: Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical application of pharmacogenetic technologies must be addressed. The ethical issues raised by pharmacogenetics can be addressed under six headings: regulatory oversight, confidentiality and privacy, informed consent, availability of drugs, access, and clinicians' changing responsibilities in the era of pharmacogenetic medicine. We (...) analyze each of these categories of ethical issues and provide policy approaches for addressing them. (shrink)

We define a family of ‘no signaling’ bipartite boxes with arbitrary inputs and binary outputs, and with a range of marginal probabilities. The defining correlations are motivated by the Klyachko version of the Kochen-Specker theorem, so we call these boxes Kochen-Specker-Klyachko boxes or, briefly, KS-boxes. The marginals cover a variety of cases, from those that can be simulated classically to the superquantum correlations that saturate the Clauser-Horne-Shimony-Holt inequality, when the KS-box is a generalized PR-box (hence a vertex of the ‘no (...) signaling’ polytope). We show that for certain marginal probabilities a KS-box is classical with respect to nonlocality as measured by the Clauser-Horne-Shimony-Holt correlation, i.e., no better than shared randomness as a resource in simulating a PR-box, even though such KS-boxes cannot be perfectly simulated by classical or quantum resources for all inputs. We comment on the significance of these results for contextuality and nonlocality in ‘no signaling’ theories. (shrink)

In this introduction to Part 1 of the Common Knowledge symposium, “Fuzzy Studies,” the journal's editor discusses four essays from the 1980s by Richard Rorty, in which Rorty chose to associate himself with various neopragmatists, Continental thinkers, and “left-wing Kuhnians” under the rubric of the “new fuzziness.” The term had been introduced as an insult by a philosopher of science with positivist leanings, but Rorty took it up as an “endearing” compliment, arguing that “to be less fuzzy” was also to (...) be “less genial, tolerant, open-minded, and fallibilist.” He defined the “new fuzziness” as “an attempt to blur just those distinctions between the objective and subjective and between fact and value which the critical conception of rationality has developed.” This introduction also examines W. V. Quine's essay “Speaking of Objects” (1957), which describes objects as fuzzy “half-entities”; Clifford Geertz's essay “Blurred Genres” (1980), which advises social scientists that being “taxonomically upstanding” is futile; and Lofti Zadeh's article “The Concept of a Linguistic Variable and Its Application to Approximate Reasoning” (1975), which abandons “Aristotelian, bivalent logic” in favor of a “fuzzy logic” based on Zadeh's “fuzzy set theory.” This introductory piece relates these theoretical works of the past half-century to the sorites paradox and to classical issues of vagueness raised and still unresolved in Western philosophy. Returning then to Rorty, the author questions how Rorty expected his endorsement of the “new fuzziness” to be applied, as proposed, to theology and politics. Suggesting that such applications are the natural work of historians, the author, having asked the historian Natalie Zemon Davis for comment, then quotes her response—which associates fuzzy studies, “common knowledge,” and peacemaking—at length. (shrink)

Quantum theory is a probabilistic theory that embodies notoriously striking correlations, stronger than any that classical theories allow but not as strong as those of hypothetical ‘super-quantum’ theories. This raises the question ‘Why the quantum?’—whether there is a handful of principles that account for the character of quantum probability. We ask what quantum-logical notions correspond to this investigation. This project isn’t meant to compete with the many beautiful results that information-theoretic approaches have yielded but rather aims to complement that work.

Emilio Santos has argued (Santos, Studies in History and Philosophy of Physics http: //arxiv-org/abs/quant-ph/0410193) that to date, no experiment has provided a loophole-free refutation of Bell’s inequalities. He believes that this provides strong evidence for the principle of local realism, and argues that we should reject this principle only if we have extremely strong evidence. However, recent work by Malley and Fine (Non-commuting observables and local realism, http: //arxiv-org/abs/quant-ph/0505016) appears to suggest that experiments refuting Bell’s inequalities could at most confirm (...) that quantum mechanical quantities do not commute. They also suggest that experiments performed on a single system could refute local realism. In this paper, we develop a connection between the work of Malley and Fine and an argument by Bub from some years ago [Bub, The Interpretation of Quantum Mechanics, Chapter VI(Reidel, Dodrecht,1974)]. We also argue that the appearance of conflict between Santos on the one hand and Malley and Fine on the other is a result of differences in the way they understand local realism. (shrink)

