Most documented extinctions of vertebrates in the last 400 years have been island endemics. In this paper, we focus on the need to develop a historical framework to establish conservation priorities for insular faunas and, in particular, to test the validity of nominal endemics. We use the example of the islands of the North Pacific Coast of North America, a region that includes approximately one-half of all mammals endemic to North American islands north of Mexico. Few of these endemics (...) have been re-evaluated since their original descriptions, although many of these islands have been heavily impacted by habitat conversion, species introductions, over-exploitation, and secondary ripple effects. Evidence from molecular genetics and paleontology suggests that many taxa arrived in the region since the last glacial advance. Some of these nominal endemics show minimal differentiation, while others comprise multiple evolutionary lineages. The NPC may also have played an important role in the in situ diversification of some taxa during the Pleistocene. Evidence, such as new fossil discoveries and numerous described endemics, lends support for refugia hypotheses. However, these ideas cannot be tested until a better understanding of geographic variation and the evolutionary relationships of the fauna and flora of the North Pacific Coast is developed. This framework would provide significant insight into the dynamic biogeographic history of the region and help prioritize conservation efforts. (shrink)

In 1980 grey-headed flying-foxes, a species now listed as "vulnerable to extinction," made camp at the Royal Botanic Gardens Melbourne (RBGM). In May 2000 the RBGM started to kill bats. The killing was halted when Humane Society International (HSI) filed for the bats’ protection under federal and state conservation laws. Over the next 13 months, conservationists, garden officials and scientists, politicians, animal activists, and others all played a part in a chain of events that demonstrates the tangled web of scientific (...) involvement in politics and how different views within the scientific community may lead to conflicting positions on conservation strategies. (shrink)

Controlled human infection challenge studies (CHIs) involve intentionally exposing research participants to, and/or thereby infecting them with, micro‐organisms. There have been increased calls for more CHIs to be conducted in low‐ and middle‐income countries (LMICs) where many relevant diseases are endemic. This article is based on a research project that identified and analyzed ethical and regulatory issues related to endemic LMIC CHIs via (a) a review of relevant literature and (b) qualitative interviews involving 45 scientists and ethicists with (...) relevant expertise. In this article we argue that though there is an especially strong case for conducting CHIs in endemic (LMIC) settings, certain ethical issues related to the design and conduct of such studies (in such settings) nonetheless warrant particularly careful attention. We focus on ethical implications of endemic LMIC CHIs regarding (a) potential direct benefits for participants, (b) risks to participants, (c) third‐party risks, (d) informed consent, (e) payment of participants, and (f) community engagement. We conclude that there is a strong ethical rationale to conduct (well‐designed) CHIs in endemic LMICs, that certain ethical issues warrant particularly careful consideration, and that ethical analyses of endemic LMIC CHIs can inform current debates in research ethics more broadly. (shrink)

The two main ways in which disease and nutrition can influence fertility are by reducing fecundity or by extending the birth interval. Fecundity refers to reproductive ability, that is the potential to breed, as compared to fertility which denotes actual childbearing . Reduced fecundity, which is usually referred to as subfecundity, results from impairment of any of the biological aspects of reproduction, including coital inability, conceptive failure as well as pregnancy loss. Subfecundity is only one factor operating to reduce fertility; (...) other factors include those governing mate exposure and birth control. (shrink)

This article postulates a method of determining the date of human settlement in the Canary Islands by establishing when species of mice, which are commensal with human beings and hence in all likelihood migrated with them, arrived in the archipelago. At the same time, the extinction of several species of endemic rodents may also correlate with such arrivals. The study establishes the outer limits for the arrival of the mouse species, between the 5th millennium BCE and the 15th century (...) CE, but, while indicative archaeological evidence indicates human settlement was established by around the middle of the 1st millennium BCE, the absence of conclusive dating of fossil mice remains leaves a definitive conclusion for the start of such settlement still open. (shrink)

Fast and effective detection of the causative agent of malaria in humans, protozoan Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment and to control a devastating disease that affects millions of people living in endemic areas. The microscopic examination of Giemsa‐stained blood films still remains the gold‐standard in Plasmodium detection today. However, there is a high demand for alternative diagnostic methods that are simple, fast, highly sensitive, ideally do not rely on blood‐drawing and can potentially (...) be conducted by the patients themselves. Here, the history of Plasmodium detection is discussed, and advantages and disadvantages of diagnostic methods that are currently being applied are assessed. (shrink)

