Recently academic freedom and academic tenure have been in the media spotlight because of concerns that academic freedom is being misused and that academic tenure provides job security to a select few. First, this paper provides a brief history of these two institutions and follow with an analysis using Stone’s (2002) policy analysis format. Second, this paper examines the university through two lenses: (a) an economic market lens; and (b) a community lens. These two lenses offer contrasting views of the (...) university and help explain the different views of academic freedom and tenure. The authors suggest that faculty make use of the economic model to increase their chances of maintaining tenure in a university atmosphere frequently characterized by a business approach rather than a collegial one. Recommendations for future research are also provided. (shrink)

This book, written by four internationally renowned bioethicists and first published in 2000, was the first systematic treatment of the fundamental ethical issues underlying the application of genetic technologies to human beings. Probing the implications of the remarkable advances in genetics, the authors ask how should these affect our understanding of distributive justice, equality of opportunity, the rights and obligations as parents, the meaning of disability, and the role of the concept of human nature in ethical theory and practice. The (...) book offers a historical context to contemporary debate over the use of these technologies by examining the eugenics movement of the late nineteenth and early twentieth centuries. The questions raised in this book will be of interest to any reflective reader concerned about science and society and the rapid development of biotechnology, as well as to professionals in such areas as philosophy, bioethics, medical ethics, health management, law, and political science. (shrink)

This book, written by four internationally renowned bioethicists and first published in 2000, was the first systematic treatment of the fundamental ethical issues underlying the application of genetic technologies to human beings. Probing the implications of the remarkable advances in genetics, the authors ask how should these affect our understanding of distributive justice, equality of opportunity, the rights and obligations as parents, the meaning of disability, and the role of the concept of human nature in ethical theory and practice. The (...) book offers a historical context to contemporary debate over the use of these technologies by examining the eugenics movement of the late nineteenth and early twentieth centuries. The questions raised in this book will be of interest to any reflective reader concerned about science and society and the rapid development of biotechnology, as well as to professionals in such areas as philosophy, bioethics, medical ethics, health management, law, and political science. (shrink)

Counterfactual scepticism holds that most ordinary counterfactuals are false. The main argument for this view appeals to a ‘chance undermines would’ principle: if ψ would have some chance of not obtaining had ϕ obtained, then ϕ □→ ψ is false. This principle seems to follow from two fairly weak principles, namely, that ‘chance ensures could’ and that ϕ □→ ψ and ϕ ⋄→ ¬ ψ clash. Despite their initial plausibility, I show that these principles are independently problematic: (...) given some modest closure principles, they entail absurdities. Moreover, on the most promising strategy for saving these principles, they do not, in the relevant sense, entail the chance-undermines-would principle. Instead, they entail a principle that only supports counterfactual indeterminism, the view that most ordinary counterfactuals are chancy, that is, not settled true. I demonstrate this by developing an indeterminist semantics that vindicates the clash and chance-ensures-could principles but not the chance-undermines-would principle. This view, I argue, offers a better account of our credal and linguistic judgements than counterfactual scepticism. (shrink)