As one of the most important ethicists to emerge since the Second World War, Alan Gewirth continues to influence philosophical debates concerning morality. In this ground-breaking book, Gewirth's neo-Kantianism, and the communitarian problems discussed, form a dialogue on the foundation of moral theory. Themes of agent-centered constraints, the formal structure of theories, and the relationship between freedom and duty are examined along with such new perspectives as feminism, the Stoics, and Sartre. Gewirth offers a picture of the philosopher's theory and (...) its applications, providing a richer, more complete critical assessement than any which has occurred to date. (shrink)

Both René Descartes and Bernard Lonergan were educated at Jesuit schools in their youth, and both had exposure—the former perhaps indirectly, the latter directly—to Ignatius of Loyola’s Spiritual Exercises. Several scholars have outlined parallels between Descartes’s Meditations on First Philosophy and the Exercises. This article reviews those parallels, and then uses them as guides for exploring traces of the Meditations in Lonergan’s Insight: A Study of Human Understanding.

This book brings together scholars from a variety of epistemological perspectives to explore the multiple ways in which sexuality does indeed matter in the arena of public education.

The aim of this study is to increase our understanding of the ethical climate of entrepreneurial firms as they grow and develop. A developmental framework is introduced to describe the formal and informal ethical structures that emerge in entrepreneurial firms over time. Factors influencing where firms are within the developmental framework are posited, including the entrepreneur's psychological profile, lifecycle stage of the business, and descriptive characteristics of the venture. It is also proposed that the implementation of ethical structures will impact (...) perceptions of the clarity and adequacy of the ethical standards of the firm and the firm's preparedness to deal with ethical challenges as they arise. Results are reported of a cross-sectional survey of small firms at different stages of development. The findings indicate the existence of four distinct clusters of firms based on their formal and informal ethical structures: Superlatives, Core Proponents, Pain and Gain, and Deficients. Evidence is also provided of statistically significant relationships between the proposed antecedent and outcome variables. Implications are drawn from the results, and priorities are established for future research. (shrink)

This study explores the impact of environmental turbulence on relationships between personal and organizational characteristics, personal values, ethical perceptions, and behavioral intentions. A causal model is tested using data obtained from a national sample of marketing research professionals in South Africa. The findings suggest turbulent conditions lead professionals to report stronger values and ethical norms, but less ethical behavioral intentions. Implications are drawn for organizations confronting growing turbulence in their external environments. A number of suggestions are made for ongoing research.

Jeffrey Masson's version of the seduction theory episode in Freud's early career, as presented in The Assault on Truth (1984), is very plaus ible as a revised account of the traditional story. However, close examination of the seduction theory papers and of other contemporary documents reveals that Freud's later reports of the episode, the foun dation on which Masson builds his case, are false. Some purported his torical events that Masson uses to buttress his case are also shown to (...) be without foundation. The several accounts of the episode Freud gave in his writings are dissected to demonstrate that they are tendentiously misleading and serve to conceal what actually occurred with his patients during the period in question. Some consequences of the widespread acceptance of the traditional account are briefly discussed. (shrink)

Derek Allen, Richard Boyd, and Alan Gilbert have suggested that Marx’s normative political views should be reconstructed as a sophisticated version of moral consequentialism. This paper investigates whether Marx’s ostensible anti-moralism differs in any interesting way from Mill’s sophisticated utilitarianism plus some Marxist social science. I present an account of the social meaning and implications of moral language and argument, based on Marx’s description of morality as a social practice based on distinctive motives, emotions and sanctions, to explain why (...) Marx would reject moral consequentialism. This account will explain how Marx can consistently reject morality yet retain a normative basis for his social criticism. (shrink)

