One of the most remarkable recent findings in developmental biology has been the colinear and homologous relationships shared between the Drosophila HOM‐C and vertebrate Hox homeobox gene complexes. These relationships pose the question of the functional significance of colinearity and its molecular basis. While there was much initial resistance to the validity of this comparison, it now appears the Hox/HOM homology reflects a broad degree of evolutionary conservation which has reawakened interest in comparative embryology and evolution.The evolutionary conservation of protein (...) motifs in many gene families (including those for growth factors, secreted and membrane bound signalling factors, adhesion molecules, cytoplasmic receptor kinases, nuclear receptors and transcription factors) has lead to speculation on the extent to which these homology relationships represent common developmental processes and underlying molecular mechanisms. Structural identities in a protein may indicate the biochemical/molecular function that a protein plays in cellular and developmental processes, without reflecting a conserved role in a cascade of developmental events. However, the analysis of genes encoding transcription factors has provided evidence suggesting that there are gene complexes in arthropods and vertebrates which are true homologues and which may share common roles in the specification of regional identity along embryonic A‐P axis. These genes comprise the Box/HOM‐C homeotic complexes. This review will detail some of the evidence for this proposed relationship and will speculate on the functional implications. (shrink)

In this article I develop an interpretation of the opening passages of Hegel's essay ‘With what must the beginning of science be made?’ I suggest firstly that Hegel is engaging there with a distinctive problem, the overcoming of which he understands to be necessary in order to guarantee the scientific character of the derivation of the fundamental categories of thought which he undertakes in the Science of Logic. I refer to this as ‘the problem of beginning’. I proceed to clarify (...) the nature of the problem, which I understand to be motivated by a concern to avoid arbitrariness, and then to detail the nature of Hegel's proposed solution, which turns on understanding how the concept of ‘pure being’, understood in a specific sense to be both mediated and immediate, avoids the concerns about arbitrariness which accompany attempts to begin merely with something mediated, or merely with something immediate. On this basis, I offer a number of criticisms of alternative approaches to the beginning of Hegel's Logic. (shrink)

Is simulation some new kind of science? We argue that instead simulation fits smoothly into existing scientific practice, but does so in several importantly different ways. Simulations in general, and computer simulations in particular, ought to be understood as techniques which, like many scientific techniques, can be employed in the service of various and diverse epistemic goals. We focus our attentions on the way in which simulations can function as (i) explanatory and (ii) predictive tools. We argue that a wide (...) variety of simulations, both computational and physical, are best conceived in terms of a set of common features: initial or input conditions, a mechanism or set of rules, and a set of results or output conditions. Studying simulations in these terms yields a new understanding of their character as well as a body of normative recommendations for the care and feeding of scientific simulations. (shrink)

