As compared with conventional vaccine production systems, plant-made vaccines are said to enjoy a range of advantages including cost of production and ease of storage for distribution in developing countries. In this article, we introduce the science of PMV production, and address ethical issues associated with development and clinical testing of PMVs within three interrelated domains: PMVs as transgenic plants; PMVs as clinical research materials; and PMVs as agents of global health. We present three conclusions: first, while many (...) of the ethical issues raised by PMVs are familiar, PMVs add a new dimension to old issues, and raise some novel issues for ethicists and policy-makers; secondly, it is premature to promise broad applicability of PMVs across the developing world without having demonstrated their feasibility; thirdly, in particular, proponents of PMVs as a solution to global health problems must, as a condition of the ethical conduct of their research, define the commercial feasibility of PMVs for distribution in the developing world. (shrink)

Public policy on the development and use of genetically modified organisms (GMOs) has mainly been concerned with defining proper strategies of risk management. However, surveys and focus group interviews show that although lay people are concerned with risks, they also emphasize that genetic modification is ethically questionable in itself. Many people feel that this technology “tampers with nature” in an unacceptable manner. This is often identified as an objection to the crossing of species borders in producing transgenic organisms. Most (...) scientists reject these opinions as based on insufficient knowledge about biotechnology, the concept of species, and nature in general. Some recent projects of genetic modification aim to accommodate the above mentioned concerns by altering the expression of endogenous genes rather than introducing genes from other species. There can be good scientific reasons for this approach, in addition to strategic reasons related to greater public acceptability. But are there also moral reasons for choosing intragenic rather than transgenic modification? I suggest three interrelated moral reasons for giving priority to intragenic modification. First, we should respect the opinions of lay people even when their view is contrary to scientific consensus; they express an alternative world-view, not scientific ignorance. Second, staying within species borders by strengthening endogenous traits reduces the risks and scientific uncertainty. Third, we should show respect for nature as a complex system of laws and interconnections that we cannot fully control. The main moral reason for intragenic modification, in our view, is the need to respect the “otherness” of nature. (shrink)

There is no doubt that soybean is the most important crop for Argentina, with a planted surface that rose 11,000,000 hectares and a production of around 35,000,000 metric tons. During the 1990s, there was a significant agriculture transformation in the country, motorize by the adoption of transgenic crops (soy-bean, maize, and cotton) under the no-tillage system. The expansion of this model has been spread not only in the Pampas but also in very rich areas with high biodiversity, opening a (...) new agricultural border to important eco-regions like the Yungas, Great Chaco, and the Mesopotamian Forest. Transgenic cropping is a powerful technology. This produced relevant transformations over the environment and society where it is allowed. Migration, concentration of agribusiness, and loss of food sovereignty are some of the social results. Landscape transformation in the rural sector is evident, and the appearance of tolerance weeds to glyphosate is a reality. Nutrient depletion, soil-structure degradation, potential desertification, and loss of species are other consequences on the environmental level. (shrink)

Transgenic plants are now being used to develop pharmaceutical and industrial products in addition to their use in crop improvement. Using confinement requirements, these transgenic plants are grown and processed under conditions that prevent intermixing with commodity crops. Regulatory agencies in the United States have provided guidance of zero tolerance of these new industrial crops with commodity crops. While this is a worthy goal, it is theoretically unattainable. In spite of the best containment practices, there is (...) a potential risk using any system of production due to unforeseen incidences including natural disasters or exposure to workers. The precautionary principle has been used for numerous regulated articles in addressing the potential risks of new products and technology based on a risk assessment in similar situations. We present here a risk assessment model that could be used as a start to develop an accepted model for the industry. The model is based on current risk models used for other regulated articles, but adapted for these types of products. This could be used to determine action levels in the event of an unintended exposure or to ensure that detection or confinement methods are adequate to avoid risks. As an example, aprotinin, a therapeutic protein now being produced in maize, was evaluated for potential risk to humans using this model. (shrink)

The potential for genetically modified (GM) crops to threaten biodiversity conservation and sustainable agriculture is substantial. Megadiverse countries and centers of origin and/or diversity of crop species are particularly vulnerable regions. The future of sustainable agriculture may be irreversibly jeopardized by contamination of in situ preserved genetic resources threatening a strategic resource for the world—s food security. Because GM crops are truly biological novelties, their release into the environment poses concerns about the unpredictable ecological and evolutionary responses that GM species (...) themselves and the interacting biota may express in the medium and long term. One of the consequences of these processes may be a generalized contamination of natural flora by GM traits and a degradation and erosion of the commonly owned genetic resources available today for agricultural development. GM plants carrying pharmaceutical and industrial traits will pose even more dangerous risks if released in the environment. (shrink)

At present, the European population sees more risks than benefits in the use of transgenic plants in food. Through the development of a learning strategy based on science dissemination projects (articles and talks) by university students, an increase in autonomous knowledge and vocations in science popularisation has been identified. On the other hand, the development of outreach talks for pre-university students has increased the knowledge of outreach and plant biotechnology, promoting the future choice of higher studies in biotechnology.

