Intradermal capsaicin in humans causes pain, primary hyperalgesia, and secondary mechanical hyperalgesia and allodynia. Parallel changes occur in the responses of primate spinothalamic tract cells and in rat behavior. Neurotransmitters that trigger secondary mechanical hyperalgesia and allodynia include excitatory amino acids and substance P. Secondary mechanical allodynia is actively maintained by central mechanisms. Our group has investigated mechanisms of central sensitization of nociceptive neurons by examining the responses to intradermal injection of capsaicin. These experiments are pertinent to (...) issues raised by coderre & katz (sect. 2). (shrink)

Journal of Philosophy of Education, Volume 56, Issue 2, Page 342-355, April 2022.

PurposeThe purpose of this paper is to develop a critique of value sensitive design (VSD) and to propose an alternative approach that does not depart from a heuristic of value(s), but from virtue ethics, called virtuous practice design (VPD).Design/methodology/approachThis paper develops a philosophical argument, draws from a philosophical method (i.e. virtue ethics) and applies this method to a particular case study that draws from a narrative interview.FindingsIn this paper, authors show how an approach that takes virtue instead of value as (...) the central notion for aiming at a design that is sensitive to ethical concerns can be fruitful both in theory and in practice.Originality/valueThis paper presents the first attempt to ground an approach aimed at ethical technology design on the tradition of virtue ethics. As such, it presents VPD as a potentially fruitful alternative to VSD. (shrink)

Psychologists and philosophers who pose moral dilemmas to understand moral judgment typically specify outcomes as certain to occur in them. This contrasts with real-life moral decision-making, which is almost always infused with probabilities (e.g., the probability of a given outcome if an action is or is not taken). Seven studies examine sensitivity to the size and location of shifts in probabilities of outcomes that would result from action in moral dilemmas. We find that moral judgments differ between actions that result (...) in an equal increase in probability of harm (equal size), but have different end-states (e.g., an increase in harm probability from 25% to 50% or from 50% to 75%). This deviation from expected value is robust under separate evaluation, and increases when the comparison between shifts is made explicit under simultaneous evaluation. Consistent with the centrality of perceived harm in some models of moral judgment, perceived harm partially mediates sensitivity to location of harm probability shift. Unlike for shifts in harm probabilities, participants are insensitive to the location of shifts in probability of beneficial outcomes. They are also insensitive to the location of shifts in probability of analogous monetary losses and gains, suggesting an asymmetry between harm and benefit in moral reasoning, as well as an asymmetry between moral and monetary decision-making more broadly. Implications for normative philosophical theory and moral psychological theory, as well as practical applications, are discussed. (shrink)

This article considers the foundation of nursing as a moral practice. Its basic claim is that all nursing knowledge and action reside on a moral foundation. The clinical gaze meets vulnerability in the patient’s human condition. To see a patient’s wound is to see his or her hurt and discomfort; it is a concerned observation. To see the factual and pathophysiological is at the same time to see the ethical: the moral realities of suffering, pain and discomfort. A nurse’s emotional (...) sensitivities are central to understanding a patient’s experiences of illness. Emotions reveal value and ascribe moral importance to certain situations; they are addressed centrally by vulnerability and the moral realities of illness. Hence, the essence of nursing knowledge and nursing performance cannot be understood merely as ontology (i.e. as being-with-the-other). Nursing is basically being-for-the-other; it is responsibility; it is ethics. (shrink)

Central sensitization and related neurochemical mechanisms are also induced in V nociceptive pathways after craniofacial injury or inflammation. Their characteristics raise additional possibilities that may explain some of the phenomena outlined by coderre & katz, dickenson, and wiesenfeld-hallin et al. They also underscore the need for therapeutic approaches to reduce nociceptive inputs to the CNS or their neuroplastic effects which can potentially enhance post-traumatic pain.

Is there a plausible argument for external world skepticism? Robert Nozick’s well-known discussion focuses upon arguments which utilize the Sensitivity Requirement and the Closure Principle. Nozick claims, correctly, that no such argument succeeds. But he gets almost all the details wrong. The Sensitivity Requirement and the Closure Principle are compatible; the Sensitivity Requirement is incorrect; and even if true, the Closure Principle is structurally incapable of generating a plausible and valid global skeptical argument. It is therefore a mistake to take (...) the Closure Principle as central in discussions of skepticism. The paper concludes by examining the prospects for a plausible skeptical argument. (shrink)