This is an account of Sceptical investigation as it is presented by Sextus Empiricus. I focus attention on the motivation behind the Sceptic’s investigation, the goal of that investigation, and on the development Sextus describes from proto-Sceptical to Sceptical investigator. I suggest that recent accounts of the Sceptic’s investigative practice do not make sufficient sense of the fact that the Sceptic finds a relief from disturbance by way of suspending judgement, nor of the apparent continuity between proto-Sceptical and Sceptical investigation. (...) I offer an alternative account which turns on the suggestion that the Sceptic accepts that justification is the norm of belief. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Thales of Miletus: The Beginnings of Western Science and PhilosophyKevin RobbPatricia F. O’Grady. Thales of Miletus: The Beginnings of Western Science and Philosophy. Aldershot, England: Ashgate, 2002. Pp xxii + 310. Paper, $84.95.This book has a consistent thesis: Thales of Miletus was the first Western scientist and philosopher not just for what he began, but for what he himself said (or, as O'Grady believes, wrote). On this view, (...) Thales made significant contributions to metaphysics ("He asked the question: 'What is real?' no less than Plato and Aristotle did," 249), cosmology (on the earth and earthquakes, 87 ff.), astronomy (notably the eclipse, 126 ff.), mathematics (Proclus attributes Euclidean theorems to Thales, 191 ff.), psychology (on psyche) and theology (on "full of the gods," 108 ff.). O'Grady's thesis is that we know enough about Thales' thoughts in these areas (each a treacherous minefield of scholarly dispute, as O'Grady admits) that, after a clarified understanding of "Scientificity and Rationality" (her awkward title for Chapter 11), we can confidently conclude that philosophy and science were well begun by Thales. "I believe I have drawn a clear and detailed picture of a brilliant, veracious, and courageously speculative Greek. I see him as a questioner of almost everything, an investigator of nature...Thales is not the mere shadowy figure of Guthrie's perception. He is a man of substance, a man of distinction and of lasting importance" (251).O'Grady had early noted that W. K. C. Guthrie considered Thales a shadowy figure historically, made all the more so, Guthrie believed, because the legend kept expanding. For example, a sixth-century Thales as the seeker after the material archê, and so the first important physikos, is unknown before fourth-century Aristotle's Metaphysics Alpha, and by the time Euclidean theorems are attributed to Thales the tendency to foist imposing discoveries on famous persons was prevalent.This raises the major issue concerning O'Grady's exhaustively researched book. To what extent can the doxographic sources (the "A" sections of Diels's 1903Die Fragmente der Vorsokratiker), be used to interpret the Presocratics, especially if the original wording from a thinker perished (any "B" section quotations). It is clear that in the fourth century nothing in writing from Thales survived for the Lyceum to read and catalogue although its scholars clearly sought it; the repeated legetai ("it is said") of Aristotle in Metaphysics Alpha and elsewhere is decisive. It is his standard way of indicating that no written work on the matter survives to be consulted, but stories or oral accounts do.O'Grady's thesis requires that the "A" section material be exploited fully, especially to present Thales as a philosopher (29-70). Many historians will be unwilling to take the entire journey with her. Some (Harold Cherniss) would balk at the first step. The demand for confirming ipsissima verba (or "B" quotations) to reconstruct the thought of any Presocratic with real confidence (as once proposed by G. S. Kirk) threatens to exclude Thales from histories of philosophy, an unsatisfactory result. Even so, Harold Cherniss proposed that drastic solution in 1935 in his magisterial Aristotle's Criticism of Presocratric Philosophy. Presocratic philosophy, he argued, should begin with Anaximander (375).The heart of Cherniss's numbingly exhaustive argument (400 + pages) was that Aristotle's purpose in surveying his predecessors's views was never historical, but dialectical. His intent was to argue for a fourfold causality (on the grounds only four archai had been turned up by all his predecessors, starting with Thales' material cause), and to fit those predecessors's views into a theory of natural causality as he had finally formulated it in his sophisticated, [End Page 107] largely technical vocabulary. Aristotle's "historical" notices on which all later accounts must depend were, thus, never history; the problem and the solution, along with their language, were Aristotle's alone. If Theophrastus paraphrased what he found in Aristotle (McDiarmid), and if the post-Aristotelian doxographic notices were largely dependent on Theophrastus (so already Diels in 1879, in Doxographi Graeci), then any attempt to extract a philosophical Thales from the later doxographic sources (or Aristotle) is methodologically doomed from... (shrink)

Hegel opens the first book of his Science of Logic with the statement of a problem: “The beginning of philosophy must be either something mediated or something immediate, and it is easy to show that it can be neither the one nor the other, so either way of beginning finds its rebuttal.” Despite its significant placement, exactly what Hegel means in his expression of this problem and exactly what his solution to it is, remain unclear. -/- In this book, (...) class='Hi'>Robb Dunphy provides a detailed engagement with Hegel’s “problem of beginning”, locating it within Hegel’s account of significant approaches to the topic of beginning in the history of Western philosophy, as well as making an extended case for the influence of Pyrrhonian Scepticism on the beginning of Hegel’s Logic. Dunphy’s discussion of the various putative solutions that Hegel might be thought to put forward contributes to debates concerning Hegel’s views on the methodology of logic, the relation between his Logic and his Phenomenology of Spirit, and differences between his Encyclopaedia presentation of logic and that of his greater Science of Logic. -/- Hegel and the Problem of Beginning also functions as a critical commentary on Hegel’s essay, “With what must the beginning of the science be made?” which should be of interest to both researchers and students working on the opening of Hegel’s Logic. (shrink)

