The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...) to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research. (shrink)

Alien species are considered by conservation biologists to be a major threat to biodiversity. To deal with alien invasions, they often recommend completely eradicating the invasive species. Animal rights groups have continually opposed eradication campaigns, sometimes successfully. One such case was the attempted eradication of the grey squirrel from northern Italy.

In 1980 grey-headed flying-foxes, a species now listed as "vulnerable to extinction," made camp at the Royal Botanic Gardens Melbourne (RBGM). In May 2000 the RBGM started to kill bats. The killing was halted when Humane Society International (HSI) filed for the bats’ protection under federal and state conservation laws. Over the next 13 months, conservationists, garden officials and scientists, politicians, animal activists, and others all played a part in a chain of events that demonstrates the tangled web of scientific (...) involvement in politics and how different views within the scientific community may lead to conflicting positions on conservation strategies. (shrink)