Globalization is often discussed as if it were a recent phenomenon relating primarily to the development of world financial markets and improvements in information and travel technologies. But globalization is an ancient process, beginning with mercantile and cultural exchanges and facilitated by advances in transportation. In the twentieth century, the results of globalization can be seen in the rise of global capitalism and in the construction of a global economy. Most recently, the process of globalization has moved beyond the world (...) of finance, however, into areas still traditionally thought of as national concerns, such as culture and healthcare. It is no surprise, therefore, that increasingly the challenges the United States is confronting in healthcare, biotechnology, and the environment are simultaneously faced by the international community as a whole. In the wake of the HIV pandemic, growing environmental consciousness, and a series of sensational advances in biotechnology, there is a dawning realization that problems such as improving public health, regulating advances in biotechnology, and achieving sustainable environmental development transcend national borders. In other words, bioethics concerns are global in nature. (shrink)

In this article we report the findings of a randomised control clinical trial that assessed the impact of a Philosophy for Children program and replicated a previous study conducted in Scotland by Topping and Trickey. A Cognitive Abilities Test was administered as a pretest and a posttest to randomly selected experimental groups and control groups. The students in the experimental group engaged in philosophy lessons in a setting of structured, collaborative inquiry in their language arts classes for one hour per (...) week for a number of weeks. The control group received the standard language arts curriculum in that one hour. The study found that the seventh grade students who had experienced the P4C program showed significant gains relative to those in the seventh grade control group at a high level of statistical significance, but the eighth grade students in the experimental group did not show such gains over the eighth grade control group. It was discovered that the seventh grade teachers started the program early in the school year and continued it for a period of 22 to 26 weeks, while the eighth grade teachers started much later and used the program for only 4 to 10 weeks. Our findings suggest that the P4C program must involve students in activities for a significant period of time before the program shows results, but that a meaningful impact on students’ cognitive abilities can be achieved in about 24 weeks of lessons, less than half the time evidenced by the study by Topping and Trickey. (shrink)

Spirituality and storytelling can be resources in aging successfully and in dying well given the constraints of modern day Western culture. This paper explores the relationship of aging to time and the dynamic process of the life course and discusses issues related to confronting mortality, including suffering, finitude, spirituality, and spiritual closure in regard to death. And, finally, the role of narrative in this process is taken up.

: Because an influenza pandemic would create the most serious hardships for those who already face most serious hardships, countries should take special measures to mitigate the effect of a pandemic on existing social inequalities. Unfortunately, there is little evidence that anybody is thinking about that.

Diseases causing inherited retinal degeneration in humans, such as retinitis pigmentosa and macular dystrophy, are genetically heterogeneous and clinically diverse. More than 40 genes causing retinal degeneration have been mapped to specific chromosomal sites; of these, at least 10 have been cloned and characterized. Mutations in two proteins, rhodopsin and peripherin/RDS, account for approximately 35% of all cases of autosomal dominant retinitis pigmentosa and a lesser fraction of other retinal conditions. This target article reviews the genes and mutations causing retinal (...) degeneration and proposes mechanisms whereby specific mutations lead to particular clinical consequences, that is, the relationship between genotype and phenotype. Retinitis pigmentosa and macular dystrophy are genetically heterogeneous diseases that cause retinal degeneration in humans and often result in severe visual impairment or blindness. Although many of the genes causing these diseases have not been identified, three photoreceptor-specific proteins have been implicated: rhodopsin, peripherin/RDS, and the P-subunit of rod phosphodiesterase. Mutations in the genes for these three proteins can cause either dominant retinitis pigmentosa, recessive retinitis pigmentosa, dominant congenital stationary night blindness, or dominant macular degeneration. Why this multiplicity of clinical phenotypes? Our target article summarizes the genetic and biochemical background to this question and proposes a number of possible explanations. Discussion focuses mainly on 73 distinct disease-causing mutations of rhodopsin. We feel that rhodopsin and other photoreceptor proteins can serve as model systems for unraveling the connection between genotype and phenotype, not only for inherited retinal diseases but for other degenerative disorders as well. (shrink)

Recent findings emphasize the complexity, both genetic and functional, of the manifold genes and mutations causing inherited retinal degeneration in humans. Knowledge of the genetic bases of these diseases can contribute to design of rational therapy, as well as elucidating the function of each gene product in normal visual processes.

