Chlorarachniophytes are amoeboflagellate, marine protists that have acquired photosynthetic capacity by engulfing and retaining a green alga. These green algal endosymbionts are severely reduced, retaining only the chloroplast, nucleus, cytoplasm and plasma membrane. The vestigial nucleus of the endosymbiont, called the nucleomorph, contains only three small linear chromosomes and has a haploid genome size of just 380 kb ‐ the smallest eukaryotic genome known. Initial characterisation of nucleomorph DNA has revealed that all chromosomes are capped with inverted repeats comprising a (...) telomere and a single ribosomal RNA operon. The nucleomorph genome is the quintessence of compactness; average space between genes is a mere 65 bp, some genes overlap, others are cotranscribed. Intense reductive pressures upon nucleomorph genes have apparently squeezed their spliceosomal‐type introns down to only 18, 19 or 20 bases in length. Studies to date indicate the nucleomorph ‐ essentially a stripped‐down eukaryotic genome ‐ encodes principally genetic housekeeping functions such as translation, transcription and splicing. (shrink)

The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. (...) Studies in the natural host have now supported these findings. Further investigations have proposed that the bony abnormalities seen in Paget's disease are due to the effects of the virus on osteoclastic interleukin‐6 and c‐FOS production, possibly via the transcription factor NF‐kB. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The present essay is addressed simultaneously to two distinct audiences.

A study in the philosophy of science, proposing a strong form of the doctrine of scientific realism' and developing its implications for issues in the philosophy of mind.

Paul Faulkner presents a new theory of testimony - the basis of much of what we know. He addresses the questions of what makes it reasonable to accept a piece of testimony, and what warrants belief formed on that basis. He rejects rival theories and argues that testimonial knowledge and testimonially warranted belief are based on trust.

Should a principle of charity be applied to the interpretation of the colour concepts exercised in visual experience? We think not. We shall argue, for one thing, that the grounds for applying a principle of charity are lacking in the case of colour concepts. More importantly, we shall argue that attempts at giving the experience of colour a charitable interpretation either fail to respect obvious features of that experience or fail to interpret it charitably, after all. Charity to visual experience (...) is therefore no motive for resisting the natural, Galilean response to a scientific understanding of light and vision. The best interpretation of colour experience ends up convicting it of widespread and systematic error. (shrink)

A Christian ethicist discusses such problems as organ transplants, caring for the terminally ill, and defining death.

In this work, Paul Weithman offers a fresh, rigorous and compelling interpretation of John Rawls' reasons for taking his so-called 'political turn'.

In behavioral ecology some authors regard the innateness concept as irretrievably confused whilst others take it to refer to adaptations. In cognitive psychology, however, whether traits are 'innate' is regarded as a significant question and is often the subject of heated debate. Several philosophers have tried to define innateness with the intention of making sense of its use in cognitive psychology. In contrast, I argue that the concept is irretrievably confused. The vernacular innateness concept represents a key aspect of 'folkbiology', (...) namely, the explanatory strategy that psychologists and cognitive anthropologists have labeled 'folk essentialism'. Folk essentialism is inimical to Darwinism, and both Darwin and the founders of the modern synthesis struggled to overcome this way of thinking about living systems. Because the vernacular concept of innateness is part of folkbiology, attempts to define it more adequately are unlikely to succeed, making it preferable to introduce new, neutral terms for the various, related notions that are needed to understand cognitive development. (shrink)

Paul Boghossian defends a meaning‐based approach to the apriority of the propositions of logic. His model is based on the idea that the logical constants are implicitly defined by some of the axioms and inference rules in which they are involved, thereby offering an alternative to those theories that deny that grasp of meaning can contribute to the explanation of a thinker's entitlement to a particular type of transition or belief.

A description of mental mechanisms that explain how emotions influence thought, from everyday decision making to scientific discovery and religious belief, and an analysis of when emotion can contribute to good reasoning.