Physiological experiments conducted over the last 60 years indicate that the plant hormone auxin regulates a diverse set of developmental processes via changes in cell division, cell elongation and cell differentiation. Recent studies using transgenic plants with altered auxin levels support these conclusions and promise to provide more detailed information on the role of auxin during plant development. Although it is possible that all auxin responses are mediated by the same primary biochemical events, the studies described in this (...) review are more consistent with multiple modes of auxin action. The development of molecular and genetic approaches to the study of hormone action should resolve this issue. The accelerated rate of progress in this field suggests that real insight into the mechanism of auxin action may be forthcoming. (shrink)

Three approaches have been used to investigate the inhibitory role of the cytokinin class of phytohormones in plant senescence: external application of cytokinins, measurement of endogenous cytokinin levels before and during senescence, and manipulation of endogenous cytokinin production in transgenic plants. In transgenic plant studies, endogenous cytokinin levels are manipulated by expression of IPT, a gene encoding isopentenyl transferase. Transgenic plants expressing IPT from a variety of promoters exhibit developmental and morphological alterations and often display (...) retarded leaf senescence. A recently developed autoregulatory senescence‐inhibition system targets cytokinin production quantitatively, spatially and temporally, and results in transgenic plants that exhibit significantly delayed senescence without abnormalities. These transgenic studies not only confirm the regulatory role of cytokinins in plant senescence, but also provide a way to manipulate senescence for potential agricultural applications. (shrink)

In Europe the use of genetically modified (GM) crops in food production has so far failed to gain wide public approval. Ordinary people are concerned about issues not covered by the existing regulation, including usefulness and unnaturalness. In response, particularly to worries about unnaturalness, biotechnologists have suggested that inserted genes should derive only from the plant itself, or from close relatives. This paper examines public perceptions of these so-called ‘cisgenic crops’ and asks whether the public shares the idea that they (...) are less unnatural and thus more acceptable than transgenic plants. Using five focus group interviews, we identified five lines of argument about naturalness with a bearing on the assessment of cisgenic crops as well as GM crops in general. The paper concludes that, depending on perceptions of naturalness, some people would agree that cisgenic crops are more acceptable than their transgenic counterparts. The finding that ordinary people value different aspects of naturalness may be relevant to a broader audience than just those interested in gene technology. It cautions against a simplistic interpretation of what counts as ‘natural’. (shrink)

In this paper we analyse how the risks associated with research on transgenic plants are regulated in Sweden. The paper outlines the way in which pilot projects in the plant sciences are overseen in Sweden, and discusses the international and national background to the current regulatory system. The historical, and hitherto unexplored, reasons for the evolution of current administrative and legislative procedures in plant science are of particular interest. Specifically, we discuss similarities and differences in the regulation of (...) medicine and plant science, and we examine the tendency towards dichotomizing risk — focusing on social/ethical risks in medicine and biological risks in plant science. The context of this article is the Synpraxia research project, an inter-disciplinary program combining expertise in sciences and the humanities. (shrink)

Legitimation of public policies that support the widespread plantings of transgenic crops presuppose, among other conditions, that evidence supports that there are no unmanageable environmental risks and there are no better ways to produce enough nourishing food that can dispense with the transgenics-oriented ways. This paper discusses: the kinds of scientific inquiry that are needed to address adequately, the connections between investigations of and , and how these investigations are related with controversial social values.A legitimação de políticas públicas que (...) apóiam o cultivo de lavouras transgênicas em larga escala pressupõe, entre outras condições, que os dados empíricos garantem não haver riscos ambientais não-administráveis e, a não-existência de modos melhores de produzir alimentos sem a utilização de técnicas transgênicas. O artigo discute: Os tipos de investigação científica necessários para um exame adequado da condição , como as investigações sobre e se relacionam entre si, e como tais investigações se relacionam com valores sociais controvertidos. (shrink)

