How epithelial tissues are able to self-renew to maintain homeostasis and regenerate in response to injury remains a persistent question. The transcriptional effectors YAP and TAZ are increasingly being recognized as central mediators of epithelial stem cell biology, and a wealth of recent studies have been directed at understanding the control and activity of these factors. Recent work by Hu et al. has added to this knowledge, as they identify an Integrin-FAK-CDC42-PP1A signaling cascade that directs nuclear YAP/TAZ activity in stem (...) cell populations of the mouse incisor, and define convergence on mTORC1 signaling as an important mediator of the proliferation of these cells. Here, we review recent studies on YAP/TAZ function and regulation in epithelial tissue-specific stem cells, merging the Hu et al. study together with our current knowledge of YAP/TAZ. The Hippo pathway effectors YAP and TAZ broadly regulate adult stem cells, and have recently been implicated in dental epithelial stem cell proliferation and restricted differentiation via an Integrin-FAK-CDC42-PP1A cascade. Here, we discuss the extracellular cues which control YAP/TAZ activity and examine downstream pathways that direct stem cell fate. (shrink)

How epithelial tissues are able to self-renew to maintain homeostasis and regenerate in response to injury remains a persistent question. The transcriptional effectors YAP and TAZ are increasingly being recognized as central mediators of epithelial stem cell biology, and a wealth of recent studies have been directed at understanding the control and activity of these factors. Recent work by Hu et al. has added to this knowledge, as they identify an Integrin-FAK-CDC42-PP1A signaling cascade that directs nuclear YAP/TAZ activity in stem (...) cell populations of the mouse incisor, and define convergence on mTORC1 signaling as an important mediator of the proliferation of these cells. Here, we review recent studies on YAP/TAZ function and regulation in epithelial tissue-specific stem cells, merging the Hu et al. study together with our current knowledge of YAP/TAZ. The Hippo pathway effectors YAP and TAZ broadly regulate adult stem cells, and have recently been implicated in dental epithelial stem cell proliferation and restricted differentiation via an Integrin-FAK-CDC42-PP1A cascade. Here, we discuss the extracellular cues which control YAP/TAZ activity and examine downstream pathways that direct stem cell fate. (shrink)

There is a constructive method to define a structure of simple k -cyclic Post algebra of order p , L p , k , on a given finite field F ( p k ), and conversely. There exists an interpretation Φ 1 of the variety $${\mathcal{V}(L_{p,k})}$$ generated by L p , k into the variety $${\mathcal{V}(F(p^k))}$$ generated by F ( p k ) and an interpretation Φ 2 of $${\mathcal{V}(F(p^k))}$$ into $${\mathcal{V}(L_{p,k})}$$ such that Φ 2 Φ 1 ( B ) (...) = B for every $${B \in \mathcal{V}(L_{p,k})}$$ and Φ 1 Φ 2 ( R ) = R for every $${R \in \mathcal{V}(F(p^k))}$$. In this paper we show how we can solve an algebraic system of equations over an arbitrary cyclic Post algebra of order p, p prime, using the above interpretation, Gröbner bases and algorithms programmed in Maple. (shrink)

Resumen En este artículo analizaremos, a través de una serie de actividades diseñadas para implementar en el aula, el modo en el que un grupo de jóvenes gallegos co-construyen el conocimiento metalingüístico y metapragmático acerca de las diferentes variedades locales del español y gallego. La exposición de su trayectoria biográfica permite que afloren diversos saberes y conocimientos metalingüísticos que los estudiantes han ido adquiriendo a lo largo de su escolarización y, además, surgen diversas categorizaciones sobre lenguas y variedades que ponen (...) de manifiesto sus ideologías lingüísticas, pp. 157–174). A través del análisis de las prácticas metalingüísticas y metapragmáticas comprobaremos cómo se reproducen las ideologías lingüísticas de estos jóvenes; por una parte, las ideologías de la institución académica y escolar; y por otra, las ideologías lingüísticas de los jóvenes presentes en el aula, en donde etiquetan, clasifican y establecen jerarquizaciones y valoraciones de su repertorio comunicativo. Finalmente, se comprueba cómo las diferentes variedades del español y del gallego actúan como índices de identidad social diferente de la reconocida en el ámbito institucional y académico, con distintos valores en el mercado lingüístico. (shrink)

The Embodied Mind provides a unique, sophisticated treatment of the spontaneous and reflective dimension of human experience.

