yellowishgreen slime. It demanded from humankind a blood-curdling tribute: to satisfy its enormous appetite, ten thousand men and women had to be delivered every evening at the onset of dark to the foot of the mountain (...) where the dragontyrant lived. Sometimes the dragon would devour these unfortunate souls upon arrival; sometimes again it would lock them up in the mountain where they would wither away for months or years before eventually being consumed. (shrink)

How do we teach medical students to protect patients? My initial reaction to the question posed by Taylor and Goodwin was like first glimpsing ‘Jaws’: we’re going to need a bigger boat. The authors’ answer makes two important claims: first, that safety should be ethically sourced by better integration between teaching of safety and ethics; second, that teaching should encourage students to think about organisational failure rather than focusing on individual blame and personal responsibility to whistleblow.1 On the first, they (...) highlight how ethics teaching often sits apart from that on safety. For the second, they use the concept normalisation of deviance, with its contained idea of structural secrecy, to depict organisational failure that is argued as largely immune to whistleblowing. Why wouldn’t these challenges warrant a bigger boat? On their first claim: it is not just for safety, but throughout the curriculum that ethics teaching needs to be integral. Given coming challenges, it should become the cake rather than the icing. Consider, for example, that artificial intelligence stands to transform many knowledge-based professions, medicine among them. Tomorrow’s doctors will have a surfeit of data and automated decision aids at their fingertips. So, as far as they remain necessary, doctors will …. (shrink)

Magic takes many forms. Supernatural magic is what our ancestors used in order to explain the world before they developed the scientific method. The ancient Egyptians explained the night by suggesting the goddess Nut swallowed the sun. The Vikings believed a rainbow was the gods’ bridge to earth. The Japanese used to explain earthquakes by conjuring a gigantic catfish that carried the world on its back—earthquakes occurred each time it flipped its tail. These are magical, extraordinary tales. But there is (...) another kind of magic, and it lies in the exhilaration of discovering the real answers to these questions. It is the magic of reality—science. Packed with clever thought experiments, dazzling illustrations and jaw-dropping facts, The Magic of Reality explains a stunningly wide range of natural phenomena. What is stuff made of? How old is the universe? Why do the continents look like disconnected pieces of a puzzle? What causes tsunamis? Why are there so many kinds of plants and animals? Who was the first man, or woman? This is a page-turning, graphic detective story that not only mines all the sciences for its clues but primes the reader to think like a scientist as well. Richard Dawkins, the world’s most famous evolutionary biologist and one of science education’s most passionate advocates, has spent his career elucidating the wonders of science for adult readers. But now, in a dramatic departure, he has teamed up with acclaimed artist Dave McKean and used his unrivaled explanatory powers to share the magic of science with readers of all ages. This is a treasure trove for anyone who has ever wondered how the world works. Dawkins and McKean have created an illustrated guide to the secrets of our world—and the universe beyond—that will entertain and inform for years to come. (shrink)

Recent work on social movement fields has expanded our view of the dynamics of social movements; it should also expand our thinking about social movement success. Such a broader view reveals a paradox: social movements often snatch defeat from the jaws of victory by narrowly targeting authorities with their actions instead of targeting the broader social movement field. Negative impacts from the wider social movement field can then reverse or overshadow initial victories. We distinguish between a social movement’s victory over (...) the immediate target, and more lasting success that arises from shifting alignments in the broader social movement field. To test the predictive value of the distinction, we compare two very similar student-led social movements, both of which targeted university policies regarding sensitivity to race issues and changes in university personnel. One built a broad coalition of support that extended across its social movement field and was thereby able to institute durable change. The other did not, and despite its clear initial success, this protest movement produced consequences mainly adverse to its preferred outcomes. We demonstrate how pervasive this paradox is with examples from other U.S. protest outcomes and studies of revolutions. The paradox is resolved by focusing on changes in the entire social movement field. We thus argue that achieving, and understanding, lasting social movement success requires attention to the entire social movement field. (shrink)