The journal continues to publish translations of chapters of the book by the famous phenomenologist Michael Marder “The Philosopher’s Plants (An Intellectual Herbarium)”. Two of the twelve stories were chosen — “Aristotle's Wheat” and “Avicenna's Celery”. The author analyzes the views of the ancient philosopher Aristotle and the medieval Persian philosopher and physician Ibn Sina (Avicenna) on the nature of plants and their place in the diverse world of living beings, showing how the images of wheat and celery (...) become an important part of their philosophical reflections. Marder emphasizes that the ancient scientists were alien to modern systems of biological classification. Each creation occupied its own niche and existed for a specific purpose. However, the contours of these teleologies were not at all what we imagine them to be. For example, for Aristotle, a noble man, a noble animal and a noble plant had more in common than two representatives of the same biological kingdom. In addition, the boundaries between them were quite shaky. A stupid person, unable to follow the strict principles of logic, was literally like a plant. Avicenna discovers in plants the “vegetable soul”, above which he puts the “animal soul”. He finds both of these levels in a person. Awareness of this totality is necessary, according to Avicenna, for genuine self-knowledge and, consequently, for the knowledge of God. The author of the book attempts to answer the question: what if the mixture of similar beings passing into and out of each other, characteristic of the ancient and medieval world, is not a fantastic fiction, but an insightful description of our transgenic present and future? (shrink)

Focused on the impact of stringent intellectual property mechanisms over the uses of plant agricultural biodiversity in crop improvement, the article delves into a systematic analysis of the relationship between institutional paradigms and their technological contexts of application, identified as mass selection, controlled hybridisation, molecular breeding tools and transgenics. While the strong property paradigm has proven effective in the context of major leaps forward in genetic engineering, it faces a systematic breakdown when extended to mass selection, where innovation often displays (...) a collective nature. However, it also creates partial blockages in those innovation schemes rested between on-farm observation and genetic modification, i.e. conventional plant breeding and upstream molecular biology research tools. Neither overly strong intellectual property rights, nor the absence of well delineated protection have proven an optimal fit for these two intermediary socio-technological systems of cumulative incremental innovation. To address these challenges, the authors look at appropriate institutional alternatives which can create effective incentives for in situ agrobiodiversity conservation and the equitable distribution of technologies in plant improvement, using the flexibilities of the TRIPS Agreement, the liability rules set forth in patents or plant variety rights themselves, and other ad hoc reward regimes. (shrink)

A short book combining extracts from the work of one of the world's greatest thinkers with commentary from one of Britain's most distinguished writers on philosophy.

In "Culture and Value" Wittgenstein remarks that the truly "religious man" thinks himself to be, not merely "imperfect" or "ill," but wholly "wretched." While such sentiments are of obvious biographical interest, in this paper I show why they are also worthy of serious philosophical attention. Although the influence of Wittgenstein's thinking on the philosophy of religion is often judged negatively (as, for example, leading to quietist and/or fideist-relativist conclusions) I argue that the distinctly ethical conception of religion (specifically Christianity) that (...) Wittgenstein presents should lead us to a quite different assessment. In particular, his preoccupation with the categorical nature of religion suggests a conception of "genuine" religious belief which disrupts both the economics of eschatological-salvationist hope, and the traditional ethical precept that "ought implies can." In short, what Wittgenstein presents is a sketch of a religion without recompense. (shrink)

A stimulating introduction to central issues of political theory, including liberty, rights and the state, and the claims of need and politics.

There is a world-wide debate at the moment about the appropriate role for the state in modern societies in the light of the world financial crisis. This book provides a comprehensive analysis and critique of Neo-liberal or economic liberal ideas on this issue.

Widespread and lasting consensus has not been philosophy's fate. Indeed, one of philosophy's most striking features is its ability to accommodate “not only different answers to philosophical questions” but also “total disagreement on what questions are philosophical” (Rorty 1995, 58). It is therefore hardly surprising that philosophers' responses to this metaphilosophical predicament have been similarly varied. This article considers two recent diagnoses of philosophical diversity: Kornblith and Rescher (respectively) claim that taking philosophical disagreement seriously does not lead to metaphilosophical scepticism. (...) The article argues that their confidence is misplaced in so far as both wrongly assume that ordinary, first-order philosophical practice and second-order metaphilosophical reflection are separate enterprises. We can say that the universe consists of a substance, and this substance we will call “atoms,” or else we will call it “monads.” Democritus called it atoms. Leibniz called it monads. Fortunately, the two men never met, or there would have been a very dull argument. (Allen 1997, 171) When will philosophers learn to be less pretentious and arrogant in their claims? One would imagine that the philosophic experiences of twenty-five centuries would have taught them the fallacy of self-esteem! (Schilpp 1935, 233). (shrink)

