Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements (...) usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. (shrink)

Despite its diminished importance amongst philosophers, the deductive-nomological framework is still important to contemporary behavioral scientists. Behavioral theorists operating within this framework must be careful to distinguish between nesting and chaining. Explanations are chained when the explanandum sentence of one explanation is one of the antecedent conditions of another. They are nested when one of the antecedent conditions or the explanandum sentence of one explanation is one of the covering laws of another. Confusion between nesting and chaining leads to explanation (...) nests that cannot be nomologically entrenched. They cannot, even in principle, be logically connected to laws arising from other sciences. This hazard should be particularly important for evolutionary psychologists to avoid, since many evolutionary psychologists tend to see themselves as dedicated to both nomological entrenchment and cognitive functionalist models. The hazard can be avoided if the intentional constructs of the behavioral sciences are construed not as ineffable and inaccessible antecedent conditions, but as complex, law-like patterns in behavior. (shrink)

In this paper I want to examine a view of the Darwinian theory of evolution which was put forward fairly recently by A. R. Manser. His approach is of interest not only in itself, but also because it may be expanded to raise some fundamental questions about the nature of the science of biology in general. I shall not consider these further implications here, but shall concentrate on an examination of his thesis in the context in which it is raised. (...) My paper falls into two sections. In the first I shall state Manser's thesis and some of the arguments with which he supports it, and shall try to show how a series of objections raised by A. G. N. Flew and K. Connolly may be answered. In the second I shall offer on my own account a positive argument to provide a possible basis for his point of view, with the aim of indicating why the theory should be of the kind he suggests, and what form the study of evolution must take. (shrink)

Main Response Topics ? Introduction ? Open display and public evaluation ? Publicity versus patient privacy ? Facial tissue donation ? Validity of Louisville Instrument for Risk Acceptance ? Patients' understanding of risk ? Face versus hand transplantation ? Rejection rates/risks ? Patient compliance ? Exit strategy ? Functional recovery ? Societietal implications ? Psychological implications ? Conclusion: Uncertainty likely to persist.

We present a general theory of scope and binding in which both crossover and superiority violations are ruled out by one key assumption: that natural language expressions are normally evaluated (processed) from left to right. Our theory is an extension of Shan’s (2002) account of multiple-wh questions, combining continuations (Barker, 2002) and dynamic type-shifting. Like other continuation-based analyses, but unlike most other treatments of crossover or superiority, our analysis is directly compositional (in the sense of, e.g., Jacobson, 1999). In (...) particular, it does not postulate a level of Logical Form or any other representation distinct from surface syntax. One advantage of using continuations is that they are the standard tool for modeling order-of-evaluation in programming languages. This provides us with a natural and independently motivated characterization of what it means to evaluate expressions from left to right. We give a combinatory categorial grammar that models the syntax and the semantics of quantifier scope and wh-question formation. It allows quantificational binding but not crossover, in-situ wh but not superiority violations. In addition, the analysis automatically accounts for a variety of sentence types involving binding in the presence of pied piping, including reconstruction cases such as Whose criticism of hisi mother did each personi resent? (shrink)

Offering an engaging and accessible portrait of the current state of the field, Philosophy of Science: A New Introduction shows students how to think philosophically about science and why it is both essential and fascinating to do so. Gillian Barker and Philip Kitcher reconsider the core questions in philosophy of science in light of the multitude of changes that have taken place in the decades since the publication of C.G. Hempel's classic work, Philosophy of Natural Science —both in the (...) field and also in history and sociology of science and the sciences themselves. They explore how philosophical questions are connected to vigorous current debates—including climate change, science and religion, race, intellectual property rights, and medical research priorities—showing how these questions, and philosophers' attempts to answer them, matter in the real world. Featuring numerous illustrative examples and extensive further reading lists, Philosophy of Science: A New Introduction is ideal for courses in philosophy of science, history and philosophy of science, and epistemology/theory of knowledge. It is also compelling and illuminating reading for scientists, science students, and anyone interested in the natural sciences and in their place in global society today. (shrink)

