In this essay, Elizabeth Campbell reviews three recent books that address the ethical nature of professional practice: Knowledge and Virtue in Teaching and Learning: The Primacy of Dispositions, by Hugh Sockett; The Good Life of Teaching: An Ethics of Professional Practice, by Chris Higgins; and Towards Professional Wisdom: Practical Deliberation in the People Professions, edited by Liz Bondi, David Carr, Chris Clark, and Cecelia Clegg. While the first two books are situated within the context of teaching and education, the (...) third book, as an edited volume, contains chapters that represent a multidisciplinary perspective on the work of professionals within nursing, social work, counseling, and the ministry, as well as in teaching. Each of the books engages in the careful inquiry into philosophy broadly and educational philosophy specifically from conceptual frameworks widely associated with Aristotelian virtue ethics. Writing from an applied perspective on the field of scholarship relating to the moral and ethical dimensions of teaching, Campbell applauds the books for their timely reminder of the central role or persona of the individual professional as a moral agent and ethical practitioner. She argues that within the contemporary context of teacher education, which tends either to neglect or narrowly define the ethics of the profession, such an emphasis on the cultivation of personal character and responsibility within a framework of clear ethical dispositions or virtues is a welcome contribution to the field. It enables teachers, teacher educators, and student teachers to concentrate on both the ethics of practice and the practice of ethics in the ongoing quest to further their own development of virtue, practical wisdom, and personal and professional knowledge. (shrink)

This chapter contains sections titled: The Righteous Are Wise and Good The Righteous Are Happy Further Reading.

This article sees the potential for Poland’s contribution to Contemporary European Civilization in its not having been submerged by the Enlightenment with its materialism and scientism. As a result Poland has resources of culture and spirit now recognized as important for these post modern and global times. For this the article points to the Czech philosopher Patočka’s sense of solidarity of the ébranlé; Adam Mickiewicz’s sense of Polish Messianism, and John Paul II’s sense of the place of religion in Polish (...) history. (shrink)

A look at the nature of the universe, God, and our place within it explores the transformational role of consciousness in all human enterprise, offering inspirational insights into questions about religion, human existence, and good and evil.

The traditional mode of explanation in physics via deduction from partial differential equations is contrasted here with explanation via simulations. I argue that the different technologies employed constitute different languages, which support different sorts of narratives. The narratives that accompany simulations and articulate their meaning are typically historical or natural historical in kind. They explain complex phenomena by growing them rather than by referring them to general laws. Examples of such growth simulations and growth narratives come from the evolution of (...) wave functions in quantum chaos, snowflake formation, and Etruscan genetics. The examples suggest a few concluding remarks on historical explanation. (shrink)

Political philosophers have been concerned for some time with the epistemic caliber of the general public, qua the body that is, ultimately, tasked with political decision-making in democratic societies. Unfortunately, the empirical data paints a pretty dismal picture here, indicating that the public tends to be largely ignorant on the issues relevant to governance. To make matters worse, social psychological research on how ignorance tends to breed overconfidence gives us reason to believe that the public will not only lack knowledge (...) on the relevant issues, but also wisdom, in the Socratic sense of an awareness of your ignorance. It might be thought that an obvious remedy would be to increase the knowledge and wisdom of the public. However, as far as sound political decision-making and action is concerned, there is nothing particularly valuable about knowledge or wisdom per se—irrespective of what account of wisdom available in the literature we opt for. In fact, it might just be that what the public needs is nothing but the most basic epistemic good: true belief. (shrink)

The ArgumentThe societal context within which science is pursued generally acts as a productive force in the generation of knowledge. To analyze this action it is helpful to consider particular modes of mediation through which societal concerns are projected into the very local and esoteric concerns of a particular domain of research. One such mode of mediation occurs through material systems. Here I treat two such systems – the steam engine and the electric telegraph – in the natural philosophy of (...) William Thomson (Lord Kelvin).The steam engine illustratesconceptualmediation. It simultaneously instantiates “labor value” in political economy and “work” in engineering mechanics, thereby identifying the two concepts in the region of their common reference. The partial identification carries with it a structural analogy between a network of concepts from political economy and a similar network in natural philosophy, providing a potent heuristic for the reformulation and further development of dynamics.The electric telegraph illustratesmethodologicalmediation. It projects the interests of engineering and industry into the interests of electromagnetic theory and vice versa, thereby establishing, in Thomson's view, a Baconian unity of truth and utility. As the common reference of theory and practice, the telegraph locates the truth of theoretical knowledge in its utility and the utility of practical knowledge in its truth.These particular cases of conceptual and methodological mediation indicate how the local practices, concepts, and interests of a research specialty, or subculture, draw on and are adapted to those of the larger culture within which they develop. Thus the analysis of mediation leads to an ecological model of the social construction of scientific knowledge. (shrink)