'Uncertainty and chance' is a subject with a broad span, in that there is no academic discipline or walk of life that is not beset by uncertainty and chance. In this book a range of approaches is represented by authors from varied disciplines: natural sciences, mathematics, social sciences and medical sciences. At one extreme, this volume is concerned with the foundations of probability. At the other extreme, we have scholars who acknowledge the concept of chance and uncertainty (...) but do not cope with it by means of systematic measurement or quantative analysis. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Abnegation as Key to Providence:Six Spiritual Theologians on ProvidenceDavid W. FagerbergIf a contest were held for the most difficult doctrine, I suppose it would be a toss-up between Trinity, Incarnation, and transubstantiation. But if the contest were over the most awkward doctrine, I predict that providence would take the prize. We believe it; we want to believe it; we find it difficult to believe it. In the continuing friction (...) between Christian faith and a modern worldview, the rivalry seems sharpest between providence and modernity's footings in secularity (no divine reality), autonomy (no divine interference), and chance (no divine steering).Several reactions might follow. One might ignore the issue; one might house the viewpoints in two heterogeneous spheres; one could believe the one but live under the regulation of the other; perhaps one would call in philosophy to conduct a workaround by metaphysics, or linguistic analysis of determinism and freedom. I do not propose to follow any of these paths, but to rather turn to a different resource, namely, consult some classic Catholic spiritual writers to examine how they treat the doctrine of providence. They believed it; they wanted to believe it; they found less difficulty in believing it than we do. In fact, they seem to find joy in the doctrine of providence. My suspicion as to why this is so is because they place the difficulty of believing providence in the heart, and not in the head, and so attunement to providence is less an intellectual struggle and more an interior accomplishment. They gazed fixedly at what God wants for the soul. Most of the actions taken by a parent might be misunderstood by the child if the child does not know the actions were designed to encourage and support coming to maturity. [End Page 343] Most of the actions taken by God might be misunderstood by the soul if the soul does not believe these graces were designed to bring about deification. Providence is the execution of God's design for the perfection of a human being as a mystical liturgist living in union with him.I have recently been researching a cast of characters I have been calling "theologians of liturgical abnegation," for whom providence is undergirded by an act of liturgical abnegation.1 Although all speak of providence, six of these authors have given significant attention to the doctrine of providence, either in a separate monograph or in large portions of their corpus, and for an understanding of providence I propose to listen to these spiritual writers instead of to the philosophers. Providence is being "abyssed" in love (de Sales), and it requires particular and personal faith (Grou), which means we do not choose our own crosses (Fénelon), but instead make trustful surrender (Saint-Jure and de la Colombière) because we prefer God's will to our own (de Caussade).Francis de Sales—Being Abyssed in Love"It is our duty to adore this amiable Providence, by casting ourselves into its arms."2 We cannot worship God as God without acknowledging his providence. The obligation to daily liturgize God with adoration, glory, and thanksgiving requires delight in his daily providence, but such acknowledgment is not primarily a rational act, it is an act of liturgical abnegation that consists of casting ourselves into God's arms in a way that will contribute to his greater glory. Even sorrow, trial, and tempest can contribute to God's glory. "I am expecting a great tempest to burst over me, but I await it joyously; and looking to the Providence of God, I hope that this will conduce to His greater glory, and the more perfect repose of my soul."3 Providence operates differently in each life because God desires a different measure of [End Page 344] glory from each life. If we are confused about providence's work in a life, it is because we are ignorant of the glory to which each life will contribute. Our life-liturgies will not be the same, but they will each delight God, who is their source. "Every one will see and love him, according to the particular measure of glory which the divine Providence... (shrink)

This paper estimates the effects of human capital skills largely created through education on life's chances over the life cycle. Qualifications as a measure of these skills affect earnings, and schooling affects private and social non-market benefits beyond earnings. Private non-market benefits include better own-health, child health, spousal health, infant mortality, longevity, fertility, household efficiency, asset management and happiness. Social benefits include increased democratisation, civil rights, political stability, reduced crime, lower prison, health and welfare costs, and new ideas. Individual benefits (...) enhance community-wide development. New 'narrow' social rates of return using UK Labour Force earnings correct for institutional costs, longitudinal trends and ability. The paper's objective, however, is to estimate these earnings plus non-market outcomes comprehensively without overlaps and also relative to costs. Non-market outcomes are measured by averaging regression coefficients from published studies that meet scientific standards. New UK 'narrow' social rates of return average 12.1 per cent for short-cycle and 13.6 per cent for bachelor's programmes. Augmented with non-market effects on life chances, they are over twice that. Short degrees are found effective for regional development and have potential for developing countries. (shrink)

Most people believe that everything happens for a reason. Whether it is “God’s will,” “karma” or “fate,” we want to believe that an overarching purpose undergirds everything, that nothing in the world--especially a disaster or tragedy--is a random, meaningless event. This dilemma presents itself provocatively in Charles Darwin’s theory of evolution that, in the conventional scientific understanding, is driven by random chance. Reconciling chance and divine purpose poses challenges to the Judeo-Christian tradition. But the Hebrew Scriptures, in the (...) ancient and powerful story of Job, reveal that questions of purpose and order have long been a part of the conversation. Although the Bible generally affirms that God blesses the righteous in an orderly way, the story of Job is a powerful counterexample to this orderly scheme. The achingly beautiful but tragic story of Job, in concert with the modern quantum picture of the world, push back against the idea that “everything happens for a reason.”. (shrink)

