Research on electroencephalogram (EEG) characteristics associated with major depressive disorder (MDD) has accumulated diverse neurophysiologic findings related to the content, topography, neurochemistry, and functions of EEG oscillations. Significant progress has been made since the first landmark EEG study on affective disorders by Davidson 35 years ago. A systematic account of these data is important and necessary for building a consistent neuropsychophysiologic model of MDD and other affective disorders. Given the extensive data on frequency-dependent functional significance of EEG oscillations, a frequency (...) domain approach may reveal the types of brain functions involved and disturbed in MDD. In this review, we systematize and integrate diverse and often unconnected observations on the content, topography, neurochemistry, and functions of EEG oscillations involved in MDD within the general concept of an EEG oscillatory pattern. (shrink)

The value of resting electroencephalogram (EEG) in revealing neural constitutes of consciousness (NCC) was examined. We quantified the dynamic repertoire, duration and oscillatory type of EEG microstates in eyes-closed rest in relation to the degree of expression of clinical self-consciousness. For NCC a model was suggested that contrasted normal, severely disturbed state of consciousness and state without consciousness. Patients with disorders of consciousness were used. Results suggested that the repertoire, duration and oscillatory type of EEG microstates in resting (...) condition quantitatively related to the level of consciousness expression in brain-damaged patients and healthy-conscious subjects. Specifically, results demonstrated that (a) decreased number of EEG microstate types was associated with altered states of consciousness, (b) unawareness was associated with the lack of diversity in EEG alpha-rhythmic microstates, and (c) the probability for the occurrence and duration of delta-, theta- and slow-alpha-rhythmic microstates were associated with unawareness, whereas the probability for the occurrence and duration of fast-alpha-rhythmic microstates were associated with consciousness. In conclusion, resting EEG has a potential value in revealing NCC. This work may have implications for clinical care and medical–legal decisions in patients with disorders of consciousness. (shrink)

Recent experiments have shown that the amplitudes of cortical gamma band oscillatory activities that occur during anesthesia are often greater than amplitudes of similar activities that occur without anesthesia. This result is apparently at odds with the hypothesis that synchronized oscillatory activities constitute the neural correlate of consciousness. We argue that while synchronization and oscillatory patterning are necessary conditions for consciousness, they are not sufficient. Based on the results of a binocular rivalry study of Fries et al. (...) (1997), we propose that the degrees of oscillatory strength and synchronization of neuronal activities determine the degree of awareness those activities produce. On the other hand, the overal firing rates of neurons in cortical sensory areas are not correlated with the degree of awareness the activities of those neurons produce. The results of the experiment of Fries et al. (1997) appear to conflict with the results of another binocular rivalry experiment, in which monkeys were trained to pull a lever in order to report which stimulus object was being perceived (Leopold & Logothetis, 1996). In the latter experiment, it was demonstrated that the firing rates of neurons in striate cortex did not change during perceptual alterations, while 90% of neurons in inferior and superior temporal cortices changed their firing rate when the perceived image changed. This result led to the conclusion that activities in temporal cortex are correlated with visual awareness, but those in striate cortex are not. We argue that activities in temporal cortex contribute little, if anything, to perceptual awareness, and that their primary function is computational. Thus the correlation between the firing rates of neurons in these areas and the responses of the monkeys is due to the recognition of a particular stimulus object, which in turn is due to the computations made there. (shrink)

Empathy is often split into an affective facet for embodied simulation or sometimes sensorial processing, and a cognitive facet for mentalizing and perspective-taking. However, a recent neurophenomenological framework proposes a graded view on empathy (i.e., “Graded Empathy”) that extends this dichotomy and considers multiple levels while integrating complex neural patterns and representations of subjective experience. In the current magnetoencephalography study, we conducted a multidimensional investigation of neural oscillatory modulations and their cortical sources in 44 subjects while observing stimuli (...) that convey vicarious pain (vs no-pain) in a broad time window and frequency range to explore rich neural representations of pain empathy. Furthermore, we collected participants’ subjective-experience of sensitivity to vicarious pain, as well as their self-reported trait levels of affective and cognitive empathy to examine the possible associations between neural mechanisms and subjective experiences and reports. While extending previous electrophysiological studies that mainly focused on alpha suppression, we found here four significant power modulation patterns corresponding to multiple facets of empathy: an early central (peaking in the paracentral sulcus) alpha (6–11 Hz) suppression pattern plausibly reflecting sensory processing, two early beta (15–23 Hz) suppression patterns in the mid-cingulate cortex (plausibly reflecting the affective component) and in the precuneus (plausibly reflecting the cognitive component), and a late anterior (peaking in the orbitofrontal cortex) alpha-beta (11–19 Hz) enhancement pattern (plausibly reflecting cognitive-control inhibitory response). Interestingly, the latter measure was negatively correlated with the subjective sensitivity to vicarious pain, thereby possibly revealing a novel inhibitory neural mechanism determining the subjective sensitivity to vicarious pain. Altogether, these multilevel findings cannot be accommodated by the dichotomous model of empathy (i.e., affective-cognitive), and provide empirical support to theGraded Empathyneurophenomenological framework. Furthermore, this work emphasizes the importance of examining multiple neural rhythms, their cortical generators, and reports of subjective-experience in the aim of elucidating the complex nature of empathy. (shrink)

In this commentary, the formation of “pre-iconic” visual-prime persistence is described in the context of prime-specific, independent-component activation at prefrontal and posterior EEG-recording sites. Although this activity subserves neural systems that are near identical to those described by Ruchkin and colleagues, we consider priming to be a dynamic process, identified with patterns of coherence and temporal structure of very high precision.