Pedro Alvares Cabral's ships left Portugal on 9 March 1500 en route for the territory that he first named Terra de Vera Cruz and that later came to be known as Brazil. On the 22 March they called at the island of São Nicolau [Caminha, 1500], one of the northernmost islands of the Cape Verde group; this was about forty years after the discovery of the archipelago in 1460-62 [Albuquerque, 1991]. It is known that Vasco da Gama had stopped at (...) the island of Santiago in 1498 on his voyage to India, and also in 1499 on the return journey. Straight after the discovery of Brazil Cabral sailed for India and on the way back also dropped anchor at Santiago. Indeed, our archipelago, which is situated off Cape Verde in Senegal (the place from which it appears to take its name), was to become an important stopover point for maritime traffic between Europe, Asia and the Americas in the fifteenth and sixteenth centuries, both to allow crews to rest and to take on water, wood and some food supplies. It also became important as a holding point for slaves (a large number of whom came from around thirty Guinean ethnic groups and subgroups). They were dispatched from Santiago, known then as Cape Verde island, to territories such as Brazil from the early sixteenth century onwards, since these territories, which had only recently been discovered and were little known, needed people to work and populate them. (shrink)

Some major leftist thinkers, including Alain Badiou, Slavoj Žižek and Terry Eagleton, have lately offered readings that claim the relevance of alternative interpretations of the Christian tradition in the face both of the conservative turn in the Catholic Church and of the contemporary secular oblivion of anything that has to do with religion. Furthermore, post-colonial studies have tended to blame the West en bloc for the disasters of past and present colonization, and have attacked the western endeavour to extend universal (...) truths as an ethnocentric device to facilitate and justify exploitation. In Holy Terror, Terry Eagleton both condemns western politics and questions its appeal to universals; but he also hears in this tradition a demand for a relationship with the other which offers an alternative to that established by current politics and capitalist exploitation. The other is the excluded, the oppressed, the exploited; the true material, rather than ideal, universal produced by global capitalist exploitation. As a consequence, anything that happens in any part of the planet belongs in our world and indicts us, though we tend to build barriers around an ideally safe and stable identity that ignores part of its own reality and that is therefore haunted by it. Texts like the Bacchae or the New Testament open the gates of the city and of the heart to the excluded. Terrorists — saints for their own communities and satanic for the rest — offer an example of the other that is impossible to comprehend within our conventional ways of life. Nevertheless, only if we hear in their violence a demand for justice can an exit be found from the vicious circle of violence and revenge. (shrink)

Some major leftist thinkers, including Alain Badiou, Slavoj Žižek and Terry Eagleton, have lately offered readings that claim the relevance of alternative interpretations of the Christian tradition in the face both of the conservative turn in the Catholic Church and of the contemporary secular oblivion of anything that has to do with religion. Furthermore, post-colonial studies have tended to blame the West en bloc for the disasters of past and present colonization, and have attacked the western endeavour to extend universal (...) truths as an ethnocentric device to facilitate and justify exploitation. In Holy Terror, Terry Eagleton both condemns western politics and questions its appeal to universals; but he also hears in this tradition a demand for a relationship with the other which offers an alternative to that established by current politics and capitalist exploitation. The other is the excluded, the oppressed, the exploited; the true material, rather than ideal, universal produced by global capitalist exploitation. As a consequence, anything that happens in any part of the planet belongs in our world and indicts us, though we tend to build barriers around an ideally safe and stable identity that ignores part of its own reality and that is therefore haunted by it. Texts like the Bacchae or the New Testament open the gates of the city and of the heart to the excluded. Terrorists — saints for their own communities and satanic for the rest — offer an example of the other that is impossible to comprehend within our conventional ways of life. Nevertheless, only if we hear in their violence a demand for justice can an exit be found from the vicious circle of violence and revenge. (shrink)