Human infection challenge studies (HCS) involve intentionally infecting research participants with pathogens (or other micro-organisms). There have been recent calls for more HCS to be conducted in low-income and middle-income countries (LMICs), where many relevant diseases are endemic. HCS in general, and HCS in LMICs in particular, raise numerous ethical issues. This paper summarises the findings of a project that explored ethical and regulatory issues related to LMIC HCS via (i) a review of relevant literature and (ii) 45 qualitative (...) interviews with scientists and ethicists. Among other areas of consensus, we found that there was widespread agreement that LMIC HCS can be ethically acceptable, provided that they have a sound scientific rationale, are accepted by local communities and meet usual research ethics requirements. Unresolved issues include those related to (i) acceptable approaches to trade-offs between the scientific aim to produce generalisable results and the protection of participants, (iii) the sharing of benefits with LMIC populations, (iii) the acceptable limits to risks and burdens for participants, (iv) the potential for third-party risk and whether the degree of acceptable third-party risk is different in endemic settings, (v) the conditions under which (if any) it would be appropriate to recruit children for disease-causing HCS, (v) appropriate levels of payment to participants and (vi) appropriate governance of (LMIC) HCS. This paper provides preliminary analyses of these ethical considerations in order to (i) inform scientists and policymakers involved in the planning, conduct and/or governance of LMIC HCS and (ii) highlight areas warranting future research. Insofar as this article focuses on HCS in (endemic) settings where diseases are present and/or widespread, much of the analysis provided is relevant to HCS (in HICs or LMICs) involving pandemic diseases including COVID19. (shrink)

This article counters the popular misunderstanding that China lacks a conception of human rights in its philosophical heritage. The authors demonstrate that even divergent traditions such as Classical Confucianism and Mohism provide strong and pervasive antecedents for human rights ideology, and both have much to contribute to the contemporary Chinese articulation of human rights theory and practice. The first part of the article shows that traditional Confucian values have the capacity to produce a social environment in which rights outcomes are (...) realized, yet without recourse to the full legal mechanisms of Western claim-rights. The second part of the article reveals that Mohism offers several insights and motivations for contemporary human rights ideology. Thus, the authors substantiate that historic Chinese philosophy supports a meaningful framework for human rights, refuting the claim that human rights is alien to the Chinese way. (shrink)

Informed consent and confidentiality supposedly minimize harm for research participants in all qualitative research methodologies, inclusive of one-on-one unstructured interviews and focus groups. This is not the case for the latter. Confidentiality and informed consent uniquely manifest themselves as endemic ethical dilemmas for focus group researchers. The principle of caveat emptor (let the buyer beware) may be a more useful tool for those involved in focus group research: that is, let the researcher, the participants and the ethics committee beware (...) that the only ethical assurance that can be given to focus group participants is that there are few ethical assurances. These ethical dilemmas are not sufficiently realized in the literature, and if they are discussed, they are often dealt with within the focus group moderator’s preamble to the group discussion. This paper encourages the mandatory use of a participant information sheet sufficiently detailed to engender the participant’s active consent. Sufficient here means the participant must be made adequately aware of these endemic ethical dilemmas in advance, to allow them to consent to share responsibility for any ensuing harm. The focus group moderator is not their sole protector. (shrink)

Individual and institutional conflicts of interest arise with increasing frequency and negative sequelae as universities and their principals, as well as individual faculty members, engage in research with support from profit/not-for-profit entities. This essay examines how institutional and individual conflicts of interest arise for ethics centers and their faculty/staff, respectively. It defines COI, endorses a reasonable person standard for determining when COI exist, and considers problems that arise when disclosure of COI is embraced as a remedy for them. It argues (...) that transparency and disclosure are generally inadequate measures to address COI, especially those of ethics centers. It concludes by sketching other measures that may be ingredients in attempts to avoid, manage, or mitigate the COI of ethics centers and their faculty/staff. (shrink)

