Introduction : schizoanalysis, digital screens and new brain circuits -- Schizoid minds, delirium cinema and powers of machines of the invisible -- Illusionary perception and powers of the false -- Surveillance screens and powers of affect -- Signs of time : meta/physics of the brain-screen -- Degrees of belief : epistemology of probabilities -- Powers of creation : aesthetics of material-force -- The open archive : cinema as world-memory -- Divine in(ter)vention : micropolitics and resistance -- Logistics of perception 2.0 (...) : multiple screens as affective weapons -- Conclusion : the neuro-image : brain-screens from the future. (shrink)

This paper proposes to read cinema in the digital age as a new type of image, the neuroimage. Going back to Gilles Deleuze's cinema books and it is argued that the neuro-image is based in the future. The cinema of Alain Resnais is analyzed as a neuro-image and digital cinema.

Der Beitrag schlägt vor, das Kino des digitalen Zeitalters als einen neuen Typus des Bildes zu lesen: als Neuro-Bild. Im Rückgriff auf Gilles Deleuzes Kino-Bücher sowie sein Werk Differenz und Wiederholung argumentiert der Beitrag, dass das Neuro-Bild in der Zukunft begründet sei. Abschließend wird das Kino von Alain Resnais als Neuro-Bild und digitales Kino avant la lettre vorgestellt. This paper proposes to read cinema in the digital age as a new type of image, the neuroimage. Going back (...) to Gilles Deleuze's cinema books and it is argued that the neuro-image is based in the future. The cinema of Alain Resnais is analyzed as a neuro-image and digital cinema. (shrink)

This essay presents some thoughts on schizoanalysis and visual culture around the proposition that cinema survives in the digital age as a type of image that, after the movement-image and the time-image, could be called the neuro-image. By considering clinical schizophrenia as ‘degree zero’ of schizoanalysis in a more critical sense, a reading of The Butterfly Effect unfolds the temporal dimensions of schizoanalysis as typical for a definition of ‘the neuro-image’. The argument is that the neuro-image speaks (...) from the (always speculative) future. (shrink)

With improved diagnostic capability and accuracy, the fields of medicine, neuroscience, psychiatry, and psychology have benefitted remarkably from the dramatic advancements in neuroimaging technology. Not only can surface and subsurface structures of the brain be mapped with incredible anatomical detail, now neural activity can be imaged across time as the brain responds to different stimuli. These sophisticated techniques have been a vital element in the recent increase in neuroimaging-based research. This increase, while producing new diagnostic techniques and improved treatment mechanisms (...) for neurological disease, has also led to a new dilemma for human subjects researchers: how should incidental findings be managed? An incidental finding is a finding concerning an individual research participant that has potential health or reproductive importance and is discovered in the course of conducting research but is beyond the aims of this study. (shrink)

This paper addresses the question of how incidental findings in clinical research should be managed by researchers, focusing in detail on IFs discovered in neuroimaging research. It begins by engaging the larger research ethics issue of whether researchers have any obligations of clinical care to participants, and assesses the content and merits of one particular framework for answering this question, Richardson and Belsky's ancillary care model. From here the paper develops an organizational structure for integrating the ancillary care model with (...) existing research ethics standards, with the aim of better understanding their respective domains. It makes a distinction between incidental findings that are anticipated by informed consent documents, and those that are unanticipated, arguing that this distinction is critical for evaluating researcher obligations. Finally, it takes on the issue of incidental findings in neuroimaging research, translating the standards discussed into recommendations for both unanticipated and anticipated findings. (shrink)

In this article, we introduce our interactive art installation Neuro Mirror that was developed in 2017 for the Cybernetic Consciousness [?] exhibition that was held in 2017 at the ITAU Cultural in Sao Paulo. This artwork enables participants to interact with their own images and those of their alter egos with the help of digital mirrors. The installation consists of three screens. The middle one shows a live image of the participant that is somewhat distorted. The one on the (...) left side also displays an image of the interacting person, but with a time delay of a few seconds. On the right screen, however, another person is shown – a young man, who is acting and moving his head. In fact, this person is programmed to be an avatar or an alter ego who reacts to the participant. He ‘learns’ new behaviours by observing and imitating the participant and reacts accordingly. A neural network programme was developed to enable him to predict the participant’s next actions from his previous ones. (shrink)