This article is devoted to the characterization of the basin of attraction of pattern solutions for some slow–fast reaction–diffusion systems with a symmetric property and an underlying oscillatory reaction part. We characterize some subsets of initial conditions that prevent the dynamical system to evolve asymptotically toward solutions which are homogeneous in space. We also perform numerical simulations that illustrate theoretical results and give rise to symmetric and non-symmetric pattern solutions. We obtain these last solutions by choosing particular random initial (...) conditions. (shrink)

BackgroundFreezing of gait is a disabling burden for Parkinson’s disease patients with poor response to conventional therapies. Combined deep brain stimulation of the subthalamic nucleus and substantia nigra moved into focus as a potential therapeutic option to treat the parkinsonian gait disorder and refractory FoG. The mechanisms of action of DBS within the cortical-subcortical-basal ganglia network on gait, particularly at the cortical level, remain unclear.MethodsTwelve patients with idiopathic PD and chronically-implanted DBS electrodes were assessed on their regular dopaminergic medication in (...) a standardized stepping in place paradigm. Patients executed the task with DBS switched off, conventional STN DBS and combined STN+SN DBS and were compared to healthy matched controls. Simultaneous high-density EEG and kinematic measurements were recorded during resting-state, effective stepping, and freezing episodes.ResultsClinically, STN+SN DBS was superior to conventional STN DBS in improving temporal stepping variability of the more affected leg. During resting-state and effective stepping, the cortical activity of PD patients in STIM OFF was characterized by excessive over-synchronization in the theta, alpha, and high-beta band compared to healthy controls. Both active DBS settings similarly decreased resting-state alpha power and reduced pathologically enhanced high-beta activity during resting-state and effective stepping compared to STIM OFF. Freezing episodes during STN DBS and STN+SN DBS showed spectrally and spatially distinct cortical activity patterns when compared to effective stepping. During STN DBS, FoG was associated with an increase in cortical alpha and low-beta activity over central cortical areas, while with STN+SN DBS, an increase in high-beta was prominent over more frontal areas.ConclusionsSTN+SN DBS improved temporal aspects of parkinsonian gait impairment compared to conventional STN DBS and differentially affected cortical oscillatory patterns during regular locomotion and freezing suggesting a potential modulatory effect on dysfunctional cortical-subcortical communication in PD. (shrink)

Here we elucidate a paradox: how a single chemoattractant‐receptor system in two individuals is used for communication despite the seeming inevitability of self‐excitation. In the filamentous fungus Neurospora crassa, genetically identical cells that produce the same chemoattractant fuse via the homing of individual cell protrusions toward each other. This is achieved via a recently described “ping‐pong” pulsatile communication. Using a generic activator‐inhibitor model of excitable behavior, we demonstrate that the pulse exchange can be fully understood in terms of two excitable (...) systems locked into a stable oscillatory pattern of mutual excitation. The most puzzling properties of this communication are the sudden onset of oscillations with final amplitude, and the absence of seemingly inevitable self‐excitation. We show that these properties result directly from both the excitability threshold and refractory period characteristic of excitable systems. Our model suggests possible molecular mechanisms for the ping‐pong communication. (shrink)

To what extent can humorism be a legitimate disposition toward the Absurd? The Absurd is born from the insurmountable contradiction between one’s ceaseless striving and the absence of an ultimate resolution – or, as I prefer to call it, the ‘dissolution of resolution’. Humoristic Absurdism is the commitment to a pattern of humorous responses to the Absurd, which regard this absurd condition, as well as its manifestation in absurd situations, as a comical phenomenon. Although the humoristic disposition seems promising, by (...) virtue of humor’s recognition of incongruity and its denial of an ultimate resolution, and succeeds in countering three major objections, it falls prey to the claim that comprehensive humorism portrays as frivolous what is earnest, thereby renouncing the gravity of the desire for ultimate resolution, which is fundamental to the notion of the Absurd. In an attempt to explore alternative roles for humor in a legitimate disposition toward the Absurd, Metamodern Absurdism is suggested, which revolves around a post-ironic oscillation between humor and earnestness. In short, only in a role limited to one pole of an oscillatory pattern of responses can humor be integrated in a legitimate disposition toward the Absurd. (shrink)