Homophobia is a real and widespread problem. It results in substantial health and welfare effects. It is a legitimate issue for health and welfare reform not only because it challenges the sincerity of policy makers who talk of human rights and social justice, but because people suffer. While this paper has focused on violence as an extreme of this phenomenon, there are many other health issues that are less well documented but of considerable importance. Because homophobia is so pervasive and (...) often sanctioned by the state, it is often viewed as the status quo and its health and welfare effects overlooked. (shrink)

Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda. We invited volunteers from a fishing community and a tertiary education community to guide the development of informed consent procedures. Consultative group discussions were held to modify educational materials on schistosomiasis, vaccines and the CHI-S model and similar discussions were held with a test group. With both groups, a mock (...) consent process was conducted. Fourteen in-depth key informant interviews and three group discussions were held to explore perceptions towards participating in a CHI-S. Most of the participants had not heard of the CHI-S. Willingness to take part depended on understanding the study procedures and the consenting process. Close social networks were key in deciding to take part. The worry of adverse effects was cited as a possible hindrance to taking part. Volunteer time compensation was unclear for a CHI-S. Potential volunteers in these communities are willing to take part in a CHI-S. Community engagement is needed to build trust and time must be taken to share study procedures and ensure understanding of key messages. (shrink)

The article discusses the structural dynamics of the Covid 19 pandemic and defines it as an essentially finite crisis. However, this definition does not simply come down to the abstract necessity that the pandemic must end at some point, but rather to the fact that the idea of an end has determined the entire course of the pandemic. From the outset, this idea took two antagonistic forms: From the first perspective, the pandemic can only be ended by eliminating the source (...) of the intrusion; from the second perspective, ending the pandemic amounts to society finding a way to adapt to the intrusion. Apart from analyzing the often paradoxical implications of this essentially antagonistic idea for the “objective” evolution of the pandemic in its various phases, the article also demonstrates the inherently sadistic structure of the prevailing societal response. Precisely because this response was aimed at an impossible total normalization, it prepared the ground for the pandemic to possibly mutate into a genuine Anthropocene crisis, the endemic pandemic. (shrink)

Economic insecurity is an endemic problem across the rich countries of the Global North. What is the solution? This paper compares and contrasts two major proposals: the conventional welfare state package of public services and regulations versus a basic income. By comparing and contrasting these systems in three different contexts – a “nightwatchman” context, a neoliberal context, and a social democratic context – and carefully modeling the monetary equivalence between them, we are able to provide a more precise and (...) compelling comparison of the two systems than has yet been accomplished. We evaluate the two systems on the basis of economic security as well as a number of other important criteria, including the economic well-being of oppressed groups, power, carbon emissions, the gender division of labor, free time, social stigma, and transformative potential. We find that without a welfare state background, services and regulations are generally preferable for most vulnerable groups. However, as the welfare state develops, into a neoliberal or a social democratic context, basic income becomes a generally superior option. (shrink)

The inflation which is endemic to late capitalism does not exempt concepts and theories; if inflated money seeks to overcome the falling rate of profit, inflated concepts seek to overcome the falling rate of intelligence. Within left and radical thought this assumes a particular form: an increase in revolutionary face value. Today every theory is more revolutionary than the previous one, or so it claims. Such an increase is a response to a depreciation, as it were, in the critical (...) substance and categories of the theories; as silver coins are now fabricated with copper, revolutionary theories are constructed with conformist and establishment concepts. The result is inflation. (shrink)

Crisis jargon has become endemic in modernity. Whether in radical or in affirmative versions, the idea that ‘crisis’ offers ‘opportunity’, in accordance with the meaning of crisis as ‘decision’, is widespread. This paper questions the relationship between modernity and crisis, first by highlighting the ways in which modernity itself has been cast as ‘crisis’: first as crisis of tradition, then as crisis of modernity itself. The main part of this paper then consists of a reading of modernity-as-crisis inspired by (...) Walter Benjamin, most notably by his Passagen-Werk. It consists of an attempt to consider ‘crisis’ as what Benjamin calls a ‘wish image’, an image that contains hidden utopian ideals. In invoking ‘crisis’, I argue, a conception of modernity as shock, raised to the level of the collective, becomes apparent. Crisis jargon thereby remains wedded to what Benjamin calls a mythical conception of history. The paper ends with a discussion of the political consequences that follow from this that are grounded in the relation between messianism and profane politics in Benjamin. (shrink)