ABSTRACT An overview of some of the main modes of making images of natural objects and processes, as they have appeared in the history of science, leads to two main conclusions. First, the dichotomies that have traditionally distinguished, for example, art from science, museums from laboratories, and geometrical from algebraic methods have produced a poverty of understanding of visualization. It is at the intersections of these dichotomies where much of the creative work of science occurs, and it is into those (...) intersections that this Focus section leads us. Second, the section suggests that we need to understand images as arguments. Generalizing, we need to develop a “materialized epistemology” that reunites sensual with ideational knowing. Recent work in the history of science is already pointing the way and producing a dramatically new historiography. (shrink)

The notion of ‘wise mother and good wife (WMGW)’ (Hyonmo Yangcho) is the traditional idealized image of Korean womanhood as one who serves her country and others through her roles as a mother and wife. This ideology may continue to have some significance in the lives of many first‐generation Korean immigrant women, but its potential role in the adjustment challenges these women may face while acculturating to the immigrant context in the United States has received little attention. In (...) this paper, we briefly review the historical background of the WMGW ideology and discussed the significance of focusing research attention on the role of this notion in contemporary first‐generation Korean immigrant women in the United States. We focus on the intersecting influences of gender, ethnicity, and immigrants’ generation status, which may further marginalize some first‐generation Korean immigrant mothers. We then outline possible unique challenges faced by some of these mothers due to the WMGW gender ideology, highlighting potential immigration‐related difficulties including changes in their social support networks, parenting burden, mental health, and language issues. Finally, we provide suggestions for researchers and practitioners working with U.S. Korean immigrant women. (shrink)

ABSTRACT An overview of some of the main modes of making images of natural objects and processes, as they have appeared in the history of science, leads to two main conclusions. First, the dichotomies that have traditionally distinguished, for example, art from science, museums from laboratories, and geometrical from algebraic methods have produced a poverty of understanding of visualization. It is at the intersections of these dichotomies where much of the creative work of science occurs, and it is into those (...) intersections that this Focus section leads us. Second, the section suggests that we need to understand images as arguments. Generalizing, we need to develop a “materialized epistemology” that reunites sensual with ideational knowing. Recent work in the history of science is already pointing the way and producing a dramatically new historiography. (shrink)