This paper argues firstly that the argument of Hegel's Phenomenology of Spirit is necessary for the justification of the beginning of his logical project, and secondly that Hegel's attempt to secure the beginning of his Science of Logic by relying upon the argument of the Phenomenology fails. I argue firstly that the position taken up at the beginning of Hegel's Logic is constructed in such a fashion that it relies upon the argument of the Phenomenology to justify it. I then (...) offer some support for the view of the relationship between the two texts defended by Maker in order to see how the two might be thought to be compatible. Finally, in the longest part of the paper, I offer a number of reasons for thinking that attempts to render the two compatible in this fashion fail. I therefore conclude that, as it stands, the beginning of Hegel's Logic is not secured against objection in the way that Hegel wants it to be. (shrink)

In this article I consider Sextus’ account of the Five Modes and of the Two Modes in his Outlines of Pyrrhonism. I suggest that from these we can derive the basic form of a number of different problems which I refer to as “Agrippan problems,” where this category includes both the epistemic regress problem and the problem of the criterion. Finally, I suggest that there is a distinctive Agrippan problem present at the beginning of Hegel’s Science of Logic.

Worries about mental causation are prominent in contemporary discussions of the mind and human agency. Originally, the problem of mental causation was that of understanding how a mental substance (thought to be immaterial) could interact with a material substance, a body. Most philosophers nowadays repudiate immaterial minds, but the problem of mental causation has not gone away. Instead, focus has shifted to mental properties. How could mental properties be causally relevant to bodily behavior? How could something mental qua mental cause (...) what it does? After looking at the traditional Problem of Interaction, we survey various versions of the property-based problem and look at proposed solutions to them. (shrink)

Recent discussions of mental causation have focused on three principles: (1) Mental properties are (sometimes) causally relevant to physical effects; (2) mental properties are not physical properties; (3) every physical event has in its causal history only physical events and physical properties. Since these principles seem to be inconsistent, solutions have focused on rejecting one or more of them. But I argue that, in spite of appearances, (1)–(3) are not inconsistent. The reason is that 'properties' is used in different senses (...) in the principles. In (1) and (3), 'properties' should be read as 'tropes' (properties here are particulars), while in (2) 'properties' should read as 'types' (properties here are universals or classes). Although mental types are distinct from physical types, every mental trope is a physical trope. This allows mental properties to be causally relevant to physical effects without violating the closed character of the physical world. (shrink)

Almost thirty years ago, in an attempt to undermine what he termed "the principle of alternate possibilities" (the thesis that people are morally responsible for what they have done only if they could have done otherwise), Harry Frankfurt offered an ingenious thought-experiment that has played a major role in subsequent work on moral responsibility and free will. Several philosophers, including David Widerker and Robert Kane, argued recently that this thought-experiment and others like it are fundamentally flawed. This paper develops a (...) new Frankfurt-style example that is immune to their objections. [Reprinted in Laura Waddell Ekstrom, ed., Agency and Responsibility: Essays on the Metaphysics of Freedom (Westview Press, 2001), pp. 241-54; and in John Martin Fischer, ed., Free Will, Vol. III (Routledge, 2005), pp. 330-42.]. (shrink)

This article discusses two topics, both commonly referred to using the label “the beginning of Hegel's Logic”: (1) Hegel's justification for the claim that a science of logic must begin by considering the concept of “pure being”. (2) Hegel's account of the concepts “being”, “nothing”, and “becoming” in the first chapter of his Logic. Discussing recent work on both of these topics, two primary claims are defended: Regarding (1): the strongest interpretations of Hegel's case for beginning a science of logic (...) with the concept of pure being are those which take him to argue that this concept must be necessarily both “immediate” and “mediated” at the same time. Regarding (2): The widespread tendency to take Hegel's treatment of the concepts of being, nothing, and becoming as an example with which to illustrate his “dialectical method” should be replaced with an interpretation of that chapter which understands it to rather make possible the kind of dialectical transitions which make up the rest of Hegel's Science of Logic. (shrink)

This article is an investigation of the nature of suspension of judgement as it is conceived by Sextus Empiricus. I carry out this investigation by examining what I take to be Sextus’ most pertinent remarks on the topic and by considering them in the context of contemporary philosophical work on the nature of suspension. Against the more frequently encountered idea that Sextus is operating with a privative conception of suspension, I argue that Sextus instead has a metacognitive account of suspension, (...) whereby suspending constitutively involves acknowledging that one is not in a position to tell whether or not p. (shrink)