Posidonia oceanica is an endemic seagrass from the mediterranean that provides key ecosystem services. A protected species, its presence is regressing due to anthropogenic pressures, some associated to the tourism economy that much of the Mediterranean coast depends on. In 1992, the European Union declared it a priority habitat, and since the early 2000s, it has occupied a central space in marine conservation debates in the Balearic Islands. Popularly known as Posidonia, this seagrass went from being considered dirt that (...) ruined virgin Balearic beaches to become an emblematic species. This article takes this U-turn in policy and public perception as a study case to think of knowledge-making practices and restoration initiatives as a form of environmental care. The relational, situated and affective character of care ethics helps to understand the human and ecological labour embedded in knowledge-making and restoration practices and its inevitable engagement with the Balearic tourism industry. Drawing on those engagements, I reflect on environmental care practices of knowledge-making and restoration, arguing that they emerge ambivalently: they challenge management logics based on economic rationales while forced to develop and coexist inside those same rationales. I conclude by arguing that developing care-centric narratives for environmental conservation and restoration is essential to continue promoting more-than-human aquatic relations in which the needs of others are the ethical basis for action. (shrink)

Change is endemic in nature yet scientists seek stability amidst change. When proposals fail scientists shift their focus and look for stability elsewhere. Scholars who study the development of science also seek stability in the scientific process. Here I explore the interaction between stability and change in nature as we understand it through the sciences and in the practice of scientific research. The concluding part argues that the search for stability meets a human intellectual need but this is compatible (...) with our finding what is actually there. Cases in which a previously accepted part of science is rejected or revised in response to contrary data indicates that we do not predetermine outcomes of observations and experiments. Still, the belief that there are loci of stability in nature is a working hypothesis. While it has been fruitful, only future scientific developments can determine if this will continue to hold. (shrink)

Displacement is an endemic phenomenon that affects those uprooted, the communities that feel the impact of those arriving, governments, and the international agencies which are increasingly engaged in organising the displaced. The current war in the north of Mozambique, which has caused a massive displacement of people from 2017 onwards, may be related to a number of factors, including economic, social and even political. Although some actors and analysts include ethnicity as part of the causes, this has more often (...) than not been analytically downplayed when grappling with the dynamics of, particularly, the groups that oppose the Mozambican government. This article analyses the dynamics of relationships between internally displaced people and host communities in Cabo Delgado, especially underlining, firstly, the resilience of communities in the face of extremist violence and, secondly, the distrust that typically shapes conflict. The latter dimension is aggravated by a historical past based on ethnic, political and social differences - cleavages that are accentuated and reproduced within the centres of displaced people and between these and host communities. We argue that factors such as poverty, hunger, lack of jobs or work opportunities, as well as poor access to arable land for family food production, exacerbate the relationship dynamics and create an environment conducive to the outbreak of small-scale conflicts that can, in the medium and long term, open spaces for radicalisation and more violence. Keywords: Mozambique, displacement, war, extremism, Cabo Delgado, resilience. (shrink)

The rediscovery of the silver-backed chevrotain, an endemic species to Vietnam, in 2019, after almost 30 years of being lost to science, is a remarkable outcome for the global conservation agenda. However, along with the happiness, there is a tremendous concern for the conservation of the species as eating wildmeat, including chevrotain, is deeply rooted in the socio-cultural values of Vietnamese. Meanwhile, conservation plans face multiple obstacles since the species has not been listed in the list of endangered, precious, (...) and rare wildlife prioritized for protection and is still classified by the IUCN as lacking data. Given the limited effectiveness of conservation measures, this essay discusses the determining roles of local actions, community cooperation, and humanistic values oriented toward eco-surplus culture in addressing the global biodiversity conservation agenda, specifically the conservation of the silver-backed chevrotain. Local actions and community cooperation for conservation can be actualized to achieve conservation goals through citizen and community sciences, integration of modern technologies (e.g., Internet, crowdfunding platforms, social media, AI, etc.), and the bonding capability of humanistic values that prioritize environmental healing. Communicating conservation information to the community, especially the children, has to stimulate their thinking and imagination about nature, develop their curiosity and desire to protect wildlife, and eventually build eco-surplus core values in their mindsets. To successfully awaken the humanistic values within the community and incorporate them into conservation endeavors, the conservation message with the name “mouse-deer”, “chevrotain”, or scientific name (Tragulus versicolor) is largely insufficient as they show an unfamiliar feeling. Therefore, we suggest calling the mouse-deer “cheo cheo”, a local name that can create familiarity and closeness, awaken the environmental conscience and humanistic values, and stimulate thinking and imagination. All these factors are essential for conservationists, scientists, and the government to support the community in building the eco-surplus culture. (shrink)