Science and Ethics inextricably intertwinedDawson and Yentis argue that research ethics committees have an obligation to consider the science of applications because this is inextricably entwined with ethics. They lament the fact that the recent English ministerial review of RECs suggests that science should be assessed by others for RECs and not by the committee members themselves. In fact, these views are not as incompatible as they might first appear.The plain truth of the matter is that in a maximum membership (...) of 18, at least a third of whom must be lay members, the capacity of each of the 186 RECs currently in the UK to review …. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Diacritics 31.1 (2001) 56-72 [Access article in PDF] Deconstruction and ZionismJacques Derrida's Specters of Marx Christopher Wise No differance without alterity, no alterity without singularity, no singularity without here-now. —Jacques Derrida, Specters of Marx Introduction Following Jacques Derrida's first sustained critique of Marx and Marxism in Specters of Marx: The State of the Debt, the Work of Mourning, and the New International (1994), an expanded version of his (...) lectures delivered at the University of California, Riverside, in May 1993, numerous "Marxist" theorists have responded to his provocative (and, for some, "untimely") intervention. Several of these critical responses have been gathered in Michael Sprinker's volume Ghostly Demarcations: A Symposium on Jacques Derrida's "Specters of Marx" (1999), which includes contributions from such diverse theorists as Pierre Macherey, Antonio Negri, Fredric Jameson, Terry Eagleton, Aijaz Ahmad, and many others. Important omissions from Sprinker's book include Gayatri Chakravorty Spivak's "Ghostwriting" (1995), an essay that Derrida nonetheless comments upon in his response "Marx & Sons," or any other feminist analysis of Specters of Marx, a curious absence in a text so riveted by questions of patriarchal affiliation. An even more startling omission from Sprinker's book is any analysis of Derrida's discussion of the Middle East, especially his remarks on the State of Israel and "a certain Jewish [i.e. Zionist] discourse on the Promised Land" [Specters of Marx 60] ("un certain discours juif de la Terre" [Spectres de Marx 104]). The myopic range of Marxist critiques of Specters of Marx is regrettable insofar as both Derrida and his Marxist critics ostensibly offer "radical" or "oppositional" perspectives on George H. W. Bush's New World Order while ignoring imperialist practices in places like Jerusalem, Golan Heights, the West Bank, and the Gaza Strip. In The End of the Peace Process (2001), Edward W. Said observes, "[w]hen one considers the broad lines of Jewish philosophy from [Martin] Buber to [Emmanuel] Levinas and perceives in it an almost total absence of reflection on the ethical dimensions of the Palestinian issue, one realizes how far one has to go" [208]. Said does not include Derrida in this trajectory of Jewish philosophers, possibly because Derrida has repeatedly disavowed any explicit affiliation with Judaism as religion, but I will argue here that Derrida's disavowal is implausible if not altogether disingenuous. In Ghostly Demarcations, Marxist responses to Derrida reveal how little real progress has been made in Western literary theory since the early 1980s, when now-tired debates about the Yale School echoed in nearly every humanities' corridor in the [End Page 56] United States. There are surely more compelling reasons to read Derrida today than to settle old scores with Ithaca-Irvine varieties of deconstruction. A key goal of this article is to enunciate Derrida's elision of the Palestinian question, not so much to undermine Specters of Marx, but to extend its power by venturing into domains that Derrida himself refuses to explore, a factor that weakens without totally disabling his deconstruction of Marxist theory. 1 The Rhetoric of Alterity In Specters of Marx, Derrida offers a complex, challenging, and virtuostic evaluation of Marx, focusing largely on "The Communist Manifesto" and The German Ideology. In particular, Derrida fixes his attention upon Marx's hostile and allegedly "obsessive" critique of Max Stirner, a rival Hegelian and "egological" anarchist. Derrida's criticisms of Marx turn on questions of spectrality, a suggestive way of describing the process whereby alienated or reified objects project illusory autonomy back upon the human subject. For purposes of the present essay, I draw attention to the rhetorical dimensions of the exchange between Derrida and his Marxist interlocutors, rather than the many subtleties implied by their respective analyses of this "new" concept formation. Such a strategy is useful not only because Derrida himself relies upon it in his essay "Marx & Sons," but also because it reveals key assumptions held by Derrida about deconstruction's political value, especially in the Middle East. Various contributors to Sprinker's volume do an impressive job of analyzing Derrida's critique of spectrality, especially Jameson, Warren Montag... (shrink)

Who owns feminist theory? and just what is meant by the idea of ‘theory’? We explore these fundamental questions as part of interrogating some emergent orthodoxies about feminist theory, proposing that there is a ‘missing revolution’ in feminist thinking, for while ideas about feminist epistemology, methodology and ethics have been fundamentally reworked, those concerning feminist theory have not. Our purpose is to stimulate a debate about the form of feminist theory, rather than the more usual controversies about its content; and (...) thus our concern is with promoting the development of feminist metatheory. We argue that the now-dominant version of feminist theory is a parallel project to that of mainstream/malestream social theory, and that a feminist autocritique of this and related developments is needed, with the aim of achieving a transformation of the fundamental categories of feminist theory. (shrink)

This study offers a new perspective on the much-discussed debate between French phenomenologist Jean-Luc Marion and postructuralist theorist Jacques Derrida on the question of ‘negative theology’ and the Christian mystical tradition. It argues that Marion's critique of Derrida betrays a fundamental misunderstanding, specifically, that it fails to recognise that Derrida is not interested in negative theology qua theology, but rather as a discursive practice with certain resources for the performative ‘unsaying’ of logocentric systems. It continues to show that Derrida's principal (...) object is not the God of apophatic theology, but the broader, juridico-political implications of all ‘transcendental signifieds’. Finally, it suggests that Marion's oversight of these facts in his defence of the apophatic tradition unwittingly legitimates Derrida's critique, to the extent that it insulates the Christian tradition from external criticism, and thereby limits the responsiveness of that tradition to the demands of justice. (shrink)