In Religion and the Obligations of Citizenship Paul J. Weithman asks whether citizens in a liberal democracy may base their votes and their public political arguments on their religious beliefs. Drawing on empirical studies of how religion actually functions in politics, he challenges the standard view that citizens who rely on religious reasons must be prepared to make good their arguments by appealing to reasons that are 'accessible' to others. He contends that churches contribute to democracy by enriching political (...) debate and by facilitating political participation, especially among the poor and minorities, and as a consequence, citizens acquire religiously based political views and diverse views of their own citizenship. He concludes that the philosophical view which most defensibly accommodates this diversity is one that allows ordinary citizens to draw on the views their churches have formed when voting and offering public arguments for their political positions. (shrink)

It is unreasonable to assume that our pre-scientific emotion vocabulary embodies all and only those distinctions required for a scientific psychology of emotion. The psychoevolutionary approach to emotion yields an alternative classification of certain emotion phenomena. The new categories are based on a set of evolved adaptive responses, or affect-programs, which are found in all cultures. The triggering of these responses involves a modular system of stimulus appraisal, whose evoluations may conflict with those of higher-level cognitive processes. Whilst the structure (...) of the adaptive responses is innate, the contents of the system which triggers them are largely learnt. The circuits subserving the adaptive responses are probably located in the limbic system. This theory of emotion is directly applicable only to a small sub-domain of the traditional realm of emotion. It can be used, however, to explain the grouping of various other phenomena under the heading of emotion, and to explain various characteristic failings of the pre-scientific conception of emotion. (shrink)

Reverence is an ancient virtue that survives among us in half-forgotten patterns of civility and moments of inarticulate awe. Reverence gives meaning to much that we do, yet the word has almost passed out of our vocabulary.Reverence, says philosopher and classicist Paul Woodruff, begins in an understanding of human limitations. From this grows the capacity to be in awe of whatever we believe lies outside our control -- God, truth, justice, nature, even death. It is a quality of character (...) that is especially important in leadership and in teaching, although it figures in virtually every human relationship. It transcends religious boundaries and can be found outside religion altogether.Woodruff draws on thinking about this lost virtue in ancient Greek and Chinese traditions and applies lessons from these highly reverent cultures to today's world. The book covers reverence in a variety of contexts -- the arts, leadership, teaching, warfare, and the home -- and shows how essential a quality it is to a well-functioning society.First published by Oxford University Press in 2001, this new edition of Reverence is revised and expanded. It contains a foreword by Betty Sue Flowers, Distinguished Teaching Professor Emeritus at the University of Texas at Austin, a new preface, two new chapters -- one on the sacred and one on compassion -- and an epilogue focused on renewing reverence in our own lives. (shrink)

Psychologists and philosophers often work hand in hand to investigate many aspects of moral cognition. In this paper, we want to highlight one aspect that to date has been relatively neglected: the stability of moral judgment over time. After explaining why philosophers and psychologists should consider stability and then surveying previous research, we will present the results of an original three-wave longitudinal study. We asked participants to make judgments about the same acts in a series of sacrificial dilemmas three times, (...) 6–8 days apart. In addition to investigating the stability of our participants’ ratings over time, we also explored some potential explanations for instability. To end, we will discuss these and other potential psychological sources of moral stability (or instability) and highlight possible philosophical implications of our findings. (shrink)

The twentieth century has witnessed an unprecedented 'crisis in the foundations of mathematics', featuring a world-famous paradox, a challenge to 'classical' mathematics from a world-famous mathematician, a new foundational school, and the profound incompleteness results of Kurt Gödel. In the same period, the cross-fertilization of mathematics and philosophy resulted in a new sort of 'mathematical philosophy', associated most notably with Bertrand Russell, W. V. Quine, and Gödel himself, and which remains at the focus of Anglo-Saxon philosophical discussion. The present collection (...) brings together in a convenient form the seminal articles in the philosophy of mathematics by these and other major thinkers. It is a substantially revised version of the edition first published in 1964 and includes a revised bibliography. The volume will be welcomed as a major work of reference at this level in the field. (shrink)

For over twenty years, Paul Weithman has explored the thought of John Rawls to ask how liberalism can secure the principled allegiance of those people whom Rawls called 'citizens of faith'. This volume brings together ten of his major essays, which reflect on the task and political character of political philosophy, the ways in which liberalism does and does not privatize religion, the role of liberal legitimacy in Rawls's theory, and the requirements of public reason. The essays reveal Rawls (...) as a thinker deeply engaged with political and existential questions that trouble citizens of faith, and explore how - in firm opposition to political realism - he tries to show that the possibility of liberal democracy and the natural goodness of humanity are objects of reasonable faith. The volume will be of interest to political philosophers, political theorists, moral theologians, and religious ethicists. (shrink)