In this paper I develop an aesthetic of horror film music based on the film sound theorist Kevin Donnelly's "direct access thesis". This states that horror film scores have the power to provide "direct accesses" to the bodies of an audience; they "produce bodily sensations, excite (mainly negative) emotions and insert in the audience "frames of mind and attitudes...much like a direct injection". I first argue that two dominant theories in the field, namely, the culturalist theory of film music and (...) Peter Kivy's cognitivist theory of music and emotion are inadequate. Then I will show that by aligning the direct access thesis with Jenefer Robinson's theory of music and emotion, Mark Johnson and Steve Larson's contention that musical meaning is primarily embodied, we will be able to reveal a deeper meaning of horror film scores than musical convention. I illustrate my proposal with the shark motif in Jaws and Dies Irae in The Shining. (shrink)

Anyone familiar with some of Dewey’s major works knows that they are highly critical of nearly all that has traditionally passed under the name of “epistemology” or “theory of knowledge”. Even a casual reading of a few chapters of Reconstruction in Philosophy, The Quest for Certainty or Experience and Nature reveals Dewey’s iconoclasm toward “that species of confirmed intellectual lock-jaw called epistemology”. The source of this attitude is Dewey’s belief that all theories of knowledge previous to his own are based (...) upon an unexamined and mistaken conception of knowing. This is that knowing is a relation between a knower and a thing known, in which the knower is essentially a viewer or passive spectator of the thing known. Knowing is conceived on the analogy of seeing an object; it is, as Dewey says, “modeled on what [is] supposed to take place in the act of vision”. For Dewey, it is not a matter of consequence how the two members of the knowledge-relation are described. Whether the knower is identified with the self and the thing known with a material thing, or the knower with the mind and the thing known with an idea or collection of sense-data, or the knower with the knowing “subject” and the thing known with the “object”, is not important. Dewey’s contention is that no matter how one characterizes the spectator and the thing known, this conception of knowing is fundamentally mistaken, mythological. He collectively dubs all theories which share it “The Spectator Theory of Knowledge”. This common label reflects the fact that for Dewey theories as different as direct realism and epistemological dualism, British empiricism and continental rationalism, are simply variations on the same unlikely theme. (shrink)

On March 27, 1784, Goethe writes to Johann Gottfried Herder: -/- I have found–neither gold nor silver, but what makes me unspeakably happy–the os intermaxillare in the human! With Loder I compared human and animal skulls, came upon its trace, and look, there it is. Only, I beg of you not to mention it, since it must be handled confidentially. (WA 4.6:258). -/- The bone whose discovery so elated Goethe, then called the "intermaxillary bone" but now the "premaxilla," is a (...) pair of cranial bones that are located at the front of the upper jaw and bear the incisors in animals that have these teeth. Goethe expresses happiness in finding this bone specifically in humans, a discovery that opposed the prevailing anatomical opinion at the time. Goethe in the Roman Campagna (1787) – Johann Heinrich Wilhelm Tischbein -/- In his essay that was finished by the end of October 1784 and later given the title, "An Intermaxillary Bone of the Maxilla Is to Be Ascribed to the Human as well as to Animals." Goethe claims, citing the work of J. F. Blumenbach and Petrus Camper, that the bone has recently garnered attention as a "distinguishing mark" between humans and apes (LA 1.9:154). -/- Yet, upon reexamination of these anatomists' works, I argue that Goethe misrepresents their positions and overstates the significance of his discovery, at least in a certain sense: while Camper and Blumenbach do deny the intermaxillary bone to humans, they do not construe its absence as an important distinguishing mark between humans and animals. Not only did Goethe's discovery not have the significance he attributed to it, but also historians of science claim that he did not discover it all: the intermaxillary bone had already been described in the human by several anatomists before him. It would thus seem that Goethe misinterpreted the significance of what he had not found, and that his unspeakable happiness was unwarranted. -/- However, Goethe's discovery holds another, heretofore-unrecognized significance. I argue that it signals a change in his vision of nature to one that criticizes and departs from the anthropocentric ontology that grounded the natural sciences of his time. If this anthropocentricism is not overturned and the foundation of natural science not reconceived, Goethe maintains, then the study of nature will be indefinitely frustrated, always floundering, and never able to progress. In light of this threat, Goethe reconceives the foundation of natural science by developing anonathropocentric concept of nature that attempts to escape the pitfalls of the human-centered perspective. His concept of nature's harmony, which I argue reflects a nonathropocentric visions of nature, requires the revaluation of the terms in which historians have disputed his discovery of the intermaxillary bone; the originality of his discovery cannot be limited to establishing the bone's presence in humans but must be extended to the concept of nature's harmony complementary to it. -/- Goethe's discovery, I conclude, remains valuable and worthy of the excitement it initially incites in him. I show how it responds to a paradox of contemporary natural science in which the objective methods intended to eliminate anthropocentrism from the investigation of nature surreptitiously reintroduced it to that investigation. Furthermore, I argue that Goethe's nonanthropocentric vision of nature and his criticism of anthopocentricism are applicable to current questions in environmental ethics. By undermining the foundation of anthropocentric ethics, Goethe also challenges the present anthropocentric modus operandi that continues to condone the environmentally destructive anthropogenic activities responsible for species extinction, chemical pollution, and the loss of natural habitats and biodiversity, in addition to other signs of the Anthropocene. (shrink)