Safe-by-Design (SBD) frameworks for the development of emerging technologies have become an ever more popular means by which scholars argue that transformative emerging technologies can safely incorporate human values. One such popular SBD methodology is called Value Sensitive Design (VSD). A central tenet of this design methodology is to investigate stakeholder values and design those values into technologies during early stage research and development (R&D). To accomplish this, the VSD framework mandates that designers consult the philosophical and ethical literature (...) to best determine how to weigh moral trade-offs. However, the VSD framework also concedes the universalism of moral values, particularly the values of freedom, autonomy, equality trust and privacy justice. This paper argues that the VSD methodology, particularly applied to nano-bio-info-cogno (NBIC) technologies, has an insufficient grounding for the determination of moral values. As such, an exploration of the value-investigations of VSD are deconstructed to illustrate both its strengths and weaknesses. This paper also provides possible modalities for the strengthening of the VSD methodology, particularly through the application of moral imagination and how moral imagination exceed the boundaries of moral intuitions in the development of novel technologies. (shrink)

Offering a solution to the skeptical puzzle is a central aim of Nozick's sensitivity account of knowledge. It is well-known that this account faces serious problems. However, because of its simplicity and its explanatory power, the sensitivity principle has remained attractive and has been subject to numerous modifications, leading to a of sensitivity accounts. I will object to these accounts, arguing that sensitivity accounts of knowledge face two problems. First, they deliver a far too heterogeneous picture of higher-level beliefs (...) about the truth or falsity of one's own beliefs. Second, this problem carries over to bootstrapping and Moorean reasoning. Some beliefs formed via bootstrapping or Moorean reasoning are insensitive, but some closely related beliefs in even stronger propositions are sensitive. These heterogeneous results regarding sensitivity do not fit with our intuitions about bootstrapping and Moorean reasoning. Thus, neither Nozick's sensitivity account of knowledge nor any of its modified versions can provide the basis for an argument that bootstrapping and Moorean reasoning are flawed or for an explanation why they seem to be flawed. (shrink)

Evidence that central sensitization needs to be maintained in an ongoing manner by nociceptive input from the periphery makes the peripheral drive, rather than the central amplification process, the highest priority target for understanding and control. To stop the peripheral drives to kill two birds with one stone. Moreover, the amplification that central sensitization does provide is selective and not necessarily striking in intensity. A that neutralized central sensitization would probably be less effective (...) in controlling persistent pain than many investigators would like to believe. [berkley; blumberg et al.; coderre & katz; dickenson; mcmahon; weisenfeld-hallin et al.]. (shrink)

An overarching aim of education is the promotion of children's personal well-being. Liberal educationalists also support the promotion of children's personal autonomy as a central educational aim. On some views, such as John White's, these two goals—furthering well-being and cultivating autonomy—can come apart. Our primary aim in this paper is to argue for a species of a stronger view: assuming preferentism as our axiology, we suggest that there is an essential association between the autonomy of our springs of action, (...) such as desires and beliefs, on the one hand, and personal well-being, on the other. If we are right about this link, then we have at our disposal a partial (non-instrumental) validation of the liberal ideal of autonomy. (shrink)

An overarching aim of education is the promotion of children’s personal well-being. Liberal educationalists also support the promotion of children’s personal autonomy as a central educational aim. On some views, such as John White’s, these two goals—furthering well-being and cultivating autonomy—can come apart. Our primary aim in this paper is to argue for a species of a stronger view: assuming preferentism as our axiology, we suggest that there is an essential association between the autonomy of our springs of action, (...) such as desires and beliefs, on the one hand, and personal well-being, on the other. If we are right about this link, then we have at our disposal a partial (non-instrumental) validation of the liberal ideal of autonomy. (shrink)

ABSTRACTThis article defends the importance of epistemic safety for legal evidence. Drawing on discussions of sensitivity and safety in epistemology, the article explores how similar considerations apply to legal proof. In the legal context, sensitivity concerns whether a factual finding would be made if it were false, and safety concerns how easily a factual finding could be false. The article critiques recent claims about the importance of sensitivity for the law of evidence. In particular, this critique argues that sensitivity does (...) not have much of an effect on the value of legal evidence and that it fails to explain legal doctrine. By contrast, safety affects the quality of legal evidence, and safety better explains central features of the law of evidence, including probative value, admissibility rules, and standards of proof. (shrink)

Aristotle in the central chapters of his Sophistical Refutations gives advice on how to counter unfair argumentation by similar means, all the while taking account not only of the adversary's arguments in themselves, but also of his philosophical commitments and state of mind, as well as the impression produced on the audience. This has offended commentators, and made most of them, medieval and modern alike, pass lightly over the relevant passages. A commentary that received the last touch in the (...) very early 13th century is more perceptive because, it is argued, the commentator had lived in a 12th-century environment of competing Parisian schools that was in important respects similar to the one of Aristotle's Athens. (shrink)

Most contemporary philosophers accept Kant's view1 that the central question of morality is what ought I to do. This gives choice a pivotal role, for choice is what one faces when the question has to be answered. Since what is chosen is an action, this view of morality—I shall call it the current view —is action-orientated. And since actions are directed towards people, the current view stresses altruism and universalizability. Morality is thus supposed to be activist and social. It (...) is a sensible, public-spirited enterprise in which responsible members of society will participate because they realize that reason requires it. Kantians, Utilitarians, Contractarians, and Marxists disagree, of course, about the nature of the relation between reason and morality. But they agree that choice intending to lead to action contributing to the welfare of others is the central concern of morality. (shrink)

