"... provocative and rewarding... " --Religious Studies Review "... a tour de force." --Theological Studies Theology and Difference reconceives the options confronting modern theology and investigates the disputed questions that underlie it. Pressing beyond the ready-made enlightenment offered by the subject-object framework, Walter Lowe uncovers a number of remarkable convergences between the contemporary philosopher Jacques Derrida and the early twentieth-century theologian Karl Barth.

The transplantation of cholinergic neurons into the hippocampal formation has been well characterized. We describe our studies on the effects of cholinergic transplants in the retrosplenial cortex. These transplants were capable of ameliorating spatial navigation deficits in rats with septohippocampal lesions. In addition, we provide evidence for the modulation of transplanted neurons by the host brain.

In contrast to the views put forth by Stein & Glasier, we support the use of inbred strains of rodents in studies of the immunobiology of neural transplants. Inbred strains demonstrate homology of the major histocompatibility complex (MHC). Virtually all experimental work in transplantation immunology is performed using inbred strains, yet very few published studies of immune rejection in intracerebral grafts have used inbred animals.

Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.

Boolean-valued models of set theory were independently introduced by Scott, Solovay and Vopěnka in 1965, offering a natural and rich alternative for describing forcing. The original method was adapted by Takeuti, Titani, Kozawa and Ozawa to lattice-valued models of set theory. After this, Löwe and Tarafder proposed a class of algebras based on a certain kind of implication which satisfy several axioms of ZF. From this class, they found a specific 3-valued model called PS3 which satisfies all the axioms of (...) ZF, and can be expanded with a paraconsistent negation *, thus obtaining a paraconsistent model of ZF. The logic (PS3 ,*) coincides (up to language) with da Costa and D'Ottaviano logic J3, a 3-valued paraconsistent logic that have been proposed independently in the literature by several authors and with different motivations such as CluNs, LFI1 and MPT. We propose in this paper a family of algebraic models of ZFC based on LPT0, another linguistic variant of J3 introduced by us in 2016. The semantics of LPT0, as well as of its first-order version QLPT0, is given by twist structures defined over Boolean agebras. From this, it is possible to adapt the standard Boolean-valued models of (classical) ZFC to twist-valued models of an expansion of ZFC by adding a paraconsistent negation. We argue that the implication operator of LPT0 is more suitable for a paraconsistent set theory than the implication of PS3, since it allows for genuinely inconsistent sets w such that [(w = w)] = 1/2 . This implication is not a 'reasonable implication' as defined by Löwe and Tarafder. This suggests that 'reasonable implication algebras' are just one way to define a paraconsistent set theory. Our twist-valued models are adapted to provide a class of twist-valued models for (PS3,*), thus generalizing Löwe and Tarafder result. It is shown that they are in fact models of ZFC (not only of ZF). (shrink)

We propose in this paper a family of algebraic models of ZFC based on the three-valued paraconsistent logic LPT0, a linguistic variant of da Costa and D’Ottaviano’s logic J3. The semantics is given by twist structures defined over complete Boolean agebras. The Boolean-valued models of ZFC are adapted to twist-valued models of an expansion of ZFC by adding a paraconsistent negation. This allows for inconsistent sets w satisfying ‘not (w = w)’, where ‘not’ stands for the paraconsistent negation. Finally, our (...) framework is adapted to provide a class of twist-valued models generalizing Löwe and Tarafder’s model based on logic (PS 3,∗), showing that they are paraconsistent models of ZFC. The present approach offers more options for investigating independence results in paraconsistent set theory. (shrink)

