The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle transport from a protocoatomer complex. IFT thus shares common ancestry with (...) all protocoatomer derivatives, including all vesicle coats and the nuclear pore complex (NPC). This has major implications for the evolutionary origin of the cilium. First, it reinforces the tenet that duplication and divergence of pre-existing structures, rather than symbiosis, were the major themes during cilium evolution. Second, it suggests that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex. We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient. BioEssays 28: 191–198, 2006. © 2006 Wiley periodicals, Inc. (shrink)

An entirely different mechanism and localization were recently proposed for the COPII coat complex, challenging its well‐accepted function to select and concentrate cargo into small COPII‐coated spherical transport vesicles. Instead, the COPII complex is suggested to form a dynamic yet stationary collar that forms a boundary between the ER and the ER export membrane domain. This membrane domain, the ER exit site (ERES), is the site of COPII‐mediated sorting and concentration of transport competent proteins. Subsequently, the ERES is implicated (...) to mature and bud to form a sizeable pleiomorphic transport carrier that translocate on microtubules to fuse with the Golgi apparatus. Despite this drastic mechanistic dogma shift, most of the underlying protein‐protein and protein‐membrane interactions remain unchanged. Here, we attempt to provide a detailed description of the newly proposed model of how ER to Golgi transport works by describing the role of several essential proteins of the transport machinery. (shrink)

This book is an important study in the philosophy of the mind; drawing on the work of philosopher Wilfrid Sellars and the theory of critical realism to develop a novel argument for understanding perception and metaphysics.

According to a well-known argument, originally due to David Armstrong, powers theory is objectionable, as it leads to a ‘Meinongian’ ontology on which some entities are real but do not actually exist. I argue here that the right conclusion to draw from this argument has thus far not been identified and that doing so has significant implications for powers theory. Specifically, I argue that the key consequence of the argument is that it provides substantial grounds for trope powers theorists, but (...) not other powers theorists, to accept one version of the view that properties are powerful qualities. In particular, they have grounds to favour the view that powerful properties are properties with exclusively qualitative natures that ground modal facts. (shrink)

What is it to blame someone, and when are would-be blamers in a position to do so? What function does blame serve in our lives, and is it a valuable way of relating to one another? The essays in this volume explore answers to these and related questions.

History presents us with a unity which is also a plurality. Both materialism and idealism subordinate the plurality to the unity, interpreting the particular either in terms of racial and social laws, or in terms of a unitary Idea or Spirit; and both, when developed to their logical conclusion, lead to a denial of significance to individual personality. According to the opposite point of view ‘objective spirit’ and economic ‘laws’ are equally abstractions of an individual’s mind, whose existence as a (...) separately willing and experiencing self is prior and irresolvable. The problem is then to account for the unity of history in terms of individuals who are historically related but essentially separate. (shrink)

The issue of what distinguishes systems which have original intentionalityfrom those which do not has been brought into sharp focus by Saul Kripke inhis discussion of the sceptical paradox he attributes to Wittgenstein.In this paper I defend a sophisticated version of the dispositionalistaccount of meaning against the principal objection raised by Kripke in hisattack on dispositional views. I argue that the objection put by the sceptic,to the effect that the dispositionalist cannot give a satisfactory account ofnormativity and mistake, in fact (...) comprises a number of distinct lines ofargument, all of which can be satisfactorily answered by the dispositionalist.Two central problems raised by the sceptic consist in explaining (1) theextension of the term which a subject uses, and (2) the fact that the subjectintends to use the term with that extension, and is thus justified in her use.I adapt a suggestion of Blackburn's, that the extension of a word is fixed bya person's extended first-order dispositions to use it, and suggest that thereis no coherent possibility of a subject being disposed to makesystematic mistakes in connection with many ordinary words; the scepticalproblem does not apply in the same way throughout language. It is furtherargued that an account which appeals to a subject's second-orderdispositions to maintain a consistent pattern of extended first-orderdispositions to use words is able to provide a naturalistic basis to answerthe normative questions about justification of use. Three other variants ofthe mistake objection which are also revealed by a careful examination ofKripke's arguments are distinguished and it is shown that the dispositionalisthas adequate resources to meet them.The appeal to second-order dispositions provides a principled way ofdistinguishing between those systems (animal or machine) which have originalintentionality, and those which do not. (shrink)