This paper concerns Philippe Van Parijs’s case for an unconditional basic income. It argues that given central egalitarian commitments-to wit, (i) equal concern and respect; (ii) endowment-insensitivity (which can be seen to include Van Parijs’s project of maximizing or leximinning real freedom); (iii) ambition-sensitivity; and (iv) neutrality-endorsed by Van Parijs, a basic income does not appear to be a requirement of justice. The core claim defended is that there is a serious tension between (iii) and the idea of an (...) unconditional basic income. (shrink)

Safe-by-Design (SBD) frameworks for the development of emerging technologies have become an ever more popular means by which scholars argue that transformative emerging technologies can safely incorporate human values. One such popular SBD methodology is called Value Sensitive Design (VSD). A central tenet of this design methodology is to investigate stakeholder values and design those values into technologies during early stage research and development (R&D). To accomplish this, the VSD framework mandates that designers consult the philosophical and ethical literature (...) to best determine how to weigh moral trade-offs. However, the VSD framework also concedes the universalism of moral values, particularly the values of freedom, autonomy, equality trust and privacy justice. This paper argues that the VSD methodology, particularly applied to nano-bio-info-cogno (NBIC) technologies, has an insufficient grounding for the determination of moral values. As such, an exploration of the value-investigations of VSD are deconstructed to illustrate both its strengths and weaknesses. This paper also provides possible modalities for the strengthening of the VSD methodology, particularly through the application of moral imagination and how moral imagination exceed the boundaries of moral intuitions in the development of novel technologies. (shrink)

Introduction to Context-Sensitivity and Semantic Minimalism: Essays on Semantics and Pragmatics, 2007, Oxford University Press, (eds. Preyer and Peter).

Background: Clinical tests for detecting central and peripheral shoulder fatigue are limited. The discrimination of these two types of fatigue is necessary to better adapt recovery intervention. The Kinematic Theory of Rapid Human Movements describes the neuromotor impulse response using lognormal functions and has many applications in pathology detection. The ideal motor control is modeled and a change in the neuromuscular system is reflected in parameters extracted according to this theory. Objective: The objective of this study was to assess (...) whether a shoulder neuromuscular fatigue could be detected through parameters describing the theory, if there is the possibility to discriminate central from peripheral fatigue, and which handwriting test gives the most relevant information on fatigue. Methods: Twenty healthy participants performed two sessions of fast stroke handwriting on a tablet, before and after a shoulder fatigue. The fatigue was in internal rotation for one session and in external rotation during the other session. The drawings consisted of simple strokes, triangles, horizontal and vertical oscillations. Parameters of these strokes were extracted according to the Sigma-Lognormal model of the Kinematic Theory. The evolution of each participant was analyzed through a U-Mann-Whitney test for individual comparisons. A Hotelling’s T² test and a U-Mann-Whitney test were also performed on all participants to assess the group evolution after fatigue. Moreover, a correlation among parameters was calculated through Spearman coefficients to assess intrinsic parameters properties of each handwriting test. Results: Central and peripheral parameters were statistically different before and after fatigue with a possibility to discriminate them. Participants had various responses to fatigue. However, when considering the group, parameters related to the motor program execution showed significant increase in the handwriting tests after shoulder fatigue. The test of simple strokes permits to know more specifically where the fatigue comes from, whereas the oscillations tests were the most sensitive to fatigue. Conclusion: The results of this study suggest that the Sigma-Lognormal model of the Kinematic Theory is an innovative approach for fatigue detection with discrimination between the central and peripheral systems. Overall, there is a possibility to implement the setting for clinics and sports personalized follow-up. (shrink)

In the face of environmental crises such as climate change, pollution and biodiversity loss—which all adversely impact on health—Gils-Schmidt and Salloch explore whether physicians can be justified in taking climate issues into account in clinical care.1 While their approach centres on the ‘climate-sensitive’ decisions, physicians can carry out on the micro-level of clinical decision-making, they encourage further discussions on how climate-related issues can be included across different levels of decision-making in healthcare. We propose a list of tasks and a model (...) to assist with navigating the range of factors and structural elements an environmentally sensitive ethics must address. Stephen Gardiner’s notion of a perfect moral storm is central to understanding these issues.2 Gardiner describes how a perfect moral storm occurs in the centre of three overlapping conditions for human action and policymaking in the face of climate change. This storm is driven by: (1) a lack of interest among current generations to meet global needs and accommodate the well-being of future generations, (2) a lack of ecological concerns for other parts of nature than humans and (3) weak ethical and political theories and institutions shaping policy decisions on issues with severe implications across borders and generations. Moreover, these conditions are embedded in the existing, complex world of ethically unjustified power imbalances and social injustice. The growing awareness of healthcare’s climate footprint has amplified and accelerated global, grassroots action to make healthcare more environmentally friendly. This includes incorporating environmental impacts into quality improvement methodologies, building communities of practice to explore how to make …. (shrink)