Although a fascination with language is a familiar feature of 20th-century empiricism, its origins reach back at least to the early modern period empiricists. John Locke offers a detailed (if sometimes puzzling) treatment of language and uses it to illuminate key regions of the philosophical topography, particularly natural kinds and essences. Locke's main conceptual tool for dealing with language is 'signification'. Locke's central linguistic thesis is this: words signify nothing but ideas. This on its face seems absurd. Don't we need (...) words to signify things as well? But its very absurdity – our inclination to dismiss Locke as a 'linguistic idealist'– should signal to us that we have not yet understood Locke. Doing so must begin with an analysis of signification. Each of the three main interpretations on offer allows Locke to escape the charge of linguistic idealism, although they do so in very different ways. Locke's text also offers an influential account of linguistic particles, words like 'is', 'and' and 'if'. These signify, not ideas, but acts of the mind. These acts can either take place within a proposition, uniting its constituent ideas into a thought that admits of a truth-value, or they can take propositions as their objects, in which case they express attitudes like doubt, assertion and so on. Even this seemingly innocuous sketch of Locke's view is controversial, and many writers, from J.S. Mill onwards, have argued that Locke cannot make sense of propositional attitudes. Apart from the intrinsic interest of these questions, understanding how Locke thinks language works is a prerequisite for understanding his arguments against scholastic essentialism. It also illuminates later discussions of language in Berkeley, Hume and Mill. Author Recommends: 1. Losonsky, Michael. 'Language, Meaning, and Mind in Locke's Essay. ' The Cambridge Companion to Locke's Essay . Ed. Lex Newman. Cambridge: Cambridge UP, 2007. 286–313. In addition to making some original points, Losonsky provides an excellent overview of the three main competing positions on Lockean signification: the Fregean reading, the Scholastic reading and the Indicator theory (see entries 2–5 in the following). 2. Kretzmann, Norman. 'The Main Thesis of Locke's Semantic Theory.' Locke on Human Understanding . Ed. I. C. Tipton. Oxford: Oxford UP, 1975. 123–40. Kretzmann's influential paper offers a broadly Fregean analysis, according to which primary signification is sense and secondary, reference. Locke can then avoid the charge of linguistic idealism, as it is not the case that words signify only ideas. 3. Ashworth, E. J. 'Do Words Signify Ideas or Things?' Journal of the History of Philosophy 19 (1981): 299–326. Ashworth rejects Kretzmann's view, partly on the grounds of anachronism, and sets Locke in his historical context. As she reads Locke, he holds a scholastic position, according to which signification amounts to 'making known' or 'expressing'. This preserves the portmanteau analysis of Kretzmann: words can primarily signify or express ideas, while secondarily signifying things. 4. Lowe, E. J. 'Language and Meaning,' chapter 4. Locke . London: Routledge, 2005. This is a spirited defense of Locke's claim that words signify ideas against contemporary prejudices. Like Ian Hacking (see entry 7 in the following), Lowe argues that Locke is not offering a semantic theory in anything like the contemporary sense; rather, he is concerned with explaining human communication. 5. Ott, Walter. Locke's Philosophy of Language . Cambridge: Cambridge UP, 2004. On the interpretation offered in chapter 1, Lockean signification is indication: words signify ideas in the same sense in which clouds signify rain. If this view is correct, Locke is departing from the particular scholastic tradition Ashworth focuses on, and embracing instead a tradition running from the Stoics through Thomas Hobbes. http://www.springerlink.com/content/xv362655719101n3/ 6. Winkler, Kenneth. 'Signification, Intention, Projection.' Forthcoming, Philosophia . http://www.springerlink.com/content/xv362655719101n3 Although previous commentators acknowledge the role of intentions in Locke's view (see especially Kretzmann's argument from the uses of words), Winkler claims that they are far more central to Locke's view than has been supposed. In particular, Winkler uses these considerations to criticize the indicator interpretation. 7. Hacking, Ian. Why Does Language Matter to Philosophy? Cambridge: Cambridge UP, 1975. Much broader in focus than these other works, Hacking's classic text has much to say about early modern views on language. Hacking argues that Hobbes and Locke do not, properly speaking, even have theories of meaning. Online Materials The Stanford Encyclopedia of Philosophy's entry on Locke, by William Uzgalis: http://plato.stanford.edu/entries/locke/ > The Internet Encyclopedia of Philosophy's entry on Locke, author unknown: http://www.utm.edu/research/iep/l/locke.htm > Sample Syllabus Weeks 1–2: What is Locke's linguistic thesis? Is it a semantic thesis at all? Ashworth, E. J. 'Do Words Signify Ideas or Things?' Journal of the History of Philosophy 19 (1981): 299–326. Kretzmann, Norman. 'The Main Thesis of Locke's Semantic Theory.' Locke on Human Understanding . Ed. I. C. Tipton. Oxford: Oxford UP, 1975. 123–40. Locke, Essay III. i–iii. Lowe, E. J. 'Language and Meaning,' chapter 4. Locke . London: Routledge, 2005. Week 3: Propositions and attitudes Locke, Essay III. vii. Ott, Walter. 'Propositional Attitudes in Modern Philosophy.' Dialogue 41 (2002): 1–18. Owen, David. 'Locke on Judgment.' The Cambridge Companion to Locke's Essay . Ed. Lex Newman. Cambridge: Cambridge UP, 2007. 406–35. If one wanted to explore whether and how Locke applies his semiotic theory in his anti-essentialist argument, one might add (or perhaps replace Week 3 with): Week 4: Applications Bolton, Martha. 'The Relevance of Locke's Theory of Ideas to his Doctrine of Nominal Essence and Anti-Essentialist Semantic Theory.' Locke . Ed. Vere Chappell. Oxford: OUP, 1998. pp. 214–225 Locke, Essay III. vi; III.xi. 4–22. Ott, Walter. 'Locke's Argument from Signification.' Locke Studies 2 (2002): 145–76. Focus Questions 1. What is a semantic theory? What do we want out of such a theory, and does Locke even purport to provide one? 2. What are the differences among the three main competing readings of Locke? What is at stake here? What, if anything, turns on which of them accurately captures Locke's view? 3. How does Locke think his linguistic thesis tells against competing views, such as those of the scholastics? 4. What is the difference between a proposition and a list? Can Locke account for this difference? 5. There is clearly a difference between merely thinking that the cat is on the mat and asserting that it is. Can Locke account for this difference? (shrink)