In a recent paper, Michael Friedman and Hilary Putnam argued that the Luders rule is ad hoc from the point of view of the Copenhagen interpretation but that it receives a natural explanation within realist quantum logic as a probability conditionalization rule. Geoffrey Hellman maintains that quantum logic cannot give a non-circular explanation of the rule, while Jeffrey Bub argues that the rule is not ad hoc within the Copenhagen interpretation. As I see it, all four are wrong. Given (...) that there is to be a projection postulate, there are at least two natural arguments which the Copenhagen advocate can offer on behalf of the Luders rule, contrary to Friedman and Putnam. However, the argument which Bub offers is not a good one. At the same time, contrary to Hellman, quantum logic really does provide an explanation of the Luders rule, and one which is superior to that of the Copenhagen account, since it provides an understanding of why there should be a projection postulate at all. (shrink)

REVOLUTIONARY POLITICS AND LOCKE S TWO TREATISES OF GOVERNMENT by Richard Ashcraft Princeton: Princeton University Press, 1986. 613 pp., $65.00, $15.00 (paper) LOCKE'S TWO TREATISES OF GOVERNMENT by Richard Ashcraft London: Allen & Unwin, 1987. 316 pp., $34.95.

In lieu of an abstract, here is a brief excerpt of the content:IntroductionAnna Mastroianni (bio) and Jeffrey Kahn (bio)In this issue of the Kennedy Institute of Ethics Journal, we subject the work of the Advisory Committee on Human Radiation Experiments to examination from many angles. Nearly one year has passed since the release of the Committee’s final report and recommendations, and it seems an appropriate time to invite discourse and reflection on the influence and impact of the Committee and (...) its efforts. Our intent is to advance understanding of the Committee and its work, its place in the evolution of bioethics and public policy, as well as the broader legacy of restoring trust in the conduct of human subjects research.In 1993, President Clinton and Secretary of Energy Hazel O’Leary initiated an investigation of America’s involvement in radiation experiments on its citizens during the Cold War. The investigation resulted in the appointment of the Committee in January 1994. Some issues raised by these radiation experiments were brought to the attention of the nation by revelations contained in a Pulitzer Prize-winning series of newspaper stories about plutonium injections carried out by the government on allegedly unsuspecting subjects during the Cold War. The Committee faced a broad mandate, which included piecing together the history of Cold War radiation experiments and human subjects research, as well as recommending remedies for past wrongs and mechanisms to ensure that such wrongs could not be repeated in the future.This issue of the Journal consists of articles and accompanying commentaries on historical, philosophical, policy, and political aspects of the Committee’s work that are important to bioethics. This collection of articles, authored by Committee members, staff, and leading scholars, is designed to paint a picture of the breadth and complexity of the Committee’s efforts and to provide context and to stimulate discussion of significant issues.In the first article, Ruth Faden provides her unique perspective as chair of the Committee. She goes beyond the necessary overview and background of the Committee to reflect on the impact and meaning of the Committee’s work to bioethics and public policy.Much of the Committee’s effort was directed at gathering and uncovering information about the history of Cold War radiation experiments, an endeavor fairly foreign to bioethics but critically important to understanding the context in which to make moral judgments about the past. Jonathan Moreno and Susan Lederer discuss how the Committee’s work changed some of the traditional views of the history of research ethics. The commentary by Allan Brandt and Lara Freidenfelds further illuminates the value of understanding this recovered history. [End Page ix]In making moral judgments about the past, the Committee confronted complex questions about how to assess wrongdoing and the culpability of the government and its agents. Allen Buchanan explains why this was such a difficult but crucial task and how the Committee worked through some of the answers to these questions. His discussion illustrates the challenges to consensus in the committee decision-making process described in Ruth Macklin’s article in this issue on committees and consensus. Tom Beauchamp analyzes the frameworks for making retrospective moral judgments developed by two committees, the Advisory Committee and the University of California at San Francisco Ad Hoc Fact Finding Committee on World War II Human Radiation Experiments, and critiques their applications of the frameworks in the case of the plutonium injection experiments.The Committee recognized that in order to prevent wrongs seen in the past from occurring in the future, it would be necessary to understand the human subjects protections now in place. Nancy Kass and Jeremy Sugarman discuss the results of the Committee’s attempts to measure the operation and effectiveness of the current system for protection of human subjects. Paul Appelbaum comments on the relevance and value of the Committee’s empirical projects to contemporary human subjects research.The Committee’s work, and the products of any commission’s work, must be viewed partly in light of the place of commissions in bioethics scholarship and policymaking. Appointed commissions can have significant impacts on scholarly and public thinking, policymaking, and future direction, and bring high visibility to issues. It is important to realize that the conclusions of the Committee... (shrink)