Travelling waves crossing the nervous networks at mesoscopic/macroscopic scales have been correlated with different brain functions, from long-term memory to visual stimuli. Here we investigate a feasible relationship between wave generation/propagation in recurrent nervous networks and a physical/chemical model, namely the Belousov–Zhabotinsky reaction. Since BZ’s nonlinear, chaotic chemical process generates concentric/intersecting waves that closely resemble the diffusive nonlinear/chaotic oscillatory patterns crossing the nervous tissue, we aimed to investigate whether wave propagation of brain oscillations could be described in terms (...) of BZ features. We compared experimentally detected oscillations during the spontaneous activity of the brain with BZ-like concentric waves simulated by a recently introduced artificial network. The observed overlap and agreement between simulated and measured oscillatory patterns suggests that changes in cortical areas’ neural activity might be described in terms of a recognizable diffusion pattern. We describe biological plausibility, benefits and limits of our approach and discuss the relationship among BZ-like networks, Pandemonium-like architectures and the spontaneous activity of the brain. ER -. (shrink)

The occurrence of oscillatory behaviours in living cells can be viewed as a visible consequence of stable, regulatory homeostatic cycles. Therefore, they may be used as experimental windows on the underlying physiological mechanisms. Recent studies show that growing pollen tubes are an excellent biological model for these purposes. They unite experimental simplicity with clear oscillatory patterns of both structural and temporal features, most being measurable during real‐time in live cells. There is evidence that these cellular oscillators involve (...) an integrated input of plasma membrane ion fluxes, and a cytosolic choreography of protons, calcium and, most likely, potassium and chloride. In turn, these can create positive feedback regulation loops that are able to generate and self‐sustain a number of spatial and temporal patterns. Other features, including cell wall assembly and rheology, turgor, and the cytoskeleton, play important roles and are targets or modulators of ion dynamics. Many of these features have similarities with other cell types, notably with apical‐growing cells. Pollen tubes may thus serve as a powerful model for exploring the basis of cell growth and morphogenesis. BioEssays 23:86–94, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The orderly sequence of events that constitutes the cell cycle is carefully regulated. A part of this regulation depends upon the ubiquitous calcium signalling system. Many growth factors utilize the messenger inositol trisphosphate (InsP3) to set up prolonged calcium signals, often organized in an oscillatory pattern. These repetitive calcium spikes require both the entry of external calcium and its release from internal stores. One function of this calcium signal is to activate the immediate early genes responsible for inducing resting (...) cells (G0) to re‐enter the cell cycle. It may also promote the initiation of DNA synthesis at the G1/S transition. Finally, calcium contributes to the completion of the cell cycle by stimulating events at mitosis. The role of calcium in cell proliferation is highlighted by the increasing number of anticancer therapies and immunosuppressant drugs directed towards this calcium signalling pathway. (shrink)

In the characterization of the ArCl2 'van der Waals complex', a recognizable pattern of well-defined peaks is observed in the microwave absorption spectrum. In the control of chaos in a chemical oscillatory reaction the power spectrum progressively becomes simpler, at length yielding a single peak. Since both of these cases generate coherences that are centers of agency, they should be considered to produce new chemical entities. Applicability of this ontological approach to coherences of wider societal interest is suggested.

Temporal patterns in human movement, and in speech in particular, occur on multiple timescales. Regularities in such patterns have been observed between speech gestures, which are relatively quick movements of articulators (e.g., tongue fronting and lip protrusion), and also between rhythmic units (e.g., syllables and metrical feet), which occur more slowly. Previous work has shown that patterns in both domains can be usefully modeled with oscillatory dynamical systems. To investigate how rhythmic and gestural domains interact, an (...) experiment was conducted in which speakers performed a phrase repetition task, and gestural kinematics were recorded using electromagnetic articulometry. Variance in relative timing of gestural movements was correlated with variance in rhythmic timing, indicating that gestural and rhythmic systems interact in the process of planning and producing speech. A model of rhythmic and gestural planning oscillators with multifrequency coupling is presented, which can simulate the observed covariability between rhythmic and gestural timing. (shrink)

During somitogenesis an oscillatory mechanism termed the “segmentation” clock generates periodic waves of gene expression, which translate into the periodic spatial pattern manifest as somites. The dynamic expression of the clock genes shares the same periodicity as somitogenesis. Notch signaling is believed to play a role in the segmentation clock mechanism. The paper by Hirata et al.(1) identifies a biological clock in cultured cells that is dependent upon the Notch target gene Hes1, and which shows a periodicity similar to (...) that of the segmentation clock. This finding opens the possibility that the same oscillator mechanism might also operate in other tissues or cell types. BioEssays 25:200–203, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

During somitogenesis an oscillatory mechanism termed the “segmentation” clock generates periodic waves of gene expression, which translate into the periodic spatial pattern manifest as somites. The dynamic expression of the clock genes shares the same periodicity as somitogenesis. Notch signaling is believed to play a role in the segmentation clock mechanism. The paper by Hirata et al.(1) identifies a biological clock in cultured cells that is dependent upon the Notch target gene Hes1, and which shows a periodicity similar to (...) that of the segmentation clock. This finding opens the possibility that the same oscillator mechanism might also operate in other tissues or cell types. BioEssays 25:200–203, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Ongoing electroencephalography signals are recorded as a mixture of stimulus-elicited EEG, spontaneous EEG and noises, which poses a huge challenge to current data analyzing techniques, especially when different groups of participants are expected to have common or highly correlated brain activities and some individual dynamics. In this study, we proposed a data-driven shared and unshared feature extraction framework based on nonnegative and coupled tensor factorization, which aims to conduct group-level analysis for the EEG signals from major depression disorder patients and (...) healthy controls when freely listening to music. Constrained tensor factorization not only preserves the multilinear structure of the data, but also considers the common and individual components between the data. The proposed framework, combined with music information retrieval, correlation analysis, and hierarchical clustering, facilitated the simultaneous extraction of shared and unshared spatio-temporal-spectral feature patterns between/in MDD and HC groups. Finally, we obtained two shared feature patterns between MDD and HC groups, and obtained totally three individual feature patterns from HC and MDD groups. The results showed that the MDD and HC groups triggered similar brain dynamics when listening to music, but at the same time, MDD patients also brought some changes in brain oscillatory network characteristics along with music perception. These changes may provide some basis for the clinical diagnosis and the treatment of MDD patients. (shrink)