In this paper I introduce and critically examine a paradox about perceiving that is in some ways analogous to the paradox about meaning which Kripke puts forward in his exegesis of Wittgenstein's views on Rule-following. When applied to vision, the paradox of perceiving raises a metaphysical scepticism about which object a person is seeing if he looks, for example, at an apple on a tree directly in front of him. Physical objects can be seen when their appearance is distorted in (...) various ways by illusions. The question therefore arises as to how can we answer the sceptic who suggests the following: although the viewer appears to be seeing the green apple in front of him, he is actually suffering a bizarre illusion of a blue car situated somewhere behind him. The sceptic is not concerned with epistemic problems about how we know which object, if any, the subject is seeing; the sceptic is raising the more fundamental question: whatfact of the matter underlies a person's perceptual relation to the physical world, in virtue of which that person may be justified in arriving at a perceptual belief about the environment? Among the various different issues raised by the sceptic, I focus on the question: what determines the perceiving relation? I canvass a number of possible proposals in answer to it, concentrating mainly on two opposed accounts: the Disjunctive View and the Causal Theory of Perception. I argue in particular for the following two claims: that the paradox highlights the fact that the Disjunctive View fails to provide a coherent positive account of what perceiving is. that the problem of 'deviant causal chains', often thought to raise particular difficulties for the Causal theorist, can also be raised against other accounts of perception, including versions of the Disjunctive View. I conclude that unless the Causal Theory of Perception can be upheld, there will be no way of answering the sceptic. (shrink)

According to a well-known argument against dispositional essentialism, the nature of unmanifested token powers leaves dispositional essentialists with an objectionable commitment to the reality of non-existent entities. The idea is that, because unmanifested token powers are directed at their non-existent token manifestations, they require the reality of those manifestations. Arguably the most promising response to this argument works by claiming that, if properties are universals, dispositional directedness need only entail the reality of actually existing manifestation types. I argue that this (...) response fails, because no version of the response can adequately accommodate dispositions of the sort that follow from Coulomb’s law. This result both defeats an important argument that dispositional essentialists ought to be realists about universals and appears to leave dispositional essentialists with a problematic commitment to either non-relational connections or a Meinongian ontology. (shrink)

In this paper I introduce and critically examine a paradox about perceiving that is in some ways analogous to the paradox about meaning which Kripke puts forward in his exegesis of Wittgenstein's views on Rule-following. When applied to vision, the paradox of perceiving raises a metaphysical scepticism about which object a person is seeing if he looks, for example, at an apple on a tree directly in front of him. Physical objects can be seen when their appearance is distorted in (...) various ways by illusions. The question therefore arises as to how can we answer the sceptic who suggests the following: although the viewer appears to be seeing the green apple in front of him, he is actually suffering a bizarre illusion of a blue car situated somewhere behind him. The sceptic is not concerned with epistemic problems about how we know which object, if any, the subject is seeing; the sceptic is raising the more fundamental question: whatfact of the matter underlies a person's perceptual relation to the physical world, in virtue of which that person may be justified in arriving at a perceptual belief about the environment? Among the various different issues raised by the sceptic, I focus on the question: what determines the perceiving relation? I canvass a number of possible proposals in answer to it, concentrating mainly on two opposed accounts: the Disjunctive View and the Causal Theory of Perception. I argue in particular for the following two claims: that the paradox highlights the fact that the Disjunctive View fails to provide a coherent positive account of what perceiving is. that the problem of 'deviant causal chains', often thought to raise particular difficulties for the Causal theorist, can also be raised against other accounts of perception, including versions of the Disjunctive View. I conclude that unless the Causal Theory of Perception can be upheld, there will be no way of answering the sceptic. (shrink)

The intent of the exploration is not an attempt to uncover Oakeshott's intellectual influences, but rather to show the importance and coherence of Oakeshott's various themes by showing how they modify, amplify, and contrast with similar and related themes in the thought of seven better known thinkers - Montaigne, St. Augustine, Hegel, Hobbes, Benjamin Constant, Rousseau, and Hume."--BOOK JACKET.

There has been increased attention on how scientific communities should respond to spurious dissent. One proposed method is to hide such dissent by preventing its publication. To investigate this, I computationally model the epistemic effects of hiding dissenting evidence on scientific communities. I find that it is typically epistemically harmful to hide dissent, even when there exists an agent purposefully producing biased dissent. However, hiding dissent also allows for quicker correct epistemic consensus among scientists. Quicker consensus may be important when (...) policy decisions must be made quickly, such as during a pandemic, suggesting times when hiding dissent may be useful. (shrink)