Recent neuro-psychoanalytic literature has emphasized the view that our subjective identity rests on ancient subcortical neuro-psychic processes expressing unthinking forms of experience, which are “affectively intense without being known” (Solms and Panksepp, 2012). Devoid of internal representations, the emotional states of our “core-Self” (Panksepp, 1998b) are entirely “projected” towards the external world and tend to be discharged through instinctual action-patterns. However, due to the close connections between the subcortical and the cortical midline brain, the emotional drives may also (...) find a way to be reflected within an intrinsic self-referential processing, evident when the organism is not actively engaged with the external world. Thanks to such endogenous functioning, the core-Self emotional dispositions are not overtly executed, but they are organized within coherent dynamic mental structures, called “feeling-toned complexes” by C.G. Jung and “unconscious phantasies” by Melanie Klein. The intrinsic self-referential dynamism of the ‘brainmind’ originated from REM sleep arousal and then evolved in the resting-state activity of a complex of cortico-limbic midline brain structures (CMS), also called Default Mode Network (DMN). From our neuro-ethological perspective, it is sustained by an “introverted” SEEKING activity leading to the subjective exploration of internally constructed virtual scenarios. This “mind wandering” function, implicated in dreaming, fantasy processing, remembering and thinking, is the essence of the imaginative function and constitutes the first form of reflection, where intentions and drives gain a primordial form of conscious (but not self-conscious) representation. During postnatal development, this original (“archetypal”) imaginative function is slowly attuned in a relational “transitional” space and may be expressed first in non-verbal and eventually in abstract-verbal social communicative patterns. Our view has noticeable implications for psychotherapy. Instead of trying to directly modify interpersonal, extrinsic relationships (a top-down approach), dysfunctional emotional-relational patterns may be modified by a process in which the patient is helped to let-go of the perceived feeling-objects in favor of an immersion, via the actual feeling, from the superficial level of perception towards a void feeling-state, empty of images. Only starting from this “anoetic” feeling-state, the deep imaginal creative and re-structuring self-referential activity may be reactivated by a process of spontaneous imagination. (shrink)

In recent years, complementary and alternative medicine (CAM) has grown both in popularity and economic importance. I argue that this success is primarily the result of domestication to the dominant culture of biomedicine and is readily observable in images and metaphors of the body used both in CAM and biomedical discourse. It is suggested that this shared imagery points to a new phase in the relationship between the body and society. The domestication of CAM is further illustrated through processes of (...) dissemination and professionalization. The article concludes by discussing the domestication of CAM as a reflection of an epistemological shift in biomedicine alongside its continued hegemony. (shrink)

In the debate over the ontological structures of the entity that exists as being-in-the-world, the French philosopher Henri Maldiney focuses his theoretical developments on the unintentional and pre-predicative dimension of experience, where sensing (sentir) takes its origin, and based on which the Existentials of “encounter”, “surprise” and “rhythm”, that are key to understanding the aesthetic-artistic experience, are explained in the horizon of transpassibility and transpossibility. Given that that dimension is the privileged field of encounter with art, this paper will raise (...) the question of the nexus of the articulation between art and image. This question will be developed through the opposition of form and image, of the reality of image and the image of reality, and the aesthetic vision and imaginative vision. In this analysis, we will rely upon the Heideggerian conception of Existence, as well as some of Husserl’s and the neuro-psychiatrist Erwin Straus’s researches into the passive dimension of experience, with the purpose of showing how Maldiney, starting from them, contributed in a singular and significant way to the deepening of that unintentional dimension of existence which he calls “pathic”. (shrink)

This paper discusses the possible use of functional magnetic-resonance imaging as potentially useful in jury selection. The author suggests that neuro-voir could provide greater impartiality of trials than the standard voir, while also preserving existing privacy protections for jurors. He predicts that ability to image and understand a wide range of brain activities, most notably bias-apprehension and lie detection, will render neuro-voir dire invaluable. However currently, such neuro-solutions remain preliminary.

Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of patients, but often at lower titers. The symptoms of ataxia may be mild at the onset but lead to permanent damage if remain untreated. It is characterized by damage to the cerebellum however, the pathophysiology of the disease is not clearly understood. The present study investigated the neurochemical profile of vermis and (...) right cerebellum and structural changes in various brain regions of patients with gluten ataxia and compared it with healthy controls. Volumetric 3-D T1 and T1-weighted magnetic resonance imaging in the three planes of the whole brain and single-voxel 1H- magnetic resonance spectroscopy of the vermis and right cerebellum were acquired on 3 T human MR scanner. The metabolite concentrations were estimated using LC Model while brain volumes were estimated using the online tool volBrain pipeline and CERES and corrected for partial volumes. The levels of neuro-metabolites were found to be significantly lower in vermis, while N-acetyl aspartate + N-acetyl aspartate glutamate and glycerophosphocholine + phosphocholine was lower in cerebellum regions in the patients with gluten ataxia compared to healthy controls. A significant reduction in the white matter of ; reduction in the volumes of cerebellum lobe and thalamus while lateral ventricles were increased in the patients with gluten ataxia compared to healthy controls. The reduced neuronal metabolites along with structural changes in the brain suggested neuronal degeneration in the patients with gluten ataxia. Our preliminary findings may be useful in understanding the gluten-induced cerebral damage and indicated that MRI and MRS may serve as a non-invasive useful tool in the early diagnosis, thereby enabling better management of these patients. (shrink)

The contemporary epistemic status of mental health disciplines does not allow the cross validation of mental disorders among various genetic markers, biochemical pathway or mechanisms, and clinical assessments in neuroscience explanations. We attempt to provide a meta-empirical analysis of the contemporary status of the cross-disciplinary issues existing between neuro-biology and psychopathology. Our case studies take as an established medical mode an example cross validation between biological sciences and clinical cardiology in the case of myocardial infarction. This is then contrasted (...) with the incoherence between neuroscience and psychiatry in the case of bipolar disorders. We examine some methodological problems arising from the neuro-imaging studies, specifically the experimental paradigm introduced by the team of Wayne Drevets. Several theoretical objections are raised: temporal discordance, state independence, and queries about the reliability and specificity, and failure of convergent validity of the inter-disciplinary attempt. Both modern neuroscience and clinical psychology taken as separate fields have failed to reveal the explanatory mechanisms underlying mental disorders. The data acquired inside the mono-disciplinary matrices of neurobiology and psychopathology are deeply insufficient concerning their validity, reliability, and utility. Further, there haven’t been developed any effective trans-disciplinary connections between them. It raises the requirement for development of explanatory significant multi-disciplinary “meta-language” in psychiatry (Berrios, 2006, 2008). We attempt to provide a novel conceptual model for an integrative dialogue between psychiatry and neuroscience that actually includes criteria for cross-validation of the common used psychiatric categories and the different assessment methods. The major goal of our proactive program is the foundation of complementary “bridging” connections of neuroscience and psychopathology which may stabilize the cognitive meta-structure of the mental health knowledge. This entails bringing into synergy the disparate discourses of clinical psychology and neuroscience. One possible model accomplishment of this goal would be the synergistic (or at least compatible) integration of the knowledge under trans-disciplinary convergent cross-validation of the commonly used methods and notions. (shrink)

In The Future of the Image (2007) Jacques Rancière states that the end of images is behind us. He argues for an aesthetics of the image that acknowledges the continuing power of images as educating documentations of traces of history, as directly affecting interruptions, and as open-to-combining signs of the visible and the sayable ad infinitum. But does Rancière's claim also concern the future of cinema? His cinematic references, in a Deleuzian sense, are mostly to modern time-images. Is the future (...) of film indeed a form of the time-image, or has the ‘heart’ of cinema moved beyond this image-type? This paper proposes to look at a third category of cinematographic images, based in the third synthesis of time as developed by Deleuze in Difference and Repetition. This filmic image, that could be called the neuro-image, is connected to the impure regime of images typical for the database logic of the digital age. By comparing Alain Resnais's Hiroshima Mon Amour (1959) to the television seriesFlashForward (2009), I will analyse the temporal operations of the image of the time-image to these images of a new regime of images, the image of and from the future.1. (shrink)

Jacques Mehler was notoriously charitable in embracing a diversity of approaches to science and to the use of many different methodologies. One place where his ecumenism brought the two of us into disagreement is when the evidence of brain imaging was cited in support of different psychological doctrines, such as the picture-theory of mental imagery. Jacques remained steadfast in his faith in the ability of neuroscience data (where the main source of evidence has been from clinical neurology and (...) class='Hi'>neuro-imaging) to choose among different psychological positions. I personally have seen little reason for this optimism so Jacques and I frequently found ourselves disagreeing on this issue, though I should add that we rarely disagreed on substantive issues on which we both had views. This particular bone of contention, however, kept us busy at parties and during the many commutes between New York and New Jersey, where Jacques was a frequent visitor at the Rutgers Center for Cognitive Science. Now that I am in a position where he is a captive audience it seems an opportune time to raise the question again. (shrink)