In this paper I attempt to explore the significance of the terms ‘accident’ and ‘chance’ when they are used in connection with events that are sometimes said to happen ‘by accident’ and sometimes ‘by chance’. The significance of these terms is not always made clear in everyday conversation, and here I shall try to discuss the distinction between them and the sorts of situation therefore to which they properly apply. Perhaps an example will show that these expressions are (...) different. Thus ‘I met Smith in the library by chance’ is different from ‘I met Smith in the library by accident’, different because these statements reflect different interpretations of the events referred to. We see accidental and chance events in a different light. And this is the point; ‘accident’ and ‘chance’ are terms of interpretation, not of description. And I hope to show that the expression ‘by chance’ is appropriate in contexts which develop as a result of human decisions and intentions in a way in which the expression ‘by accident’ is not appropriate. (shrink)

In the months preceding the writing of this review, bioethics has been in the news a great deal. In congressional and public policy debates surrounding stem cell research, human cloning, and the Human Genome Project, bioethics and bioethicists have gained national attention and been subject to public scrutiny. Commentators have asked who these self-appointed moral experts are to tell us what is right and wrong.

During his lifetime Peirce was appreciated for his erudite and accurate thinking by experts in a few borderline philosophical subjects—in particular the history and philosophy of physics, semeiotics, mathematical logic, the theory of probability—and was suspected by a few prescient souls to be a general philosopher of outstanding genius; but by academic and other publishers he was consistently regarded as a bad bet. These facts largely explain the history of Peircean publication in the last few decades. It was only in (...) 1958, nearly fifty years since Peirce stopped writing, that the wealthiest university in the wealthiest nation in the world was able to complete its eight volume edition of his Collected Papers; but in the meanwhile at least three useful smaller anthologies of Peirce’s writings had been put before the public. Professor Wiener’s volume makes a fourth. And the obvious initial question is: was this additional anthology really necessary? (shrink)

Besides serving us at the growing edge of science and beyond, metaphor figures even in our first learning of language; or, if not quite metaphor, something akin to it. We hear a word or phrase on some occasion, or by chance we babble a fair approximate ourselves on what happens to be a pat occasion and are applauded for it. On a later occasion, then, one that resembles the first occasion by our lights, we repeat the expression. Resemblance of (...) occasions is what matters, here as in metaphor. We generalize our application of the expression by degrees of subjective resemblance of occasions, until we discover from other people's behavior that we have pushed analogy too far and exceeded the established usage. If the crux of metaphor is creative extension through analogy, then we have forged a metaphor at each succeeding application of that early word of phrase. These primitive metaphors differ from the deliberate and sophisticated ones, however, in that they accrete directly to our growing store of standard usage. They are metaphors stillborn. It is a mistake, then, to think of linguistic usage as literalistic in its main body and metaphorical in its trimming. Metaphor, or something like it, governs both the growth of language and our acquisition of it. What comes as a subsequent refinement is rather cognitive discourse itself, at its most dryly literal. The neatly worked inner stretches of science are an open space in the tropical jungle, created by clearing tropes away. W. V. Quine is the Edgar Pierce professor emeritus of philosophy at Harvard University. His many influential works include Methods of Logic, Word and Object, and The Roots of Reference. "On the Nature of Moral Values," his previous contribution to Critical Inquiry, appeared in the Spring 1979 issue. (shrink)