In this chapter, Robb Dunphy is concerned with the nature of G.E. Schulze's scepticism as he presents it in his 1792 work Aenesidemus, and with its relation to the metaphysical projects of Kant, Reinhold, and later German Idealists. After introducing Schulze's text, Dunphy turns to a recent interpretation offered by Jessica Berry, who claims that the extent to which Schulze endorsed a genuinely Pyrrhonian Scepticism has gone unacknowledged, both by his idealist contemporaries and by the majority of the secondary (...) literature on the period. Berry suggests that this unacknowledged Pyrrhonism in Aenesidemus provides the resources for a more radical criticism of the German Idealists' scientific, systematic metaphysical ambitions, to which they remain fundamentally vulnerable. Despite agreeing that an exploration of Schulze's debt to Pyrrhonism represents a valuable addition to our understanding of his scepticism, in the latter parts of the chapter Dunphy suggests that the Berry's attribution of a Pyrrhonian Scepticism to Schulze should to some extent be rejected, and that such a scepticism is perhaps not quite as problematic for the projects of Kant and the German Idealists as she suggests. (shrink)

The author gives a brief reconstruction of Mary Hobgood's position, then poses two responses-one, a reflection on justice as restitution, is directly related to the article; the other, reflection on the welfare system itself, constitutes a a musing about how to do social ethics. In closing, the author poses a question to those who are attempting to reflect morally on welfare policy, which includes Mary Hobgood, though the question is not directed to her personally: What kind of public policy is (...) appropriate to substantiate reproductive rights in an ecological age? (shrink)

Talents often play a significant role in our personal and social lives. For example, our talents may shape the choices we make and the goods that we value, making them central to the creation of a meaningful life. Differences in the level of talents also affect how social institutions are structured, and how social goods and resources are distributed. Despite their normative importance, it is surprising that talents have not yet received substantial philosophical analysis in their own right. As a (...) result, the current literature is rife with conceptual ambiguity: a talent is referred to as all of a skill, potential, ability, capacity, endowment, and a natural gift. In response to this confusion, in this paper I develop an account of what a talent is, based on the debate concerning the metaphysics of ability and dispositions. I argue for a position that I call ‘talent dispositionalism’: S has a talent for skill A in circumstances C iff S has the general disposition to excellently develop and maintain A when, in circumstances C, she tries to excellently develop and maintain A. On this account, a talent is not the skill itself, but a general iterated ability for the excellent development and up-keep of a particular skill, constituted by an agent’s dispositional properties. I defend the account against four objections usually levelled against traditional dispositionalist theories of ability, and highlight some ways the account may influence debates in other areas of philosophical inquiry. (shrink)

A central feature of being a celebrity is experiencing a divide between one's public image and private life. By appealing to the phenomenology of Sartre and Merleau-Ponty, we analyze this experience as paradoxically involving both a disconnection and alienation from one's public persona and a sense of close connection with it. This ‘uncanny’ experience presents a psychological conflict for celebrities: they may have a public persona they feel alienated from and that is at the same time closely connected to them (...) and shapes many of their personal interactions. We offer three ways in which a celebrity might approach this conflict: (i) eradicating the divide between their public and private selves, (ii) splitting or separating their private and public selves, or (iii) embracing the arising tension. We argue that it is only this third approach that successfully mitigates the negative effects of the alienation felt by many celebrities. (shrink)

This article is concerned with some of the criteria which Hegel believes apply to a scientific treatment of logic. I briefly address criteria which I take Hegel to inherit from German rationalism before focusing on two fairly idiosyncratic criteria: the requirement that a science of logic exhibit a circular structure and that it begin with the concept of pure being. I offer an explanation of these criteria which understands them as motivated by anti-sceptical concerns, before arguing that Hegel’s mature treatment (...) of the latter criterion is problematically ambiguous. (shrink)

_Philosophy of Mind: Contemporary Readings_ is a comprehensive anthology that draws together leading philosophers writing on the major topics within philosophy of mind. Robb and O'Connor have carefully chosen articles under the following headings: *Substance Dualism and Idealism *Materialism *Mind and Representation *Consciousness Each section is prefaced by an introductory essay by the editors which guides the student gently into the topic in which leading philosophers are included. The book is highly accessible and user-friendly and provides a broad-ranging exploration (...) of the subject. Ideal for any philosophy student, this book will prove essential reading for any philosophy of mind course. The readings are designed to complement John Heil's _Philosophy of Mind: A Contemporary Introduction, Second edition _, although the anthology can also be used as a stand-alone volume. (shrink)

This is a draft translation of the fourth letter of G.E. Schulze's Aenesidemus. Comments and corrections welcome.