A tacit assumption since the 19th Century has been that the neocortex serves as the "seat of consciousness." An unexpected challenge to that assumption arose in 1949 with the discovery that high-frequency EEG activation associated with an alert state requires the intactness of the brainstem reticular formation. This discovery became the impetus for nearly three decades of research on what came to be known as the reticular activating system. By the 1970s, however, methodological and philosophical controversies led to general abandonment (...) of subcortical theories of attention and consciousness, with a return to an almost exclusive focus upon the cortex. With recent advances in the neurosciences the focus is shifting once more, this time to the unique contributions of cortical, thalmic, and brainstem structures in mediating selective attention and perceptual awareness. This paper offers a nontechnical review of the history of these developments up to contemporary interest in the putative role of oscillatory EEG patterns in the integration of perceptual features of experience. It puts forward the thesis that a key to understanding attention and consciousness is an appreciation of contributions of the thalmus to these cognitive processes. (shrink)

In the classical Turing test, participants are challenged to tell whether they are interacting with another human being or with a machine. The way the interaction takes place is not direct, but a distant conversation through computer screen messages. Basic forms of interaction are face-to-face and embodied, context-dependent and based on the detection of reciprocal sensorimotor contingencies. Our idea is that interaction detection requires the integration of proprioceptive and interoceptive patterns with sensorimotor patterns, within quite short time lapses, (...) so that they appear as mutually contingent, as reciprocal. In other words, the experience of interaction takes place when sensorimotor patterns are contingent upon one’s own movements, and vice versa. I react to your movement, you react to mine. When I notice both components, I come to experience an interaction. Therefore, we designed a “minimal” Turing test to investigate how much information is required to detect these reciprocal sensorimotor contingencies. Using a new version of the perceptual crossing paradigm, we tested whether participants resorted to interaction detection to tell apart human from machine agents in repeated encounters with these agents. In two studies, we presented participants with movements of a human agent, either online or offline, and movements of a computerized oscillatory agent in three different blocks. In each block, either auditory or audiovisual feedback was provided along each trial. Analysis of participants’ explicit responses and of the implicit information subsumed in the dynamics of their series will reveal evidence that participants use the reciprocal sensorimotor contingencies within short time windows. For a machine to pass this minimal Turing test, it should be able to generate this sort of reciprocal contingencies. (shrink)

Given what we know about the segregated nature of the brain and the relative absence of multi-modal association areas in the cortex, how percepts become unified is not clear. However, if we could work out how and where the brain joins together segregated outputs, we would have a start in localizing the neuronal processes that correlate with conscious perceptual experiences. In this essay, I critically examine data relevant for understanding the neurophysiological underpinnings of perception. In particular, I examine the possibility (...) that 40 Hz. oscillatory firing patterns in cortex are important lower-level neuronal events related to perceptual experiences. I suggest that `binding' - understood as a process of hooking together disparate psychological units - reduces to a property inherent in the structure of our brain's firing patterns. However, this reduction may not reflect the firing rates of individual cells, but instead a `higher level' order superimposed on individual cells' activity. (shrink)

Animals search for food and shelter by locomotion through time and space. The elemental step is the action-perception cycle, which has three steps. In the first step a volley of action potentials initiated by an act of search triggers the formation of a macroscopic wave packet that constitutes the memory of the stimulus. The wave packet is filtered and sent to the entorhinal cortex, where it is combined with wave packets from all sensory systems. This triggers the second step forming (...) a unified memory that is passed through the hippocampal formation where it is assigned a place in the life-long memory of the subject. In the third step the output of the entorhinal cortex triggers the formation of a global wave packet that synchronizes the oscillatory activity of most of not all of the cerebral cortex. This shared oscillation caries a pattern of amplitude modulation, that can be observed non-invasively from the scalp EEG of human volunteers perceiving the stimulus and correlated with the stimulus. The same dendritic electric currents that drive the output of the brains of the wave packet drive the observed EEG signs. Therefore I postulate that the global wave packet, the third step in the cycle requiring only 0.2 seconds expresses the memory of the global accommodation that initiates the next action-perception cycle. Some unspecified fraction of the AM pattern is available to me the observer, and some other unspecified fraction of the total activity in the subject who is expected to respond to the stimulus. There is reason to hope that these fractions will coincide often enough to support refinements in techniques for extending these correlates of consciousness. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}. (shrink)