Haeckels theory of recapitulation shall be extended by the following rule: During the ontogenetical recapitulation of the phenotypical effects, the recapitulation of the phylogenetical natural selection factors according to the genotypical potentials is a condition of manifestation. The phylogenetical natural selectionfactor produces the activation of the gen as ontogenetical manifestation-stimulus. Factor of natural selection is the one of the extern or intern environment to which has happened the adaption in the phylogenesis. Concerning the intern environments the phenotypical effect of the (...) preliminary phase of development is not only the phylogenetical factor of natural selection according to the genotypical potential of the following phase of development, but also the ontogenetical stimulus of manifestation for the phenotypical effect of the following phase of development. Phenotypical effects can present themselves as stimulus-dependencial modifications, which are bound to the manifestation-stimulus and cease after its disappearence. They can also present themselves as stimulus-independencial lasting modifications, which become independent from the manifestation-stimulus and remain preserved after its ceasing, because the gen once activated by the stimulus reproduces itself in the state of being activated and is so transmitted during the multiplication of cells from cell to cell and during the multiplication of organisms from generation to generation. This view gives new chances for interpretating causal connections of the phylogenetical evolution and involution as well as new possibilities for an explanation of evolutionary mechanism of maturation and of involutionary mechanism of ageing in the ontogenesis and also the occuring appearences of acceleration and retardation.DieHaeckel'sche Rekapitulationstheorie wird durch die folgende Rekapitulationsregel erweitert: Bei der ontogenetischen Rekapitulation der erscheinungsbildlichen Leistungen ist die Rekapitulation der phylogenetischen Auslesefaktoren der entsprechenden erbildlichen Fähigkeiten Manifestationsbedingung. Der phylogenetische Auslesefaktor bewirkt als ontogenetischer Manifestationsreiz die Genaktivierung. Auslesefaktor ist derjenige Faktor der äusseren oder inneren Umwelt, an den in der Phylogenese die Anpassung erfolgt ist. Im Bereich der inneren Umwelt ist daher die erscheinungsbildliche Leistung der vorhergehenden Entwicklungsstufe sowohl der phylogenetische Auslesefaktor für die erbbildliche Fähigkeit der nachfolgenden Entwicklungsstufe als auch der ontogenetische Manifestationsreiz für die erscheinungsbildliche Leistung der nachfolgenden Entwicklungsstufe. Die erscheinungsbildlichen Leistungen können als reizabhängige Modifikation auftreten, die also vom Manifestationsreiz abhängig bleibt und nach seinem Aufhören auch wieder verschwindet, sie können aber auch als reizunabhängige Dauermodifikation auftreten, die also vom Manifestationsreiz unabhängig wird und nach seinem Aufhören erhalten bleibt, weil das durch den Reiz einmal aktivierte Gen sich im Status des Aktiviertseins bei der Zellvermehrung von Zelle zu Zelle und bei der Vermehrung der Organismen von Generation zu Generation fortpflanzt. Damit ergeben sich neue Möglichkeiten einer Deutung der Kausalzusammenhänge bei der phylogenetischen Evolution und Involution, sowie neue Ansätze einer Erklärung des Evolutionsmechanismus der Reifung und des Involutionsmechanismus des Alterns in der Ontogenese, sowie der dabei auftretenden Erscheinungen der Acceleration und der Retardation. (shrink)

In modern approaches to phonology a lack of clarity exists on the issue of whether phonetic facts are psychological or physical realities. The results from an experiment suggest that phonetic facts can be considered as psychological realities, but with the restriction that they can take acoustical shape. More specifically, the syntactic material consisted of ambiguous French sentences of the following sort: On a tourné ce film intéressant pour les étudiants. They were spoken in disambiguating contexts, without the readers noticing the (...) ambiguities, and without context, but with the instruction to make a conscious effort to disambiguate. By tape splicing, the contexts were removed from the context-embedded sentences. Twenty-eight native speakers of French listened to the sentences and judged whether one or the other meaning had been intended by the speaker. Subjects performed significantly above chance: 60% correct identifications for context-embedded sentences, 75% for context-free sentences. Pitch-amplitude analyses were made to determine the acoustical differences involved. (shrink)