To the extent that one subscribes to the proposition, by now a virtual principle of criticism , that literary texts constitute sites for the negotiation, often vigorous, of power relations within a society, the reader of Catullus can hardly avoid some consideration of the poet's attitude toward contemporary political matters. It is a subject on which two principal lines of thought can be traced. Mommsen argued that Catullus responded to the enormities that followed the reinvigoration of the First Triumvirate at (...) the conference of Luca in 56 by occupying a thoroughly optimate position. Wilamowitz, on the other hand, insisted that Catullus' lyrics reflect only moments of the author's individual experience, amongst which expressions of personal distaste for certain public figures naturally appear but nothing which can appropriately be taken as indications of a political stance. The approach of Wilamowitz has proved more influential, followed in spirit if not in specifics by numerous commentators. To the degree that Catullus has been assimilated to the Augustan elegists, whose poems have been deemed by a scholar of the stature of Veyne to be anti-political in nature, it has been all the easier to reject the idea that Catullus adopts a political position, an assessment strongly maintained in a recent study by Paul Allen Miller, for whom the rejection of all political engagement is the sine qua non of true lyric poetry. Mommsen's optimate Catullus has lately found his champion, however, in a careful article by H. P. Syndikus. Although Miller and Syndikus, like Wilamowitz and Mommsen, draw diametrically opposed conclusions concerning politics in Catullus' poetry, they are agreed nevertheless that politics can be regarded as a relatively straightforward term: it refers to statecraft, matters of government, and party strife. Other readers, however, have been more self-conscious in their theoretical concerns, a salutary consequence of which has been a shift by some to a less narrow conception of the field of reference appropriate to discussions of ‘the political’ in Latin literature. (shrink)