An educated healthcare professional or student is sensitive and able to make good judgements, understanding existential challenging issues. It is argued that the ideas within phenomenology and hermeneutics can function as a basis for comprehension. This article focuses on how choice of perspective and knowledge is of importance to what we do in practice. However, education does not consist of mere accumulation of knowledge and ways of explanation. We do not become competent practitioners by being able to reproduce philosophical ideas. (...) These are merely perspectives by means of which we can seek to go beyond what we take for granted, or what we assume to know, thus enabling us to take a new direction understanding problems and issues that until now may have been hidden to us. In other words, understanding is of an existential character, whereas an observing healthcare professional must be aware and open to the mental aspects of life. It is therefore important to attune ourselves to being sensitive to and aware of experiences from our lifeworld, understanding what they imply. It is argued that literature provides insight into human nature through the written depiction of real or imagined experiences. To develop such narrative imagination, it is suggested that literature should be part of the curriculum of various educations. This is relevant to healthcare professionals who thereby can get an important insight into human nature and begin to develop the self‐awareness and sensitivity to others that is so central to care. (shrink)

This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think of central sensitization as comprised of both an initial central sensitization and an ongoing central (...) class='Hi'>sensitization driven by inputs from peripheral sources. Each of these factors, initial sensitization, ongoing central sensitization, and inputs from peripheral sources, contributes to the net activity in dorsal horn neurons and thus influences the expression of persistent pain or hyperalgesia. Since each factor, peripheral inputs and central sensitization (initial or ongoing), can contribute to both the initiation and maintenance of persistent pain, therapies should target both peripheral and central sources of pathology. (shrink)

While the theses that (1) human beings are primarily passional creatures and that (2) religion is fundamentally a product of our sensible nature are both closely linked to David Hume, Hume's contemporary Henry Home, Lord Kames (1696–1782), also defended them and explored their implications. Importantly, Kames does not draw the same sceptical conclusions as does Hume. Employing a sophisticated account of the rationality of what he calls the 'sensitive branch' of human nature, Kames argues that religion plays a central (...) role in the development and perfection of human life. (shrink)

While the theses that human beings are primarily passional creatures and that religion is fundamentally a product of our sensible nature are both closely linked to David Hume, Hume's contemporary Henry Home, Lord Kames , also defended them and explored their implications. Importantly, Kames does not draw the same sceptical conclusions as does Hume. Employing a sophisticated account of the rationality of what he calls the ‘sensitive branch’ of human nature, Kames argues that religion plays a central role in (...) the development and perfection of human life. (shrink)

Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury to the spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response to innocuous stimuli. In its short-lasting phase the allodynia can be relieved with the [gamma]-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses the hyperexcitability of dorsal horn interneurons to mechanical stimuli. Furthermore, there is a reduction in GABA immunoreactivity in the dorsal horn of allodynic rats. Clinical (...) neuropathic pain of peripheral and central origin often cannot be relieved by opiates at doses that do not cause side effects. The loss of sensitivity to opiates may be associated with the up-regulation of endogenous antiopioid substances, such as the neuropeptide cholecystokinin (CCK). CCK and its receptor (CCK-R) protein is normally not detectable in rat dorsal root ganglion cells. After peripheral nerve section, both CCK and CCK-R are up-regulated in the dorsal root ganglia. Furthermore, CI 988, an antagonist of the CCK-B receptor, chronically coadministered with morphine, reduces autotomy, a behavior that may be a sign of neuropathic pain following peripheral nerve section. Thus, opiate insensitivity may be due to the release of CCK from injured primary afferents. Similarly, in the chronic phase of the spinal ischemic model of central pain, the allodynia-like symptom is not relieved by systemic morphine, but is significantly reversed by the CCK-B antagonist. Consequently, up-regulation of CCK and CCK-R in the CNS may also underlie opiate drug insensitivity following CNS injury. Thus, dysfunction of central inhibition involving GABA and endogenous opioids may be a factor underlying the development of sensory abnormalities and/or pain following injury to neural tissue. (shrink)

Hyperalgesia can arise from peripheral sensitization, on-going peripheral activation, and central plasticity. In the target article, coderre & katz argue that all three mechanisms contribute to hyperalgesia. In contrast, we believe that existing experimental evidence suggests that central plasticity plays only an insignificant role in most experimental models and clinical presentations of hyperalgesia induced by tissue injury or chemical activation of sensory receptors.