In many cases, the “therapeutic misconception” may be an unavoidable part of the imperfect process of recruitment and consent in medical researchPaul Appelbaum, Loren Roth, and Charles Lidz coined the term “therapeutic misconception” in 1982.1 They described it as the misconception that participating in research is the same as receiving individualised treatment from a physician. It referred to the research subject’s failure to appreciate that the aim of research is to obtain scientific knowledge, and that any benefit to the subject (...) is a by-product of that knowledge. More recent studies by Appelbaum and Lidz have shown that this phenomenon is just as pervasive now as it was twenty four years ago.2 The problem pertains not to any duty of care for researchers but to participants’ unfounded belief in the therapeutic potential of research.3 It is especially acute in phase I oncology trials, which aim to test the toxicity and highest tolerable dose of anticancer drugs.To remedy this situation, many have argued that both clinicians and researchers need to do more in explaining to subjects the differences between experimental research and standard care. Clinicians and researchers recruiting potential subjects for research must present information about the expected risks and benefits of participation in research in a more realistic and straightforward way.4 In one recent examination of consent forms for phase I oncology trials, Sam Horng et al found that, in the section on “benefit”, only one of 272 forms stated that the subjects were expected to benefit. They also found that 11 consent forms stated clearly that subjects would not benefit, 25 forms communicated uncertainty about benefit, and 5 forms said nothing about the chance of benefit. Interestingly, 139 forms alluded to the …. (shrink)

Odysseus' man, disguised as the captain of a merchant ship, is explaining to Neoptolemus how he chanced unexpectedly to meet Neoptolemus' sailors. Jebb's note, ‘the same land ; not, strictly, the same “spot” ’, and his rendering, ‘off the same coast’, somewhat contradict one another.

356 nonquit O, oinquit Q, linquit Q corr., oinquid G, noscit Lachmann. 359 adsittens OQ, adsistens Q corr. In the summer of 1919, in the high Sierra of California, I chanced to talk with a cattleman who had driven his herd from the lower valleys to the highlands for summer pasture. When he had arrived at his destination he found a cow missing. He retraced his route, and forty miles below he found the cow by the roadside.Her calf, by reason (...) of its weakness, had been picked up by a waggoner and brought on, and the cow was found at the identical spot where the calf had been taken from the ground; the cow had found the place and had remained there for five days. The occurrence gave rise to a general discussion by the cattlemen present concerning the habits of these animals. When a cow misses her calf she will go by memory to the place where the calf was last seen by her, and will stay there for days; but she will graze and not go hungry herself. The cow will also search by smell; she can smell a herd or the odour left on bushes or that attached to footsteps for hours certainly, possibly for days. The calf also will stay for days where the mother left it. The bereaved cow will try to find her calf first by sight, then by memory, and lastly by smell. (shrink)

In any list of famous last words, Socrates' are likely to figure near the top. Details of the final moments of celebrities tend anyway to exert a peculiar fascination upon the rest of us: life's very contingency provokes a need to see lives nevertheless as meaningful organic wholes, defined as such precisely by their final closure; so that even the most trivial aspects of their ending can come to seem bearers of profound significance, soliciting moral reflections apparently not less urgent (...) for their being quite unwarranted. From earliest times, this fascination with last moments has come to be concentrated in particular upon last words: situated at that most mysterious of borders, between life and death, they seem to look backwards and forwards at once, judging the speaker's own past life from the vantage-point of a future realm he is about to attain and hinting at the nature of what awaits us all from the perspective of that past life he still – however tenuously – shares with us. A moment earlier, and there is no reason to privilege any one discourse of the speaker's above another; a moment later, and his lips are sealed for ever. Only in that final moment can he seem to pass an unappealable judgement on himself, to combine in a single body two incompatible subjectivities, the one suffering and extremely mortal, the other dispassionate and transcendent. If he is a thinker or a man of action, this is his last chance to summarize a lifetime's meditation or experience in a pithy, memorable aphorism.If he is a celebrated poet, he can be imagined to have composed his own epitaph; if he is a Hellenistic poet, he may even in fact have done so. (shrink)

In any list of famous last words, Socrates' are likely to figure near the top. Details of the final moments of celebrities tend anyway to exert a peculiar fascination upon the rest of us: life's very contingency provokes a need to see lives nevertheless as meaningful organic wholes, defined as such precisely by their final closure; so that even the most trivial aspects of their ending can come to seem bearers of profound significance, soliciting moral reflections apparently not less urgent (...) for their being quite unwarranted. From earliest times, this fascination with last moments has come to be concentrated in particular upon last words: situated at that most mysterious of borders, between life and death, they seem to look backwards and forwards at once, judging the speaker's own past life from the vantage-point of a future realm he is about to attain and hinting at the nature of what awaits us all from the perspective of that past life he still – however tenuously – shares with us. A moment earlier, and there is no reason to privilege any one discourse of the speaker's above another; a moment later, and his lips are sealed for ever. Only in that final moment can he seem to pass an unappealable judgement on himself, to combine in a single body two incompatible subjectivities, the one suffering and extremely mortal, the other dispassionate and transcendent. If he is a thinker or a man of action, this is his last chance to summarize a lifetime's meditation or experience in a pithy, memorable aphorism.If he is a celebrated poet, he can be imagined to have composed his own epitaph; if he is a Hellenistic poet, he may even in fact have done so. (shrink)