One of the primary concerns in animal research is ensuring the welfare of laboratory animals. Modern views on animal welfare emphasize the role of animal sentience, i.e. the capacity to experience subjective states such as pleasure or suffering, as a central component of welfare. The increasing official recognition of animal sentience has had large effects on laboratory animal research. The Cambridge Declaration on Consciousness (Low et al., University of Cambridge, 2012) marked an official scientific recognition of the presence of sentience (...) in mammals, birds, and cephalopods. Animal sentience has furthermore been recognized in legislation in the European Union, UK, New Zealand and parts of Australia, with discussions underway in other parts of the world to follow suit. In this paper, we analyze this shift towards recognition of sentience in the regulation and practice in the treatment of laboratory animals and its effects on animal welfare and use. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.3 (2002) 265-269 [Access article in PDF] The Psychology and Physiology of Depression Walter Glannon Trauma and stressful events can disrupt the physiologic homeostasis of our bodies and brains. The physiologic stress response consists of neural and endocrine mechanisms whose function is to reestablish homeostasis. These mechanisms include the secretion of glucocorticoids (cortisol) and catecholemines (epinephrine and norepinephrine). Once an external event has ceased (...) to be a stressor or threat to a human organism, an integrated system of negative feedback loops inhibits the continued production of these hormones and effectively shuts down the stress response. These mechanisms are adaptive in the sense that they ensure the survival of the organism by reestablishing homeostasis. But prolonged exposure to real or perceived stressors can trigger prolonged secretion of stress hormones, thereby disrupting the feedback systems and causing a cascade of pathogenic events. The stress response is a double-edged sword. An acute stress response can protect an organism from external threats and reestablish homeostasis. But a chronic stress response can cause the body's defenses to become damaging rather than protective and to result in various disorders. Acute stress responses are adaptive. Chronic stress responses are often maladaptive and pathogenic.In "Depression as a Mind-Body Problem," I characterized major clinical depression as a disorder resulting from a maladaptive chronic stress response (Glannon 2003). Specifically, I argued that depression often results when our beliefs and emotions are out of proportion to the true nature of external events. The mind prolongs rather than constrains the physiologic stress response. Depression is not a disorder of the brain alone or the mind alone, however. Endocrine and immune dysfunction can contribute to the dysfunction in the brain and central nervous system that are involved in depression. Moreover, the contents of the mental states that initiate the sequence of events leading to depression are reflections of the person's natural and social environment. Thus, a satisfactory account of depression requires an analysis of the interconnections among the central nervous, endocrine, and immune systems, as well as the mind and the environment. All of these factors support the description of depression as a psychoneuroimmunologic disorder.Mike Martin (Martin 2003) and Thomas Fuchs (Fuchs 2003) discuss important aspects of depression that I did not elaborate in my paper. Martin argues that I fail to distinguish between depression as a mood and depression as a disorder. This is pertinent to the distinction evolutionary psychiatrists draw between moods that are adaptive and moods that are maladaptive. In contrast to my negative characterization of depression, Martin also makes a case for the positive [End Page 265] contributions of depression to meaningful life. Fuchs explores the notion of the brain as an organ of translation enabling patients to have meaningful subjective experience. The emphasis on subjectivity has important implications for potential preventive and therapeutic interventions for depression. For whether a person perceives an external event as a stressor may play a crucial role in the physiologic stress response. I will address the main points of these two authors in turn.Contrary to what Martin claims, I explicitly defined chronic depression as an affective (mood) disorder. My focus was on the clinical definition of major depression as a moderately severe to severe chronic disorder. It consists of affective, cognitive, and even physical dysfunction that interferes with a person's ability to carry out the normal tasks of daily life. This characterization of major chronic depression distinguishes it from milder forms of depression, such as dysthymia. Because these milder forms do not involve the same type or degree of dysfunction as more severe forms, they are not appropriately characterized as pathologies. For this reason, I focused on Nesse's (2000) discussion of depression rather than on his discussion of low mood. In fairness to Nesse and Stevens and Price (2000), not all forms of depression are pathologic according to the evolutionary view they defend. Some passive aspects of mild depression may be useful in alerting us to dangerous or wasteful behavior. It does seem plausible to describe depressed moods as falling along a continuum from those that... (shrink)

This chapter contains sections titled: At Home in the Commonplace Re‐Thinking Proto‐Modernism: Dickinson Re‐Thinking High Modernism: Stevens.