In this collection of provocative essays, historians and literary theorists assess the influence of Michel Foucault, particularly his History of Sexuality, on the study of classics. Foucault's famous work presents a bold theory of sexuality for both ancient and modern times, and yet until now it has remained under-explored and insufficiently analyzed. By bringing together the historical knowledge, philological skills, and theoretical perspectives of a wide range of scholars, this collection enables the reader to explore Foucault's model of Greek culture (...) and see how well his interpretation accounts for the full range of evidence from Greece and Rome. Not only do the essays bring to light the assumptions, ideas, and practices that constituted the intimate lives of men and women in the ancient Mediterranean world, but they also demonstrate the importance of the History of Sexuality for fields as diverse as Greco-Roman antiquity, women's history, cultural studies, philosophy, and modern sexuality. The essays include "Situating The History of Sexuality" (the editors), "Taking the Sex Out of Sexuality: Foucault's Failed History" (Joel Black), "Incipit Philosophia" (Alain Vizier), "The Subject in Antiquity after Foucault" (Page duBois), "This Myth Which Is Not One: Construction of Discourse in Plato's Symposium" (Jeffrey S. Carnes), "Foucault's History of Sexuality: A Useful Theory for Women?" (Amy Richlin), "Catullan Consciousness, the 'Care of the Self,' and the Force of the Negative in History" (Paul Allen Miller), "Reversals of Platonic Love in Petronius' Satyricon" (Daniel B. McGlathery), and an essay from Dislocating Masculinity (Lin Foxhall). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Dark Arts of Politics:Aesthetics and Engineering in Nazism and FascismJonathan AllenThe Cult of Art in Nazi Germany, by Eric Michaud, translated by Janet Lloyd. Stanford: Stanford University Press, 2004, 271 pp.Building Fascism, Communism, and Liberal Democracy: Gaetano Ciocca—Architect, Inventor, Farmer, Writer, Engineer, by Jeffrey T. Schnapp. Stanford: Stanford University Press, 2004, 291 pp.Despite their obvious centrality to the history of the twentieth century, sixty years after the (...) defeat of the Axis powers fascism and Nazism remain elusive phenomena, hard to define with any real clarity. Scholars wrangle not only over the identification of their central characteristics but also over whether the similarities between fascism and Nazism are close enough to justify considering them as parts of a single category. A growing number of studies, however, ranging from general histories such as Norman Davies's Europe: A History and Mark Mazower's Dark Continent: Europe's Twentieth Century, to more specialized works such as Zeev Sternhell's Neither Left Nor Right and Robert Paxton's fine The Anatomy of Fascism, argue the case for treating fascism and Nazism together.1 A mark of all of these books is their willingness to give serious attention to fascist ideologies and to the interactions between these ideologies and fascist practice and culture. This interest, in turn, makes it necessary to examine anew broader questions about the relations between fascism and the circumstances and attitudes of modern life.The two works under consideration here—The Cult of Art in Nazi Germany, by Eric Michaud, and Building Fascism, Communism, and Liberal Democracy, by Jeffrey T. Schnapp—share the growing concern to take seriously fascist ideology and culture as essential to an understanding of the movement. Michaud sets out to present an analysis of Nazi myth, which he argues was constructed with reference to two models: art and Christianity (xii). His immensely erudite study relates Nazi conceptions of the leader to Romantic views of genius and Christian doctrines concerning the role of the Savior. This allows him to present a distinctive view of Nazi ideology, one that relates it to themes and debates that have figured prominently in the history of European culture and belief. [End Page 113]Schnapp, on the other hand, focuses on the career of a single man—Gaetano Ciocca. Though Ciocca is now an obscure figure, unlikely to be familiar even to most students of fascism, Schnapp argues that his career deserves attention for several reasons. In the first place, he "strove to translate a fascist politics into the language of modern technics in the domains of architecture, urbanism, theater design, animal husbandry, drainage and transportation systems" (7). What is more, Ciocca was no power-hungry opportunist but rather a committed and reflective intellectual, who spent much of his time writing books and articles aimed at explaining and justifying his various projects to a general audience. Last but not least, though Ciocca's passionate commitment to fascism cooled as World War II wore on, this had no visible effect on his engineering projects. In the aftermath of the war, Ciocca presented himself as a nonpolitical "rebuilder" concerned to provide for popular need. In this guise, he served Italy's postwar liberal democracy as enthusiastically as he had previously devoted his projects to the cause of fascism. Ciocca thus presents us with an intriguing puzzle: a committed and reflective fascist intellectual—no Eichmann, Schnapp insists—who was nevertheless able to function equally effectively after the demise of the fascist regime. Schnapp argues that Ciocca's career forces us to examine with care the complex relations between technologies and political ideologies. In fact, I think it compels us to consider more general questions about the extent to which Ciocca's conception of himself as a modernizing technocrat could be equally at home in the political contexts of fascism and a certain kind of elite-centered liberal democracy. Schnapp hints at this issue at several moments but does not address it in a sustained way.Though there have been some notable exceptions, most studies of Nazism in particular have tended to gravitate toward one of two explanatory options. The first, more common in philosophical circles, has been to view... (shrink)

This book explores Kant's views on the concept of God and on the attempt to demonstrate God's existence as a means of understanding Kant's work as a whole and of achieving a proper appreciation of the contents of Kant's moral faith.

This masterful work on Kant's Religion within the Boundaries of Mere Reason explores Kant's treatment of the Idea of God, his views concerning evil, and the moral grounds for faith in God. Kant and Religion works to deepen our understanding of religion's place and meaning within the history of human culture, touching on Kant's philosophical stance regarding theoretical, moral, political, and religious matters. Wood's breadth of knowledge of Kant's corpus, philosophical sharpness, and depth of reflection sheds light not only on (...) Kant, but also on the fate of religion and its relation to philosophy in the modern world. (shrink)