Se efectuó un estudio en dos fases: una observacional descriptiva y otra correlacional, para caracterizar psicológicamente al niño y adolescente con Retinosis Pigmentaria y su familia, en el Centro Provincial que atiende a este paciente en la ciudad de Camagüey. El estudio se hizo aplicando una encuesta elaborada a los efectos del trabajo y una batería de pruebas psicológicas para niños y otra para adolescentes. Se realizó un muestreo intencional puro, no probabilístico de 41 pacientes. Las Pruebas Psicológicas aplicadas fueron: (...) Encuesta, Dibujo Libre, Rotter, Wechller Bellevue, Test Gráfico de la Familia para ambos grupos e Historietas de Madelaine Thomas, 3 Alegrías, 3 Roñas y 3 Miedos para niños y Técnica de los 10 Deseos, Inventario de Problemas Juveniles, Escala de Autovaloración de Dembo Rubinstein, para los adolescentes. A todas las madres de los pacientes se les aplicó el Cuestionario FFSIL para determinar su funcionamiento familiar. En lo metodológico, se realizaron modificaciones a las pruebas psicológicas, adaptándolas al entorno sociocultural cubano. Se reportaron hallazgos típicos explicables por el tipo de enfermedad. Como resultado de este estudio, se confirmó lo expuesto por otros autores que más que la enfermedad misma, lo que influye en su formación personológica es el proceso de socialización que se efectúe An study was made to characterize psychologically the childs and adolescent suffering from pigmentary retinosis and their family, in the Provincial Center that assists those patients in Camagüey. The study was carried out applying a battery of psychological tests for children and another for adolescents. The applied Psychological Tests were: interviews, Free Drawing, Rotter, Graphic Test of the Family for both groups and Comics of Madelaine Thomas, 3 Happiness, 3 Dirts and 3 Fears for children and Technique of the 10 Desires, Inventory of Juvenile Problems and the Scale of Dembo Rubinstein, for the adolescents. Methodological modifications to the psychological tests were carried out, adapting them to the Cuban sociocultural environment. Accountable typical discoveries were reported by the illness type. As results of this study, the most important fact for the patients' personalities is the socialization process. (shrink)

I discuss Aristotle’s opening argument against Platonic Forms in _Metaphysics_ A.9, ‘the Razor’, which criticizes the introduction of Forms on the basis of an analogy with a hypothetical case of counting things. I argue for a new interpretation of this argument, and show that it involves two interesting objections against the introduction of Forms as formal causes: one concerns the completeness and the other the adequacy of such an explanatory project.

The study of conscious experience per se has not kept pace with the dramatic advances in PET, fMRI and other brain-scanning technologies. If anything, the standard approaches to examining the 'view from within' involve little more than cataloguing its readily accessible components. Thus the study of lived subjective experience is still at the level of Aristotelian science, leading to a widespread scepticism over the possibility of a truly scientific study of conscious experience. Drawing on a wide range of approaches -- (...) from phenomenology to meditation -- The View From Within examines the possibility of a disciplined approach to the study of subjective states. The focus is on the practical issues involved. (shrink)

This paper responds to the issues raised by D. Chalmers by offering a research direction which is quite radical because of the way in which methodological principles are linked to scientific studies of consciousness. Neuro-phenomenology is the name I use here to designate a quest to marry modern cognitive science and a disciplined approach to human experience, thereby placing myself in the lineage of the continental tradition of Phenomenology. My claim is that the so-called hard problem that animates these Special (...) Issues can only be addressed productively by gathering a research community armed with new pragmatic tools for the development of a science of consciousness. I will claim that no piecemeal empirical correlates, nor purely theoretical principles, will really help us at this stage. We need to turn to a systematic exploration of the only link between mind and consciousness that seems both obvious and natural: the structure of human experience itself. In what follows I motivate my choice by briefly examining the current debate about consciousness at the light of Chalmer’s hard problem. Next, I outline the phenomenological strategy. Finally I conclude by discussing some of the main difficulties and consequences of this strategy. (shrink)

"Knowing how we know" is the subject of this book. Its authors present a new view of cognition that has important social and ethical implications, for, they assert, the only world we humans can have is the one we create together through the actions of our coexistence. Written for a general audience as well as for students, scholars, and scientists and abundantly illustrated with examples from biology, linguistics, and new social and cultural phenomena, this revised edition includes a new afterword (...) by Dr. Varela, in which he discusses the effect the book has had in the years since its first publication. (shrink)

Different explanations of color vision favor different philosophical positions: Computational vision is more compatible with objectivism (the color is in the object), psychophysics and neurophysiology with subjectivism (the color is in the head). Comparative research suggests that an explanation of color must be both experientialist (unlike objectivism) and ecological (unlike subjectivism). Computational vision's emphasis on optimally prespecified features of the environment (i.e., distal properties, independent of the sensory-motor capacities of the animal) is unsatisfactory. Conceiving of visual perception instead as the (...) visual guidance of activity in an environment that is determined largely by that very activity suggests new directions for research. (shrink)

Aristóteles parece negar el estatuto ontológico de los artefactos que no serían sustancias. Se analizan los textos básicos al respecto y sus principales interpretaciones. Se discute la opinión de R. Katayama, para mostrar que acierta en remarcar la importancia de la separabilidad de los compuestos, pero se equivoca en la noción de separación. Se sostiene que las formas no son separables de sus compuestos tanto naturales como artefactos, pero los primeros poseen un tipo de separación de otras formas o especies (...) que no poseen los segundos y, por ello, son substancias. Aristotle seems to deny the ontological status of artifacts which are not substances. In this paper I discuss the basic regarding this topic and its main intepretations. I discuss R. Katayama's opinion to show that he is right to underline the importance of the trait of separation, but he is wrong regarding the the notion of separation. My thesis is that neither the forms of natural things nor those of artifacts are separable from the composites, but the former possess a different kind of separation from other forms or species, which the latter do not possess. Hence, the former are substances. (shrink)

This ambitious work aims to shed new light on the relations between Husserlian phenomenology and the present-day efforts toward a scientific theory of cognition—with its complex structure of disciplines, levels of explanation, and ...