Biology arises from the crowded molecular environment of the cell, rendering it a challenge to understand biological pathways based on the reductionist, low‐concentration in vitro conditions generally employed for mechanistic studies. Recent evidence suggests that low‐affinity interactions between cellular biopolymers abound, with still poorly defined effects on the complex interaction networks that lead to the emergent properties and plasticity of life. Mass‐action considerations are used here to underscore that the sheer number of weak interactions expected from the complex mixture of (...) cellular components significantly shapes biological pathway specificity. In particular, on‐pathway—i.e., “functional”—become those interactions thermodynamically and kinetically stable enough to survive the incessant onslaught of the many off‐pathway (“nonfunctional”) interactions. Consequently, to better understand the molecular biology of the cell a further paradigm shift is needed toward mechanistic experimental and computational approaches that probe intracellular diversity and complexity more directly. Also see the video abstract here https://youtu.be/T19X_zYaBzg. (shrink)

BackgroundIn the early stages of the COVID-19 pandemic, many health systems, including those in the UK, developed triage guidelines to manage severe shortages of ventilators. At present, there is an insufficient understanding of how the public views these guidelines, and little evidence on which features of a patient the public believe should and should not be considered in ventilator triage.MethodsTwo surveys were conducted with representative UK samples. In the first survey, 525 participants were asked in an open-ended format to provide (...) features they thought should and should not be considered in allocating ventilators for COVID-19 patients when not enough ventilators are available. In the second survey, 505 participants were presented with 30 features identified from the first study, and were asked if these features should count in favour of a patient with the feature getting a ventilator, count against the patient, or neither. Statistical tests were conducted to determine if a feature was generally considered by participants as morally relevant and whether its mean was non-neutral.ResultsIn Survey 1, the features of a patient most frequently cited as being morally relevant to determining who would receive access to ventilators were age, general health, prospect of recovery, having dependents, and the severity of COVID symptoms. The features most frequently cited as being morally irrelevant to determining who would receive access to ventilators are race, gender, economic status, religion, social status, age, sexual orientation, and career. In Survey 2, the top three features that participants thought should count in favour of receiving a ventilator were pregnancy, having a chance of dying soon, and having waited for a long time. The top three features that participants thought should count against a patient receiving a ventilator were having committed violent crimes in the past, having unnecessarily engaged in activities with a high risk of COVID-19 infection, and a low chance of survival.ConclusionsThe public generally agreed with existing UK guidelines that allocate ventilators according to medical benefits and that aim to avoid discrimination based on demographic features such as race and gender. However, many participants expressed potentially non-utilitarian concerns, such as inclining to deprioritise ventilator allocation to those who had a criminal history or who contracted the virus by needlessly engaging in high-risk activities. (shrink)

ABSTRACT A growth mixture modeling (GMM) analysis of neutralization scores in 1,830 youth across six waves of data revealed evidence of a three-class model in which moral neutralization either increased (low accelerating), decreased (high decelerating), or remained the same (moderate stable) over time. Controlling for age, sex, race, group assignment, and Wave 1 delinquency, an analysis of covariance revealed a significantly greater increase in Wave 6 delinquency in the moderate stable group than in the low accelerating group. When the average (...) neutralization score was added as a control variable, the low accelerating group was highest, the moderate stable group next highest, and the high decelerating group lowest on Wave 6 delinquency. These results indicate that change in the pattern of neutralization scores (accelerating, stable, decelerating) may be as important as the level of moral neutralization at any particular point in time in determining the effect of neutralization on future delinquency. (shrink)

Two experiments examined the contribution of working memory (WM) to the retrieval and inhibition of background knowledge about counterexamples (alternatives and disablers, Cummins, ) during conditional reasoning. Experiment 1 presented a conditional reasoning task with everyday, causal conditionals to a group of people with high and low WM spans. High spans rejected the logically invalid AC and DA inferences to a greater extent than low spans, whereas low spans accepted the logically valid MP and MT inferences less frequently than high (...) spans. In Experiment 2, an executive-attention-demanding secondary task was imposed during the reasoning task. Findings corroborate that WM resources are used for retrieval of stored counterexamples and that people with high WM spans will use WM resources to inhibit the counterexample activation when the type of counterexample conflicts with the logical validity of the reasoning problem. (shrink)

The focus of the article is the self-predication principle, according to which the/a such-and-such is such-and-such. We consider contemporary approaches (Frege, Russell, Meinong) to the self-predication principle, as well as fourteenth-century approaches (Burley, Ockham, Buridan). In crucial ways, the Ockham-Buridan view prefigures Russell’s view, and Burley’s view shows a striking resemblance to Meinong’s view. In short the Russell-Ockham-Buridan view holds: no existence, no truth. The Burley-Meinong view holds, in short: intelligibility suffices for truth. Both views approach self-predication in a uniform (...) way. We were unable to find a medieval philosopher who, like Frege, approaches self-predication in a non-uniform way. We do not want to dispute that there are also considerable differences between the contemporary and the fourteenth-century approach to self-predication. Importantly, fourteenth-century accounts of self-predication rely strongly on the identity theory of predication, and this theory is not endorsed by contemporary philosophers of language. Nevertheless, some basic tenets seem to us to be clearly shared between fourteenth-century and contemporary thinkers. (shrink)