The recently extinct thylacine, endemic to Australia, has become a potent cultural icon in the state of Tasmania, with implications for Australian ecotourism and Tasmanian conservation strategies. While the thylacine's iconicity has been analyzed by naturalists and cultural historians, its significance in Tasmanian tourism has yet to be examined. Thylacine representations in tourism-related writings and images, because of their high degree of ambivalence, function as a rich site of conflicting values regarding national identity and native species protection. Drawing on (...) cultural studies of the thylacine and constructivist theories of tourism, this study identifies and documents three polarities in thylacine representation: the thylacine as wild yet domesticated, present yet absent, and an Australian national—yet distinctly regional—subject. A close reading of contradictory textual and visual elements in tourist guides, travel writing, specialized maps, and museum exhibits illuminates ongoing debates about Australian econationalism in the global tourism economy. (shrink)

Domestic violence is endemic across Latin America. It is legitimated by patriarchal Christian theologies and widespread gender inequality. Drawing on the work of women theologians and activists working in Argentina, Uruguay and elsewhere, this article explores women's networks of resistance against violence. These include public and legal acknowledgement of domestic violence; the transmission of life-affirming values; pastoral support in the denouncement of violence; and the development of open and fluid household structures.

Crisis is endemic to capitalism. But can it be proved that capitalism will bring about its own terminal crisis? This article frames this question in light of ongoing debates in theories of crisis and value by polemically comparing two related but divergent perspectives. The first, that of Robert Kurz and several Wertkritik authors, argues that cyclical crises of capital necessarily lead to a terminal crisis – and that this terminal crisis is already underway. The second, that of Michael Heinrich, (...) argues that there is no way to demonstrate that capital will not continue reinventing new sites and forms for creating surplus value. Through this comparison, this article achieves two aims: first, it establishes the general point that how we understand value determines how we understand crisis; and, second, it shows limitations of the ‘terminal crisis’ hypothesis, and concludes that Kurz’s terminal crisis theory risks making crisis a transhistorical concept. (shrink)

Alcoholism is endemic in Nigeria’s traditional religion and society. This abuse is especially common at New Yam festivals, Ekpe, Ekpo and Nmanwu masquerades festivals, burial rituals, birth, marriage and naming ceremonies. Some claim that this is driven by specific beliefs and activities in African culture, such as beliefs in ancestors, libation, hospitality and entertaining guests and strangers and the desire to maintain the cultural traditions of the ancestors. Alcohol abuse has generated major health and social issues for abusers, their (...) families and society, plunging families, towns and tribes into crises and conflicts that bring economic and political retrogression. This research studied how the African traditional religion encourages alcohol misuse and how to decrease it for national development. This study was on Nigeria’s South-South region. The study uses qualitative and ethnographic research methodologies, including key informants, in-depth and focus group interviews and the reward deficiency syndrome as a theoretical framework. Although African Traditional Religion (ATR) supports alcohol usage, greed, a lack of self-control, peer pressure, indiscipline and lack of moral upbringing led to alcohol misuse, which harms the person, family, community and country as a whole. Education and enlightenment are a remedy to free alcoholics and utilise them for national integration and development.Contribution: Some say Africans drink a lot because their religious heritage promotes drinking, leading to abuse. However, peer pressure, selfishness, a lack of self-control, bad parenting and not religion push persons with reward deficiency syndrome into alcoholism, according to this research. (shrink)