PREFACE. THE Author of this very practical treatise on Scotch Loch - Fishing desires clearly that it may be of use to all who had it. He does not pretend to have written anything new, but to have attempted to put what he has to say in as readable a form as possible. Everything in the way of the history and habits of fish has been studiously avoided, and technicalities have been used as sparingly as possible. The writing of this (...) book has afforded him pleasure in his leisure moments, and that pleasure would be much increased if he knew that the perusal of it would create any bond of sympathy between himself and the angling community in general. This section is interleaved with blank shects for the readers notes. The Author need hardly say that any suggestions addressed to the case of the publishers, will meet with consideration in a future edition. We do not pretend to write or enlarge upon a new subject. Much has been said and written-and well said and written too on the art of fishing but loch-fishing has been rather looked upon as a second-rate performance, and to dispel this idea is one of the objects for which this present treatise has been written. Far be it from us to say anything against fishing, lawfully practised in any form but many pent up in our large towns will bear us out when me say that, on the whole, a days loch-fishing is the most convenient. One great matter is, that the loch-fisher is depend- ent on nothing but enough wind to curl the water, -and on a large loch it is very seldom that a dead calm prevails all day, -and can make his arrangements for a day, weeks beforehand whereas the stream- fisher is dependent for a good take on the state of the water and however pleasant and easy it may be for one living near the banks of a good trout stream or river, it is quite another matter to arrange for a days river-fishing, if one is looking forward to a holiday at a date some weeks ahead. Providence may favour the expectant angler with a good day, and the water in order but experience has taught most of us that the good days are in the minority, and that, as is the case with our rapid running streams, -such as many of our northern streams are, -the water is either too large or too small, unless, as previously remarked, you live near at hand, and can catch it at its best. A common belief in regard to loch-fishing is, that the tyro and the experienced angler have nearly the same chance in fishing, -the one from the stern and the other from the bow of the same boat. Of all the absurd beliefs as to loch-fishing, this is one of the most absurd. Try it. Give the tyro either end of the boat he likes give him a cast of ally flies he may fancy, or even a cast similar to those which a crack may be using and if he catches one for every three the other has, he may consider himself very lucky. Of course there are lochs where the fish are not abundant, and a beginner may come across as many as an older fisher but we speak of lochs where there are fish to be caught, and where each has a fair chance. Again, it is said that the boatman has as much to do with catching trout in a loch as the angler. Well, we dont deny that. In an untried loch it is necessary to have the guidance of a good boatman but the same argument holds good as to stream-fishing... (shrink)

It is widely recognized that prioritizing health care resources by their relative cost-effectiveness can result in lower priority for the treatment of disabled persons than otherwise similar non-disabled persons. I distinguish six different ways in which this discrimination against the disabled can occur. I then spell out and evaluate the following moral objections to this discrimination, most of which capture an aspect of its unethical character: it implies that disabled persons' lives are of lesser value than those of non-disabled persons; (...) it constitutes “double jeopardy” or violates Frances Kamm's non-linkage principle; it conflicts with equality of opportunity; it conflicts with fairness, which requires ignoring (some/most) differential impacts of treatment; it wrongly gives lower priority to disabled persons for equally effective treatment; it conflicts with giving all persons an equal chance to reach their full potential; and, it is in conflict with giving priority to the worse off. (shrink)