Historical studies may become classics for the wrong reasons, as did Henry Thode's Francis of Assisi or Michelet's Joan of Arc, which we now regard as cultural icons in their own right, emblems of specific elements of the cultures of the era in which they were written. We do not, however, read them for the insight they provide into their declared subjects, nor are their conclusions those of current scholarship. Other studies become classics for the right reasons. The year 1999 (...) marks the eightieth anniversary of the publication of Johan Huizinga's Herfsttij der Middeleeuwen: Studie over levens- en gedachtenvormen der veertiende en vijftiende eeuw in Frankrijk en de Nederlanden, “The Autumn [or Harvest, or Waning, or Decline, or Evening] of the Middle Ages: A Study of the Forms of Life and Thought in the Fourteenth and Fifteenth Centuries in France and the Netherlands [or the Low Countries, or the Burgundian Low Countries].”. (shrink)

The Medication Event Monitoring System (MEMS) is a relatively new device designed to overcome some of the disadvantages of traditional adherence-measuring techniques. MEMS has also been found useful in tracking adherence behaviour without the need to visit patients frequently. In this study each patient was given a pre-filled, labelled MEMS bottle and cap. Patients were monitored for 24 weeks. For patients specifically studied, there were periods when drug levels may have been low and some exhibited erratic medication-taking behaviour. It is (...) concluded that MEMS can measure adherence behaviour objectively, and so might be used to improve prescribing decisions, identify drug wastage and improve carer support. Further research is needed before the routine use of electronic medication monitoring can be recommended. (shrink)

BackgroundCurrent advances in biomedical research have introduced new ethical challenges in obtaining informed consent in low and middle-income settings. For example, there are controversies about the use of broad consent in the collection of biological samples for use in future biomedical research. However, few studies have explored preferred informed consent models for future use of biological samples in Malawi and South Africa. Therefore, we conducted an empirical study to understand preferred consent models among key stakeholders in biomedical studies that involve (...) collection of biological samples in Malawi and South Africa. The main objective of the study was to explore views of key stakeholders on current policies on informed consent in Malawi and South Africa. MethodsThis was a qualitative study involving in-depth interviews and focus group discussions. Thirty-four in-depth interviews and 6 focus group discussions were conducted with REC members, Funders, Policymakers, CAB members and Research Participants in Malawi and South Africa to gather their views on models of informed consent. The study was conducted in Cape Town, South Africa, and Blantyre and Lilongwe in Malawi.ResultsMost key stakeholders preferred broad consent and tiered consent to specific consent. Some participants expressed a strong preference for specific consent to other models of informed consent in biomedical research. Few participants did not have any preference for a consent model, opting for any consent model which provides adequate information about the proposed research and what their national consent regulations require. Finally, very few participants preferred blanket consent to other informed consent models.ConclusionsThis study aimed to help fill the gap in the scientific literature on key stakeholder views on consent models for future use of biological samples in Malawi and South Africa. The findings of the study have provided some evidence that may support policies on permissible consent models for future use of biological samples in sub-Saharan Africa considering the differences in informed consent regulations and guidelines. Finally, the findings can inform ongoing discussions on permissible consent models to be used for future use of biological samples. (shrink)

Ducklings were placed either singly or in pairs on a platform at two different heights. Both height and pairing influenced performance: More ducklings descended from the platform at low heights, and more single ducklings descended than paired ducklings. The social factor, pairing, made behavior more cautious and decreased the number of distress calls. A similar trend for pairing to influence performance was shown on the visual cliff. Without its peers, the duckling is a distressed animal. Previous careless behavior by ducklings (...) on the visual cliff may be ascribed to testing the ducklings outside their normal social environment. (shrink)

The Covid‐19 pandemic has sparked rapid and voluminous production of bioethics commentary in popular media and academic publications. Many of the discussions are new twists on an old theme: how to fairly allocate scarce medical resources, such as ventilators and intensive care unit beds. In this essay, we do not add another allocation scheme to the growing pile, partly out of appreciation that such schemes should be products of inclusive and transparent community engagement and partly out of recognition of their (...) limited utility for physicians working in the field. Instead, we make the more modest claim that context matters when making such decisions and, more specifically, that recommendations from high‐income countries about fair allocation during Covid‐19 should not be cut and pasted into low‐income settings. We offer a few examples of why seemingly universal, well‐intentioned ethical recommendations could have adverse consequences if unreflectively applied in sub‐Saharan Africa. (shrink)

The so-called Disability Paradox arises from the apparent tension between the popular view that disability leads to low well-being and the relatively high life-satisfaction reports of disabled people. Our aim in this essay is to make some progress toward dissolving this alleged paradox by exploring the relationship between disability and various “goods of life”—that is, components of a life that typically make a person’s life go better for her. We focus on four widely recognized goods of life (happiness, rewarding relationships, (...) knowledge, achievement) and four common types of disability (sensory, mobility, intellectual, and social) and systematically examine the extent to which the four disability types are in principle compatible with obtaining the four goods of life. Our findings suggest that that there is a high degree of compatibility. This undermines the widespread view that disabilities, by their very nature, substantially limit a person’s ability to access the goods of life, and it provides some guidance on how to dissolve the Disability Paradox. (shrink)