Republic 596a introduces a One over Many principle that has traditionally been considered as an argument for the existence of Forms, according to which, one Form should be posited for each like-named plurality. This interpretation was challenged by (Smith, J. A. 1917. “General Relative Clauses in Greek.” Classical Review 31: 69–71.), who interpreted it rather as a statement that each Form is unique and correlated to a plurality of things that have the same name as it. (Sedley, D. 2013. “Plato (...) and the One-over-Many Principle”, in Chiaradonna & Galluzzo 2013, 113–37.) has offered a forceful defence of Smith’s interpretation. I argue that Sedley’s defence fails and that the traditional interpretation should be preferred. (shrink)

How can science be brought to connect with experience? This book addresses two of the most challenging problems facing contemporary neurobiology and cognitive science. Firstly, understanding how we unconsciously execute habitual actions as a result of neurological and cognitive processes that are not formal actions of conscious judgment but part of a habitual nexus of systematic self-organization. Secondly, attempting to create an ethics adequate to our present awareness that there is no such thing as a transcendental self, a stable subject (...) or soul. The author combines researches in cognitive science and phenomenology with two representatives of what he calls the 'wisdom traditions': Confucianism and Buddhist epistemology. (shrink)

In the first argument of Metaphysics Μ.2 against the Platonist introduction of separate mathematical objects, Aristotle purports to show that positing separate geometrical objects to explain geometrical facts generates an ‘absurd accumulation’ of geometrical objects. Interpretations of the argument have varied widely. I distinguish between two types of interpretation, corrective and non-corrective interpretations. Here I defend a new, and more systematic, non-corrective interpretation that takes the argument as a serious and very interesting challenge to the Platonist.

Aristotle formulates in _Metaphysics_ M.9 an aporia about Forms, according to which, those who introduce Forms make them universal substances and, at the same time, separate entities and, hence, particulars. But, he claims, it is not possible that both attributes, being a universal and being a particular, inhere in the same thing. The interpretation that scholars have offered of this objection is external, in that they hold that it derives from Aristotle’s own conception of separation: only what is particular is (...) separate. Here I defend an internal interpretation which claims that the objection derives from an assumption about the explanatory role of Forms that Aristotle attributes to the Platonists. (shrink)

In this paper I examine Crispin Wright's modal anti-realism as based on the availability of a certain attitude of Caution towards judgements of necessity. I think that Wright's account should be attractive in several ways for modal theorists with an anti-realist bend. However, the attitude of Caution to which it appeals has attracted some controversy. Wright himself has later come to doubt whether Caution is ultimately coherent. Here I first address Wright's worries concerning the coherence of Caution and show that (...) they are unfounded. But then I argue that although the attitude of Caution is coherent, it cannot provide a suitable basis for a non-eliminativist account of necessity. I offer two different objections against Caution. I argue that Wright's appeal to Caution, if successful, would show not only that modal judgement is non-objective but also that it is dispensable. Thus, I claim that appeal to Caution would seem to serve more as a threat against a non-eliminativist account of necessity, rather than as a potential adequate basis for it. However, I argue that Wright's appeal to Caution is unsuccessful, for there is no genuine Caution: Caution is a mere verbal attitude. (shrink)

En este trabajo realizo un examen crítico del reciente libro de Silvana Gabriela Di Camillo sobre la crítica de Aristóteles a la teoría platónica de las Ideas. El libro de Di Camillo es un trabajo muy serio cuya lectura recomiendo ampliamente. Sin embargo, considero que cuatro de las principales tesis que la autora defiende tienen varias dificultades y mi objetivo aquí es presentar argumentos detallados en contra de ellas: la interpretación de la distinción entre argumentos más y menos rigurosos del (...) tratado Sobre las Ideas; la tesis de que la separación es el blanco esencial de las críticas aristotélicas a las Ideas; la interpretación de las opciones que Platón tiene para responder al argumento del tercer hombre, y la tesis de que la separación de las Ideas debe entenderse como homonimia. In this paper I examine Silvana Gabriela Di Camillo's recent book on Aristotle's criticisms of Plato's theory of Ideas. Di Camillo's book is a very serious work that I highly recommend. Nevertheless, I consider that four of the main theses that the author defends face several difficulties and my aim here is to offer detailed arguments against them: the interpretation of the distinction between more and less accurate arguments of the treatise On Ideas; the thesis that separation is the essential target of Aristotle's criticisms against Plato's Ideas; the interpretation of the options available to Plato to reply to the third man argument; and the thesis that the separation of Ideas should be understood as homonymy. (shrink)