This book presents a new approach to studying the syntax of human language, one which emphasizes how we think about time. Tilsen argues that many current theories are unsatisfactory because those theories conceptualize syntactic patterns with spatially arranged structures of objects. These object-structures are atemporal and do not lend well to reasoning about time. The book develops an alternative conceptual model in which oscillatory systems of various types interact with each other through coupling forces, and in which the (...) relative energies of those systems are organized in particular ways. Tilsen emphasizes that the two primary mechanisms of the approach - oscillators and energy levels - require alternative ways of thinking about time. Furthermore, his theory leads to a new way of thinking about grammaticality and the recursive nature of language. The theory is applied to a variety of syntactic phenomena: word order, phrase structure, morphosyntax, constituency, case systems, ellipsis, anaphora, and islands. The book also presents a general program for the study of language in which the construction of linguistic theories is itself an object of theoretical analysis. (shrink)

: The natural philosopher Michael Faraday and the psychologist Jean Piaget experimented directly with natural phenomena and children. While Faraday originated evidence for spatial fields mediating force interactions, Piaget studied children's cognitive development. This paper treats their experimental processes in parallel, taking as examples Faraday's 1831 investigations of water patterns produced under vibration and Piaget's interactions with his infants as they sought something he hid. I redid parts of Faraday's vibrating fluid activities and Piaget's hiding games. Like theirs, my (...) experiences showed that incomplete observations and confusions accompanied—and facilitated —experimental developments. While working with things in their hands, these experimenters' minds were also engaged, inferring new, more coherent understandings of the behaviors under study. Transitory ripples disclosed distinct patterns; infants devised more productive search methods. From the ripples, Faraday discerned an oscillatory condition that informed his subsequent speculations about light. From the infant search, Piaget identified experimenting as a child's means of developing self and world, later envisioning its infusion into education. Taken together, these two stories demonstrate that cognitive capacities emerge in the actual process of experimenting. This finding eclipses the historical context in its implications for education today. When learners pursue their own experiments, their minds develop. (shrink)

This dissertation is meant to interpret Whitehead's basic unit of ontology in energetic terms. The actual entity is to be understood as an oscillating unit of existence that is nothing other than its oscillatory activity. There is nothing substantial underlying it: it is essentially a vibrating entity that has nothing more primary appended to it. Through such vibratory activity, it realizes itself out of its own conative drive and its deeply interrelated adventures with other entities and objects. Energizing actuality (...) makes such entities objectively stubborn, subjectively agentive, massively interrelated to others, and entirely aesthetic in constitution. There are two main ways to analyze this metaphysical energy. This is mirrored by Whitehead's twofold analysis of actuality from the genetic and coordinate perspectives, which itself is an adaptation of James's Pragmatic analysis of experience. The quantum oscillation model of atomicity perfectly matches Whitehead's genetic analysis, and thus the phases of actuality, the poles of existence, and the formation of an atomic unit, are all developed in oscillatory terms. Conversely there is the coordinate analysis, where issues of ontological rhythmicity, identity via agentive repetition, unification via cyclical patternings, and coeval concrescence among entities will be dealt with according to the principles of wave transmission. Each analysis develops important characteristics of actuality, but neither analysis on its own can capture the totality of what actuality is. For such a generic interpretation to occur, unification between the genetic and the coordinate analyses must take place. The energy thesis accomplishes this by adopting the language of energy fields. The actual entity is a field of energy that is both the center of agentive activity that defines the field, and the center of attention of other entities. Whitehead calls this ontologically agentive attention 'concern,' a term that allows Whitehead to be closely compared to Heidegger, whose existential analysis of Dasein will be used to further develop the character of actuality. The aesthetic core of Whiteheadian ontology will be developed by comparing it to Dewey's aesthetic theory of consummatory experience. Together, a fully concerned and consummatory actual entity will stand as the most generic rendering of actuality. (shrink)

Position measurement-induced collapse states are shown to provide a unified quantum description of diffraction of particles passing through a single slit. These states, which we here call ‘quantum location states’, are represented by the conventional rectangular wave function at the initial time of position measurement. We expand this state in terms of the position eigenstates, which in turn can be represented as a linear combination of energy eigenfunctions of the problem, using the closure property. The time-evolution of the location states (...) in the case of free particles is shown to have position probability density patterns closely resembling diffraction patterns in the Fresnel region for small times and the same in Fraunhofer region for large times. Using the quantum trajectory representations in the de Broglie–Bohm, modified de Broglie–Bohm and Floyd–Faraggi–Matone formalisms, we show that Fresnel and Fraunhofer diffractions can be described using a single expression. We also discuss how to obtain the probability density of location states for the case of particles moving in a general potential, detected at some arbitrary point. In the case of the harmonic oscillator potential, we find that they have oscillatory properties similar to that of coherent states. (shrink)