This article introduces the N170 component and event related potential methodologies and interpretation, and provides a brief review of some important research questions that are addressed by employing the N170 as an electrophysiological marker of face processing. It discusses the basic properties of the N170 component, its neural basis, as well as some methodological issues needed when using this component to study face-specific processes, and when evaluating the results from previous N170 experiments. A recent methodological challenge to the claim that (...) the N170 reliably reflects face-specific brain processes is evaluated. The article reviews research that has employed the N170 component to investigate two central and interrelated issues in face processing. It deals with the domain-specificity or generality of face processing, as well as the possible role of expertise. Finally, some avenues for future research are outlined. (shrink)

The central issue of this essay is whether contextualism in epistemology is genuinely in conflict with recent claims that ‘know’ is not in fact a contextsensitive word. To address this question, I will first rehearse three key aims of contextualists and the broad strategy they adopt for achieving them. I then introduce two linguistic arguments to the effect that the lexical item ‘know’ is not context sensitive, one from Herman Cappelen and Ernie Lepore, one from Jason Stanley. I find (...) these and related arguments quite compelling. In particular, I think Cappelen and Lepore (2003, 2005a) show pretty definitively that ‘know’ is not like ‘I’/‘here’/‘now’, and Stanley (2004) shows that ‘know’ is not like ‘tall’/‘rich’.1 One could try to find another model for ‘know’. Instead, I consider whether one can rescue ‘‘the spirit of contextualism in epistemology’’—that is, achieve its aims by deploying a strategy of appealing to speaker context—even while granting that ‘know’ isn’t a context-sensitive word at all. My conclusion, in a nutshell, is this: If there are pragmatic determinants of what is asserted/stated, and contextualism can overcome independent problems not having to do specifically with the context-sensitivity of the word ‘know’, then the spirit of contextualism can be salvaged. Even though, for reasons sketched by the aforementioned authors, ‘know’ doesn’t actually belong in the class of context-sensitive words. (shrink)

There are three main metaphysical positions on race. Anti-realists do not believe there are any races. Natural kind approaches find sub-groups of homo sapiens that have scientific importance and label those groups races, generally taking them to be biological categories. This book argues that anti-realism is false, and the groups natural kind theorists point to, if real, are not the groups we care about in ordinary discussions of race. This book defends, instead, a social kind view, which considers races to (...) exist because of contingent social practices. I argue for a social kind view that recognizes that biological features we use to classify people racially do not make races natural kinds. Racial groups could theoretically exist independently of any social constructions, since they are just groups of people, but social constructions single out certain groups of people as races, give them social importance, and allow us to name them as races. This book also identifies several kinds of context-sensitivity in our racial classification and sees that context-sensitivity as central to how racial categorization works. In terms of our moral response to these metaphysical realities, we need racial categories to identify problems in how our racial constructions are formed, including addressing harmful effects, rather than seeking to eliminate the categories in any direct way, but we should also make efforts to change the conditions that generate those problematic elements, with a goal of retaining only the unproblematic aspects. (shrink)

This commentary provides experimental data in support of the critical role of capsaicin-sensitive primary afferent fibers in the initiation and maintenance of pathological pain. The demonstration of capsaicin-induced, centrally-evoked cutaneous hyperalgesia, and of neuroplastic changes elicited by the degeneration of C-fiber primary afferent terminals following peripheral nerve damage, indicates a significant contribution of capsaicin-sensitive sensory ganglion neurons in the development of pathological pain conditions. [coderre & katz].

One aim of this essay is to contribute to understanding aesthetic communication—the process by which agents aim to convey thoughts and transmit knowledge about aesthetic matters to others. Our focus will be on the use of aesthetic adjectives in aesthetic communication. Although theorists working on the semantics of adjectives have developed sophisticated theories about gradable adjectives, they have tended to avoid studying aesthetic adjectives—the class of adjectives that play a central role in expressing aesthetic evaluations. And despite the wealth (...) of attention paid to aesthetic adjectives by philosophical aestheticians, they have paid little attention to contemporary linguistic theories of adjectives. We take our work to be a first step in remedying these lacunae. In this paper, we present four experiments that examine one aspect of how aesthetic adjectives ordinarily function: the context-sensitivity of their application standards. Our results present a prima facie empirical challenge to a common distinction between relative and absolute gradable adjectives because aesthetic adjectives are found to behave differently from both. Our results thus also constitute a prima facie vindication of some philosophical aestheticians’ contention that aesthetic adjectives constitute a particularly interesting segment of natural language, even if the boundaries of this segment might turn out to be different from what they had in mind. (shrink)

