Molecules are transferred to lysosomes, the major, acid pH, digestive compartment in eukaryotic cells, by a complex series of pathways that converge at a late endosome/prelysosomal compartment. Here, we discuss the relationship between this compartment and the lysosome. We propose that lysosomes are maintained within cells by a repeated series of kiss and run, transient fusion and fission processes with the late endosome/prelysosome compartment. Directionality to these processes may be conferred by pH gradients and retrieval mechanisms. The future challenge in (...) testing this and any other proposed hypothesis for lysosomal biogenesis will be the establishment of molecular mechanisms. (shrink)

Schopenhauer’s invective is legendary among philosophers, and is unmatched in the historical canon. But these complaints are themselves worthy of careful consideration: they are rooted in Schopenhauer’s philosophy of language, which itself reflects the structure of his metaphysics. This short chapter argues that Schopenhauer’s vitriol rewards philosophical attention; not because it expresses his critical take on Fichte, Hegel, Herbart, Schelling, and Schleiermacher, but because it neatly illustrates his philosophy of language. Schopenhauer’s epithets are not merely spiteful slurs; instead, they reflect (...) deep-seated theoretical and methodological commitments to transparency of exposition. (shrink)

CONTEMPORARY ISSUES IN BUSINESS ETHICS, 6E introduces readers to business ethics by focusing on the influence of market mechanisms and social values on workplace norms. And because business is increasingly a global enterprise, this edition emphasizes the role of ethics both at home and abroad.

... PREFACE Paul Gochet (Liege) "[...] une entite physique ne peut etre envisagee que comme une sorte de concretisation, de consolidation locale dans un ...

‘Philosophical dialogue’ indicates both a form of philosophical inquiry and its corresponding literary genre. In its written form, it typically features two or more characters who engage in a discussion concerning morals, knowledge, as well as a variety of topics that can be widely labelled as ‘philosophical’. Our philosophical dialogue takes place in Krakow, Poland. It is a rainy morning and two strangers are waiting at a tram stop. One of them is dressed neatly, and cannot stop fidgeting with his (...) closed umbrella. The other was caught unprepared by the morning downpour and water is dripping from his worn, soaked jacket. (shrink)

Economic development approaches are increasingly entailing local geographic scales and encouraging the mobilization and organization of territorial actors given local conditions and resources. Lebanon is a country facing frequent uncertainty with recent economic and social difficulties. Its popular cuisine may play a key role in its development and that of its rural space. In fact, that cuisine incorporates a traditional cultural practice called “Mouneh” which consists of preserved pantry foods, historically used to ensure household nutrition. Today, rural food cooperatives are (...) engaging in that practice using agricultural produce from local farmers and are employing women. Despite strong internal and external challenges, they remain attractive actors as their principles of collective benefit, participation and democracy form a strong link with sustainable development goals. This study transversally analyzes the status of food cooperatives in a major agricultural region in Lebanon, the Bekaa valley. Findings mainly quantified size and production and provided a mapped representation of the spatial dependencies on local farmers versus urban markets for trade. With 75% women members and firm reputation in authenticity, food cooperatives in the Bekaa specifically and Lebanon generally are also extensively supported by donors but are being labeled as donor-dependent. Yet, cooperatives are localized in a largely agricultural territory with sufficient evidence of differentiation that could potentially be valorized. Hence, with optimal framing, regulation and networking of cooperatives, one can assume a protection of culinary heritage is possible with scalable contribution to food security and needed local development given major recent setbacks. (shrink)

Michel Weber, Éléments de routine ayurvédique. Autonomie, rituel et ascèse, Les Éditions Chromatika, 2021. (978-2-930517-82-7 ; pdf 978-2-930517-83-4 ; 104 pp., 14€) -/- L’Ayurvéda propose une philosophie de vie qui articule un vaste système métaphysique (une cosmologie théorique) avec une visée thérapeutique profonde (une anthropologie pratique). -/- À la croisée de la théorie et de la pratique, on trouve la routine (« dinacharya ») dont le but est de susciter l’individuation et la solidarité, c’est-à-dire l’autonomie (de chacun) respectueuse de (...) la communauté (de tous). Ce faisant, elle constitue une ascèse dont l’efficacité a été longuement éprouvée et rarement égalée. (shrink)