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

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Blackburn’s dilemma (as commonly understood) is that in explaining truths of the form ‘Necessarily-P’ we have to appeal either to a necessary truth, in which case we don’t seem to make the right kind of progress, or to a contingent truth, in which case we seem to undermine the necessity we were meant to be explaining. This paper advances two claims. First, it is argued that the dilemma is wider in scope than usually supposed. The standard assumption (evident also in (...) Black-burn’s original paper (1993)) is that the dilemma applies to explanations of truths of the form ‘Necessarily-P’. I argue that the real problem identified by Blackburn doesn’t just apply to explanations of truths of this form, but to explanations of necessary truths in general (e.g. truths of logic, mathematics, etc.). In the course of this argument it also transpires that the real problem on the necessity horn is rather different—and rather less susceptible to obvious objections—than it is usually taken to be. It concerns the antinaturalistic core of necessity. Second, it is argued that there is an escape from the antinaturalistic core on the contingency horn. In the footsteps of Wright (1985), the claim is that the contingency horn is tenable for those who believe that the necessary truth in question is analytic, i.e. follows from its meaning. (shrink)

Adults and infants display a robust ability to perceive the unity of a center-occluded object when the visible ends of the object undergo common motion (e.g. Kellman, P.J., Spelke, E.S., 1983. Perception of partly occluded objects in infancy. Cognitive Psychology 15, 483±524). Ecologically oriented accounts of this ability focus on the primacy of motion in the perception of segregated objects, but Gestalt theory suggests a broader possibility: observers may perceive object unity by detecting patterns of synchronous change, of which common (...) motion is a special case. We investigated this possibility with observations of adults and 4-month-old infants. Participants viewed a center-occluded object whose visible surfaces were either misaligned or aligned, stationary or moving, and unchanging or synchronously changing in color or bright- ness in various temporal patterns (e.g. ¯ashing). Both alignment and common motion con- tributed to adults' perception of object unity, but synchronous color changes did not. For infants, motion was an important determinant of object unity, but other synchronous changes and edge alignment were not. When a stationary object with aligned edges underwent syn- chronous changes in color or brightness, infants showed high levels of attention to the object, but their perception of its unity appeared to be indeterminate. An inherent preference for fast over slow ¯ash rates, and a novelty preference elicited by a change in rate, both indicated that infants detected the synchronous changes, although they failed to use them as information for object unity. These ®ndings favor ecologically oriented accounts of object perception in which surface motion plays a privileged role. Ó 1999 Elsevier Science B.V. All rights reserved. (shrink)

This volume provides a concentrated and powerful dialog about the nexus between schools, prisons, and the free-market economy where youth are on fast tracks from schools to prisons.

Establishing that nature has intrinsic value has been the primary goal of environmental philosophers. This goal has generated tremendous confusion. Part of the confusion stems from a conflation of two quite distinct concerns. The first concern is with establishing the moral considerability of the natural world which is captured by what I call "intrinsic value p ." The second concern attempts to address a perceived problem with the way nature has traditionally been valued, or as many environmentalists would suggest, undervalued, (...) what I call "intrinsic value v ." In this paper I argue against further development of both types of theories of the intrinsic value of nature. There are, I believe, intermediate valuations that have been almost entirely overlooked in discussions of value. Much of the confusion currently plaguing environmental ethics can be avoided by abandoning intrinsic value and refocusing environmental ethics. (shrink)

Vesilind, P.A. There Is No Such Thing As Environmental Ethics,Science and Engineering Ethics 2:307–318.Dr. Gruen is Co-editor ofReflecting on Nature: Readings in Environmental Philosophy and has published on the topics of animals, ethies, and the environment.

On what basis do we attribute phenomenal states to others? One answer, defended by John Stuart Mill, appeals to an analogy between ourselves and the similar bodies and actions of others (1865, p. 208). Despite its intuitive plausibility, this position is often rejected (Arico et al., 2011; Buckwalter & Phelan, 2014; Knobe & Prinz, 2008). In line with Mill’s account, we propose that the primary factors used when making phenomenal state ascriptions are the appropriate display of functional and behavioral cues (...) and having bodies with the right kind of physical composition. To test this account, we gave five groups of participants a vignette followed by three to six questions. For four of the groups, the vignette described an alien-human encounter and the participants had to judge the likelihood (on a 7-point scale) that the alien had a non-phenomenal state (a belief) and the likelihood that it could have a phenomenal state (pain). The fifth group, as a control, read a vignette about a similar interaction between two humans. We found that, as appropriate functional and behavioral cues and then humanoid features are added to the alien, people are more willing to attribute a phenomenal state to it. Attributions of the non-phenomenal state are primarily dependent on the appropriate functional and behavioral cues, not on having humanoid features. (shrink)