The article re-examines the relationship between the works of Alfred Schütz and Harold Garfinkel, focusing on their respective approaches to temporality in interaction. Although there are good reasons to emphasize the differences between Schütz’s notion of individual projects of action and Garfinkel’s interest in communicative sequencing, there is also an interesting historical connection. In order to elucidate this connection, the article provides a close reading of the steps that lead Schütz from his premise of ‘egological’ time consciousness to his understanding (...) of the reflexive and interactive process of meaning establishment and interpretation developed in his first book, _The Phenomenology of the Social World_ (1967 [1932]). The article reflects further upon which aspects of Schütz’s considerations resonated with Garfinkel in his formative years and how Garfinkel related to them variously in his later development of ethnomethodology. Hence, it appears that Garfinkel’s ethnomethodology successively departs from many of Schütz’s premises while simultaneously incorporating and further developing some of his notions on the sequential organization and temporal flux of interactive processes. (shrink)

The following abstracts were selected by AJOB-Neuroscience judges as the best submitted to the International Neuroethics Society 2021 Annual Meeting.

In this paper we discuss studies that show that most people do not find determinism to be incompatible with free will and moral responsibility if determinism is described in a way that does not suggest mechanistic reductionism. However, if determinism is described in a way that suggests reductionism, that leads people to interpret it as threatening to free will and responsibility. We discuss the implications of these results for the philosophical debates about free will, moral responsibility, and determinism.

The problem of the richness of visual experience is that of finding principled grounds for claims about how much of the world a person actually sees at any given moment. It is argued that there are suggestive parallels between the two-component analysis of experience defended by Wilfrid Sellars, and certain recently advanced information processing accounts of visual perception. Sellars' later account of experience is examined in detail, and it is argued that there are good reasons in support of the claim (...) that the sensory nonconceptual content of experience can vary independently of conceptual awareness. It is argued that the Sellarsian analysis is not undermined by recent work on change blindness and related phenomena; a model of visual experience developed by Ronald Rensink is shown to be in essential harmony with the framework provided by Sellars, and provides a satisfactory answer to the problem of the richness of visual experience. (shrink)

Robert Brandom makes several mistakes in his discussion of Sellars's "Two-Ply" account of observation. Brandom does not recognize the difference in "level" between observation reports concerning physical objects and 'looks'-statements. He also denies that 'looks'-statements are reports or even make claims. They then demonstrate a more correct reading of Sellars on 'looks'-statements.

The question in philosophy of whether History is a Science is rather like the question in Politics of the expediency of a Channel Tunnel: it is one which provides a perennial subject for debate, there is no indication that it will ever be decided one way or the other, and it does not after all seem to matter much even if it never is decided; we can get along well enough by neglecting it altogether. One might argue indeed that the (...) dispute is not much more than a matter of words, of the intension and extension of terms. It is evident that the method and aim of the historian differ widely from those of the physicist, and on the other hand resemble closely those of the geologist. Why trouble to go splitting hairs? (shrink)

Last year the B.B.C. arranged for certain eminent men to broadcast their Points of View to the public. The result was a most interesting series of talks; but for the sceptical philosopher the series was chiefly entertaining for its brilliantly illustrating the old tag: quot homines, tot sententiæ. One was struck not merely by the discrepancy of opinion, but by how each speaker was ‘true to type': the biologist, the physicist with a taste for spiritualism, the Christian Platonist, and the (...) rest—each spoke his part and told of a world built according to his own particular measuring-rod. (shrink)

If one takes a course in philosophy to-day at a British university, a discreet silence is usually observed about existentialism. Often the professors understand little of its methods or its doctrine. If their excuse in part is the inaccessibility in English of standard existentialist texts, it is true also that philosophers trained in the “critical philosophy” now in vogue feel a certain aversion to existentialism or, at all events, to the notion they have formed of it. If Christianity was a (...) scandal to the Greeks and remains a scandal, as Dr. Brunner has recently told us, to contemporary humanists, existentialism is a scandal to the positivists. The latter are aware that the existentialists habitually trespass in the fields of religion, ethics, aesthetics and psychology, fields which, on the positivist view, should be reserved to other disciplines than philosophy, which has its own distinctive subject-matter and approach. They know that certain existentialists, notably Heidegger, provide a happy hunting ground for examples of “metaphysics.” They have heard that existentialism has sought to turn the tables on positivism by accusing it, if not of metaphysics, at all events of a barrenness of significant content, of a preoccupation with mere logistics which removes philosophy completely from men's business and bosoms. If the positivist accuses the existentialist of perpetrating “nonsense” in a technical sense, the latter retorts by accusing the positivist of reducing philosophy to nonsense in a pragmatic sense. (shrink)

If the end of metaphysics is not upon us, then phenomenology must be at an end instead. Or so we are told, at least, by the “new realists,” or at least by some of the thinkers I’ll refer to using this term. And why shouldn’t we agree with them? If there’s anything at all to be said for the line of thinking that they advance, then today, we are at long last licensed to speak about beings once again; but apparently, (...) phenomenology deals only with consciousness, which we must admit—assuming we have a realist bone in our bodies—does not determine beings themselves at all. To persist with the phenomenological method, rather, would be to block all progress in philosophy—or so, again, some of these “new realists” will... (shrink)