I argue that Kant’s primary epistemological concern in the Critique of Pure Reason’s transcendental deduction is empirical cognition. I show how empirical cognition is best understood as “rational sensory discrimination”: the capacity to discriminate sensory objects through the use of concepts and with a sensitivity to the normativity of reasons. My dissertation focuses on Kant’s starting assumption of the transcendental deduction, which I argue to be the thesis that we have empirical cognition. I then show how Kant’s own subjective deduction (...) fleshes out his conception of empirical cognition and is intertwined with key steps in the transcendental deduction’s arguments that the categories have objective validity and that we have synthetic a priori cognition. (shrink)

One of Lisa Tessman's central claims in Burdened Virtue: Virtue Ethics for Liberatory Struggles (OUP, 2005) is that virtue is much less reliably connected to flourishing than Aristotle imagined and might in fact impede flourishing under nonideal conditions. The central burdened virtue is the meta-virtue of sensitivity to others’ suffering. I raise two critical questions about this meta-virtue. First, does this meta-virtue of sensitivity to others’ suffering, as Tessman understands this virtue, have sufficient liberatory scope? Second, is the (...) virtue of sensitivity to others’ suffering burdensome because of the psychological pain and guilt that attends it, as Tessman claims, or are there other reasonable accounts of the burden of this particular virtue? (shrink)

In a recent article, Fridland characterises a central capacity of skill users, an aspect she calls ‘control’. Control, according to Fridland, is evidenced in the way in which skill users are able to marshal a variety of mental and bodily resources in order to keep skill deployment operating fluidly and appropriately. According to Fridland, two prevalent contemporary accounts of skill—Stanley & Krakauer’s and Hubert Dreyfus’s —fail to account for the features of control, and do so necessarily. While I agree (...) with Fridland that features of control represent desiderata for a satisfactory characterisation of the capacity of skills to respond to perturbations, I argue that her account is limited in two ways; first it is applicable only to a particular class of skills I call motor skills, leaving other classes of skills unaccounted for; second, she employs a problematic distinction that rules out the automatic and pre-reflective use of discursive, propositional cues in skill deployment. I put forward a critical elaboration of Fridland’s account based on two more general characteristic features of skills I call opportunistic robustness and normative sensitivity. I suggest that these features avoid the difficulties isolated, while preserving the substance of Fridland’s account of control. (shrink)

Information technology is widely used to fulfill societal goals such as safety and security. These application areas put ever changing demands on the functionality of the technology. Designing technological appliances to be reconfigurable, thereby keeping them open to functionalities yet to be determined, will possibly allow the technology to fulfill these changing demands in an efficient way. In this paper we present a first exploration of potential societal and moral issues of reconfigurable sensors developed for application in the safety and (...) security domain, in the context of a large scale R&D-project in the Netherlands. We discuss the subtle distinction between the relevant notions of reconfigurability, function creep, and unrestricted or unforeseen technological affordances. We argue that the feature of reconfigurability makes context of use the central issue in the assessment of the societal and moral impact of the technology. It follows that the design of good policies for new application contexts has to be central in a value sensitive design approach to reconfigurable technology. (shrink)

Providing effective care to patients and making the right decisions in difficult working environments depend on moral sensitivity. Emotional intelligence and ethical sensitivity affect nursing care. This study aimed to investigate the relationship between nursing students’ emotional intelligence and ethical sensitivity levels. The research employed a descriptive-correlational design, 201 nursing students studying at a university in the Central Anatolia region, Turkey, participated in the study. Students’ ethical sensitivity was found to be significant. The nursing students received the highest score (...) in the “Interpersonal Orientation” sub-dimension of the Moral Sensitivity Scale, while their lowest score was observed in the “Experiencing ethical dilemma” sub-dimension. The SSREIT and MMSQSN total scores of the students who willingly chose the nursing department and loved their field were found to be higher. It was found that the ethical sensitivity of nursing students was at a significant level and gender, family type, having sibling and perception of economic status affected the level of ethical sensitivity. (shrink)

The notion that an independent central bank reduces a country’s inflation is a controversial hypothesis. To date, it has not been possible to satisfactorily answer this question because the complex macroeconomic structure that gives rise to the data has not been adequately incorporated into statistical analyses. We develop a causal model that summarizes the economic process of inflation. Based on this causal model and recent data, we discuss and identify the assumptions under which the effect of central bank (...) independence on inflation can be identified and estimated. Given these and alternative assumptions, we estimate this effect using modern doubly robust effect estimators, i.e., longitudinal targeted maximum likelihood estimators. The estimation procedure incorporates machine learning algorithms and is tailored to address the challenges associated with complex longitudinal macroeconomic data. We do not find strong support for the hypothesis that having an independent central bank for a long period of time necessarily lowers inflation. Simulation studies evaluate the sensitivity of the proposed methods in complex settings when certain assumptions are violated and highlight the importance of working with appropriate learning algorithms for estimation. (shrink)