A relation between Sartre's phenomenological ontology and the German idealist tradition is frequently assumed in the secondary literature on Sartre. The literature that confronts this question usually adopts a piecemeal approach, treating individual philosophers, usually Hegel, in the mode of comparison and contrast. This approach, though fruitful in a limited fashion, obscures the broader question of Sartre's relation to German idealism as a whole. This study attempts to place Sartre in the context of an internal debate within idealist thought, as (...) one player in an ongoing dialogue. Its task is the establishment of Sartre's phenomenological ontology in Being and Nothingness as essentially idealist in both form and content. ;This work proceeds primarily through interaction with primary texts, beginning with Sartre's early piece, Imagination: A Psychological Critique. From this book we abstract a critical methodology that we discover is ubiquitous in Sartre's early works. In particular, we examine the application of it to the idealists in Being and Nothingness, learning both its failures in terms of representational accuracy and its successes in advancing Sartre's argument. These discoveries lead us to explore the distinction Sartre draws between metaphysics and ontology, which is critical to understanding the nature of Sartre's entire project. Having clarified this distinction, we return our attention to the critical methodology, which displays both an intimate connection to, and important distinctions from, Hegel's dialectical logic. Notably, if Sartre's position is best understood as an ongoing 'moment' in the developing narrative of idealist thought, we conclude that the profound nature of Sartre's relation to Hegel is that of opposition. Sartre's opposition to Hegel in turn may be seen as analogous to the Kantian project of establishing intellectual space for ethics in the face of scientific rationalism. Sartre, I argue, reinstitutes Kant's "Copernican revolution" on the ontological level as a response to the necessitarianism issuing from Hegel's dialectical logic. This response intends to place the realm of ethics forever beyond the possibility of doubt by forbidding metaphysical speculation any functional relevance to human existence. To live as anything other than free moral agents is to live in bad faith. (shrink)

Film is a powerful medium that can influence audience’s perceptions, values and ideals. As filmmaking evolved into a serious art form, it became a powerful tool for telling stories that require us to re-examine our ideology. While it remains popular to adapt a literary novel or text for the screen, filmmakers have more freedom to pick and choose the stories they want to tell. This freedom allows filmmakers to explore narratives that might otherwise go unheard, which include stories that feature (...) marginal figures, such as serial killers, as sympathetic protagonists, which is what director Patty Jenkins achieves in her 2003 film Monster. Charlize Theron’s transformation into and performance as Aileen Wuornos, and Jenkins’s presentation of the subject matter, make this film an example of rogue cinema. In addition, Aileen Wuornos is portrayed as a clear example of the rogue character. This character trope frequently defies social standards, suffers from past trauma, is psychologically complex, and is often exiled. As a prostitute and social outcast, Aileen Wuornos exists on the fringes of society and rejects the hegemonic power structure and later heteronormativity of society, which makes her a rogue figure. While there are several aspects to consider when analyzing Jenkins’s film, my intention is to argue that this film is an example of rogue cinema because of its content. In order to accomplish this task, I examine Theron’s bodily transformation and her performance as Wuornos. Furthermore, I look at how Jenkins handles the depiction of romantic love and gendered violence and argue that her treatment of this content renders this film rogue. (shrink)

McCoy and colleagues (2023) offer a reflective framework for data ethics and governance with several historical bioethics principles as a foundation. Their framework is one among a plethora of othe...

Responding to Ike Kamphof’s “Webcams to save nature: Online space as affective and ethical space,” this essay considers the further contextualization of Kamphof’s analysis using the idea of agencement and the provocation to consider further the politics of affect.

Delusions are studied in two philosophical traditions: the continental or phenomenological tradition and the Anglo-American or analytic tradition. Each has its own view of delusions. Broadly stated, phenomenologists view delusions as a disturbed experience whilst most analytic researchers view them as beliefs. It is my contention that the most plausible account of delusions must ultimately incorporate valuable insights from both traditions. To illustrate the potential value of integration I provide a novel model of the Capgras delusion which describes how an (...) analytic, cognitive neuropsychological two-factor account of the Capgras delusion and the phenomenological view of delusions might be integrated. (shrink)

Support functions $s(h,e)=p(h\backslash e)-p(h)$ are widely used in discussion of explanation, causality and, recently, in connection with the possibility or otherwise of probabilistic induction. With this latter application in view, a rather complete analysis of the variety of support functions, their interrelationships and their "non-deductive" and "inductive" components is presented. With the restriction to two propositions, three variable probabilities are enough to discuss such problems. The analysis is illustrated by graphs, a Venn diagram and by using the Laplace Rule of (...) Succession as an illustrative example. It is concluded that within this framework one cannot prove or disprove the possibility of probabilistic induction. (shrink)

This paper considers W.E.B. Du Bois’s short story, “Jesus Christ in Texas,” in the perspective of his analysis of the concept of beauty in Darkwater (1920); his exposition of the idea that “all art is propaganda” in “Criteria of Negro Art” (1926); and his moral psychology of white supremacy. On my account, Du Bois holds that beautiful art can help to undermine white supremacy by using representations of moral goodness to expand the white supremacist’s ethical horizons. To defend this thesis, (...) he relies on an image of “the cross and the lynching tree” to revise imagery that he draws from Albrecht Dürer’s 1504 painting, “The Adoration of Kings.”. (shrink)