This paper examines the ethics of using assistive technology such as video surveillance in the homes of people living with dementia. Ideation and concept elaboration around the introduction of a camera-based surveillance service in the homes of people with dementia, typically living alone, is explored. The paper reviews relevant literature on surveillance of people living with dementia, and summarises the findings from ideation and concept elaboration workshops, designed to capture the views of those involved in the care of people living (...) with dementia at home. The research question relates to the ethical considerations of using assistive technologies that include video surveillance in the homes of people living with dementia, and the implications for a person living with dementia whenever video surveillance is used in their home and access to the camera is given to the person’s family. The review of related work indicated that such video surveillance may result in loss of autonomy or freedom for the person with dementia. The workshops reflected the findings from the related work, and revealed useful information to inform the service design, in particular in fine-tuning the service to find the best relationship between privacy and usefulness. Those who took part in the workshops supported the concept of the use of camera in the homes of people living with dementia, with some significant caveats around privacy. The research carried out in this work is small in scale but points towards an acceptance by many caregivers of people living with dementia of surveillance technologies. This paper indicates that those who care for people living with dementia at home are willing to make use of camera technology and therefore the value of this work is to help shed light on the direction for future research. (shrink)

The Ockhamist claims that our ability to do otherwise is not endangered by God’s foreknowledge because facts about God’s past beliefs regarding future contingents are soft facts about the past—i.e., temporally relational facts that depend in some sense on what happens in the future. But if our freedom, given God’s foreknowledge, requires altering some fact about the past that is clearly a hard fact, then Ockhamism fails even if facts about God’s past beliefs are soft. Recent opponents of Ockhamism, including (...) David Widerker and Peter van Inwagen, have argued along precisely these lines. Their arguments, if successful, would undermine Ockhamism while avoiding the controversy over the alleged softness of facts about God’s past beliefs. But these arguments do not succeed. The past facts they rely on must be clear and uncontroversial examples of hard facts about the past, and these facts must be such that an ability to refrain from the relevant future action implies an ability to alter the relevant hard fact. We demonstrate the flaw in these arguments by showing how they rely on past facts that do not satisfy these criteria. The Ockhamist may have troubles, but this type of argument is not one of them. (shrink)

According to the powerful qualities view, properties are both powerful and qualitative. Indeed, on this view the powerfulness of a property is identical to its qualitativity. Proponents claim that this view provides an attractive alternative to both the view that properties are pure powers and the view that they are pure qualities. It remains unclear, however, whether the claimed identity between powerfulness and qualitativity can be made coherent in a way that allows the powerful qualities view to constitute this sort (...) of alternative. I argue here that this can be done, given a particular conception of both the qualitativity and powerfulness of properties. On this conception, a property is qualitative just in the sense that its essence is fixed independently of any distinct properties, and it is powerful just if its essence grounds its dispositional role. (shrink)

Epistemic akrasia arises when one holds a belief even though one judges it to be irrational or unjustified. While there is some debate about whether epistemic akrasia is possible, this paper will assume for the sake of argument that it is in order to consider whether it can be rational. The paper will show that it can. More precisely, cases can arise in which both the belief one judges to be irrational and one’s judgment of it are epistemically rational in (...) the sense that both are supported by sufficient evidence. (shrink)

This is the first chapter to our edited collection of essays on the nature and ethics of blame. In this chapter we introduce the reader to contemporary discussions about blame and its relationship to other issues (e.g. free will and moral responsibility), and we situate the essays in this volume with respect to those discussions.

Blame is usually discussed in the context of the free will problem, but recently moral philosophers have begun to examine it on its own terms. If, as many suppose, free will is to be understood as the control relevant to moral responsibility, and moral responsibility is to be understood in terms of whether blame is appropriate, then an independent inquiry into the nature and ethics of blame will be essential to solving (and, perhaps, even fully understanding) the free will problem. (...) In this article we first survey and categorize recent accounts of the nature of blame – is it action, belief, emotion, desire, or something else? – and then we look at several proposed requirements on appropriate blame that look beyond the transgressor himself, considerations that will form part of a full account of the ethics of blame. (shrink)

