In this paper, the thematic context for Fichte’s early concern with the character of the forms of intuition, and specifically inner intuition, is adumbrated. This context is provided by means of a brief exposition of Kant’s doctrine of time as the form of inner sense, and its dual role; its positive role in the “order of (synthetic) cognition” or ordo cognoscendi, and its negative role in the critique of Seelenlehre or “doctrine of the soul.” It is then argued, on this (...) basis, that Fichte’s critique of Kant’s doctrine can serve as a principle for our understanding both of the context for, and the content of, Fichte’s early, propaedeutic writings, and thus of the character of the development of post-Kantian theoretical philosophy and doctrine of knowledge. The paper develops in three parts; through (1) an introduction, in which the importance of the theme to the development of German idealism is intimated, to (2) an exposition of the basic theses of Kant’s Sinnenlehre in the Critique of Pure Reason, and to (3) a summary of Fichte’s critique thereof, as this is set out in the Grundriss. (shrink)

The title already announces Henrich’s methodological reorientation, from the trajectory von Kant bis Hegel, to a constellation of post-Kantian theoretical philosophies comprehended as “three comparable and competing positions [those of Fichte, Schelling, and Hegel] that cannot be reduced to each other”. Chapters 1 through 3 provide the context for the later content of the work by introducing the theme of the formal interdependence of mind and world, of “internal experience” and our experience of a law-governed world external to us. This (...) co-relation Henrich understands as fundamental to both Kant’s own and post-Kantian philosophy, theoretical and practical. Henrich takes as basic “the insight that mental activity always implies a world within which such activity occurs.” This yields the claim that “the concept of mind as the subject of knowledge is not possible without the idea of a world that laws govern”. Henrich then adumbrates the ways in which Kant’s account of the structure and dynamics of this relation were taken to be either problematic or insufficient in theoretical philosophy between Kant and Hegel. (shrink)

In his commentary, Oaksford makes two main claims: (1) that the externalisation method used by Green, Over, and Pyne (1997) enforces the correlation observed between probability estimates and selection, and (2) that these estimates support the prediction of a downward revision of P(p) when P(p) > P(q). In this reply, we rebut claim 1 by describing the instructions more comprehensively, and claim 2 by reiterating the importance of making certain theoretical distinctions which Oaksford does not make. Our interest is (...) the psychological process of reaching decision: externalisation methods provide a means of exploring this process and of assessing the value of Bayesian approaches. (shrink)

Mesoscale modeling is often considered merely as a practical strategy used when information on lower-scale details is lacking, or when there is a need to make models cognitively or computationally tractable. Without dismissing the importance of practical constraints for modeling choices, we argue that mesoscale models should not just be considered as abbreviations or placeholders for more “complete” models. Because many systems exhibit different behaviors at various spatial and temporal scales, bottom-up approaches are almost always doomed to fail. Mesoscale models (...) capture aspects of multi-scale systems that cannot be parameterized by simple averaging of lower-scale details. To understand the behavior of multi-scale systems, it is essential to identify mesoscale parameters that “code for” lower-scale details in a way that relate phenomena intermediate between microscopic and macroscopic features. We illustrate this point using examples of modeling of multi-scale systems in materials science and biology, where identification of material parameters such as stiffness or strain is a central step. The examples illustrate important aspects of a so-called “middle-out” modeling strategy. Rather than attempting to model the system bottom-up, one starts at intermediate scales where systems exhibit behaviors distinct from those at the atomic and continuum scales. One then seeks to upscale and downscale to gain a more complete understanding of the multi-scale system. The cases highlight how parameterization of lower-scale details not only enables tractable modeling but is also central to understanding functional and organizational features of multi-scale systems. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

This work identifies Kant’s doctrine of inner sense as a central element within the ‘architectonic of pure reason’ of the first Critique, exposes its variant construals, and considers the implications of its problematicity for Kant’s theoretical philosophy most generally.

This work identifies Kant’s doctrine of inner sense as a central element within the ‘architectonic of pure reason’ of the first Critique, exposes its variant construals, and considers the implications of its problematicity for Kant’s theoretical philosophy most generally.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Two experiments using a realistic version of the selection task examined the relationship between participants' probability estimates of finding a counter example and their selections. Experiment 1 used everyday categories in the context of a scenario to determine whether or not the number of instances in a category affected the estimated probability of a counter-example. Experiment 2 modified the scenario in order to alter participants' estimates of finding a specific counter-example. Unlike Kirby 1994a, but consistent with his proposals, both studies (...) showed that probability estimates significantly predicted selection. Overall results point to the value of understanding selections in terms of their subjective expected utility. (shrink)

Advanced Cell Technology's Ethics Advisory Board has been called window dressing for a corporate marketing plan. But the scientists and managers have paid attention, and the lawyers have gone along.