Mark Dooley has recently argued (principally against Simon Critchley) that the attempt to establish too strong a ‘connection’ between Jacques Derrida and Emmanuel Levinas not only distorts crucial disparities between their respective philosophies, it also contaminates Derrida’s recent work with Levinas’s inherent ‘political naivety’. In short, on Dooley’s reading, Levinas is only of ‘inspirational value’ for Derrida. I am not concerned with defending Critchley’s own reading of the ‘Derrida–Levinas connection’. My objective is rather to demonstrate, first, the way in which (...) Dooley’s argument hinges upon a misreading of Levinas and Derrida, and, second, why Derrida’s recent thinking is in fact fundamentally Levinasian. Key Words: contingency • guilt • Holocaust • hospitality • institutions • nature • suffering • third party • violence. (shrink)

In Culture and Value Wittgenstein remarks: ‘Thoughts that are at peace. That's what someone who philosophizes yearns for’. The desire for such conceptual tranquillity is a recurrent theme in Wittgenstein's work, and especially in his later ‘grammatical-therapeutic’ philosophy. Some commentators (notably Rush Rhees and C. G. Luckhardt) have cautioned that emphasising this facet of Wittgenstein's work ‘trivialises’ philosophy – something which is at odds with Wittgenstein's own philosophical ‘seriousness’ (in particular his insistence that philosophy demands that one ‘Go the bloody (...) hard way’). Drawing on a number of correlations between Wittgenstein's conception of philosophy and that of the Pyrrhonian Sceptics, in this paper I defend a strong ‘therapeutic’ reading of Wittgenstein, and show how this can be maintained without ‘trivialising’ philosophy. (shrink)

The paper explicates Bonhoeffer's dense statement, made in a 1932 lecture, that `Reality is the sacrament of [the ethical] command'. It begins with a summary of William T. Cavanaugh's rich description of the Eucharist as that act which makes the Church Christ's body, thereby constituting the true res publica. A comparison is drawn with Bonhoeffer's account of the sacramental foundation of the Church's public proclamation of God's ethical command. Bonhoeffer differs from Cavanaugh, I suggest, not only in his conviction that (...) the Church speaks God's command penultimately and with humility, but in regarding the state as one of the means by which God acts within the penultimate to preserve creation. (shrink)

This article argues for four interrelated claims: Metaphilosophy is not one sub-discipline of philosophy, nor is it restricted to questions of methodology. Rather, metaphilosophical inquiry encompasses the general background conditions of philosophical practice. These background conditions are of various sorts, not only those routinely considered “philosophical” but also those considered biographical, historical, and sociological. Accordingly, we should be wary of the customary distinction between what is proper and merely contingent to philosophy. “What is philosophy?” is best understood as a practical (...) question concerning how members of different philosophical sub-communities identify what is pertinent to their respective activities and self-conceptions. Given –, understanding what philosophy is requires us to take more seriously the social-institutional dimension of contemporary philosophical practice. (shrink)

First published in 1980. Routledge is an imprint of Taylor & Francis, an informa company.

_Wittgenstein and Levinas_ examines the oft-neglected relationship between the philosophies of two of the most important and notoriously difficult thinkers of the twentieth century. By bringing the work of each philosopher to bear upon the other, Plant navigates between the antagonistic intellectual traditions that they helped to share. The central focus on the book is the complex yet illuminating interplay between a number of ethical-religious themes in both Wittgenstein's mature thinking and Levinas's distinctive account of ethical responsibility.

IN his running debate with Fr Joseph Owens, Dr Joseph Bobik at one point raises this issue.

First published in 1973 this volume demonstrates the interconnection between Hegel's political and metaphysical writings. This book provides a point of entry into Hegel's system of ideas. Condemned unread, and when read far too often misunderstood, Hegel's thought has once more begun to make its impact on contemporary ideas with many of today's most important social and political thinkers.

