This article discusses the identification of the wajhs regarded as weak in Kâsım b. Fîrruh esh-Shâtıbî’s poetical book Ḥırzu’l-emânî wa wajhu’t-tehânî that he wrote to make the differences of seven recitations (kırâ’ât-i sebaʻ) easy to memorize and the status of the practice of these wajhs in the Recitation Education. It is understood that Shatibi weakened these wajhs, sometimes explicitly with expressions such as leyse müʻavvelâ (لَيْسَ مُعَوَّلاَ) and lem yeṣıḥḥa fe yuḥmelâ (لَمْ يَصِحَّ فَيُحْمَلاَ), and sometimes indirectly with words such (...) as yüftelâ (يُفْتَلاَ)”, helhelâ (هَلْهَلاَ), uḫmilâ (اُخْمِلَا)” and mâce (مَاجَ)”. It is seen that there are eight of these wajhs in total; two of them are about method and six of them are about farshi differences. First of all, in the article the relevant wajhs are divided into two as the differences in the method and fersh. Afterwards it is narrated how these wajhs were handled in the significant sources of the qiraat field in addition to the interpretation style of the shârihs whom were accepted as authority in Ḥırzu’l-emânî. Finally, it is remarked that the wajhs of the tarîqs of Istanbul and Egypt which are in circulation in our country moreover the conditions of the practice of these wajhs in the qiraat education activities which are run in Arab world. (shrink)

In order to determine the authenticity of the hadiths, some conditions were determined by the hadiths regarding the proof and text of the hadith. There are aspects of these terms regarding the deed and the text. One of these conditions is that the hadith is not illegitimate. There are some types and reasons for the disease known as a hidden defect that harms the health of the hadith, and there are some methods used by the hadiths to detect the disease. (...) It is possible to divide these methods into two main headings. One of them is the method of reaching the cause of the hadith by making cem-i turk, and the other is the ability of the hadiths to reach the disease of the hadith with the skills they have acquired due to their preoccupation with hadiths. The cem-i turuk method, which is used in the detection of malady, concerns a wider area of use, while the detection of malady with the faculty of hadith concerns a more specific and relatively narrow field in scope. One of the methods used by hadith scholars in determining malady is the criticism that "it does not resemble the narration of so-and-so". This method of taqīd is a method applied by the hadith faculties of hadith. In this study, it will be tried to determine the usage area of the relevant pedestal and to determine the reasons why this pedestal is used. (shrink)

Autophagy and YAP1‐WWTR1/TAZ signalling are tightly linked in a complex control system of forward and feedback pathways which determine different cellular outcomes in differing cell types at different time‐points after perturbations. Here we extend our previous experimental and modelling approaches to consider two possibilities. First, we have performed additional mathematical modelling to explore how the autophagy‐YAP1 crosstalk may be controlled by posttranslational modifications of components of the pathways. Second, since analogous contrasting results have also been reported for autophagy as a (...) regulator of other transduction pathways engaged in tumorigenesis (Wnt/β‐catenin, TGF‐β/Smads, NF‐kB or XIAP/cIAPs), we have considered if such discrepancies may be explicable through situations involving competing pathways and feedback loops in different cell types, analogous to the autophagy‐YAP/TAZ situation. Since distinct posttranslational modifications dominate those pathways in distinct cells, these need to be understood to enable appropriate cell type‐specific therapeutic strategies for cancers and other diseases. (shrink)

Many bodily sensations are connected quite closely with specific actions: itches with scratching, for example, and hunger with eating. Indeed, these connections have the feel of conceptual connections. With the exception of D. M. Armstrong, philosophers have largely neglected this aspect of bodily sensations. In this paper, I propose a theory of bodily sensations that explains these connections. The theory ascribes intentional content to bodily sensations but not, strictly speaking, representational content. Rather, the content of these sensations is an imperative: (...) in the case of itches, 'Scratch!' The view avoids non-intentional qualia and hence accords with what could be called, generalizing Lycan slightly, the 'hegemony of intentionality'. (shrink)

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review recent reports that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells differentiate an apical membrane domain, and being activated when cells contact the extracellular matrix via their basal membrane domain. Apical signalling occurs via the canonical Crumbs/CRB‐Hippo/MST‐Warts/LATS kinase cascade to phosphorylate and inhibit YAP/TAZ. Basal signalling occurs (...) via Integrins and Src family kinases to phosphorylate and activate YAP/TAZ. Thus, YAP/TAZ is localised to the nucleus in basal stem/progenitor cells and cytoplasm in differentiated squamous cells or columnar cells. In addition, other signals such as mechanical forces, tissue damage and possibly receptor tyrosine kinases (RTKs) can influence MST‐LATS or Src family kinase activity to modulate YAP/TAZ activity. (shrink)