Direct neurological and especially imaging-driven investigations into the structures essential to naturally occurring cognitive systems in their development and operation have motivated broadening interest in the potential for artificial consciousness modeled on these systems. This first paper in a series of three begins with a brief review of Boltuc’s (2009) “brain-based” thesis on the prospect of artificial consciousness, focusing on his formulation of h-consciousness. We then explore some of the implications of brain research on the structure of consciousness, finding limitations (...) in biological approaches to the study of consciousness. Looking past these limitations, we introduce research in artificial consciousness designed to test for the emergence of consciousness, a phenomenon beyond the purview of the study of existing biological systems. (shrink)

In this original work of cultural criticism, Allen S. Weiss explores the meaning of radio to the modern imagination.

This third paper locates the synthetic neurorobotics research reviewed in the second paper in terms of themes introduced in the first paper. It begins with biological non-reductionism as understood by Searle. It emphasizes the role of synthetic neurorobotics studies in accessing the dynamic structure essential to consciousness with a focus on system criticality and self, develops a distinction between simulated and formal consciousness based on this emphasis, reviews Tani and colleagues' work in light of this distinction, and ends by forecasting (...) the increasing importance of synthetic neurorobotics studies for cognitive science and philosophy of mind going forward, finally in regards to most- and myth-consciousness. (shrink)

The latest volume in the Cambridge Histories of Philosophy series, The Cambridge History of Philosophy in the Nineteenth Century brings together twenty-nine leading experts in the field and covers the years 1790-1870. Their twenty-seven chapters provide a comprehensive survey of the period, organizing the material topically. After a brief editor's introduction, it begins with three chapters surveying the background of nineteenth century philosophy: followed by two on logic and mathematics, two on nature and natural science, five on mind and language, (...) including psychology, the human sciences and aesthetics, four on ethics, three on religion, seven on society, including chapters on the French Revolution, the decline of natural right, political economy, and social discontent, and three on history, dealing with historical method, speculative theories of history and the history of philosophy. The essays are framed by an editor's introduction and a bibliography. (shrink)

Discoverability: the urgent need of an ecology of human creativity from the prolific Lorenzo Magnani is worthy of direct attention. The message may be of special interest to philosophers, ethicists and organizing scientists involved in the development of AI and related technologies which are increasingly directed at reinforcing conditions against which Magnani directly warns, namely the “overcomputationalization” of life marked by the gradual encroachment of technologically “locked strategies” into everyday decision-making until “freedom, responsibility, and ownership of our destinies” are ceded (...) and we, in parallel, build a future fit for artifacts over human beings. Professional educators - teachers and administrators serious about teaching - and policy-makers including the concerned public, parents and social activists concerned about the effects of technologies on development and well-being may benefit, as well. (shrink)

In this book, Newell makes the case for unified theories by setting forth a candidate.

The phenomenon of altruism extends from the biological realm to the human sociocultural realm. This article sketches a coherent outline of multiple types of altruism of progressively increasing scope that span these two realms and are grounded in an ever-expanding sense of “self.” Discussion of this framework notes difficulties associated with altruism at different levels. It links scientific ideas about the evolution of cooperation and about hierarchical order to perennial philosophical and religious concerns. It offers a conceptual background for inquiry (...) into societal challenges that call for altruistic behavior, especially the challenge of environmental and social sustainability. (shrink)

This book articulates a systematic vision of an international legal system grounded in the commitment to justice for all persons. It provides a probing exploration of the moral issues involved in disputes about secession, ethno-national conflict, "the right of self-determination of peoples," human rights, and the legitimacy of the international legal system itself. Buchanan advances vigorous criticisms of the central dogmas of international relations and international law, arguing that the international legal system should make justice, not simply peace among states, (...) a primary goal, and rejecting the view that it is permissible for a state to conduct its foreign policies exclusively according to what is in the "national interest." He also shows that the only alternatives are not rigid adherence to existing international law or lawless chaos in which the world's one superpower pursues its own interests without constraints. This book not only criticizes the existing international legal order, but also offers morally defensible and practicable principles for reforming it. Justice, Legitimacy, and Self-Determination will find a broad readership in political science, international law, and political philosophy. (shrink)