The COVID‐19 pandemic has raised important universal public health challenges. Conceiving ethical responses to these challenges is a public health imperative but must take context into account. This is particularly important in sub‐Saharan Africa (SSA). In this paper, we examine how some of the ethical recommendations offered so far in high‐income countries might appear from a SSA perspective. We also reflect on some of the key ethical challenges raised by the COVID‐19 pandemic in low‐income countries suffering from chronic shortages in (...) health care resources, and chronic high morbidity and mortality from non‐COVID‐19 causes. A parallel is drawn between the distribution of severity of COVID‐19 disease and the classic “Fortune at the bottom of the pyramid” model that is relevant in SSA. Focusing allocation of resources during COVID‐19 on the ‘thick’ part of the pyramid in Low‐to‐Middle Income Countries (LMICs) could be ethically justified on utilitarian and social justice grounds, since it prioritizes a large number of persons who have been economically and socially marginalized. During the pandemic, importing allocation frameworks focused on the apex of the pyramid from the global north may therefore not always be appropriate. In a post‐COVID‐19 world, we need to think strategically about how health care systems can be financed and structured to ensure broad access to adequate health care for all who need it. The root problems underlying health inequity, exposed by COVID‐19, must be addressed, not just to prepare for the next pandemic, but to care for people in resource poor settings in non‐pandemic times. (shrink)

We ran a pilot experiment to explore, using a new psychophysical method, the hypothesis proposed by Zietz and Werner in the ’30s, that a sound presented simultaneously with an afterimage can change its phenomenal appearance in non-synaesthetes. The method we adopted is able to directly collect and visualise the apparent changes in intensity of the afterimages, by recording observers’ interactions with a physical feedback mechanism, without referring to verbal descriptions. These first findings support some of the most meaningful observations reported (...) by Werner and Zietz, according to which the colours of the afterimages ‘disintegrate’ at the hearing of a low sound and ‘concentrate’ for a high sound. This relationship is particularly evident with the Yellow stimulus, where the perceived colour intensity of its afterimage seems to have a faster negative change with a low-pitched tone sound, and an increase in intensity and duration when perceived simultaneously with a soprano sound. These data are also coherent with the crossmodal correspondences between both pitch and loudness in audition and lightness and brightness in vision reported in the literature. (shrink)

The sequencing of the human genome has opened the way for using bioinformatics to identify sets of genes controlled by specific regulatory signals. Here, we review the unexpected diversity of DNA response elements mediating transcriptional regulation by estrogen receptors (ERs), which control the broad physiological effects of estrogens. Consensus palindromic estrogen response elements are found in only a few known estrogen target genes, whereas most responsive genes contain only low‐affinity half palindromes, which may also control regulation by other nuclear receptors. (...) ERs can also regulate gene expression in the absence of direct interaction with DNA, via protein–protein interactions with other transcription factors or by modulating the activity of upstream signaling components, thereby significantly expanding the repertoire of estrogen‐responsive genes. These diverse mechanisms of action must be taken into account in screening for potential estrogen‐responsive sequences in the genome or in regulatory regions of target genes identified by expression profiling. BioEssays 24:244–254, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10066. (shrink)

BackgroundOver the past two decades, Uganda has experienced a significant increase in clinical research driven by both academia and industry. This has been combined with a broader spectrum of research proposals, with respect to methodologies and types of intervention that need evaluation by Research Ethics Committees (RECs) with associated increased requirement for expertise. We assessed the competencies of REC members regarding review of research protocols with complex and emerging research study designs. The aim was to guide development of a training (...) curriculum to improve the quality of scientific and ethical review.MethodsThis was a cross-sectional study design, with quantitative data collection methods. Research Ethics Committee members completed a structured pre-coded questionnaire on current competence with complex and emerging study design. REC members were asked to outline a list of additional topics for which they needed training. Data from coded questions were entered into Epidata Version 3.1 and then exported to STATA Version14.1 for analysis. Descriptive analysis was performed and findings are presented using percentages and frequencies.ResultsWe enrolled 55 REC members from 6 RECs who have a total of 97 members. The majority of whom were males (56.4%, n = 31/55). The level of competence for review of selected study design was lowest for Controlled Human Infection Model (10.9%, n = 6) and reverse pharmacology design (10.9%, n = 6), and highest for cluster randomized study design (52.7%, n = 29) and implementation science research (52.7%, n = 29).ConclusionCompetence for review of research protocols with complex and emerging study design was low among participating REC members. We recommend prioritising training of REC members on complex and emerging study designs to enhance quality of research protocol review. (shrink)

The objective of this paper is to provide an overview of corporate social responsibility (CSR) in Greece and present the challenges that need to be met in order to further promote socially responsible business behaviour in the domestic economy. This is the first attempt to provide a systematic analysis of CSR in Greece and adds to the existing pool of knowledge of CSR embeddedness in countries where CSR awareness is still rather low, a literature field that is still quite limited. (...) Drawing from prior literature, the paper is built around three basic questions in relation to the Greek context: how is CSR perceived by Greek business professionals? How is CSR practised in Greece? And which issues evident in the modern domestic environment act as underlying barriers to the broader dissemination of CSR in Greece? The extant empirical work suggests that, while CSR in Greece appears to be developing, there is still scope for improvement and further diffusion of relevant practices. While some of the patterns shaping CSR in Greece have been analysed, much work still remains to be carried out in extending and deepening our knowledge in this part of Europe. (shrink)