The concept of emotion can be organized within a hypothetical space comprising a limited number of dimensions representing essential properties of emotion. The present study examined cultural influences on such conceptual structure by comparing the performance of emotion word classification between Japanese and Korean individuals. Two types of emotional words were used; central concepts, highly typical examples of emotion, and less typical peripheral concepts. Participants classified 30 words into groups based on conceptual similarity. MDS analyses revealed a three-dimensional structure (...) with valence, social engagement, and arousal dimensions for both cultures, with the valence dimension being the most salient one. The Japanese prioritized the social engagement over the arousal while the Koreans showed sensitivities to the arousal dimension. Although the conceptual structure was similar for the two countries, the weight of importance among the three dimensions seems to be different, reflecting each culture’s values and communication styles. (shrink)

Our initial response to COVID-19 has been plagued by a series of failures—many of which have extended inequity within and across populations, especially in low- and middle-income countries. The global health governance of pandemic preparedness and response needs to move further away from the advocacy of a one-size-fits-all approach that tends to prioritize the interests of high-income countries towards a context-sensitive approach that gives equity a central role in guiding our pandemic preparedness and response strategies.

The introduction of the euro gave a unique opportunity to empirically disentangle two components of utility: intrinsic value, a rational component central in economics, and the numerosity effect (going by numbers while ignoring units), a descriptive and irrational component central in prospect theory and underlying the money illusion. We measured relative risk aversion in Belgium before and after the introduction of the euro, and could consider changes in intrinsic value while keeping numbers constant, and changes in numbers while (...) keeping intrinsic value constant. Intrinsic value significantly affected risk aversion, and the numerosity effect did not. Our study is the first to confirm the classical hypothesis of increasing relative risk aversion while avoiding irrational distortions due to the numerosity effect. (shrink)

Biomass such as crops and agricultural waste is increasingly used as the primary resource for products like bioplastics and biofuels. Incorporating the needs, knowledge, skills and values of biomass producers in the design of global value chains – the steps involved in creating any finished product from design to delivery – can contribute to sustainability, reliability and fairness. However, how to involve biomass producers, especially if they are resource poor, remains a challenge. To make sure that inclusion in global biobased (...) value chains is both fair and effective, the capabilities of relevant actors need to be taken into account, especially of those producing biomass. Access to resources determines to what extent a specific actor can participate in a global value chain. Therefore, differences in capabilities should be a central consideration when new (biobased) value chains are designed. Using the capability approach as an ethical framework to realize inclusion, we discern three complementary strategies for setting up inclusive value chains. Firstly, designing for local conversion factors second, providing adaptive design for new capabilities, and third, investing in local conversion factors. Applying these strategies can lead to context-sensitive design of biorefineries that allow for true inclusion of local stakeholders. We support these claims with reference to case-studies of sugarcane production in Jamaica, modified tobacco in South Africa and the non-edible parts of corn (stover) in the US. (shrink)

In this paper I explore various themes in Alfred Mele's Manipulated Agents: A Window to Moral Responsibility. I develop four points. First, I argue that Mele's historical requirement for moral responsibility for developed morally responsible agents should be coupled with a nonhistorical theory of initially developing agents. Second, I argue that one might resist Mele's negative historical requirement with a minimal positive historical requirement according to which an agent has a history wherein she did not undergo any responsibility-defeating events, like (...) being severely manipulated.Third, I also explore the idea that one who defended a nonhistorical view, such as Harry Frankfurt's, might rely on a different conception of what moral responsibility is. This might explain why some resisting Mele would not have the intuition that in certain cases a manipulated agent is not responsible. Finally, I question how we should think of the role of intuition in thought experiments figuring centrally in Mele's work. (shrink)

Political and cultural diversity in contemporary Europe can be encountered on many levels and in a variety of forms. The significance of such political and cultural diversity is, however, differently understood, and conceptualized, and not always sufficiently appreciated in distinct perceptions of Europe. A variety of perceptions of Europe have played a role in the project of Eastern enlargement, even if a communitarian/unitarian vision of a single European identity seemed to prevail. Such a vision was not only promoted by Western (...) European political forces, but also actively endorsed by some of the new-comers themselves, who, in a way, embedded the unitarian understanding of European identity in their local self-identification as `Central Europe'. A unitary vision of Europe was, however, at odds with a number of connotations associated with the myth of a distinct Central European identity as it had emerged in the 1980s. The article identifies three understandings of the idea of Central Europe as they have historically emerged, and suggests their contemporary relevance for the European integration project. Subsequently, the usage and understanding of Central Europe will be briefly looked at in the context of the fifth enlargement project. Finally, the future of political and cultural integration in the post-enlargement era is hypothesized. While the unitary vision of European identity remains an important marker, a diversity-sensitive, post-national, and deliberative understanding of European identity seems increasingly important, an identity that can significantly build on an emancipatory reading of Central Europe. (shrink)