Confucian moral philosophy doesn't seem to provide a theory of excuses. I explore an explanatory hypothesis to explain how excuse conditions might be built into the Confucian doctrine of rectifying names. In the process, I address the issue of the motivation for the theory. The hypothesis is that the theory provides not only excuse conditions, but also exception and conflict resolution roles for an essentially positive morality rooted in the traditional code of 禮 li/ritual, transmitted from the ancient sage kings. (...) The relatively fixed content of this text-like moral code required aggressive interpretive leeway to cope with the problems endemic in rule deontological and etiquette-like normative schemes. (shrink)

In 2010, randomized controlled trials (RCTs) of two different biomedical strategies to prevent HIV infection had positive findings. However, despite ongoing very high levels of HIV infection in some countries and population groups, it has been made clear by regulatory authorities that the evidence remains insufficient to support either product being made available outside of research contexts in the developing world for at least two years. In addition, prevention trials in endemic areas will continue to test new interventions against (...) placebo. But the judgments of evidentiary standards are never value-neutral. Using the recent trials and their contexts as case studies, we examine the basis for these decisions, which will potentially delay access to scientific innovation to the people who are most urgently in need of it. (shrink)

Charles Taylor argues that recognition begins with the politics of "self-image," as groups represented in the past by others in ways harmful to their own identity replace negative historical self-images with positive ones of their own making. Given the centrality of "self image" to his politics of recognition, it is striking that Taylor, himself, represents disabled people in language that is both limiting and depreciating. The author argues such negative self-images are not unique to Taylor but endemic to modern (...) political thought from John Locke to John Rawls, as the disabled are constituted in direct opposition to the rational person and/or citizen. Using contemporary social theories of disability, as articulated by disabled scholars and advocates, the author concludes that such negative self-images must be purged from political theory and replaced with an alternative theory of personhood/citizenship rooted in the image of interdependency. (shrink)

Socialist republicans advocate public ownership and control of the means of production in order to achieve the republican goal of a society without endemic domination. While civic republicanism is often attacked for its conservatism, the relatively neglected radical history of the tradition shows how a republican form of socialism provides powerful conceptual resources to critique capitalism for leaving workers and citizens dominated. This analysis supports a programme of public ownership and economic democracy intended to reduce domination in the workplace (...) and wider society. I defend this socialist republicanism from both the Marxist objection that it overlooks the impersonal nature of domination under capitalism and the left-liberal objections that property-owning democracy or worker codetermination are sufficient to suppress dominating relationships. The resulting position identifies the need for more ambitious institutional grounds for republican liberty than is often supposed, while offering us a distinctive emancipatory justification for socialism. (shrink)

No one really knows where nanotechnology is leading, what its pursuit will mean, and how it may affect human and other forms of life. Nevertheless, its research and development are moving briskly into that unknown. It has been suggested that rapid movement towards 'who knows where' is endemic to all technological development; that its researchers pursue it for curiosity and enjoyment, without knowing the consequences, believing that their efforts will be beneficial. Further, that the enthusiasm for development comes with (...) no malicious intent but rather from simple ignorance. Contrary to that commonly held perception about the collective pursuit of technological development, there are individual research scientists and engineers who are quite willing to reflect on the meaning of their work in nanotechnology. Nanotalk is a book of conversations and explorations with thirty five such nano-research scientists and engineers who share their ideas, experiences, perceptions, and beliefs about their work, humanity, nature, change, and the future of the world with nanotechnology. Precisely because of the unknowable nature of nanotechnology research and development, conscientious foresight and ethical reflection are warranted every step of the way. Not only do nanotechnology research and development represent enormous financial commitments, but they also require a profound leap of faith regarding its possible outcomes. Using these conversations as the basis of reflection and deliberation, the author explores the possible significance of nanotechnology to humanity and how it might be pursued conscientiously and ethically. (shrink)

Effectiveness is a key criterion in assessing the justification of antibiotic resistance interventions. Depending on an intervention’s effectiveness, burdens and costs will be more or less justified, which is especially important for large scale population-level interventions with high running costs and pronounced risks to individuals in terms of wellbeing, integrity and autonomy. In this paper, we assess the case of routine hospital screening for multi-drug-resistant Gram-negative bacteria (MDRGN) from this perspective. Utilizing a comparison to screening programs for Methicillin-Resistant Staphylococcus aureus (...) (MRSA) we argue that current screening programmes for MDRGN in low endemic settings should be reconsidered, as its effectiveness is in doubt, while general downsides to screening programs remain. To accomplish justifiable antibiotic stewardship, MDRGN screening should not be viewed as a separate measure, but rather as part of a comprehensive approach. The program should be redesigned to focus on those at risk of developing symptomatic infections with MDRGN rather than merely detecting those colonised. (shrink)