The striking color patterns of butterflies and birds have long interested biologists. But how these animals see color is less well understood. Opsins are the protein components of the visual pigments of the eye. Color vision has evolved in butterflies through opsin gene duplications, through positive selection at individual opsin loci, and by the use of filtering pigments. By contrast, birds have retained the same opsin complement present in early-jawed vertebrates, and their visual system has diversified primarily through tuning (...) of the short-wavelength-sensitive photoreceptors, rather than by opsin duplication or the use of filtering elements. Butterflies and birds have evolved photoreceptors that might use some of the same amino acid sites for generating similar spectral phenotypes across 540 million years of evolution, when rhabdomeric and ciliary-type opsins radiated during the early Cambrian period. Considering the similarities between the two taxa, it is surprising that the eyes of birds are not more diverse. Additional taxonomic sampling of birds may help clarify this mystery. (shrink)

A narrow focus on the jaw (or on motor generators) does not account for individual and language-specific differences in babbling and early speech. Furthermore, data from Yoshinaga-Itano's laboratory support earlier findings that show glottal rather than oral stops in deaf infants' babbling: audition is crucial for developing normal syllables.

Generalizing the notion that muscles are positional frames of reference, a high-dimensional muscle space is defined for multi-muscle systems with an embedded low-dimensional motor manifold of functional articulators. A central representation of such a manifold is proposed as computational body schema. The example of the jaw-tongue system is presented, discussing the relation of functional articulators with kinematic invariances and control problems.

The Australian dingo, like the dog, descends from the wolf. However, although dogs have undergone a lengthy taming process that allows them to fit into human society, dingoes retain many wolf characteristics. Like the wolf and unlike the dog, dingoes do not bark. Dingoes howl; they come into season once a year, and they can dislocate their powerful jaws to seize prey. Since the arrival of settlers and their farming practices in Australia 200 years ago, dingoes have killed sheep, and (...) dogs have learned to protect and control those sheep. Medieval texts admire dogs for their intelligence while denigrating wolves as "cunning"—a word defined as deceitful, crafty, and treacherous. A study of Australian colonial texts reveals a popular representation of the dingo as cowardly, promiscuous, vicious—and cunning. This study compares the representation of dingoes with the representation of dogs . Finally, the paper examines those colonial writers who, either deliberately or unintentionally, allowed the dingo to escape the denigrating representation of cunning. (shrink)

This article argues that Walter Benjamin’s aesthetico-political philosophy cannot be understood without reconsidering Hamlet. It elucidates Benjamin’s Hamlet via his theory of Baroque “mourning” and its counter-measure, the “Saturnine Dialectic.” It likewise offers an analysis of the 1877 Herman Ulrici edition of Hamlet, the German edition Benjamin cites exclusively. This analysis reconciles the differences in the secondary literature regarding Benjamin’s Hamlet, expounding upon the edition’s singular use of the word “foreordination”. Finally, by rereading Benjamin’s Hamlet through Carl Schmitt’s Hamlet or (...) Hecuba, it argues that Fortinbras’s succession, effectuated by Hamlet’s dying voice, conditions the repetition of sovereignty in Hamlet, betraying the emergence of the new. Despite this betrayal, the revolutionary potential that is sunken into the content of Hamlet is disjunctively brought to the surface by examining the “dialectical image” of Laertes’s rebellion, rescuing what I term the revolutionary-new from the jaws of defeat. (shrink)