A probability distribution is regular if no possible event is assigned probability zero. While some hold that probabilities should always be regular, three counter-arguments have been posed based on examples where, if regularity holds, then perfectly similar events must have different probabilities. Howson (2017) and Benci et al. (2016) have raised technical objections to these symmetry arguments, but we see here that their objections fail. Howson says that Williamson’s (2007) “isomorphic” events are not in fact isomorphic, but Howson is speaking (...) of set-theoretic representations of events in a probability model. While those sets are not isomorphic, Williamson’s physical events are, in the relevant sense. Benci et al. claim that all three arguments rest on a conflation of different models, but they do not. They are founded on the premise that similar events should have the same probability in the same model, or in one case, on the assumption that a single rotation-invariant distribution is possible. Having failed to refute the symmetry arguments on such technical grounds, one could deny their implicit premises, which is a heavy cost, or adopt varying degrees of instrumentalism or pluralism about regularity, but that would not serve the project of accurately modelling chances. (shrink)

Patients who search for a better treatment, an increased quality of life, or even a chance to preserve life itself may claim to have an interest in accessing investigational medicinal products (IMP), particularly when no validated treatment for their disease or condition exists. For many, awaiting the uncertain and time-consuming process of converting an IMP into an approved drug may not appear a realistic option, as prognoses may be grim and a dramatic outcome may seem hard to avert. Gaining (...) access to an IMP, however, often proves to be a difficult enterprise with a highly uncertain outcome. In addition, the process of seeking access to IMP is surrounded by various ethical issues that will be explored in this article. This paper explores the ethical concerns in two potential tracks of seeking access to IMP for minors: on an individual basis, or collectively, as a patient organisation. In this discourse, several unique ethical and regulatory concerns related to the direct negotiation of access to IMP for minor patients are identified, with a focus on product safety, the recruitment of research subjects, the unnoticed entry of market mechanisms in the recruitment of research subjects, and the sidelining of third parties in the recruitment process. The paper concludes with a concise reflection on the way forward. The quest for access to investigational drugs is particularly relevant to paediatric practice, in which a significant share of the drugs prescribed has never been tested in children or labelled for use in the paediatric population. (shrink)

The claims that Dr. F. H. George makes on behalf of his machines are obscurely stated. Does he claim that a machine has been made and has actually produced a kind of response which is incalculable, given the specification to which it has been built and also the prescribed conditions, what is put in for the particular performance in question? “Incalculable” does not mean that nobody has bothered to calculate, but that somebody has bothered, that the calculations show that the (...) response in question is not among the calculated ones, that it is not chance or mechanical breakdown, but a specific response to something specific among the given conditions. If he could substantiate this claim, then I would reluctantly agree that some machines are cleverer and more thoughtful than I thought possible, and some men sillier and less thoughtful, for they deliberately design machines to do they know not what. (shrink)

Reilly approaches his topic by presenting the spirit of science and the phases of scientific inquiry as Peirce saw it, keeping before the reader, at all times, Peirce’s overarching view of man and the universe. The two prevailing themes guiding Peirce’s thought are 1) that there is a special conformity of the human mind to nature and of nature to God, and 2) that there is an architectonic qualifying all the various types and levels of treatment which occupy the philosopher’s (...) interest. The first question examined is the nature of the scientific concern. For Peirce, the scientist’s spirit is marked by the pure love of knowledge. It is important to note the theoretical aspect because it explains the possibility of holding belief in abeyance while examining nature: the purity of motive allows that proper questions will be asked and errors will be readily corrected. The scientist’s purpose is the real truth of things; he begins with questions about the world. There are four stages of scientific method: 1) The scientist observes nature as a thinking, analytic inquirer. Observation presupposes that nature is intelligibly structured. 2) He formulates an explanatory hypothesis which is a process of bringing a manifold of characters to a unified whole. 3) By deduction, the inquirer gathers experiential consequents of the hypothesis. 4) By induction the question is put to nature and observed phenomena are matched to the predicted phenomena, resulting in either truth or a modified hypothesis. Peirce’s principle of the kinship of man’s mind to nature supports his dictum to follow instinct over reasoned likelihood in choosing hypotheses. Also important is the doctrine of moderate fallibilism which holds that there is a convergence upon the truth founded upon the regularity of nature, but that chance is a real factor due to nature’s evolution. Reilly’s book gives an adequate account of the aspects of Peirce’s scientific method sacrificing specific and detailed analysis to a more general approach wherein he shows the unity operative throughout Peirce’s thinking. A good index and copious notes are provided.—W. A. F. (shrink)