Sex differences in physical and indirect aggression have been found in many societies but, to our knowledge, have not been studied in a population of hunter-gatherers. Among Aka foragers of the Central African Republic we tested whether males physically aggressed more than females, and whether females indirectly aggressed more than males, as has been seen in other societies. We also tested predictions of an evolutionary theory of physical strength, anger, and physical aggression. We found a large male bias in (...) physical aggression. Controlling for anger, we found an adult female bias in indirect aggression. Physical strength predicted anger, which predicted hitting, although results were sensitive to the inclusion or exclusion of traditional healers, who were physically and emotionally distinct from other Aka. With some important caveats, our results generally support the predicted sex differences in physical aggression and indirect aggression, and the predicted relationships among anger, strength, and aggression. (shrink)

SNAREs (soluble N‐ethylmaleimide‐sensitive factor attachment protein receptors) are a large family of proteins that are present on all organelles involved in intracellular vesicle trafficking and secretion. The interaction of complementary SNAREs found on opposing membranes presents an attractive lock‐and‐key mechanism, which may underlie the specificity of vesicle trafficking. Moreover, formation of the tight complex between a vesicle membrane SNARE and corresponding target membrane SNAREs could drive membrane fusion. In synapses, this tight complex, also referred to as the synaptic core complex, (...) is essential for neurotransmitter release. However, recent observations in knockout mice lacking major synaptic SNAREs challenge the prevailing notion on the executive role of these proteins in fusion and open up several questions about their exact role(s) in neurotransmitter release. Persistence of a form of regulated neurotransmitter release in these mutant mice also raises the possibility that other cognate or non‐cognate SNAREs may partially compensate for the loss of a particular SNARE. Future analysis of SNARE function in central synapses will also have implications for the role of these molecules in other vesicle trafficking events such as endocytosis and vesicle replenishment. Such analysis can provide a molecular basis for synaptic processes including certain forms of short‐term synaptic plasticity. BioEssays 24:926–936, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Standing upon Leonardo Polo's interpretation about Aristotle's doctrine on sensitive cognition, some aspects of the sensorial organical inmutation required in it are examined, and a thesis concerning de common sense as center and root of sensibility -not only exterior, but also interior- is suggested. According to this thesis, even the sensorial and organical inmutations belonging to the other internal senses can return to de organ of the common sense, which becomes the central and radical organ. Therefore all sensible objectivation (...) should take place in the common sense. This conclusion does not agree with Polo's position. (shrink)

In social scientific studies of Europe’s new democracies, there has emerged an analytical approach which transcends the teleology of ‘transitology’ and, focusing on the impact of culture and history, is sensitive to the contingencies and ‘eventfulness’ of social transformations. The main thrust of this article is that such a culturo-historical approach may prove useful not only in assessing the different results to which the processes of democratization lead at the national level, but also to assess the general direction of political (...) change after 1989 towards democracy. Building on Eisenstadt’s notion of modernity as a cultural and political program, this article therefore attempts to understand the revolutions of 1989 not only as the mere sum of particular national events, but also as part of an ‘entangled history’, that is, as a common, transnational phenomenon which was based on and articulated a shared cultural understanding. (shrink)

Central sensitization refers to the increased responsiveness of nociceptive neurons in the central nervous system after repeated or sustained peripheral nociceptor activation. It is hypothesized to play a key role in the development of chronic pain. A hallmark of central sensitization is an increased sensitivity to noxious mechanical stimuli extending beyond the injured location, known as secondary hyperalgesia. For its ability to modulate the transmission and the processing of nociceptive inputs, attention could constitute a promising (...) target to prevent central sensitization and the development of chronic pain. It was recently shown that the experimental induction of central sensitization at both forearms of healthy volunteers using bilateral high-frequency electrocutaneous stimulation (HFS), can be modulated by encouraging participants to selectively focus their attention to one arm, to the detriment of the other arm, resulting in a greater secondary hyperalgesia on the attended arm as compared to the unattended one. Given the potential value of the question being addressed, we conducted a preregistered replication study in a well-powered independent sample to assess the robustness of the effect, i.e., the modulatory role of spatial attention on the induction of central sensitization. This hypothesis was tested using a double-blind, within-subject design. Sixty-seven healthy volunteers performed a task that required focusing attention toward one forearm to discriminate innocuous vibrotactile stimuli while HFS was applied on both forearms simultaneously. Our results showed a significant increase in mechanical sensitivity directly and 20 min after HFS. However, in contrast to the previous study, we did not find a significant difference in the development of secondary hyperalgesia between the attended vs. unattended arms. Our results question whether spatial selective attention affects the development of secondary hyperalgesia. Alternatively, the non-replication could be because the bottom-up capture of attention caused by the HFS-mediated sensation was too strong in comparison to the top-down modulation exerted by the attentional task. In other words, the task was not engaging enough and the HFS pulses, including those on the unattended arm, were too salient to allow a selective focus on one arm and modulate nociceptive processing. (shrink)