There is debate within the literature as to whether emotion dysregulation (ED) in Attention-Deficit Hyperactivity Disorder (ADHD) reflects deviant attentional mechanisms or atypical perceptual emotion processing. Previous reviews have reliably examined the nature of facial, but not vocal, emotion recognition accuracy in ADHD. The present meta-analysis quantified vocal emotion recognition (VER) accuracy scores in ADHD and controls using robust variance estimation, gathered from 21 published and unpublished papers. Additional moderator analyses were carried out to determine whether the nature of VER (...) accuracy in ADHD varied depending on emotion type. Findings revealed a medium effect size for the presence of VER deficits in ADHD, and moderator analyses showed VER accuracy in ADHD did not differ due to emotion type. These results support the theories which implicate the role of attentional mechanisms in driving VER deficits in ADHD. However, there is insufficient data within the behavioural VER literature to support the presence of emotion processing atypicalities in ADHD. Future neuro-imaging research could explore the interaction between attention and emotion processing in ADHD, taking into consideration ADHD subtypes and comorbidities. (shrink)

Humphreys and Forde argue that semantic memory is divided into separate substores for different kinds of information. However, the neuro-imaging results cited in support of this view are inconsistent and often methodologically and statistically unreliable. Our own data indicate no regional specialisation as a function of semantic category or domain and support instead a distributed unitary account.

Purpose: Whereas ethical considerations on imaging techniques and interpretations of neuroimaging results flourish, there is not much work on their preconditions. In this paper, therefore, we discuss epistemological considerations on neuroimaging and their implications for neuroethics. Results: Neuroimaging uses indirect methods to generate data about surrogate parameters for mental processes, and there are many determinants influencing the results, including current hypotheses and the state of knowledge. This leads to an interdependence between hypotheses and data. Additionally, different levels of description (...) are involved, especially when experiments are designed to answer questions pertaining to broad concepts like the self, empathy or moral intentions. Interdisciplinary theoretical frameworks are needed to integrate findings from the life sciences and the humanities and to translate between them. While these epistemological issues are not specific for neuroimaging, there are some reasons why they are of special importance in this context: Due to their inferential proximity, 'neuro-images' seem to be self-evident, suggesting directness of observation and objectivity. This has to be critically discussed to prevent overinterpretation. Additionally, there is a high level of attention to neuroimaging, leading to a high frequency of presentation of neuroimaging data and making the critical examination of their epistemological properties even more pressing. Conclusions: Epistemological considerations are an important prerequisite for neuroethics. The presentation and communication of the results of neuroimaging studies, the potential generation of new phenomena and new 'dysfunctions' through neuroimaging, and the influence on central concepts at the foundations of ethics will be important future topics for this discipline. (shrink)

Participants recruited for high levels of imaginative absorption were administered a questionnaire based on Calkins' original study that first established a wide continuum of childhood synaesthesias and synaesthetic associations, along with separate questionnaires assessing childhood imaginary companions, positive altered states of consciousness and negative states of nightmares and night terrors. Their inter-relation and relation to measures of adult imaginative absorption helps to establish these states as aspects of an underlying imagistic dimension, while their relative differentiation is explored through different forms (...) of adult absorption, early stressors from childhood, and degree of parental support for creative activities. The connection of this wider continuum of adult recalled childhood synasesthesias, imaginary companions, and altered states of consciousness to adult imaginative absorption is consistent with recent neuro-imaging synaesthetic research supporting its relation to symbolic cognition, metaphor, and creativity. (shrink)

The essay introduces how Paul A. Weiss (1898-1989) analyzed his data on neuronal outgrowth and axonal transport, supported by constriction experiments of thousands of living mature nerve fibers. At the University of Chicago his group measured the steady proximo-distal flow of nerve fibers. To visualize the data he used tissue culturing, light microscopy, radioactive tracers, time-lapse motion pictures and electronmicroscopy. The work resulted in the discovery of fasciculation of outgrowing nerves and a computation of the rate of axonal transport, published (...) in a classical article in 1948. He stated that the outgrowth of nerve fibers occurs from nerve centers in their nucleated cell bodies by fasciculation and protein synthesis. However, at that time one suspected the published microphotograph to be an idealized image and, therefore, did not accept the analysis, or the 'new' knowledge. In the mid 1960s the improved technique of autoradiography confirmed in an indirect way Weiss' data and analysis of axonal transport. The objective here is to show (1) how Weiss employed the visibility of micrographs and drawings to corroborate his observations and analysis on axonal dynamics, and (2) to offer some tentative suggestions why his colleagues did not accept the 'neuro-images' as an evidence of new knowledge. (shrink)