The author offers an accessible, non-dogmatic guide to sharing secrets of the Direct Path that are rarely revealed. Rather than a prescriptive, step-by-step book, After Awareness is a presentation of how the Direct Path works, examining lesser-known aspects of the path and providing context, examples, and critiques of its methods. You'll learn how to use the tools of non-dual self-inquiry-as well as when to discard them-and find a set of less doctrinaire terms and pointers for discussing non-dual awareness and the (...) Direct Path in a twenty-first-century context. With this open, pragmatic, and deconstructive approach, you'll see the Direct Path from all angles and be able to draw your own conclusions. You'll also discover ways to talk about self-inquiry and non-dual awareness in mixed settings. Most important, you'll learn how an exploration that begins with everyday perspectives and experiential investigations into the nature of the "I" can lead to a sense of true peace, free from all judgments and self-consciousness. (shrink)

Narrative accounts misrepresent discovery by reconstructing worlds ordered by success rather than the world as explored. Such worlds rarely contain the personal knowledge that informed actual exploration and experiment. This article describes an attempt to recover situated learning in a material environment, tracing the discovery of the first electromagnetic motor by Michael Faraday in September 1821 to show how he modeled new experience and invented procedures to communicate that novelty. The author introduces a notation to map experiment as an active (...) process in a real-world environment and to display the human agency written out of most narratives. Comparing maps of accounts shows how knowledge-construction depends on narrative reconstruction. It is argued that invention processes can be interpreted in the same way as discovery, and a study is proposed to compare packaging learned skills into demonstration devices with the innovative strategies of inventors such as Edison. If situational knowledge is as important as is claimed, computationalists need to join science studies scholars in coming to grips with nonverbal and procedural aspects of discovery and invention. (shrink)

I argue that thought experiments are a form of experimental reasoning similar to real experiments. They require the same ability to participate by following a narrative as real experiments do. Participation depends in turn on using what we already know to visualize, manipulate and understand what is unfamiliar or problematic. I defend the claim that visualization requires embodiment by an example which shows how tacit understanding of the properties of represented objects and relations enables us to work out how such (...) objects might behave in a postulated world. This knowledge is that of embodied agents. That thought experiments require embodied participation is what makes them experiments rather than arguments. Unlike real experiments, from which ordinary perception has been displaced by instrumentation, thought experiments still appeal to relatively unmediated common sense, even when their purpose is to criticize or subvert common sense notions. (shrink)

This paper presents a study of the generation, manipulation and use of visual representations in different episodes of scientific discovery. The study identifies a common set of transformations of visual representations underlying the distinctive methods and imagery of different scientific fields. The existence of common features behind the diversity of visual representations suggests a common dynamical structure for visual thinking, showing how visual representations facilitate cognitive processes such as pattern-matching and visual inference through the use of tools, technologies and other (...) cultural resources. This dynamical model suggests a way of theorizing the interaction of cognitive, socio-cultural and technological aspects of science without losing sight of the essential contribution each makes to the processes of discovery. Whereas scientific work is often construed epistemically, as having the aim of improving the fit between theories and phenomena or culturally given notions of what counts as reality, this study shows that scientists use transformations to modify visual representations in ways that achieve other kinds of match: between a representation and the cognitive demands of a task or between an emerging representation and the social need to communicate and negotiate new meanings in a context of culturally embedded conventions. By showing how images connect each of the overlapping contexts of scientific work the proposed model negotiates the sometimes contested boundary between cognitive and social aspects of science. (shrink)

This innovative volume is an extended intellectual conversation about the ways personal lives are being undone and remade today. Examining the ethnography of the modern subject, this preeminent group of scholars probes the continuity and diversity of modes of personhood across a range of Western and non-Western societies. Contributors consider what happens to individual subjectivity when stable or imagined environments such as nations and communities are transformed or displaced by free trade economics, terrorism, and war; how new information and medical (...) technologies reshape the relation one has to oneself; and which forms of subjectivity and life possibilities are produced against a world in pieces. The transdisciplinary conversation includes anthropologists, historians of science, psychologists, a literary critic, a philosopher, physicians, and an economist. The authors touch on how we think and write about contingency, human agency, and ethics today. (shrink)