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

Are the words that a novelist uses adequate to his or her elusive subject&—the human condition? Are they pertinent, accurate, invariably fair, unflinchingly honest? Or do the novelist's words execute essentially formal maneuvers, engaging our interest through their patterns rather than their reach? And what about a possible third, synthesizing option? Robert W. Greene discovers that the two apparently divergent intentions in question (metalinguistic vs. moralistic) often paradoxically coexist in French fiction. Also, no doubt because it is more consistently self-conscious (...) than that of any previous era, the fiction of twentieth-century France seems to illustrate this convergence with special brillance. From L'lmmoralist (1902) to L'Usage de la parole (1980) Greene explores combinations and permutations of moralistic analysis and metalinguistic commentary in a particular sequence of prose narrative. Along the way, he observes Gide, Proust, Malraux, Camus, Duras, and Sarraute, each in his or her own fashion, moving ceaselessly back and forth between soundings of the heart and diagnoses of the tongue. (shrink)

This study examines firms that have experienced an industrial and/or environ-mental crisis and proposes that top management team (TMT) characteristics will affect a firm's ability to minimize the severity of these crisis events. Specifically, heterogeneity in the TMT will exhibit a curvilinear (U-shaped) relationship with the severity of firm crises. Our results suggest that a moderate level of age and tenure heterogeneity are positively related to a firm's ability to successfully minimize the severity of crises. Variance in educational backgrounds was (...) unrelated to crisis severity. Functional background heterogeneity exhibited a curvilinear relationship with crisis severity but was not U-shaped as hypothesized. (shrink)

This paper develops the view that in arguing informally individuals construct a dual representation in which there is a coupling of arguments and the structure of the qualitative (mental) causal model to which these refer. Invited to consider a future possibility, individuals generate a causal model and mentally simulate the consequences of certain actions. Their arguments refer to the causal paths in the model. Correspondingly, faced with specific arguments about a policy option they generate a model with particular causal paths (...) and mentally simulate the outcomes. The results of Experiment 1 are consistent with this notion. Decisions on the percentage of funds to be allocated to genetically modified (GM) crop research depended on the structure of the arguments elicited in response to imagining a future state of affairs. Specifically, the presence of a dissuasive argument eliminated the impact of any persuasive argument. The non-monotonic properties of everyday informal argument can then be seen as a corollary of change to causal structure in the model. The dual representation view predicts that the impact of a dissuasive argument will depend on the structure of the causal model. Experiment 2 tested and confirmed this prediction by requiring individuals to judge the relative persuasiveness of two cases referring either to a model with two independent causal paths or to a model in which one causal path depended on the other. In contrast to Experiment 1, prior opinion on GM crop research did not affect allocation decisions. An advisory role in contrast to a participant role may encourage a more decontextualised mode of thinking. According to the dual representation view, ease of mental simulation should exert wide-ranging effects on judgements and the rhetoric of arguments should also be important. The paper concludes with a discussion of some of these expectations. (shrink)

In this book, Arnold Green discusses the standards that define moral appraisal. Standards assume roles of conduct which can be imposed during socialization only within the traditional family. Otherwise, the basis of order, which is not collective but individual, is undermined by the extreme degree of disaffection we now face. All the panaceas offered, and in some cases enforced, by one intellectual minority or another, will inevitably have a destructive impact upon our communication with one another. Contents: Perception and (...) Ideology; Self and Family; Relativism and the Family Institution; Religion as Vital Force; Social Class and Prejudice. (shrink)

Professor Tucker in the C.R. vol. xi. pp. 341 sqq. has revolutionized our notions of ‘doubtful syllables’: we have now learned that such syllables are normally short, and that lengthening is the licence.

This paper was originally a discussion proposal but data has been collected since June and we would like to share some results in this proceedings article. Our goal is to link the CSR literature with the social entrepreneurship literature by studying the growth of an international organization and discuss our methodologies and findings to date.

The three introductory questions posed by Hobson et al. point toward further investigations of cellular, circuit, and systems mechanisms involved in cognitive function that include the effect of CNS-state related modulatory systems on these mechanisms. [Hobson et al.].