In this conversation, four experts in animal research oversight—Christopher Stodgell, Lori Hill, Robert Kesterson, and Angelika Rehrig—discuss the complexities of stem cell-based chimeric animal experiments, especially in relation to traditional animal welfare practices. Each expert shares their experiences and suggestions for how best to conduct chimeric animal research, including discussing the importance of communication and collaboration between experts in animal behavior and welfare and the investigators conducting or proposing chimeric research studies.

We use Concurrent Game Models (CGM) in which simple conditional promises are assigned the role of negotiation steps aiming to represent the formation of temporary coalitions and their agendas. By transforming these extended CGMs into equivalent CGMs with incomplete information, established methods for rational synthesis become enabled. The interpretation of promises is compatible with that of announcements as in dynamic epistemic logics. To accommodate requirements on plays that are written wrt the runs of the original model, we use temporal projection (...) that hides negotiation steps. (shrink)

In their article, Fabi and Goldberg discuss concerns of racial injustice and the continued exclusion of people—based on race—in ethics research funding allocation, and how that impacts knowl...

I follow the distinction of predicative versus attributive adjectives introduced by P.T. Geach in 1956 and discuss Atina Knowles' arguments contra the revisions of Geach's original conception.

This article provides an overview of the key philosophical themes and debates in discussions of pornography. In particular, I consider the major positions on how pornography ought to be defined, when (and if ) it should be regulated, whether it is best understood as speech (or action), whether there is evidence that is it harmful. I argue in favor of what is known as the civil rights approach to pornography, as reflected in the work of Catharine MacKinnon.

“What do you see when you look at your face in the mirror?” asks J. David Velleman in introducing his philosophical theory of action. He takes this simple act of self-scrutiny as a model for the reflective reasoning of rational agents: our efforts to understand our existence and conduct are aided by our efforts to make it intelligible. Reflective reasoning, Velleman argues, constitutes practical reasoning. By applying this conception, _Practical Reflection_ develops philosophical accounts of intention, free will, and the foundation (...) of morals. This new edition of _Practical Reflection_ contains the original 1989 text along with a new introduction and is the latest entry in The David Hume Series of Philosophy and Cognitive Science Reissues, which keeps in print previously published indispensable works in the area of cognitive science. _ _ _ _. (shrink)

This essay argues that Mark C. Murphy's original contribution to natural law ethics succeeds in finding a way between older metaphysical and newer purely practical approaches in this genre. Murphy's reconstruction of the function argument, critique of subjectivist theories of well-being, and rigorous formulation of a flexible welfarist theory of value deserve careful attention. I defend Kant against Murphy's critique and argue that Murphy faces the problem of showing that all his basic goods are morally inviolable. Although I endorse Murphy's (...) critique of radical virtue ethics, I raise objections to the basic moral norms he derives from his list of goods, and to the analysis of peace of mind and happiness as basic goods. (shrink)

The ‘indispensability argument’ for the existence of mathematical objects appeals to the role mathematics plays in science. In a series of publications, Joseph Melia has offered a distinctive reply to the indispensability argument. The purpose of this paper is to clarify Melia’s response to the indispensability argument and to advise Melia and his critics on how best to carry forward the debate. We will begin by presenting Melia’s response and diagnosing some recent misunderstandings of it. Then we will discuss four (...) avenues for replying to Melia. We will argue that the three replies pursued in the literature so far are unpromising. We will then propose one new reply that is much more powerful, and—in the light of this—advise participants in the debate where to focus their energies. (shrink)

Personal Versus Political Affairs in Churchill's This is a Chair There are plenty of issues in the world to petition and fight for, yet each individual also has "battles" at home to contend with. Which is of more importance? We often separate the two indefinitely. In studying Caryl Churchill's work This Is a Chair, however, I would suggest the personal and political to be intimately related and possibly each even a causation of the other. To take care of one may (...) be eliminating the problem of the other as well. Might political problems stem from petty, personal qualms? Even more specifically might jeopardizing moral norms affect the greater social order? If so, this would be a revelation and fresh pursuit in solving many of the monumental political issues which are faced today. (shrink)