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently activated during the growth and progression of many solid tumors, including lung, colorectal, breast, pancreatic, and liver carcinomas as well as melanoma and glioma. YAP/TAZ bind to TEAD‐family co‐activators to drive cancer cell survival, proliferation, invasive migration, and metastasis. YAP/TAZ activation may also confer resistance to chemotherapy, radiotherapy, or immunotherapy. YAP‐TEAD cooperates with the RAS‐induced AP‐1 (FOS/JUN) transcription factor to drive tumor growth and cooperates with MRTF‐SRF to promote (...) activation of cancer‐associated fibroblasts, matrix stiffening, and metastasis. The key upstream repressor of YAP/TAZ activation is the Hippo (MST1/2‐LATS1/2) pathway and the key upstream activators are mechanically induced Integrin‐SRC and E‐cadherin‐AJUBA/TRIP6/LIMD1, growth factor induced PI3K‐AKT, and inflammation‐induced G‐protein coupled receptor (GPCR) signals, all of which antagonize the Hippo pathway. In this review, strategies to target YAP/TAZ activity in cancer are discussed along with the prospects for synergy with established pillars of cancer therapy. (shrink)

The treatise attempts to approach and deal with some of the most fundamental problems facing anyone who wishes to uphold some version of the so-called theory of tropes. Three assumptions serve as a basis for the investigation: tropes exist, only tropes exist, and a one-category trope-theory along these lines should be developed so that the tropes it postulates are able to serve as truth-makers for all kinds of atomic propositions. Provided that these assumptions are accepted, it is found that the (...) trope-theorist will have to deal with two important problems. First, some atomic propositions seem to require universal truth-makers. Second, some atomic propositions seem to require concrete truth-makers. As tropes are abstract particulars, it follows that the trope-theorist, in order to fulfil assumption, must provide an account of exactly how he or she could construct universality and concreteness from his or her basic stock of tropes. In the treatise such constructions are attempted and some basic problems with such constructions are revealed. Although these problems are serious enough it is argued that it is nevertheless possible to deal with these basic issues while staying squarely within the boundaries of a one-category trope-ontology. (shrink)

When several agents together produce suboptimal outcomes, yet no individual could have made a difference for the better, Act Consequentialism counterintuitively judges that all involved agents act rightly. I address this problem by supplementing Act Consequentialism with a requirement of modal robustness: Agents not only ought to produce best consequences in the actual world, but they also ought to be such that they would act optimally in certain counterfactual scenarios. I interpret this Modally Robust Act Consequentialism as Act Consequentialism plus (...) a requirement of moral virtue, namely, to reliably act rightly and to act rightly for the right reasons. (shrink)

Establishing effective pharmaceutical governance is a challenge for government agencies, private enterprises, and professionals working on the ground, demanding complex ethical decisions from the actors involved, especially in a lower-middle-income country like Ghana. This letter aims to share the author’s perspectives and additional considerations on the analyses of the reports in the paper “It is very difficult in this business if you want to have a good conscience”: pharmaceutical governance and on-the-ground ethical labor in Ghana by Hampshire et al. The (...) letter's authors discuss the need to advance universal health coverage in Ghana, the everyday ethics, and the disparities between the collective and individual moral consciousness of the participants, as well as other aspects of governance in the pharmaceutical sector. (shrink)

This paper deals with the truth conditions of conditional sentences. It focuses on a particular class of problematic examples for semantic theories for these sentences. I will argue that the examples show the need to refer to dynamic, in particular causal laws in an approach to their truth conditions. More particularly, I will claim that we need a causal notion of consequence. The proposal subsequently made uses a representation of causal dependencies as proposed in Pearl (2000) to formalize a causal (...) notion of consequence. This notion inserted in premise semantics for counterfactuals in the style of Veltman (1976) and Kratzer (1979) will provide a new interpretation rule for conditionals. I will illustrate how this approach overcomes problems of previous proposals and end with some remarks on remaining questions. (shrink)

Wordly internalists claim that while internal duplicates always share the same evidence, our evidence includes non-trivial propositions about our environment. It follows that some evidence is false. Worldly internalism is thought to provide a more satisfying answer to scepticism than classical internalist views that deny that these propositions about our environment might belong to our evidence and to provide a generally more attractive account of rationality and reasons for belief. We argue that worldly internalism faces serious difficulties and that its (...) apparent advantages are illusory. First, it cannot adequately handle some not terribly strange cases of perceptual error. Second, it cannot explain why one should plan to use their evidence to update their beliefs. The second issue allows us to explain why cases of misplaced certainty do not require us to introduce false evidence into our views and that why the alleged advantage of worldly internalism in resisting sceptical pressures is illusory. (shrink)

The idea of phenotypic novelty appears throughout the evolutionary literature. Novelties have been defined so broadly as to make the term meaningless and so narrowly as to apply only to a limited number of spectacular structures. Here I examine some of the available definitions of phenotypic novelty and argue that the modern synthesis is ill equipped at explaining novelties. I then discuss three frameworks that may help biologists get a better insight of how novelties arise during evolution but warn that (...) these frameworks should be considered in addition to, and not as potential substitutes of, the modern synthesis. †To contact the author, please write to: Departments of Ecology and Evolution and Philosophy, Stony Brook University, Stony Brook, NY 11794; e‐mail: [email protected]. (shrink)