This is a draft translation of the first letter of G.E. Schulze's Aenesidemus. Comments and corrections welcome.

G.E. Schulze's Aenesidemus, despite its importance for the development of post-Kantian idealism, has not been fully translated into English. Now and then, when I have time, I will upload draft translations of parts of the text here, with the goal of, at some point, providing a complete translation. These drafts will be rough and I welcome feedback! -/- This document contains only the Title page, Schulze's indication of the contents of the work, and the preface.

This is a translation of the short, third letter in G.E. Schulze's Aenesidemus, without its lengthy appendix. -/- Excerpts of the appendix which follows this letter have been translated into English by George di Giovanni in Between Kant and Hegel, eds. G. di Giovanni and H.S. Harris, (Indianapolis, IN: Hackett Publishing Company Inc., 2000).

This volume is dedicated to questions about the nature and method of metaphysics in Classical German Philosophy. Its chapters offer original investigations into the metaphysical projects of many of the major figures in German philosophy between Wolff and Hegel. The period of Classical German Philosophy was an extraordinarily rich one in the history of philosophy, especially for metaphysics. It includes some of the highest achievements of early modern rationalism, Kant's critical revolution, and the various significant works of German Idealism that (...) followed in Kant's wake. The contributions to this volume critically examine certain common themes among metaphysical projects across this period, for example, the demand that metaphysics amount to a science, that it be presented in the form of a system, or that it should proceed by means of demonstration from certain key first principles. This volume also includes material on influential criticisms of metaphysical projects of this kind. Metaphysics as a Science in Classical German Philosophy is a useful resource for contemporary metaphysicians and historians of philosophy interested in engaging with the history of the methodology and epistemology of metaphysics. (shrink)

Ethics, Policy & Environment, Volume 15, Issue 1, Page 21-24, March 2012.

In this paper Mele and Robb defend their (1998) paper against a variety of objections and further their develop their defense of Frankfurt-style cases.

Winfield’s explication of Hegel’s theory of mind, especially Hegel’s theory of intelligence, is, he suggests, important for solving three problems that continue to haunt contemporary work in the philosophy of mind and epistemology: 1) A problem concerning the acquisition of language and its place in an account of consciousness, 2) A problem concerning the objectivity of representations, and 3) A problem concerning the grounds of knowing. I think Winfield is correct in identifying all three problems as having their source in (...) Kantian philosophy. I examine these three problems more carefully through a critical lens aimed at recent work by John McDowell and Robert Brandom. Both philosophers claim certain Hegelian influences. I argue that, in crucial ways, both Brandom and McDowell have each inherited the problems Hegel sought to solve and that are so clearly articulated in Winfield’s essay. (shrink)

In this chapter we analyse the nature and ethical implications of parasocial relationships. While this type of relationship has received significant attention in other interdisciplinary fields such as celebrity studies and fan studies, philosophers have so far had very little to say about them. Parasocial relationships are usually defined as asymmetrical, in which a media-user closely relates to a media-personality as if they were a friend or family member, and where this connection is mostly unreciprocated. We focus on the most (...) typical form of this kind of relationship, between fans and celebrities. We argue that a parasocial relationship between fan and celebrity is a distinct kind of personal relationship, constituted by three basic structural asymmetries: attention, communication, and epistemic. These asymmetries give rise to a more substantial asymmetry concerning the way in which celebrities and fans have ‘directive’ or ‘interpretative’ influence over each other’s identity. This can lead to a failure of recognition respect, and generates ethical responsibilities for both fans and celebrities. We conclude by noting that the structural asymmetries we find in parasocial relationships are present in many other types of relationship, especially those in which one person holds a position of power. As such, it is valuable to pay attention to the way in which asymmetries point to forms of parasociality in these other relationships, and the extent to which they give rise to distinct ethical responsibilities. (shrink)