This study demonstrates that Dewey did not reject Hegelianism during the 1890s, as scholars maintain, but developed a humanistic/historicist reading that was indebted to an American Hegelian tradition. Scholars have misunderstood the "permanent Hegelian deposit" in Dewey's thought because they have not fully appreciated this American Hegelian tradition and have assumed that his Hegelianism was based primarily on British neo-Hegelianism. ;The study examines the American reception of Hegel in the nineteenth-century by intellectuals as diverse as James Marsh and Frederic Henry (...) Hedge and how it flowered in late nineteenth-century St. Louis. The St. Louis Hegelians read Hegel as a particularly practical and politically liberal philosopher whose social philosophy promoted both social diversity and unity. Led by W. T. Harris, they studied Hegel in German and published their own scholarship, as well as translations of German scholarship, in their Journal of Speculative Philosophy. Their efforts to make "Hegel talk English" and to base the St. Louis public schools on Hegel's philosophy of education won them national, and even, international attention. The St. Louis Hegelians sought to adapt Hegel's thought to their American context by assuaging elitist elements within it; Dewey's intellectual development was profoundly shaped by their appropriation of his philosophy. ;Dewey drew upon Hegel's argument that humans form societies because of their differences, not in spite of them. Hegel's rejection of the self-sufficient, atomistic individual entailed that the individual is dependent upon others for the satisfaction of material needs. Moreover, like Hegel, Dewey rejected the hedonistic basis of the British political tradition by arguing that humans seek recognition from their equals as well as satisfaction of material needs. Dewey believed Hegel's emphasis upon equality and diversity provided a model of society in which there was fertile ground for the individual to conceive and articulate cultural criticism. The study ends by comparing recent Hegel scholarship to Dewey's, demonstrating that American Hegelianism has returned, in important ways, to a Deweyan reading of Hegel. (shrink)

Elliott Sober''s selection for/selection of distinction has been widely used to clarify the idea that some properties of organisms are side-effects of selection processes. It has also been used, however, to choose between different descriptions of an evolutionary product when assigning biological functions to that product. We suggest that there is a characteristic error in these uses of the distinction. Complementary descriptions of function are misrepresented as mutually excluding one another. This error arises from a failure to appreciate that selection (...) processes can be described at several different theoretical levels. (shrink)

Abstract:The examination of racist, normalized ideology within American education is not new. Theoretical and practical conceptions of social justice in education have attempted to attend to educational inequality. Oftentimes, these attempts have reinstated the status quo because they were framed within the same Eurocentric paradigm. To address this, Django Paris proposed culturally sustaining pedagogy as a means of empowering minoritized students by sustaining the cultural competence of their communities and dismantling coloniality within educational practices. He, Michael Domínguez, and others argue (...) that epistemic expansion is imperative for equitizing educational spaces and closing the ontological distance between teachers and students. Drawing from their work as well as scholarship from the fields of educational policy, urban education, Afrocentrism, and Indigenous studies, this paper seeks to expand the discussion about culturally relevant and responsive music education to account for students’ musical epistemologies and the ways in which “epistemic travel” might inform normalized musical practices. (shrink)

Cadherins are a large family of single‐pass transmembrane proteins principally involved in Ca2+‐dependent homotypic cell adhesion. The cadherin molecules comprise three domains, the intracellular domain, the transmembrane domain and the extracellular domain, and form large complexes with a vast array of binding partners (including cadherin molecules of the same type in homophilic interactions and cellular protein catenins), orchestrating biologically essential extracellular and intracellular signalling processes. While current, contrasting models for classic cadherin homophilic interaction involve varying numbers of specific repeats found (...) in the extracellular domain, the structure of the domain itself clearly remains the main determinant of cell stability and binding specificity. Through intracellular interactions, cadherin enhances its adhesive properties binding the cytoskeleton via cytoplasmic associated factors α‐ catenin, β‐catenin and p120ctn. Recent structural studies on classic cadherins and these catenin molecules have provided new insight into the essential mechanisms underlying cadherin‐mediated cell interaction and catenin‐mediated cellular signalling. Remarkable structural diversity has been observed in β‐catenin recognition of other cellular factors including APC, Tcf and ICAT, proteins that contribute to or compete with cadherin/catenin functioning. BioEssays 26:497–511, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This article examines not only how events are verbally reported in everyday and institutional storytelling episodes, but also how the actions witnessed are enacted by participants. This is particularly important to not only the believability of what occurred and is being discussed, but also how ordinary audience members react to stories and how they believe the truthfulness of them. As is seen in data analyzed from multiple sources, the way in which something is both reported and enacted has major implications (...) for not only the telling of stories, but what we know about the world around us. Questions about the idea of ‘direct reported actions’ are also considered. (shrink)