The objective of this paper is to provide an overview of corporate social responsibility (CSR) in Greece and present the challenges that need to be met in order to further promote socially responsible business behaviour in the domestic economy. This is the first attempt to provide a systematic analysis of CSR in Greece and adds to the existing pool of knowledge of CSR embeddedness in countries where CSR awareness is still rather low, a literature field that is still quite limited. (...) Drawing from prior literature, the paper is built around three basic questions in relation to the Greek context: how is CSR perceived by Greek business professionals? How is CSR practised in Greece? And which issues evident in the modern domestic environment act as underlying barriers to the broader dissemination of CSR in Greece? The extant empirical work suggests that, while CSR in Greece appears to be developing, there is still scope for improvement and further diffusion of relevant practices. While some of the patterns shaping CSR in Greece have been analysed, much work still remains to be carried out in extending and deepening our knowledge in this part of Europe. (shrink)

ObjectivesIndividuals with irregular physical activity participation are defined as fluctuators. This study aimed to comprehend how fluctuators’ perceived barriers and motivators in their subjective theories are exhibited and cognitively represented in relation to their everyday PA practices and lapses.MethodsThe design of “Research Program Subjective Theories” was used to explore and present fluctuators’ cognition concerning PA participation. Thirty fluctuators were invited to a semi-structured interview. By inductive and deductive coding, fluctuators’ verbal data were converted into word categories for extracting commonalities and (...) comparing differences. By retaining the remaining word categories of high frequency and exploring the interrelationships among the remained word categories using statistical analyses, a superstructure including fluctuators’ main PA motivators, barriers, and behavioral outcomes was compiled.ResultsFluctuators face common motivators as barriers, such as lack of time, lack of willpower, lack of social support, and physical reasons. Fluctuators’ subjective theories primarily differed in motivational configurations. The physically motivated fluctuators were more linked with low PA level, while the mixed motivated fluctuators were more likely associated with moderate PA level. The exemplars of the three typical fluctuators were also demonstrated to reveal their real experiences and situations in the daily life context.ConclusionDue to the fact that fluctuation research is still in its infancy, this study represents a significant opportunity to promote knowledge growth in this area. Future studies are recommended to convert findings of the present study into interventions that benefit fluctuators in overcoming perceived barriers and enhancing motivations to eventually participate in regular PA. (shrink)

SummaryThis article offers a novel and comprehensive account of Walter Bagehot's political thought. It ties together an interpretation of Bagehot's liberal commitment to norms of discussion and deliberation, with an analysis of Bagehot's extensive arguments about the institutions of representative government. We show how Bagehot's opposition to American-style presidentialism, to parliamentary democracy, and to proportional representation were profoundly shaped by his conceptions of government by discussion, and the rule of public opinion. Bagehot's criticisms of English parliamentarianism, both of its (...) pre-1832 and post-1832 varieties were also motivated by those principles, as was his own proposal for parliamentary reform. By examining the whole range of Bagehot's writings on representative government and by connecting his institutional recommendations to his liberal principles, we are also able to better clarify Bagehot's position in Victorian political thought. The article concludes with a discussion of the debate leading up to the Second Reform Act, in which we elucidate Bagehot's disagreements with other prominent exponents of liberalism including John Stuart Mill, the “university liberals,” and Robert Lowe. (shrink)

In his review, Walter (2012) links conceptual perspectives on empathy with crucial results of neurocognitive and genetic studies and presents a descriptive neurocognitive model that identifies neuronal key structures and links them with both cognitive and affective empathy via a high and a low road. After discussion of this model, the remainder of this comment deals more generally with the possibilities and limitations of current neurocognitive models, considering ways to develop process models allowing specific quantitative predictions.