This paper falls into two parts. In the first part, I argue that consideration of general indicative conditionals, e.g., sentences like If a donkey brays it is beaten, provides a powerful argument that a pure material implication analysis of indicative if p, q is correct. In the second part I argue, opposing writers like Jackson, that a Gricean style theory of pragmatics can explain the manifest assertability conditions of if p, q in terms of its conventional content – assumed to (...) be merely (p⊃q) – and the conversational implicature contents which utterance of if p, q may gain in certain contexts. I also defend the pragmatic approach against a recent objection by Edgington that appeal to pragmatics cannot explain what we are inclined to say about the believability conditions, as opposed to the assertability conditions, of indicative if p, q. (shrink)

This ~4000 word essay introduces topics of essentialism, as they arise in social sciences. It distinguishes empirical (e.g., psychological) from philosophical studies of essentialisms, and both metaphysical and scientific essentialisms within philosophy. Essentialism issues in social science are shown to be more subtle and complex than often presumed.

The author has constructed a concept of conditionals by synthetizing and developing unconnected insights scattered through the literature. The result is incorporated in a formal deductive system, based on a series of "paradox-free" systems initiated by Alonzo Church and interpreted according to principles suggested chiefly by Everett Nelson and by Anderson and Belnap. The basic concept is the sufficiency relation holding between clauses of a conditional, or rather between the relevant states of affairs asserted by the clauses. The logic of (...) sufficiency is developed by using a phenomenological method, much like that of the ordinary-language linguists, to place restrictions on truth-functional logic. For example, conjunction is replaced by adjunction [ = df. ~ ] and this concept is used to modify modus ponens and simplification. Relevance requirements avoid the paradoxes of material implication. These principles, together with a number of physical modalities and some modifications of the concept of induction, are used to attack Goodman's paradox and the paradoxes of confirmation, and to form a concept of cause. The formal system incorporates the principles judged desirable by the analysis of how conditionals are used in discourse. Mr. Barker is modest in his claims, emphasizing that his material is not original and saying only that some of the famous paradoxes "show signs of yielding." Interested students will be grateful for this monograph. It is a valuable compendium of widely scattered work of a difficult and complicated subject, and should be both helpful and stimulating. Moreover, it is particularly clear and readable.--L. G. (shrink)

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

The view that it is better for life to be created free of disability is pervasive in both common sense and philosophy. We cast doubt on this view by focusing on an influential line of thinking that manifests it. That thinking begins with a widely-discussed principle, Procreative Beneficence, and draws conclusions about parental choice and disability. After reconstructing two versions of this argument, we critique the first by exploring the relationship between different understandings of well-being and disability, and the second (...) by more briefly focusing on the idea of a significant reason. By placing these results against the broader historical and ongoing contexts in which the lives of those with disabilities have been deemed of inferior quality, we conclude with a call for greater humility about disability and well-being in thought and practice. (shrink)

Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

Are the sculpture and the mass of gold which permanently makes it up one object or two? In this article, we argue that the monist, who answers ‘one object’, cannot accommodate the asymmetry of material constitution. To say ‘the mass of gold materially constitutes the sculpture, whereas the sculpture does not materially constitute the mass of gold’, the monist must treat ‘materially constitutes’ as an Abelardian predicate, whose denotation is sensitive to the linguistic context in which it appears. We motivate (...) this approach in terms of modal analyses of material constitution, but argue that ultimately it fails. The monist must instead accept a deflationary, symmetrical use of ‘materially constitutes’. We argue that this is a serious cost for her approach. (shrink)

We argue that in contemporary business organizations, in which fundamental purpose is construed to be increased value—especially in ‘participative’ organizations, in which non–hierarchal interaction (for example, work teams) is the norm; and in ‘adaptive’ organizations, in which unpredictable change is the rule—a process of values covenanting will be much more valueable than just espoused values or even values covenants. We propose such a process model for organizational values covenanting and argue that such covenanting reflects an anthropomorphism of the human character (...) development process, validated in terms of the theory of viable systems. (shrink)

An examination of verbal hallucinations and thought insertion as examples of "alienated self-consciousness.".