Yoga et spiritualité est le témoignage émerveillé mais lucide d'un voyageur en quête des valeurs essentielles. Bien avant que ne déferle sur l'Occident désorienté la mode de la route et du périple oriental, Arnaud Desjardins a voulu délaisser les voies touristiques afin d'écouter battre le coeur de l'Inde. C'est cette pulsation qu'il tente ici de nous livrer, la face cachée d'une Inde encore fervente, enracinée dans les millénaires de tradition. L'auteur procède du même coup à une mise au point (...) et aide ses lecteurs à se frayer un chemin à travers le fatras d'idées reçues, de contresens et de présupposés à propos du "Yoga" et des "mystiques orientales". Carnet de bord essentiel pour comprendre le cheminement intérieur d'Arnaud Desjardins, cet ouvrage donne quelques clefs fondamentales et constitue un document limpide sur une société bien mal connue de nous, et aujourd'hui plus que jamais menacée. (shrink)

Maître Eckhart affirme dans son oeuvre latine (Commentaire au saint Évangile selon Jean) et dans sa prédication vernaculaire (Sermon allemand 08) son désir d’exposer par les outils de la physique les vérités révélées auxquelles il convient d’adhérer par la foi. Un tel programme exégétique a de quoi surprendre autant le lecteur des traités et sermons allemands qui, pour des raisons que rend évidentes l’histoire de sa réception, s’attend à trouver sous la plume du Thuringien une mystique, pensée aussi spéculative que (...) supra-rationnelle ; que le lecteur de l’oeuvre latine, qui pourrait s’attendre à trouver chez un dominicain du tournant des xiiie et xive siècles une forme de thomisme se refusant à toute tentative de rendre connaissables par la raison les mystères que révèlent les Écritures. Envisagée sérieusement, cette ambition d’expliquer la Révélation par les outils de la physique, science théorétique philosophique, pose donc au lecteur de Maître Eckhart un réel problème herméneutique dans la mesure où elle appelle une réflexion approfondie sur les limites de la connaissance humaine et sur la nature du savoir scientifique. En proposant une reconstruction de l’épistémologie procurant son cadre à la pensée eckhartienne, cette étude se veut l’occasion d’un nouvel éclairage de thèses bien connues de sa « mystique », qui permette de comprendre de quelle manière la conceptualité (méta-)physique de l’aristotélisme s’articule à la Révélation biblique pour rendre intelligible la nature et la surnature, ainsi que les rapports causaux les unissant l’une à l’autre. (shrink)

Despite the burgeoning interest in new and more complex accounts of the organism-environment dyad by biologists and philosophers, little attention has been paid in the resulting discussions to the history of these ideas and to their deployment in disciplines outside biology—especially in the social sciences. Even in biology and philosophy, there is a lack of detailed conceptual models of the organism-environment relationship. This volume is designed to fill these lacunae by providing the first multidisciplinary discussion of the topic of organism-environment (...) interaction. It brings together scholars from history, philosophy, psychology, anthropology, medicine, and biology to discuss the common focus of their work: entangled life, or the complex interaction of organisms and environments. (shrink)

In “Spandrels,” Gould and Lewontin criticized what they took to be an all-too-common conviction, namely, that adaptation to current environments determines organic form. They stressed instead the importance of history. In this paper, we elaborate upon their concerns by appealing to other writings in which those issues are treated in greater detail. Gould and Lewontin’s combined emphasis on history was three-fold. First, evolution by natural selection does not start from scratch, but always refashions preexisting forms. Second, preexisting forms are refashioned (...) by the selection of whatever mutational variations happen to arise: the historical order of mutations needs to be taken into account. Third, the order of environments and selection pressures also needs to be taken into account. (shrink)

While many recognize that rigid historical and compositional goals are inadequate in a world where climate and other global systems are undergoing unprecedented changes, others contend that promoting ecosystem services and functions encourages practices that can ultimately lower the bar of ecological management. These worries are foregrounded in discussions about Novel Ecosystems (NEs); where some researchers and conservationists claim that NEs provide a license to trash nature as long as some ecosystem services are provided. This criticism arises from what we (...) call the " anything goes " problem created by the release of historical conditions. After explaining the notion of NE, we identify numerous substantive motivations for worrying about the anything-goes-problem and then go on to show the problem can be solved by correcting two mistaken assumptions. In short, we argue that the problem is a product of adopting an overly sparse functional perspective and one that assumes an unrealistically high degree of convergence in the trajectories of natural processes. Our analysis illuminates why such assumptions are unwarranted. Finally, we further argue that adopting an appropriate ethical framework is essential to overcoming the anything-goes-problem and suggest that a certain virtue ethics conception of ecological management provides useful resources for framing and resolving the problem. (shrink)

Revonsuo proposed an intriguing and detailed evolutionary theory of dreams which stipulates that the biological function of dreaming is to simulate threatening events and to rehearse threat avoidance behaviors. The goal of the present study was to test this theory using a sample of 212 recurrent dreams that was scored using a slightly expanded version of the DreamThreat rating scale. Six of the eight hypotheses tested were supported. Among the positive findings, 66% of the recurrent dream reports contained one or (...) more threats, the threats tended to be dangerous and aimed at the dreamer, and when facing a threat, the dreamer tended to take defensive or evasive actions that were possible and reasonable. However, less than 15% of the recurrent dreams depicted realistic and probable situations critical for one’s physical survival or reproductive success and the dreamer rarely succeeded in fleeing the threat despite important and appropriate efforts. The findings thus provide mixed support for the threat simulation theory. (shrink)