Philosophy and Kafka is a collection of original essays interrogating the relationship of literature and philosophy. The essays either discuss specific philosophical commentaries on Kafka’s work, consider the possible relevance of certain philosophical outlooks for examining Kafka’s writings, or examine Kafka’s writings in terms of a specific philosophical theme, such as communication and subjectivity, language and meaning, knowledge and truth, the human/animal divide, justice, and freedom.

This volume brings together Paul Williams's previously published papers on the Indian and Tibetan interpretations of selected verses from the eighth and ninth chapters of the Bodhicaryavatara. In addition, there is a much longer version of the paper 'Identifying the Object of Negation', and nearly half the book consists of a wholly new essay, 'The Absence of Self and the Removal of Pain', subtitled 'How Santideva Destroyed the Bodhisattva Path'. This book will be of interest to those concerned with (...) the history and interpretation of Indian and Tibetan philosophy. (shrink)

Cognitive science is the interdisciplinary investigation of mind and intelligence, embracing psychology, neuroscience, anthropology, artificial intelligence, and philosophy. There are many important philosophical questions related to this investigation, but this short chapter will focus on the following three. What is the nature of the explanations and theories developed in cognitive science? What are the relations among the five disciplines that comprise cognitive science? What are the implications of cognitive science research for general issues in the philosophy of science? I will (...) argue that cognitive theories and explanations depend on representations of mechanisms and that the relations among the five disciplines, especially psychology and neuroscience, depend on relations between kinds of mechanisms. These conclusions have implications for central problems in general philosophy of science such as the nature of theories, explanations, and reduction between theories at different levels. (shrink)

Focusing on the logistics of perception, this title introduces the author's understanding of 'picnolepsy' - the epileptic state of consciousness produced by speed, or rather, the consciousness invented by the subject through its very absence: the gaps, glitches, and speed bumps lacing through and defining it.

In just a few years, children achieve a stable state of linguistic competence, making them effectively adults with respect to: understanding novel sentences, discerning relations of paraphrase and entailment, acceptability judgments, etc. One familiar account of the language acquisition process treats it as an induction problem of the sort that arises in any domain where the knowledge achieved is logically underdetermined by experience. This view highlights the 'cues' that are available in the input to children, as well as children's skills (...) in extracting relevant information and forming generalizations on the basis of the data they receive. Nativists, on the other hand, content that language-learners project beyond their experience in ways that the input does not even suggest. Instead of viewing language acqusition as a special case of theory induction, nativists posit a Universal Grammar, with innately specified linguistic principles of grammar formation. The 'nature versus nurture' debate continues, as various "poverty of stimulus" arguments are challenged or supported by developments in linguistic theory and by findings from psycholinguistic investigations of child language. In light of some recent challenges to nativism, we rehearse old poverty-of stimulus arguments, and supplement them by drawing on more recent work in linguistic theory and studies of child language. (shrink)

The ancient Greeks almost universally accepted the thesis that virtues are skills. Skills have an underlying intellectual structure (logos), and having a particular skill entails understanding the relevant logos. possessing a general ability to diagnose and solve problems (phronesis). as well as having appropriate experience. Two implications of accepting this thesis for moral epistemology and epistemology in general are considered. Thinking of virtues as skills yields a viable virtue epistemology in which moral knowledge is a species of a general kind (...) of knowledge that is not philosophically suspect. Also, the debate between internalists and externalists in epistemology is subversively resolved as moot by adopting this strategy: the locus of justification for a belief is in the nature of skill. Thus, the contingent fact that some skills allow Homo Sapiens an ‘internal access’. while others do not, is theoretically neutral when considering the nature of justification per se. (shrink)