Ordinarily, we take moral responsibility to come in degrees. Despite this commonplace, theories of moral responsibility have focused on the minimum threshold conditions under which agents are morally responsible. But this cannot account for our practices of holding agents to be more or less responsible. In this paper we remedy this omission. More specifically, we extend an account of reasons-responsiveness due to John Martin Fischer and Mark Ravizza according to which an agent is morally responsible only if she is appropriately (...) receptive to and reactive to reasons for action. Building on this, we claim that the degree to which an agent is responsible will depend on the degree to which she is able to recognize and react to reasons. To analyze this, we appeal to relations of comparative similarity between possible worlds, arguing that the degree to which an agent is reasons-reactive depends on the nearest possible world in which given sufficient reason to do otherwise, she does so. Similarly, we argue that the degree to which an agent is reasons-receptive will depend on the intelligibility of her patterned recognition of reasons. By extending an account of reasons-responsiveness in these ways, we are able to rationalize our practice of judging people to be more or less responsible. (shrink)

Background Escalating levels of obesity place enormous and growing demands on Health care provision in the (U.K.) United Kingdom. Resources are limited with increasing and competing demands upon them. Ethical considerations underpin clinical decision making generally, but there is limited evidence regarding the relationship between these variables particularly in terms of treating individuals with obesity. Research aim To investigate the views of National Health Service (NHS) clinicians on navigating the ethical challenges and decision making associated with obesity management in adults (...) with chronic illness. Research design A cross-sectional, multi-site survey distributed electronically. Participants A consensus sample of nurses, doctors, dietitians and final year students in two NHS Trusts and two Universities. Ethical considerations Ethical and governance approvals obtained from a National Ethics Committee (11NIR035), two universities and two teaching hospitals. Results Of the total ( n = 395) participants, the majority were nurses (48%), female (79%) and qualified clinicians (59%). Participants strongly considered the individual to have primary responsibility for a healthy weight and an obligation to attempt to maintain that healthy weight if they wish to access NHS care. Yet two thirds would not withhold treatment for patients with obesity. Discussion While clinicians were clear about patient responsibility and obligations, the majority prioritised their duty of care and would not invoke a utilitarian approach to decision making. This may reflect awareness of obesity as a multi-faceted entity, with responsibility for support and management shared amongst society in general. Conclusions The attitudes of this sample of clinicians complemented the concept of the health service as being built on a principle of community, with each treated according to their need. However limited resources challenge the concept of needs-based decisions consequently societal engagement is necessary to agree a pragmatic way forward. (shrink)

In this entry we provide a critical review of recent work on the nature and ethics of blame, including issues of moral standing.

Drawing on examples from the history of warfare from the crusades to the present day, "The ethics of war" explores the limits and possibilities of the moral regulation of war. While resisting the commonly held view that 'war is hell', A.J. Coates focuses on the tensions which exist between war and morality. The argument is conducted from a just war standpoint, though the moral ambiguity and mixed record of that tradition is acknowledge and the dangers which an exaggerated view of (...) the justice or moral worth of war poses are underlined. In the first part, the broad image of the just war is compared with the competing images of realism, militarism and pacifism. In the second part, the moral issues associated both with the decision to go to war and with the manner in which war is conducted are explored. Was the allied decision to go to war in the Gulf premature? were economic sanctions a more effective and morally preferable option? was Britain justified in going to war over the Falklands? did the allied bombing of Germany in the Second World War constitute a war crime? should the IRA's claim to belligerent status be recognised? these questions and more are raised in this important book. (shrink)

Discussions about the nature of essence and about the inference problem for non-Humean theories of nomic modality have largely proceeded independently of each other. In this article I argue that the right conclusions to draw about the inference problem actually depend significantly on how best to understand the nature of essence. In particular, I argue that this conclusion holds for the version of the inference problem developed and defended by Alexander Bird. I argue that Bird’s own argument that this problem (...) is fatal for David Armstrong’s influential theory of the laws of nature but not for dispositional essentialism is seriously flawed. In place of this argument, I develop an argument that whether Bird’s inference problem raises serious difficulties for Armstrong’s theory depends on the answers to substantial questions about how best to understand essence. The key consequence is that considerations about the nature of essence have significant, underappreciated implications for Armstrong’s theory. (shrink)

Blame is usually discussed in the context of the free will problem, but recently moral philosophers have begun to examine it on its own terms. If, as many suppose, free will is to be understood as the control relevant to moral responsibility, and moral responsibility is to be understood in terms of whether blame is appropriate, then an independent inquiry into the nature and ethics of blame will be essential to solving (and, perhaps, even fully understanding) the free will problem. (...) In this article we first survey and categorize recent accounts of the nature of blame – is it action, belief, emotion, desire, or something else? – and then we look at several proposed requirements on appropriate blame that look beyond the transgressor himself, considerations that will form part of a full account of the ethics of blame. (shrink)