Summary In this paper we examine the reaction of the Leiden low-temperature laboratory of Heike Kamerlingh Onnes to new ideas in quantum theory. Especially the contributions of Albert Einstein (1906) and Peter Debye (1912) to the theory of specific heat, and the concept of zero-point energy formulated by Max Planck in 1911, gave a boost to solid state research to test these theories. In the case of specific heat measurements, Kamerlingh Onnes's laboratory faced stiff competition from Walter Nernst's Institute (...) of Physical Chemistry in Berlin. In fact, Berlin got the better of it because Leiden lacked focus. After the liquefaction of helium in 1908, Kamerlingh Onnes transformed his laboratory into an international facility for low temperature research, and for this reason it was impossible to make headway with the specific heat measurements. In the case of zero-point energy, Leiden developed a magnetic research programme to test the concept. Initially the balance of evidence seemed to be tipping in favour of zero-point energy. After 1914, however, Leiden would desert the theory in fovour, of a concept from calssical physics. A curious move that illustrates Kamerlingh Onnes's discomfort with the new quantum theory. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK R]]JVIEWS room for different theories and new developments. He does not try to tie up every loose end. Furthermore, he avoids the rut of the specialist by willingly and capably addressing questions of biblical exegesis, philosophy, psychology, science, and popular culture with even-handed competence. Space does not permit me to discuss his fascinating analysis of the psychology of near-death experiences or specific rejoinders to important objections (e.g., the (...) Bible depicts the dead as bodily beings, not immaterial spirits; dualism is a result of the Fall; dualism implies that the whole person does not die; at death we pass out of time, and, hence, there is no intermediate state). But I can assure you that his account is cogent and illuminating. Lenoir-Rhyne College Hickory, North Carolina PHILIP BLOSSER: The Crisis of Liberal Democracy: A Straussian Perspective. Edited by KENNETH L DEUTSCH AND WALTER SOFFER. Albany: State University of New York Press, 1987. Pp. ix+ 304. $54.50 (cloth); $18.95 (paper). For Leo Strauss, the superiority of classical political philosophy over modern social science (and political theory based on social science) lies in at least four principles. First, it treats political matters as they actually appear to man qua philosopher and, in a qualified way, to the good citizen. Because Strauss claims that social science (and much post-classical political philosophy) abstracts from his canon of intelligibility, he thinks that it cannot lead to a humane, rational politics. (See "What is Political Philosophy?", in What is Political Philosophy? [Westport: Greenwood], pp. 27-28, and "Distinction between Facts and Values" in Natural Right and History [Chicago: Univ. of Chicago Press, 1953], pp. 78-80.) Second, Plato and Aristotle believed that only the good man properly judges politics. This belief attracts Strauss, because it identifies virtue as the best claimant to political rule. ("What is Political Philosophy? ", pp. 36-38.) A third principle is derived immediately from this second: politics ought to be organized hierarchically. In the hierarchy, either the truly virtuous or gentlemen should rule, and those having a passive, obediential form of virtue should be the ruled. Fourth, this arrangement is rational and humane. For although the virtues of the ruler and the ruled are complementary in justice and necessary to it, still they are different and, in fact, require the stratification just mentioned. ("Classic Natural Right" in Natural Right and History, pp. 130-44.) BOOK REVIEWS 527 Because of the controversial nature of these principles and Strauss's eminence in political philosophy, one welcomes the present collection of essays by his disciples. They believe that in liberal democracies people confuse liberty with the uses to which liberty can and ought to be put. Doing so, people undermine that regime's foundations. Strauss and his disciples believe that modern natural right makes the clash between liberty and natural right inevitable, because its principal founders, Thomas Hobbes and John Locke, conceived man as non-political. They conceived individuals as gaining certain advantages from governments hut as gaining no good in the exercise of politics itself. Classic natural right, by contrast, bases itself on the assumption that man is radically political. Moreover, it conceives politics as an arena for liberating, ennobling activities. Hobbes and Locke viewed the individual as independent of politics, which they placed at the low end of the range of human activity, along with everyday concerns and popular morality, rather than at the high end, as Strauss would. Thus for Strauss, liberal democracy is founded on modern principles, which are either apolitical and liberal (Locke) or apolitical and illiberal (Hobbes). Consequently, it cannot withstand the individualist and collectivist onslaughts that we have seen in this century. What, then, have Strauss's disciples to say about liberal democracy and the prospect of classic natural right in a Western world which is more or less permanently Hobbesian-Lockean? This can be answered by describing first the hook's divisions and then its diagnoses and prescriptions. In part one the contributors appraise the work of Strauss itself; in part two they define issues in liberalism ; and in part three they discuss liberalism in American political life. In the first part, Michael Platt outlines how Strauss's thought... (shrink)

Summary In this paper we examine the reaction of the Leiden low-temperature laboratory of Heike Kamerlingh Onnes to new ideas in quantum theory. Especially the contributions of Albert Einstein (1906) and Peter Debye (1912) to the theory of specific heat, and the concept of zero-point energy formulated by Max Planck in 1911, gave a boost to solid state research to test these theories. In the case of specific heat measurements, Kamerlingh Onnes's laboratory faced stiff competition from Walter Nernst's Institute (...) of Physical Chemistry in Berlin. In fact, Berlin got the better of it because Leiden lacked focus. After the liquefaction of helium in 1908, Kamerlingh Onnes transformed his laboratory into an international facility for low temperature research, and for this reason it was impossible to make headway with the specific heat measurements. In the case of zero-point energy, Leiden developed a magnetic research programme to test the concept. Initially the balance of evidence seemed to be tipping in favour of zero-point energy. After 1914, however, Leiden would desert the theory in fovour, of a concept from calssical physics. A curious move that illustrates Kamerlingh Onnes's discomfort with the new quantum theory. (shrink)

E. J. Lowe; The problem of the many and the vagueness of constitution, Analysis, Volume 55, Issue 3, 1 July 1995, Pages 179–182, https://doi.org/10.1093/analys/.