In arguing that Nietzsche's _Thus Spoke Zarathustra_ is a philosophical explanation of the possibility of modernism—that is, of the possibility of radical cultural change through the creation of new values—the author shows that literary fiction can do the work of philosophy. Nietzsche takes up the problem of modernism by inventing Zarathustra, a self-styled cultural innovator who aspires to subvert the culture of modernity by creating new values. By showing how Zarathustra can become a creator of new values, notwithstanding the forces (...) that hinder his will to innovate, Nietzsche answers the skeptic who proclaims that new-values creation is impossible. _Zarathustra_ is a story of repeated clashes between Zarathustra's avant-garde, modernist intentions and figures of doubt who condemn those intentions. Through a close reading of _Zarathustra_, the author reconstructs Nietzsche's explanation of the possibility of modernism. Showing how parody, irony, and plot organization frame that explanation, he also demonstrates the central significance of Zarathustra's speeches on the body and the will to power. The author argues that Nietzsche's critique of the modern philosophy of the subject revises Kant's concept of the dynamical sublime and makes allegorical use of the myth of Theseus, Ariadne, and Dionysus. He also proposes an original interpretation of the thought of eternal recurrence. Breaking with conventional Nietzsche scholarship, the author conceptualizes the thought not as a theoretical or a practical doctrine that Nietzsche endorses, but as a developing drama that Zarathustra performs. (shrink)

What makes any investigative field a scientific discipline? This article argues that disciplines are ever-changing frameworks within which scientific activity is organised. Moreover, disciplinarity is not a yes or no proposition: scientific activities may achieve degrees of identity development. Degree of consensus is the key, and consensus on many questions (conceptual, methodological, institutional, and social) varies among sciences. Lastly, disciplinary development is non-teleological. Disciplines pass through no regular stages on their way from immature to mature status, designations articulated within the (...) rhetoric of discipline formation. Scientists assemble disciplines using many elements: phenomena, methods, instruments, theories, analytical techniques, and institutional tools such as journals, government bureaus, and university positions. Scientists created geophysics during the nineteenth and twentieth centuries through such a combination. Whether geophysics became a discipline depends on how discipline is defined. (shrink)

This article draws on data from a qualitative research study undertaken in an old UK university with the main aim of investigating the issue of the gender dimension of academic careers. It examines the idea of an individualistic academic career that demands self-promotion, which is still used as a measure of achievement by those in senior positions. However, there is a basic contradiction. While this idea is upheld, men simultaneously gain by an in-built patriarchal support system. They do not have (...) to make a conscious effort to be helped by it, thereby perpetuating the cultural hegemony of individualism. Women are not admitted to this support system, and if they are seen as needing or wanting to set up their own system, this is viewed as a weakness. The answer appears to be for women to strategically harness feminist ways of working in a collaborative and supportive way. (shrink)

Case studies of diverse scientific fields show how scientists use a range of resources to generate new interpretative models and to establish their plausibility as explanations of a domain. They accomplish this by manipulating imagistic representations in particular ways. I show that scientists in different domains use the same basic transformations. Common features of these transformations indicate that general cognitive strategies of interpretation, simplification, elaboration, and argumentation are at work. Social and historical studies of science emphasize the diversity of local (...) contexts of practice. However, the existence of common strategies shows that this diversity masks an important repertoire of cognitive strategies. Scientists use this repertoire to adapt their representations to meet the cognitive demands of different contexts of practice. This paper considers the implications of this finding for the notion of scientists as cognitive agents in distributed knowledge-producing systems. (shrink)

Syntactic and structural models specify relationships between their constituents but cannot show what outcomes their interaction would produce over time in the world. Simulation consists in iterating the states of a model, so as to produce behaviour over a period of simulated time. Iteration enables us to trace the implications and outcomes of inference rules and other assumptions implemented in the models that make up a theory. We apply this method to experiments which we treat as models of the particular (...) aspects of reality they are designed to investigate. Scientific experiments are constantly designed and re-designed in the context of implementation and use. They mediate between theoretical understanding and the practicalities of engaging with the empirical and social world. In order to model experiments we need to identify and represent features that all experiments have in common. We treat these features as parameters of a general model of experiment so that by varying these parameters different types of experiment can be modelled. (shrink)

The sciences use a wide range of visual devices, practices, and imaging technologies. This diversity points to an important repertoire of visual methods that scientists use to adapt representations to meet the varied demands that their work places on cognitive processes. This paper identifies key features of the use of visualization in a range of scientific domains and considers the implications of this repertoire for understanding scientists as cognitive agents.