Aristotle formulates in _Metaphysics_ M.9 an aporia about Forms, according to which, those who introduce Forms make them universal substances and, at the same time, separate entities and, hence, particulars. But, he claims, it is not possible that both attributes, being a universal and being a particular, inhere in the same thing. The interpretation that scholars have offered of this objection is external, in that they hold that it derives from Aristotle’s own conception of separation: only what is particular is (...) separate. Here I defend an internal interpretation which claims that the objection derives from an assumption about the explanatory role of Forms that Aristotle attributes to the Platonists. (shrink)

En Metafísica M.2 Aristóteles desarrolla diversas objeciones en contra de la introducción platónica de objetos matemáticos como substancias no-sensibles, separadas de las sensibles. Su primera objeción es de carácter doble. En primer lugar, Aristóteles argumenta que la postulación de objetos geométricos separados produce una acumulación absurda. En segundo lugar, sugiere que este argumento geométrico se puede extender al caso de las unidades y los números. En este trabajo me ocupo de explicar esta extensión aritmética. Los especialistas han interpretado esta extensión (...) de una manera que denomino “maximalista”. Aquí defiendo una interpretación distinta, “minimalista”. (shrink)

En este trabajo examino la “elección imposible” que Sócrates le plantea a Teeteto y que parece consistir en elegir entre: aceptar (a) que el juicio falso es imposible, o (b) que es posible conocer y no conocer el mismo objeto (Teeteto 196c7-d2). De acuerdo con la interpretación tradicional de esta elección, Sócrates afirma que es necesario aceptar una de las dos opciones: (b). En consecuencia, Sócrates desarrollaría el Aviario como un modelo de explicación del error en el que es posible (...) conocer y no conocer lo mismo. Aquí argumento en contra de esta lectura. Según mi interpretación, lo que dice Sócrates es que se deben rechazar los dos términos de la “elección imposible”, (a) y (b), y, por ende, el Aviario presenta un modelo en el que el juicio falso es posible sin tener que aceptar que es posible conocer y no conocer lo mismo. (shrink)

Nos proponemos, en este artículo, sentar las bases necesarias para investigar la correlación entre algunas formas de epojé y las reducciones a las que dichas suspensiones abren, y que corresponden a una concreción cada vez más rica. Nuestra aproximación de la concreción fenomenológica se apoya, abiertamente, en la mereología. Tras un breve repaso de algunos conceptos mereológicos aplicados al giro transcendental de la fenomenología, trataremos de apresar, mereológicamente, la especificidad de la problemática finkeana en su VIª Meditación Cartesiana. Habremos pues (...) de diseccionar las partes de la correlación transcendental cruzándolas con el particular lugar que, en esa concreción, ocupa esa “parte” no concrescente que es el yo fenomenologizante. Ella conformará la “parte” antecedente del “todo” de la cinestesia fenomenologizante que tratamos de elucidar, y cuyo consecuente será el todo de la correlación transcendental. Intentamos así contribuir al esclarecimiento del proceso de reducción fenomenológica, sentando las bases para una investigación sobre las articulaciones concretas entre epojé y reducción.The aim of this paper is to lay the ground for understanding the correlation between some forms of epochè and the reduction they open to, which corresponds, each time, to a richer type of concreteness. Our approach of phenomenological concreteness is mereological. Therefore, after remembering some basic concepts of the husserlian mereology and their possible use within transcendental phenomenology, we try to grasp the specificity of the questions posed by Eugen Fink in his 6 th Cartesian Meditation. We shall expose the parts of the transcendental correlation and then account for the particular role played, “within” this concretion, by this particular “part” which is the phenomenologizing ego. The phenomenologizing ego will be the antecedent “part” or term within this “whole” consisting on the phenomenologizing kinesthesis. Thereafter, the consequent term of such a kinesthesis corresponds to the whole of the transcendental correlation. We thus intend to throw some light on the process of phenomenological reduction and set the basis for further investigations regarding the concrete articulation between epochè and reduction. (shrink)