Cerebellar Purkinje cells generate two distinct types of spikes, complex and simple spikes, both of which have conventionally been considered to be highly irregular, suggestive of certain types of stochastic processes as underlying mechanisms. Interestingly, however, the interspike interval structures of complex spikes have not been carefully studied so far. We showed in a previous study that simple spike trains are actually composed of regular patterns and single interspike intervals, a mixture that could not be explained by a simple (...) rate-modulated Poisson process. In the present study, we systematically investigated the interspike interval structures of separated complex and simple spike trains recorded in anaesthetized rats, and derived an appropriate stochastic model. We found that: (i) complex spike trains do not exhibit any serial correlations, so they can effectively be generated by a renewal process, (ii) the distribution of intervals between complex spikes exhibits two narrow bands, possibly caused by two oscillatory bands (0.5–1 and 4–8 Hz) in the input to Purkinje cells and (iii) the regularity of regular patterns and single interspike intervals in simple spike trains can be represented by gamma processes of orders, which themselves are drawn from gamma distributions, suggesting that multiple sources modulate the regularity of simple spike trains. (shrink)

ObjectiveFreezing of gait is detrimental to patients with idiopathic Parkinson’s disease. Its pathophysiology represents a multilevel failure of motor processing in the cortical, subcortical, and brainstem circuits, ultimately resulting in ineffective motor output of the spinal pattern generator. Electrophysiological studies pointed to abnormalities of oscillatory activity in freezers that covered a broad frequency range including the theta, alpha, and beta bands. We explored muscular frequency domain activity with respect to freezing, and used deep brain stimulation to modulate these rhythms (...) thereby evaluating the supraspinal contributions to spinal motor neuron activity.MethodsWe analyzed 9 PD freezers and 16 healthy controls. We studied the patients after overnight withdrawal of dopaminergic medication with stimulation off, stimulation of the subthalamic nucleus or the substantia nigra pars reticulate, respectively. Patients performed a walking paradigm passing a narrow obstacle. We analyzed the frequency-domain spectra of the tibialis anterior and gastrocnemius muscles in ‘regular gait’ and during the ‘freezing’ episodes.ResultsIn stimulation off, PD freezers showed increased muscle activity of the alpha and low-beta band compared to HC in both TA and GA. This activity increase was present during straight walking and during the freezes to similar extent. STN- but not SNr-DBS decreased this activity and paralleled the clinical improvement of freezing.ConclusionWe found increased muscle activation of the alpha and lower beta band in PD freezers compared to HC, and this was attenuated with STN-DBS. Future studies may use combined recordings of local field potentials, electroencephalography, and electromyography to interrogate the supraspinal circuit mechanisms of the pathological activation pattern of the spinal pattern generator. (shrink)

I examine critically the application of information‐theoretic ideas to biological communication during embryonic development and in the functioning central nervous system (CNS). I show that intercellular communication relies mostly on simple signals whose role is to effect a selection among predetermined cellular states. Hence, a crucial role is played by cellular memory, which stabilizes such states. Memory in cells is partly located in the nuclear DNA; no less important however is (phenotypic) memory lying in the cell's organelles and compartments. Because (...) of combinatorial effects in gene expression patterns, cell memory is an enormously powerful mechanism, which also underlies plasticity, and thus constitutes the factor unifying genetic determination, plasticity and learning. Communication in the CNS is analyzed in some detail: here, cellular memory is embodied in anatomy (i.e., cell shape) and neurochemistry. These are the major, relatively “static” factors affecting the routing of neural impulses in the adult CNS. In addition, however, faster channeling is also required: action potentials must be directed to their targets along a few of exponentially many paths, and this dynamic routing is crucial for proper operation. I suggest that collective oscillatory modes may play a role in solving this addressing problem, in the same way that the clock signal gates the operation of man‐made computers. BioEssays 25:699–708, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The nature of perceptual and memory processes is examined in the light of suggested complementarity between introspective and empirical traditions. The introspective material analysed here is that found in the Buddhist Abhidhamma literature of the Pali canon on the stages of perception. Possible psychological and neurophysiological correspondences to these stages are proposed. The model of perception advanced here emphasizes two phases. The first involves sensory analysis and related memory readout. I postulate that this phase is completed when coherence in (...) class='Hi'>oscillatory neuronal patterns indicates a ‘match’ between sensory input and memory readout. The second phase results in consciousness of the object, which comes about when a connection is effected between the representation of the input as generated in phase one and a representation of self . ‘I’ is itself generated in this second phase in relation to the memory readout of phase one, since this readout includes relevant prior formations of ‘I’. It is suggested that ‘I’ functions in the organization of memory and recall. (shrink)

A nonlinear two-variable reaction-diffusion model of bone mineral metabolism, built from an overall self-oscillatory compartmental model of calcium metabolism in vivo, has been studied for its ability to generate spatial and spatio-temporal self-organizations in a two-dimensional space. Analytical and numerical results confirm the theoretical properties previously described for this kind of model. In particular, it is shown that, for a given set of reactional parameter values and certain values of the ratio of the two diffusion coefficients, there exists a (...) set of unstable wavenumbers leading spontaneously to the development, from the homogeneous steady state, of either different types of stationary spatial patterns (hexagonal, striped and re-entrant hexagonal patterns) or more or less complex spatio-temporal expressions. We discuss the relevance of analogies established between some spatial or spatio-temporal structures predicted by the model and some peculiar features of the primary bone trabecular architecture which appear during embryonic ossification. (shrink)