It is becoming increasingly clear that the deepest problems currently exercising philosophers of mind arise from an ill-begotten ontology, in particular, a mistaken ontology of properties. After going through some preliminaries, we identify three doctrines at the heart of this mistaken ontology: (P) For each distinct predicate, “F”, there exists one, and only one, property, F, such that, if “F” is applicable to an object a, then “F” is applicable in virtue of a’s being F. (U) Properties are universals, not (...) particulars. (D) Every property is either categorical or dispositional, but not both. We show how these doctrines influence current philosophical thinking about the mind, suggest and defend an alternative conception of properties, and indicate how this conception provides answers to two puzzles besetting contemporary philosophy of mind: the problem of mental causation and the problem of qualia. (shrink)

Review of George di Giovanni's Hegel and the Challenge of Spinoza.

Former students of Francis MacDonald Cornford report that the distinguished Cambridge historian was fond of what he called his “parable of the coins.” The point of the parable’s instruction was that words, especially philosophers’ words, are like coins in that they retain their “shape” or visual appearance over decades and even centuries while their “purchasing power” or meaning may be shifting drastically. The image of a coin with an enduring shape but a varying purchasing power is especially appropriate for the (...) semantic career of one of the most important of Greek philosophical words, psyche, traditionally rendered “soul.” Visually, psyche retained its shape from the earliest Greek literature known to us, which is of course Homer, down to the age of the koine spoken in the time of Christ and later used to record the gospels. That was a period of a thousand years of varied and often intense philosophical and religious exploration and development; in those centuries, the meaning of psyche, unlike its shape, was far from static. (shrink)

Blockchain’s language and terminology is confusing, contested, and rapidly changing. As a hype-driven technology, Blockchain is critical to an increasing number of projects that exist in a space of regulatory uncertainty. As communities of blockchain develop and evolve, the language they use to describe these functions changes. This causes concerns when attempting to have global regulatory certainty and clarity. Regulators and communities have different approaches to blockchain language, and this causes problems because of the translation between practical use in a (...) community, and the legal effects created by regulators. Of particular concern is the lack of clear expression amongst the broader community regarding the concept of blockchain-related assets as these ‘tokens’, ‘coins’, and ‘assets’ form a key part of financial regulation. This project uses semiotics to study the diverse language associated with blockchain. This analyzes a series of self-proclaimed ‘dictionaries of blockchain’ to assess key definitions, themes, perceptions, and misconceptions present in these communities. The study involved a case analysis of the terminology used in Australia’s proposed response to blockchain in comparison with that of wider communities. When comparing this to regulatory definitions and approaches, it becomes clear that this is an area that requires further attention. This project highlights the need for regulators to understand and use common terms in blockchain regulation. It is argued that this approach facilitates a better understanding of poorly understood concepts and clearly connects the law with those it intends to target. (shrink)

Alfred A. Robb. THEOREM 54 If P1 and P2 be a pair of parallel inertia planes while an inertia plane Q1 has parallel general lines a and b in common with P1 and P2 respectively and if Q2 be an inertia plane parallel to Q1 through some ...

The problem of disease definition is related to theproblem of proving that a certain agent is thenecessary cause of a certain disease. Natural kindterms like ‘rheumatoid arthritis’ and ‘AIDS’ refer toessences which are discoverable rather thanpredeterminate. No statement about such diseases isa priori necessarily true. Because theories onnecessary causes involve natural kind semantics,Koch's postulates cannot be used to falsify or verifysuch theories. Instead of proving that agent A is thenecessary cause of disease D, we include A in atheoretical definition of (...) D, take this to representthe real meaning of ‘D’, and discard thepretheoretical definition. This is illustrated byKoch's own attempt to prove he had discovered thenecessary cause of tuberculosis. Methodologicalarguments about disease causation require a clear viewof our use of diagnostic terms. Medical lexicographersshould do more to provide such a view. (shrink)

Marielle Franco was part of a new generation of progressive activists in Brazilian politics. She was assassinated point-blank on March 14, 2018 by an elite shooter. In this piece, Meg Stalcup and Erika Robb Larkins examine how Marielle’s death is revealing of the issues that she fought for in her life. They also ask how she continues to be present in and beyond the unfolding investigation into who killed her.