Biologists in the last 50 years have increasingly emphasized the role of historical contingency in explaining the distribution and dynamics of biological systems. However, recent work in philosophy of biology has shown that historical contingency carries various interpretations and that we are still lacking a general understanding of historicity, i.e., a framework from which to interpret why and to what extent history matters in biological processes. Building from examples and analyses of the long-term experimental evolution (LTEE) project, this paper argues (...) that historicity possess three essential conditions: (1) multiple possible pasts, (2) multiple possible outcomes at a given instant, and (3) a relationship of causal dependence between these two sets. These criteria can be further specified in two general forms of historicity: dependence on initial conditions and path dependence. More attention is devoted to developing a rigorous account of the latter, which captures the type of historicity displayed by stochastic processes. This paper also highlights that it is often more productive to adopt an instant-relative approach and think in terms of degree of historicity instead of trying to maintain a rigid and absolute dichotomy between historical and ahistorical (completely convergent) processes. (shrink)

ABSTRACT:Almost thirty years after its initial use in the Brundtland Report, the concept of “sustainability” has become ubiquitous within business, with virtually every company division across a broad range of industries developing “sustainable” models and practices. While the original Brundtland idea of sustainable development has the potential to do much good in guiding business practice, this potential is being undermined by the systematic misuse, misunderstanding, and flawed application of the concept in many business settings. Under the guise of sustainability, business (...) is being asked to do both less than and more than what should be required by a commitment to sustainable development. As a result, serious ethical and practical questions go unanswered, questions that must be addressed before sustainability can become a meaningful business strategy. This address situates sustainable business within its original context of sustainable development and argues against attempts to convert sustainability either into a narrow concept of risk management or into a broad concept of social responsibility. It then lays out a sustainability research agenda that helps us understand how to create businesses that can meet present and future needs without jeopardizing future generations via the destruction of the biosphere. (shrink)

This essay examines the claim “path dependence entails irreversibility” from the point of view of evolutionary biology. I argue that evolutionary irreversibility possesses many faces, sometimes conflicting with path dependence. I propose an account of path dependence that does not rely on irreversibility and explains why it more naturally coexists with the notion of (contingent) irreversibility developed by the Belgian paleontologist Louis Dollo. However, I argue that we should not conceive of this relationship as necessary.

This paper analyzes the relevance and interconnection of two forms of historicity in ecological restoration, namely historical fidelity and path dependence. Historical fidelity is the practice of attempting to restore an ecological system to some sort of idealized past condition. Path dependence occurs when a system can evolve in alternative local equilibria, and that the order and timing of the events that follow from the initial state influence which equilibrium is reached. Using theoretical examples and case studies, the following analysis (...) shows that path dependence can seriously impinge the feasibility of historical fidelity, thus reinforcing the idea that restoration ecology needs to move away from a rigid reliance on historical fidelity and is sometimes justified to endorse an interventionist agenda. Yet, contra recent criticisms, I argue that ecological restoration, directed by prudential and evidence-based reasoning, should maintain historical fidelity as one of its guiding objectives. (shrink)

This paper takes the form of a reflective dialogue between three teachers of business ethics working in different continents. Originating as a conference debate, it takes as its theme the notion of ideological ‘neutrality’ and the role of the business ethics teacher. A position statement outlines an argument for ‘restraint’ as a modern day Aristotleian mean to protect student academic freedom. Two responses follow. The first of these provides a moderate advocacy position based on Socratic principles. The second response outlines (...) the notion of teaching as a relational process necessitating delayed disclosure and moral courage on the part of the teacher. The paper concludes with a brief reflection by the author of the position statement. (shrink)

This volume is a wonderful introduction to Foucault and a testimony to the deep humanity of the man himself.

First published: 2010; Previous edition: 2012..

Il y a des questions concernant le droit auxquelles il n'est pas possible de répondre par la simple analyse du droit en vigueur et que pourtant ni les juristes, ni les philosophes ne peuvent éviter. Ce sont celles qui font l'objet de la philosophie du droit. Elles concernent notamment la définition du droit et d'abord celle du droit en vigueur lui-même, des rapports que le droit entretien avec d'autres phénomènes, comme le pouvoir, la force ou la morale, la possibilité d'une (...) science du droit, la structure du système juridique ou encore la spécificité du raisonnement juridique et des concepts employés par les juristes. (shrink)