In 1981, after 20 years of teaching and writing philosophy, Derrida claimed that ‘less than ever’ did he ‘know what philosophy is’. Indeed, his ‘knowledge of what ... constitutes the essence of philosophy’ remained ‘at zero degree’. 1 These were not flippant remarks. Rather, Derrida’s avowed uncertainty is part of a more general metaphilosophical view; namely, that ‘Philosophy has a way of being at home with itself that consists in not being at home with itself’. 2 In this article I (...) will critically reconstruct and develop this view, paying particular attention to the ‘institutional’ dimension of contemporary philosophy. (shrink)

The “Model for Reaching Ethical Judgments in the context of Modern Technologies — the Case of Genetic Technology”, which is presented here, has arisen from the project “Ethical Criteria bearing upon Decisions taken in the field of Biotechnology”. This project has been pursued since 1991 in the Zentrum für interdisziplinäre Technikforschung (ZIT) of the Technical University of Darmstadt, with the purpose of examining decision-making in selected activities involving the production of transgenic plants that have a useful application. The (...) model is the basis of an outline for interviews to investigate how far decisions concerning the development of such plants with genetic techniques take ethical criteria into account. It was necessary to design this new model because other models for reaching judgments of this kind were not conceptually suited for concrete application. This model represents a problem related approach and combines methodological with substantive typology. In this it differs from comparable models for reaching ethical judgments. (shrink)

Wittgenstein’s remarks on religious and magical practices are often thought to harbour troubling fideistic and relativistic views. Unsurprisingly, commentators are generally resistant to the idea that religious belief constitutes a ‘language‐game’ governed by its own peculiar ‘rules’, and is thereby insulated from the critical assessment of non‐participants. Indeed, on this fideist‐relativist reading, it is unclear how mutual understanding between believers and non‐believers (even between different sorts of believers) would be possible. In this paper I do three things: (i) show why (...) the fideist‐relativist reading of Wittgenstein is not wildly implausible (Sections 1–2); (ii) argue that, despite its initial plausibility, this reading fails to take into account Wittgenstein’s naturalism (Sections 3–4); and (iii) explain what sort of naturalism this is, and how it sheds light on Wittgenstein’s remarks on religious belief (Sections 5–6). (shrink)

According to Levinas, the history of western philosophy has routinely ‘assimilated every Other into the Same’. More concretely stated, philosophers have neglected the ethical significance of other human beings in their vulnerable, embodied singularity. What is striking about Levinas’ recasting of ethics as ‘first philosophy’ is his own relative disregard for non-human animals. In this article I will do two interrelated things: (1) situate Levinas’ (at least partial) exclusion of the non-human animal in the context of his markedly bleak conception (...) of ‘the state of nature’, and (2) drawing on Orwell, Wittgenstein and Gaita, argue that, despite his more positive evaluation of animality (specifically a dog named Bobby), Levinas is guided by a number of anthropomorphic prejudices; not least that the epithet ‘the animal’ can be used in the general singular. (shrink)

In "The History of Sexuality", Foucault maintains that "Western man has become a confessing animal" (1990, 59), thus implying that "man" was not always such a creature. On a related point, Wittgenstein suggests that "man is a ceremonial animal" (1996, 67); here the suggestion is that human beings are, by their very nature, ritualistically inclined. In this paper I examine this crucial difference in emphasis, first by reconstructing Foucault's "genealogy" of confession, and subsequently by exploring relevant facets of Wittgenstein's later (...) thinking. While there are significant correlations between Foucault and Wittgenstein, an important disparity emerges in relation to the question of the "natural." By critically analyzing this, I show how Wittgenstein's minimal naturalism provides an important corrective to Foucault's more extravagant claims. By implication, we see why any radical relativist, historicist, and/or constructivist position becomes untenable on Wittgensteinian grounds, even though Wittgenstein himself is often read as promoting such views. (shrink)

I review MacAskill's book What We Owe The Future, which makes the case for longtermism, the idea that positively influencing the longterm future is a key moral priority of our time. After summarising it, I raise four challenges to the nature or presentation of his case. First, I point out MacAskill's stated three-premise 'case' for longtermism is not a valid argument. Second, I argue his case is not, as he describes it, 'simple' and 'uncontroversial'; MacAskill brushes over crucial subtleties and (...) mauls a strawman. Third, I am unpersuaded by the argument that we can influence the longterm future; the book does not contain a single example that shows this has happened before, so we should be sceptical we can do so. Fourth, I question the practical importance of longtermism. MacAskill argues we should do more to prevent global catastrophic risks from e.g. AI and nuclear war. Longtermism may give us more reason to care about them but it is neither necessary nor sufficient to make those the priorities. (shrink)