The epistemology of risk examines how risks bear on epistemic properties. A common framework for examining the epistemology of risk holds that strength of evidential support is best modelled as numerical probability given the available evidence. In this essay I develop and motivate a rival ‘relevant alternatives’ framework for theorising about the epistemology of risk. I describe three loci for thinking about the epistemology of risk. The first locus concerns consequences of relying on a belief for action, where those consequences (...) are significant if the belief is false. The second locus concerns whether beliefs themselves—regardless of action—can be risky, costly, or harmful. The third locus concerns epistemic risks we confront as social epistemic agents. I aim to motivate the relevant alternatives framework as a fruitful approach to the epistemology of risk. I first articulate a ‘relevant alternatives’ model of the relationship between stakes, evidence, and action. I then employ the relevant alternatives framework to undermine the motivation for moral encroachment. Finally, I argue the relevant alternatives framework illuminates epistemic phenomena such as gaslighting, conspiracy theories, and crying wolf, and I draw on the framework to diagnose the undue skepticism endemic to rape accusations. (shrink)

The Frauchiger–Renner Paradox is an extension of paradoxes based on the “Problem of Measurement,” such as Schrödinger’s Cat and Wigner’s Friend. All these paradoxes stem from assuming that quantum theory has only unitary physical dynamics, and the attendant ambiguity about what counts as a ‘measurement’—i.e., the inability to account for the observation of determinate measurement outcomes from within the theory itself. This paper discusses a basic inconsistency arising in the FR scenario at a much earlier point than the derived contradiction: (...) namely, the inconsistency inherent in treating an improper mixture as a proper, epistemic mixture. This is an illegitimate procedure that is nevertheless endemic if quantum theory is assumed to be always unitary. In contrast, under a non-unitary account of quantum state reduction yielding determinate outcomes, the use of a proper mixture for measurement results becomes legitimate, and this entire class of paradoxes cannot be mounted. The conclusion is that the real lesson of the FR paradox is that it is the unitary-only assumption that needs to be critically reassessed. (shrink)

In recent years, the value-freeness of science has come under extensive critique. Early objectors to the notion of value-free science can be found in Rudner and Churchman, later objections occur in Leach and Gaa, and more recent critics are Kitcher, Douglas, and Elliott. The goal of this paper is to examine and critique two arguments opposed to the notion of a value-free science. The first argument, the uncertainty argument, cites the endemic uncertainty of science and concludes that values are (...) needed to give direction to scientific investigation. The second, or moral argument, cites the fact that scientists have moral obligations just like everyone else, and.. (shrink)

Background: Dengue Disease is a mosquito-borne tropical disease caused by the dengue virus, symptoms typically begin three to fourteen days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Dengue serology is applied in different settings, such as for surveillance, in health care facilities in endemic areas and in travel clinics in non-endemic areas. The applicability and quality of serological tests in dengue endemic regions has to be (...) judged against a background of potential cross reactivity with other flavi-viruses, difficulties in distinguishing primary from secondary infections and technological problems related to the fact that most dengue endemic regions are relatively poor of resources .Objectives: to help doctors and patients in diagnosing Dengue Disease and give them the information of how to prevent Dengue Disease and to be able to understand the signs and symptoms of Dengue Disease. Methods: We collected all relevant material for Dengue Disease. Then we designed and implemented a knowledge based system for diagnosing Dengue Disease using SL5 Object Language. Results: The knowledge based system was evaluated by a group of Patients and specialized doctors and they found it very friendly and easy to use. (shrink)