The fossil record plays a key role in reconstructing deep evolutionary relationships through its documentation of the early diverging stem groups leading to extant phyla. In the middle Cambrian Burgess Shale, two famously problematic worms, Odontogriphus and Wiwaxia, have recently been reinterpreted as stem‐group molluscs based on their shared expression of a putative radula and putative ctenidia in Odontogriphus.1 More detailed analysis of these fossil structures, however, reveals pronounced anatomical and histological discrepancies with molluscan analogues, such that they are more (...) reliably interpreted as primitive features of the superphylum Lophotrochozoa. In the absence of any obviously derived characters, Odontogriphus could be placed in the stem group of the Lophotrochozoa or on the stem of any of its constituent phyla, whereas the dorsal covering of chaetae in Wiwaxia identifies it as a stem‐group polychaete. Despite their close relationship, these two jawed, segmented worms could conceivably represent the early stages of two separate phyla. BioEssays 28: 1161–1166, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Martin was a twenty-nine-year-old anthropologist working on animism in Siberia when a bear leaped on her. He raked her with his claws, put her head into his mouth, and was about to crush her skull when she stabbed him with her ice axe. He loped off into the woods, carrying part of Martin's lower jaw and, if Martin is right, half of her soul—but leaving half of his soul in return. Martin lay bleeding in the snow. She managed to fashion (...) a tourniquet that slowed the bleeding from her leg. Miles away, a friend was fishing. He fell backward and blacked out. When he came to, he knew that something bad had happened to Martin.But was it bad?It certainly seemed so for a while. A Russian helicopter lifted her to hospital. Her wounds were treated, but the hospital seemed more brutal than the bear. She was strapped to the bed, unable to move her arms or legs. She wheezed through a tracheostomy tube. A malevolent nurse rammed food agonizingly into her with a syringe. Copulating doctors and nurses moaned and grunted in the side room next to her. Her jaw was roughly screwed together. On the plane back to France, the low cabin pressure reopened her scars. Her weeping mother dabbed at the blood with a tissue. In the French hospital, Martin took off her bandages in front of the mirror and wept “for my bear, for my old, lost face.”She had been invaded. She was now half-human, half-bear, a Siberian friend had told her: “He didn't want to kill you, he wanted to mark you. Now you are medka, she who lives between the worlds.” To be healed, she had to forgive the bear, for she would not otherwise forgive herself. At night she went “underground” to “speak to my bear.” Her head was “a ball scored with swollen red-claw marks and sutures. I am nothing like myself anymore, and yet I've never looked more like my own spirit; it has been imprinted on my body.”The invading bear had created a bridgehead into her. Other entities followed. The most immediately dangerous were bacteria and surgical scalpels. The surgeons did not know what they were toying with: “My body has become a territory where Western surgeons parley with Siberian bears. Or rather, where they try to establish communication.”The surgeons never did establish communication, and so their sort of healing would not work. Martin knew that she would only find healing in her “lair” in the Siberian forest, from those “who know bears and the questions they bring with them, who still speak with them in their dreams, who know that nothing happens by chance.” And so back she went.There was no epiphany. But there was the quiet healing that comes from recruiting all the agencies in the tundra; in distilling agency itself and dripping it over her wounds. And asking the right questions can heal too. The right questions are questions that are too big for answers.What is this book about? Martin is clear that what did not happen was that “a bear attack[ed] a French anthropologist somewhere in the mountains of Kamchatka.” What did happen was that “a bear and a woman [met] and the frontiers between two worlds implode[d].... Mythical time meets reality; past time joins the present moment; dream meets flesh.”Eye of the Wild poses an unnerving set of fundamental questions about what it means to say, as we all blithely do: “I am”—about how many souls we can accommodate, how we can broker a respectful or at least tolerable conversation between them; about our porosity to the cosmos we comfortingly assert is out there. This book is plangent, frigid, and chilling. It is a mosaic of jagged fragments that, viewed in the right light, perhaps add up to the scarred face of a young woman, all the lovelier for the scars. Yet the fragments do not add up to a proposition, for this is a book about what happens when you are brave enough to go to a place where no proposition could ever land. (shrink)