Continuing Franz Boas' work to establish anthropology as an academic discipline in the US at the turn of the twentieth century, Alfred L. Kroeber re-defined culture as a phenomenon sui generis. To achieve this he asked geneticists to enter into a coalition against hereditarian thoughts prevalent at that time in the US. The goal was to create space for anthropology as a separate discipline within academia, distinct from other disciplines. To this end he crossed the boundary separating anthropology from biology (...) in order to secure the boundary. His notion of culture, closely bound to the concept of heredity, saw it as independent of biological heredity (culture as superorganic) but at the same time as a heredity of another sort. The paper intends to summarise the shifting boundaries of anthropology at the beginning of the twentieth century, and to present Kroeber?s ideas on culture, with a focus on how the changing landscape of concepts of heredity influenced his views. The historical case serves to illustrate two general conclusions: that the concept of culture played and plays different roles in explaining human existence; that genetics and the concept of Weismannian hard inheritance did not have an unambiguous unidirectional historical effect on the vogue for hereditarianism at that time; on the contrary, it helped to establish culture in Kroeber's sense, culture as independent of heredity. (shrink)

In this essay, I explore some key notions in Bonnie Honig's A Feminist Theory of Refusal. Juxtaposing her speculative reading of Euripides' Bacchae to Ursula K Le Guin's essay on the 'Carrier Bag Theory of Storytelling,' I argue that the women in the tragedy can be considered neither as imitating masculine, violent hunter-heroes, nor as surreptiously embodying feminine, caring gatherer-mothers. Following their refusal to care and to think about tomorrow, I conclude by suggesting that a critical fabulation of the women's (...) acts of refusal should steer clear from expecting them to inspire us, as contemporary feminists. (shrink)

Critical study of of the addresses of Sir Muhammad Iqbal, 1877-1938 from philosophical and religious point of view.

On the philosophy of Sir Muhammad Iqbal, 1877-1938 with special reference to religious experiences and philosophy.

Numerous social and environmental issues are under increasing time constraints, and society is placing greater demands on organizations that foster greater social inclusion, well-being, and human flourishing. In this regard, social innovation research has gained relevance as it provides a rich context to examine how to generate and prioritize dignity-based organizing more effectively. This research aims to examine how the concepts of dignity and humanistic management can shape social innovation processes that generate better results for organizations and society. Building on (...) humanistic management and social innovation literature, a qualitative case study explores how the notions of dignity and humanistic management practices are present at every stage of the social innovation process (origin, mobilization, execution, and integration). This paper is one of the few studies exploring the relationship between humanistic management principles and social innovation processes, filling a significant gap in the literature with important praxeological implications. (shrink)

Before the semester begins, a teacher tells his students: “There will be exactly one exam this semester. It will not take place on a day that is an immediate-successor of a day that you are currently in a position to know is not the exam-day”. Both the students and the teacher know – it is common knowledge – that no exam can be given on the first day of the semester. Since the teacher is truthful and reliable, it seems that (...) the students can know that what he says is true. However, in that case, assuming the students can know that they know whatever it is they know (KK) and assuming their knowledge is closed under entailment (closure), the students can reason from what they know to the conclusion that no exam will take place during the semester. This conclusion contradicts what they supposedly know: that there will be an exam. This puzzle, we argue, gives rise to a new consideration for the rejection of KK. We discuss unique features of the argument, especially in comparison to Timothy Williamson's rejection of KK in light of other versions of the surprise exam paradox. (shrink)

I learned very early, perhaps even before 1933 and certainly after Hitler’s huge success at the time of his election to the Reichstag, of Heidegger’s sympathy toward National Socialism. It was the late Alexandre Koyré who mentioned it to me for the first time on his return from a trip to Germany. I could not doubt the news, but took it with stupor and disappointment, and also with the faint hope that it expressed only the temporary lapse of a great (...) speculative mind into practical banality. It cast a shadow over my firm confidence that an unbridgeable distance forever separated the delirious and criminal hatred voiced by Evil on the pages of Mein Kampf from the intellectual vigor and extreme analytical virtuosity displayed in Sein und Zeit, which had opened the field to a new type of philosophical inquiry.Could one question the incomparable impression produced by this book, in which it immediately became apparent that Heidegger was the interlocutor and equal of the greatest—those very few—founders of European philosophy? that here was someone, this seemed obvious, all modern thought would soon have to answer? Emmanuel Levinas has been professor of philosophy at the École Normale Supérieure Israélite de Paris and at the University of Paris I . Among his books that have been translated into English are Totality and Infinity, Ethics and Infinity, and Otherwise Than Being or Beyond Essence. Paula Wissing, a free-lance translator and editor, has recently translated Paul Veyne’s Did the Greeks Believe in Their Myths? (shrink)