BackgroundThe consent process for a genetic study is challenging when the research is conducted in a group stigmatized because of beliefs that the disease is familial. Podoconiosis, also known as 'mossy foot', is an example of such a disease. It is a condition resulting in swelling of the lower legs among people exposed to red clay soil. It is a very stigmatizing problem in endemic areas of Ethiopia because of the widely held opinion that the disease runs in families (...) and is untreatable. The aim of this study was to explore the impact of social stigma on the process of obtaining consent for a study on the genetics of podoconiosis in Southern Ethiopia.MethodsWe adapted a rapid assessment tool validated in The Gambia. The methodology was qualitative involving focus-group discussions (n = 4) and in-depth interviews (n = 25) with community members, fieldworkers, researchers and staff of the Mossy Foot Treatment and Prevention Association (MFTPA) working on prevention and treatment of podoconiosis.ResultsWe found that patients were afraid of participation in a genetic study for fear the study might aggravate stigmatization by publicizing the familial nature of the disease. The MFTPA was also concerned that discussion about the familial nature of podoconiosis would disappoint patients and would threaten the trust they have in the organization. In addition, participants of the rapid assessment stressed that the genetic study should be approved at family level before prospective participants are approached for consent. Based on this feedback, we developed and implemented a consent process involving community consensus and education of fieldworkers, community members and health workers. In addition, we utilized the experience and established trust of the MFTPA to diminish the perceived risk.ConclusionThe study showed that the consent process developed based on issues highlighted in the rapid assessment facilitated recruitment of participants and increased their confidence that the genetic research would not fuel stigma. Therefore, investigators must seek to assess and address risks of research from prospective participants' perspectives. This involves understanding the issues in the society, the culture, community dialogues and developing a consent process that takes all these into consideration. (shrink)

This paper surveys the issue of relativistic causality within the framework of algebraic quantum field theory . In doing so, we distinguish various notions of causality formulated in the literature and study their relationships, and thereby we offer what we hope to be a useful taxonomy. We propose that the most direct expression of relativistic causality in AQFT is captured not by the spectrum condition but rather by the axiom of local primitive causality, in that it entails a form of (...) local determinism for quantum fields which generalizes the constraint of no superluminal propagation of classical field theories to relativistic quantum field theory. We discuss the status of the axiom of micro-causality by locating its place within a large family of separability/independence/locality conditions developed for AQFT and also by relating it to so-called no-signalling theorems. And we also provide a critical survey of attempts to understand the implications for relativistic causality of the distant correlations endemic to the states in models of AQFT satisfying the standard axioms, and we provide an assessment of attempts to employ Reichenbach's common cause principle in AQFT to defuse worries that these distant correlations implicate direct causal connections between relatively spacelike events. (shrink)

What is the relation between the material, conventional symbol structures that we encounter in the spoken and written word, and human thought? A common assumption, that structures a wide variety of otherwise competing views, is that the way in which these material, conventional symbol-structures do their work is by being translated into some kind of content-matching inner code. One alternative to this view is the tempting but thoroughly elusive idea that we somehow think in some natural language (such as English). (...) In the present treatment I explore a third option, which I shall call the "complementarity" view of language. According to this third view the actual symbol structures of a given language add cognitive value by complementing (without being replicated by) the more basic modes of operation and representation endemic to the biological brain. The "cognitive bonus" that language brings is, on this model, not to be cashed out either via the ultimately mysterious notion of "thinking in a given natural language" or via some process of exhaustive translation into another inner code. Instead, we should try to think in terms of a kind of coordination dynamics in which the forms and structures of a language qua material symbol system play a key and irreducible role. Understanding language as a complementary cognitive resource is, I argue, an important part of the much larger project (sometimes glossed in terms of the "extended mind") of understanding human cognition as essentially and multiply hybrid: as involving a complex interplay between internal biological resources and external non-biological resources. (shrink)

A Karger 'Publishing Highlights 1890-2015' title This 2nd, revised edition is still the reference work available in print and electronically on Paracelsus by the Paracelsus authority. Furthermore, it makes a very good read. See also Pagel's last book The Smiling Spleen on Paracelsianism as a historical phenomenon. '...a work in the brilliant tradition of biographical research... even the casual reader will be impressed to learn that, four centuries ago, the man who had the courage to burn in public the writings (...) of Avicenna, recognised pulmonary disease in miners as an occupational hazard, cretinism and goitre as endemic in certain areas, and chorea and hysteria as manifestations of disease, not demonic possession.' The Lancet. (shrink)