The Metaphysical Club, a gathering of intellectuals in the 1870s associated with Harvard, is widely recognized as the crucible where pragmatism, America's distinctively original philosophy, was refined and proclaimed. Louis Menand's bestseller about the group was a dramatic publishing success. However, only three actual members - Oliver Wendell Holmes Jr., Charles S. Peirce, and William James - appear in this book, alongside other thinkers such as John Dewey who were never in the Club. The Real Metaphysical Club tells the full (...) story of how this influential group shifted the course of philosophy in America. In addition to pioneering pragmatism, the group explored radical empiricism and idealism, and formulated personalism and process philosophy, equally important developments. This volume contains thirty-seven important writings dating from 1870 to 1885 by the real members of the Metaphysical Club. The first section centers on pragmatism and science; the second part collects writings of the lawyers; and the third part covers idealist and personalist philosophers. Many of these writings have never been reprinted before, and nothing like this impressive collection has ever been attempted. A general introduction provides a narrative history, and the editors' three introductions to the volume's sections vividly bring to life the intense meetings, sustained debates, and pioneering thought from the Metaphysical Club. (shrink)

The aim of Language for those who have Nothing is to think psychiatry through the writings of Mikhail Bakhtin. Using the concepts of Dialogism and Polyphony, the Carnival and the Chronotope, a novel means of navigating the clinical landscape is developed. Bakhtin offers language as a social phenomenon and one that is fully embodied. Utterances are shown to be alive and enfleshed and their meanings realised in the context of given social dimensions. The organisation of this book corresponds with carnival (...) practices of taking the high down to the low before replenishing its meaning anew. Thus early discussions of official language and the chronotope become exposed to descending levels of analysis and emphasis. Patients and practitioners are shown to occupy an entirely different spatio-temporal topography. These chronotopes have powerful borders and it is necessary to use the Carnival powers of cunning and deception in order to enter and to leave them. The book provides an overview of practitioners who have attempted such transgression and the author records his own unnerving experience as a pseudopatient. By exploring the context of psychiatry's unofficial voices: its terminology, jokes, parodies, and everyday narratives, the clinical landscape is shown to rely heavily on unofficial dialogues in order to safeguard an official identity. (shrink)

: Faraday is often described as an experimentalist, but his work is a dialectical interplay of concrete objects, visual images, abstract, theoretically-informed visual models and metaphysical precepts. From phenomena described in terms of patterns formed by lines of force he created a general explanation of space-filling systems of force which obey both empirical laws and principles of conservation and economy. I argue that Faraday's articulation of situated experience via visual models into a theory capable of verbal expression owed much to (...) his strategy of moving—via conjectural visual models—between the phenomenology of particulars (often displayed as patterns) and the general features of dynamical phenomena which he depicted as structures. (shrink)

This collection of 30 essays covers living a moral and ethical life as a lawyer and Christian, following the example of J. Reuben Clark, Jr. The mission and history of the BYU Law School is also adressed.

This explores the role of intention in interpreting designed artefacts. The relationship between how designers intend products to be interpreted and how they are subsequently interpreted has often been represented as a process of communication. However, such representations are attacked for allegedly implying that designers' intended meanings are somehow ‘contained’ in products and that those meanings are passively received by consumers. Instead, critics argue that consumers actively construct their own meanings as they engage with products, and therefore that designers' intentions (...) are not relevant to this process. In contrast, this article asserts the validity and utility of relating intention to interpretation by exploring the nature of that relationship in design practice and consumer response. Communicative perspectives on design are thereby defended and new avenues of empirical enquiry are proposed. (shrink)

In June 1849 William Thomson wrote to Michael Faraday suggesting that the concept of a uniform magnetic field could be used to predict the motions of small magnetic and diamagnetic bodies. In his letter Thomson showed how Faraday's lines of magnetic force could represent the effect of the ‘conducting power’ for magnetic force of matter in the region of magnets. This was Thomson's extension to magnetism of an analogy between the mathematical descriptions of the distribution of static electricity and of (...) the diffusion of heat through uniform bodies. In 1850 Faraday published his first comprehensive theory of the magnetic properties of matter. He explained the behaviour of matter in the field by four assumptions: that matter has a specific disturbing effect on the normal distribution of lines of magnetic force; that this effect depends on its ability to conduct or transmit the magnetic action; and that material bodies tend to move so as to cause the least possible disturbance of the lines from their normal distribution. Faraday also assumed that diamagnetics transmit magnetic action less well than empty space, while paramagnetics transmit it more readily than space. This implied that space must have a specific conductivity between that of paramagnetic and diamagnetic materials. In order to preserve a distinction between matter and space Faraday defined ‘matter’ as either the source of action or as a conductor which is able to influence the lines of action; space was the absence of such powers. While space could conduct, it differed from matter in that it could neither originale lines of force nor influence their course and distribution. (shrink)