Niniejszy tekst jest poświęcony kwestii nicości w myśleniu Heideggera. Dokonana w Byciu i czasie analiza struktury Dasein wydobywa na jaw wiele jej istotnych aspektów, a właściwie egzystencjałów, z których jednym byłaby trwoga. W trwodze świat „staje się” nicością, ukazuje się w sposób pusty i bezlitosny, ale zarazem odsłania to Dasein możliwość jego autentycznej egzystencji, możliwość zin¬dywidualizowanego bycia-w-świecie. W wykładzie Czym jest metafizyka? Heidegger powraca do problematyki nicości, rozumiejąc ją już inaczej niż czyniła to metafizyka: mianowicie nicość była warunkiem umożliwiającym jawność (...) bytu dla człowieka. Bycie: nicość: to samo – ogólnie rzecz ujmując, Heidegger będzie twierdził, że nicość przynależy do bycia, co syntetycznie wyraża właśnie ta jego późna formuła. Ponieważ kwestia bycia jest ściśle związana z kwestią czasu, stąd problematyka nicości łączy się najściślej u Heideggera z problematyką temporalności, temporalności ujmowanej – co koniecznie trzeba podkreślić – ekstatycznie. Temporalizacja byłaby według Heideggera wolną oscylacją pierwotnej czasowości otwartego horyzontu, co umożliwiałoby światowanie (Welten), czyli wchodzenie bytów w świat. Z tej perspektywy, w wykładzie Metafizyczne podstawy logiki, nicość jest określana jako nihil originarium. Świat to nicość, która wydarza się wraz i dzięki pierwotnemu czasowaniu się, co późny Heideggera będzie także rozumiał jako czwarty wymiar czasu (Czas i bycie). Nicość jest także tematyzowana przez Heidggera w Przyczynkach do filozofii, gdzie jest z kolei objaśniana jako istotowa wibracja (Erzitterung) Bycia (Sein). Podczas seminarium w Le Thor (1969) Heidegger powie, że w wydarzaniu (Ereignis) nie zostało już pomyślane nic greckiego. Wydarzanie nie „jest”, ale „daje”, „wydarza” bycie i czas. Bycie to jednak nie metafizycznie rozumiana obecność. Bycie to także nie nieobecność, nie sprowadza się ono bowiem do metafizycznie rozumianej nicości, nicości pojmowanej w opozycji do bytu, ale to nicość w sensie nihil originarium, nicość w sensie temporalnym, a może nawet i energetycznym. Tak ujmowana przez Heideggera nicość zdaje się i tak jednak „zanikać” w nieprzedstawianym, niewyrażalnym wydarzaniu, wydarzaniu uchodzącym za ostatnie „słowo” jego filozofii. (shrink)

Current phylogenies show that paired fins and limbs are unique to jawed vertebrates and their immediate ancestry. Such fins evolved first as a single pair extending from an anterior location, and later stabilized as two pairs at pectoral and pelvic levels. Fin number, identity, and position are therefore key issues in vertebrate developmental evolution. Localization of the AP levels at which developmental signals initiate outgrowth from the body wall may be determined by Hox gene expression patterns along the lateral (...) plate mesoderm. This regionalization appears to be regulated independently of that in the paraxial mesoderm and axial skeleton. When combined with current hypotheses of Hox gene phylogenetic and functional diversity, these data suggest a new model of fin/limb developmental evolution. This coordinates body wall regions of outgrowth with primitive boundaries established in the gut, as well as the fundamental nonequivalence of pectoral and pelvic structures. BioEssays 20:371–381, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Although features of the dentition figure prominently in discussions of early hominid phylogeny, remarkably little is known of the developmental basis of the variations in occlusal morphology and dental proportions that are observed among taxa. Recent experiments on tooth development in mice have identified some of the genes involved in dental patterning and the control of tooth specification. These findings provide valuable new insight into dental evolution and underscore the strong developmental links that exist among the teeth and the jaws (...) and cranium. The latter has important implications for cladistic studies that traditionally consider features of the skull independently from the dentition. BioEssays 23:481–493, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The production of emotional speech is determined by the movement of the speaker’s tongue, lips, and jaw. In order to combine articulatory data and acoustic data of speakers, articulatory-to-acoustic conversion of emotional speech has been studied. In this paper, parameters of LSSVM model have been optimized using the PSO method, and the optimized PSO-LSSVM model was applied to the articulatory-to-acoustic conversion. The root mean square error and mean Mel-cepstral distortion have been used to evaluate the results of conversion; the evaluated (...) result illustrates that MMCD of MFCC is 1.508 dB, and RMSE of the second formant is 25.10 Hz. The results of this research can be further applied to the feature fusion of emotion speech recognition to improve the accuracy of emotion recognition. (shrink)