The current state of knowledge in psychology, cognitive neuroscience and behavioral ecology allows a fairly robust characterization of at least some, so-called ?basic emotions? - short-lived emotional responses with homologues in other vertebrates. Philosophers, however are understandably more focused on the complex emotion episodes that figure in folk-psychological narratives about mental life, episodes such as the evolving jealousy and anger of a person in an unraveling sexual relationship. One of the most pressing issues for the philosophy of emotion is the (...) relationship between basic emotions and these complex emotion episodes. In this paper, I add to the list of existing, not necessarily incompatible, proposals concerning the relationship between basic emotions and complex emotions. I analyze the writings of ?transactional? psychologists of emotion, particularly those who see their work as a contribution to behavioral ecology, and offer a view of the basic emotion that focuses as much on their interpersonal functions as on their intrapersonal functions. Locating basic emotions and their evolutionary development in a context of processes of social interaction, I suggest, provides a way to integrate our knowledge of basic emotions into an understanding of the larger emotional episodes that have more obvious implications for philosophical disciplines such as moral psychology. (shrink)

The ancient Greeks almost universally accepted the thesis that virtues are skills. Skills have an underlying intellectual structure , and having a particular skill entails understanding the relevant logos. possessing a general ability to diagnose and solve problems . as well as having appropriate experience. Two implications of accepting this thesis for moral epistemology and epistemology in general are considered. Thinking of virtues as skills yields a viable virtue epistemology in which moral knowledge is a species of a general kind (...) of knowledge that is not philosophically suspect. Also, the debate between internalists and externalists in epistemology is subversively resolved as moot by adopting this strategy: the locus of justification for a belief is in the nature of skill. Thus, the contingent fact that some skills allow Homo Sapiens an ‘internal access’. while others do not, is theoretically neutral when considering the nature of justification per se. (shrink)

The Uncontrollability Thesis is that it is metaphysically impossible consciously to believe that p at will. I review the standard ways in which this might be explained. They focus on the aim or purpose of belief being truth. I argue that these don't work. They either explain the aim in a way which makes it implausible that the Uncontrollability Thesis is true, or they fail to justify their claim that beliefs should be understood as aimed at the truth. I further (...) argue that the explanations don't cut deep enough. Making the aim of truth internal to a state does not explain why we can't produce at will states without this feature but sharing these states' motivational role. I put forward a different explanation. I argue that consciousness makes manifest the attraction of the norm of truth. If we are consciously attending to the question of whether p, we cannot help but make a judgement in line with what the evidence gives us grounds for believing true. (shrink)

What is unique and essential about theatre? What separates it from other arts? Do we need 'theatre' in some fundamental way? The art of theatre, as Paul Woodruff says in this elegant and unique book, is as necessary-and as powerful-as language itself. Defining theatre broadly, including sporting events and social rituals, he treats traditional theatre as only one possibility in an art that-at its most powerful-can change lives and bring a divine presence to earth. The Necessity of Theater analyzes (...) the unique power of theatre by separating it into the twin arts of watching and being watched, practiced together in harmony by watchers and the watched. Whereas performers practice the art of being watched-making their actions worth watching, and paying attention to action, choice, plot, character, mimesis, and the sacredness of performance space-audiences practice the art of watching: paying close attention. A good audience is emotionally engaged as spectators; their engagement takes a form of empathy that can lead to a special kind of human wisdom. As Plato implied, theatre cannot teach us transcendent truths, but it can teach us about ourselves. Characteristically thoughtful, probing, and original, Paul Woodruff makes the case for theatre as a unique form of expression connected to our most human insticts. The Necessity of Theater should appeal to anyone seriously interested or involved in theatre or performance more broadly. (shrink)

In Decision Space: Multidimensional Utility Analysis, first published in 2001, Paul Weirich increases the power and versatility of utility analysis and in the process advances decision theory. Combining traditional and novel methods of option evaluation into one systematic method of analysis, multidimensional utility analysis is a valuable tool. It provides formulations of important decision principles, such as the principle to maximize expected utility; enriches decision theory in solving recalcitrant decision problems; and provides in particular for the cases in which (...) an expert must make a decision for a group of people. The multiple dimensions of this analysis create a decision space broad enough to accommodate all factors affecting an option's utility. The book will be of interest to advanced students and professionals working in the subject of decision theory, as well as to economists and other social scientists. (shrink)