Dance has traditionally been viewed from a Eurocentric perspective as a mode of self-expression that involves the human body moving through space, performed for the purposes of art, and viewed by an audience. In this Hypothesis and Theory article, we synthesize findings from anthropology, sociology, psychology, dance pedagogy, and neuroscience to propose The Synchronicity Hypothesis of Dance, which states that humans dance to enhance both intra- and inter-brain synchrony. We outline a neurocentric definition of dance, which suggests that dance involves (...) neurobehavioral processes in seven distinct areas including sensory, motor, cognitive, social, emotional, rhythmic, and creative. We explore The Synchronicity Hypothesis of Dance through several avenues. First, we examine evolutionary theories of dance, which suggest that dance drives interpersonal coordination. Second, we examine fundamental movement patterns, which emerge throughout development and are omnipresent across cultures of the world. Third, we examine how each of the seven neurobehaviors increases intra- and inter-brain synchrony. Fourth, we examine the neuroimaging literature on dance to identify the brain regions most involved in and affected by dance. The findings presented here support our hypothesis that we engage in dance for the purpose of intrinsic reward, which as a result of dance-induced increases in neural synchrony, leads to enhanced interpersonal coordination. This hypothesis suggests that dance may be helpful to repattern oscillatory activity, leading to clinical improvements in autism spectrum disorder and other disorders with oscillatory activity impairments. Finally, we offer suggestions for future directions and discuss the idea that our consciousness can be redefined not just as an individual process but as a shared experience that we can positively influence by dancing together. (shrink)

A macroscope is proposed and tested here for the discovery of the unique argumentative footprint that characterizes how a collective manages differences and pursues disagreement through argument in a polylogue. The macroscope addresses broader analytic problems posed by various conceptualizations of large-scale argument, such as fields, spheres, communities, and institutions. The design incorporates a two-tier methodology for detecting argument patterns of the arguments performed in arguing by an interactive collective that produces views, or topographies, of the ways that issues (...) are generated in the making and defending of standpoints. The design premises for the macroscope build on insights about argument patterns from pragma-dialectical theory by incorporating research and theory on disagreement management and the Argumentum Model of Topics. The design reconceptualizes prototypical and stereotypical argument patterns for characterizing large-scale argumentation. A prototype of the macroscope is tested on data drawn from six threads about oil-drilling and fracking from the subreddit Changemyview. The implementation suggests the efficacy of the macroscope’s design and potential for identifying what communities make controversial and how the disagreement space in a polylogue is managed through stereotypical argument patterns in terms of claims/premises, inferential relations, and presentational devices. (shrink)

Bogen and Woodward claim that the function of scientific theories is to account for 'phenomena', which they describe both as investigator-independent constituents of the world and as corresponding to patterns in data sets. I argue that, if phenomena are considered to correspond to patterns in data, it is inadmissible to regard them as investigator-independent entities. Bogen and Woodward's account of phenomena is thus incoherent. I offer an alternative account, according to which phenomena are investigator-relative entities. All the infinitely (...) many patterns that data sets exhibit have equal intrinsic claim to the status of phenomenon: each investigator may stipulate which patterns correspond to phenomena for him or her. My notion of phenomena accords better both with experimental practice and with the historical development of science. (shrink)

While the subjective experience of insight during problem solving is a common occurrence, an understanding of the processes leading to solution remains relatively uncertain. The goal of this study was to investigate the restructuring patterns underlying solution of a creative problem, and how providing cues to solution may alter the process. Results show that both providing cues to solution and analyzing problem solving performance on an aggregate level may result in restructuring patterns that appear incremental. Analysis of performance (...) on an individual level provides evidence for insight-like solution patterns. However, no evidence is found for a relationship between an individual’s restructuring pattern and their subjective experience of insight during problem solving. (shrink)

Mathematics as a Science of Patterns is the definitive exposition of a system of ideas about the nature of mathematics which Michael Resnik has been elaborating for a number of years. In calling mathematics a science he implies that it has a factual subject-matter and that mathematical knowledge is on a par with other scientific knowledge; in calling it a science of patterns he expresses his commitment to a structuralist philosophy of mathematics. He links this to a defence (...) of realism about the metaphysics of mathematics--the view that mathematics is about things that really exist. Resnik's distinctive philosophy of mathematics is here presented in an accessible and systematic form: it will be of value not only to specialists in this area, but to philosophers, mathematicians, and logicians interested in the relationship between these three disciplines, or in truth, realism, and epistemology. (shrink)

John Mackie’s moral error theory is so closely associated in people’s minds with his arguments from relativity and from queerness that one might overlook the fact that there may be numerous other, and possibly better, ways of establishing that metaethical position. Perhaps, indeed, there are even further resources for arguing for a moral error theory to be unearthed in Mackie’s own book. I have in mind Mackie’s thesis of moral objectification: that the “objective prescriptivity” with which our moral judgments are (...) imbued is the result of our “tendency to read our feelings into their objects” (1977: 42). Mackie invokes Hume’s famous projectivist image of the human mind’s “great propensity to spread itself on external objects,” and, indeed, it is in his book-length analysis of Hume’s moral theory (Mackie 1980) that the topic receives a more careful discussion than in Ethics: Inventing Right and Wrong. In both books he musters some considerations in favor of the thesis, and reveals to us that he thinks that “it is very largely correct” (1980: 72). (shrink)