When the Muséum d’histoire naturelle in Paris learned in 1836 that it had the chance to buy a live, young orangutan, it was excited by the prospect. Specimens were the focus of the Museum’s activities, and this particular specimen seemed especially promising, not only because the Museum had very few orangutan specimens in its collection, but also because of what was perceived to be the orangutan’s unique place in the natural order of things, namely, at the very boundary between (...) the animal kingdom and humans. Frédéric Cuvier, the superintendent of the Museum’s menagerie, urged that studying the orangutan’s mental faculties would help resolve fundamental questions regarding the similarities and differences between animals and humans. Archival and printed sources allow one to reconstruct the orangutan’s capture, acquisition, and subsequent career at the menagerie in greater detail than has generally been possible for animals of nineteenth-century zoos. Scientists, artists, the public, the press, and even musicians sought to engage with the orangutan, seeing in it not just another ape or monkey but a special creature unto itself at the animal/human boundary. Key to their fascination with the orangutan was the question of proximity—just how close was the orangutan to humans? The orangutan’s story illuminates not only how the animal-human boundary was conceived at the time but also the problematic status of the zoo as a site for scientific research and the roles of scientific and non-scientific actors alike in constructing how the orangutan was understood. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Past, Present—and Future Perfect?Taking Psychiatry Beyond Its Single Message MythologiesK. W. M. Fulford (bio)I am grateful to John Sadler and his colleagues for their generous invitation to contribute to this collection marking Philosophy, Psychiatry, & Psychology (PPP)'s thirtieth birthday. True to our editorial tradition of "no nonsense" publishing, the "ask" was a reflection on PPP's past, present and future, limited to 500 words. In fact, one word does it (...) for me—collegiality.Collegiality was our watch word from the start. I still treasure a group photo taken at an early pre-meeting of the Association for the Advancement of Philosophy and Psychiatry (AAPP) convened by Michael Schwartz at his home in 1992, when, among other initiatives, PPP was conceived through transferring our then-nascent journal proposal from a small British publishing house to its current international publisher, the Johns Hopkins University Press. Michael and I had met earlier by phone when he had called the Royal College of Psychiatrists in London to enquire about its recently launched Philosophy Group and (by mere chance) I happened to be standing next to the person who took the call! PPP, with John and myself its founder editors, was subsequently born as, and has remained, a joint venture between our two groups: and Peter Zachar's recent initiative in building closer links with the International Network for Philosophy and Psychiatry (INPP) has taken us an important step towards the vision shared by Michael, John and myself that PPP should grow to reflect and represent a global open society of philosophy and mental health.As a pointer to the future, this global open society was no mere utopian vision but a joint commitment to what we conceived as a necessary ambition. Contemporary disenchantment with the repeated failures of translation of current narrowly empirical models of psychiatry, points to the truth of our German colleague, Paul Hoff's, characterization of the history of psychiatry as a history of serial collapses into single message mythologies. This disenchantment might seem to offer an opportunity for colonial expansion of philosophy into psychiatry (a re-assertion, perhaps, of phenomenology?). But PPP was born out of the "decade of the brain" and has remained throughout an ally of, not competitor to, the neurosciences. [End Page 3] So, while it is true that, with Peter's initiative, and with editorial and other innovations introduced by John, PPP is actively extending its reach (to new areas of philosophy, and to new voices, informed notably by experience as well as by training), this expansion remains a collegial not colonial enlargement of the field. I need hardly point to the challenges presented by the inclusive ambitions of such enlargement (not least to maintaining the highest standards of editorial and peer review). But PPP's collegiality provides the foundation for the work needed to deliver on these challenges. Even if imperfectly realized, this collegiality will help to take us beyond the single message mythologies by which our discipline has too long been hobbled. [End Page 4]K. W. M. Fulford K.W.M. (Bill) Fulford is a Fellow of St Catherine's College and Member of the Philosophy Faculty, University of Oxford; Emeritus Professor of Philosophy and Mental Health, University of Warwick Medical School; and Founder Director of the Collaborating Centre for Values-based Practice, St Catherine's College, Oxford (valuesbasedpractice.org).Copyright © 2023 Johns Hopkins University Press... (shrink)