TThis paper aims to evidence the inherently metonymic nature of co-speech gestures. Arguing that motivation in gesture involves iconicity (similarity), indexicality (contiguity), and habit (conventionality) to varying degrees, it demonstrates how a set of metonymic principles may lend a certain systematicity to experientially grounded processes of gestural abstraction and enaction. Introducing visuo-kinetic signs as an umbrella term for co-speech gestures and signed languages, the paper shows how a frame-based approach to gesture may integrate different cognitive/functional linguistic and semiotic accounts of (...) metonymy (e.g., experiential domains, frame metonymy, contiguity, and pragmatic inferencing). The guiding assumption is that gestures metonymically profile deeply embodied, routinized aspects of familiar scenes, that is, the motivating context of frames. The discussion shows how gestures may evoke frame structures exhibiting varying degrees of groundedness, complexity, and schematicity: basic physical action and object frames; more complex frames; and highly abstract, complex frame structures. It thereby provides gestural evidence for the idea that metonymy is more basic and more directly experientially grounded than metaphor and thus often feeds into correlated metaphoric processes. Furthermore, the paper offers some initial insights into how metonymy also seems to induce the emergence of schematic patterns in gesture which may result from action-based and discourse-driven processes of habituation and conventionalization. It exemplifies how these forces may engender grammaticalization of a basic physical action into a gestural marker that shows strong metonymic form reduction, decreased transitivity, and interacting pragmatic functions. Finally, addressing basic metonymic operations in signed lexemes elucidates certain similarities regarding sign constitution in gesture and sign. English and German multimodal discourse data as well as German Sign Language (DGS) are drawn upon to illustrate the theoretical points of the paper. Overall, this paper presents a unified account of metonymy’s role in underpinning forms, functions, and patterns in visuo-kinetic signs. (shrink)

Traditional frameworks for evaluating scientific models have tended to downplay their exploratory function; instead they emphasize how models are inherently intended for specific phenomena and are to be judged by their ability to predict, reproduce, or explain empirical observations. By contrast, this paper argues that exploration should stand alongside explanation, prediction, and representation as a core function of scientific models. Thus, models often serve as starting points for future inquiry, as proofs of principle, as sources of potential explanations, and as (...) a tool for reassessing the suitability of the target system. This is illustrated by a case study of the varied career of reaction-diffusion models in the study of biological pattern formation, which was initiated by Alan Turing in a classic 1952 paper. Initially regarded as mathematically elegant, but biologically irrelevant, demonstrations of how, in principle, spontaneous pattern formation could occur in an organism, such Turing models have only recently rebounded, thanks to advances in experimental techniques and computational methods. The long-delayed vindication of Turing’s initial model, it is argued, is best explained by recognizing it as an exploratory tool. (shrink)

The mandate to make disciples of all nations remains the churches’ task before the return of Christ. Church planting is the best way to achieve this mandate. Hence, the biblical patterns as exemplified by Paul the apostle and their relevance to achieving the Great Commission have been the focus of this work. Paul shows through his patterns of church planting the relevance and influence of the Holy Spirit in establishing new centres of worship. Thus, contemporary church planters must (...) seek to emulate Paul in obedience to the Great Commission through church planting, which remains the most effective evangelistic methodology. (shrink)

This study used bibliometric data from Language Testing, a prestigious international peer-reviewed journal in the language testing field, to investigate research trends and development patterns in language testing. The bibliometric information included the number of publications, the most frequently researched test types and topics, the most cited publications and authors, the most prolific countries/regions and institutions and the most frequently collaborating countries/regions. The results showed that interest in language testing has increased over time and that regional tests and international (...) tests have been major concerns, while classroom tests/assessments have received less attention. Research topics were wide-ranging and addressed almost all language testing related issues, among which validity/validation received the highest interest across periods. Moreover, the publications were produced by a wide range of countries/regions and institutions and included collaborative research spanning various institutions and regions, although collaborative publications across countries were relatively scarce. Based on the findings of this study, implications and suggestions have been highlighted for future research, academic agencies and this journal. (shrink)

Test anxiety is a widespread and primarily detrimental emotion in learning and achievement settings. This research aimed to explore the autonomic nervous system response patterns of test-anxious individuals in response to evaluative stress. By presenting a standard interview task, an evaluative scenario was effectively induced. Heart rate variability, a biomarker that can accurately reflect the ANS activity, was used to reflect the physiological responses of 48 high test-anxious subjects and 49 low test-anxious subjects. Results indicate that: both groups show (...) a significantly increased emotional arousal in the evaluative scenario; high test-anxious individuals show a significantly decreased emotional pleasantness in the evaluative scenario, whereas low test-anxious individuals show no significant changes; both groups show a significantly increased low-frequency HRV; high test-anxious individuals show a significantly decreased high-frequency HRV and root mean square of successive heartbeat interval differences, whereas low test-anxious individuals remain stable. These findings suggest that high test-anxious individuals display an increased sympathetic nervous system activity and a decreased parasympathetic nervous system activity in response to evaluative stress, while low-anxious individuals display an increased SNS activity and a stable PNS activity in response to evaluative stress. (shrink)