This volume features a collection of essays on consciousness, which has become one of the hot topics at the crossroads between neuroscience, philosophy, and religious studies. Is consciousness something the brain produces? How can we study it? Is there just one type of consciousness or are there different states that can be discriminated? Are so called "higher states of consciousness" that some people report during meditation pointing towards a new understanding of consciousness? Meditation research is a new discipline that shows (...) new inroads into the study of consciousness. If a meditative practice changes brain structure itself this is direct proof of the causal influence of consciousness onto its substrate. If different states of consciousness can be linked with properties and states of the brain this can be used to study consciousness more directly. If the sense of self is modifiable through meditative techniques and this can be objectively shown through neuro-imaging, this has profound implications for our understanding of who we are. Can consciousness, in deep states of meditative absorption, actually access some aspect of reality which we normally don't? Meditation research can potentially foster us with a new access to the phenomenological method in general. This has even been branded with a new catch-phrase: Contemplative Science. It brings together the most modern neuroscientific approach and the most advanced phenomenological methodology of studying the mind from within, through highly skilled self-observation that has gone through many thousand hours of honing the capacity to look carefully, without distraction. This book addresses these issues by bringing together some of the leading researchers and thinkers in the field. The scope of the volume reaches from first person neuroscience to Indian philosophy, from pedagogic applications to epistemological aspects and from compassion meditation to the study of brain activity. (shrink)

This entry has two general aims. The first is to profile the practices of neuromarketing (both current and hypothetical), and the second is to identify what is ethically troubling about these practices. It will be claimed that neuromarketing does not really present novel ethical challenges, and that marketers are simply continuing to do what they have always done, only now they have at their disposal the tools of neuroscience which they have duly recruited. What will be presupposed is a principle (...) of proportionality: marketing practices are morally objectionable commensurate with the degree to which they impugn the moral sovereignty of market actors. With this principle in mind, it is important to consider the literature which is sceptical about the potential for neuromarketing to be successful. If its claims are overblown, as will be suggested, then the ethical threat neuromarketing is said to pose, can be viewed also as overblown. An area that has worried many is that neuromarketing poses a threat to brain privacy, and so an analysis will be given of the nature of this threat, given the principle of proportionality. It will be argued that worries about brain privacy seem, prima facie, to be justified, but on closer analysis, fall away. However, a residual threat to privacy does remain: the collection over time, and aggregation of private brain information, where the target loses control over its ownership and distribution. (shrink)

The misconception of communication by means of language is rife in early modern, modern and contemporary philosophy, philosophy of language, theoretical linguistics, neuro‐linguistics and psychology. An investigation into the essence or nature of the imagination is an investigation into the use of the word 'imagination', for essence is expressed by grammar. Someone who insists that he can imagine a stone's being conscious is indulging in mere image‐mongery. Unlike the narrator of a fairy‐tale or fable, his putative imagining has no (...) consequences, save to stir up philosophical clouds of dust. The criteria of understanding lie in behaviour, in explanations and in the use one makes of a word or sentence, not in accompanying mental imagery. One can, for example, draw what one imagines, and this may illuminate the use of a sentence and clarify its sense. But in other cases, e.g. those of imagining another person dreaming, a wholly misleading picture may obtrude itself. (shrink)

The present contribution is mainly intended to illustrate how some recent discoveries in the field of neurosciences have revolutionized our ideas about perception, action and cognition, and how these new neuro-scientific perspectives can shed light on the human relationship to art and aesthetics, in the frame of an approach known as "experimental aesthetics". Experimental aesthetics addresses the problem of artistic images by investigating the brain-body physiological correlates of the aesthetic experience and human creativity, providing a perspective that is complementary, (...) and not in opposition, to the humanistic one on the arts and the aesthetic. (shrink)

The determination of death by neurological criteria (brain death) is practiced in at least 80 countries, though it is a matter of continuing controversy. At the same time, the brain is central to human life, thinking, and behavior; however, a growing “neurocentrism” or a brain‐focused image of human identity became established in most Western and in many non‐Western societies and acts as a forceful ideology. This paper seeks a broader theoretical and sociocultural basis to approaching death bioethically by analyzing criticisms (...) aimed at a neurologically focussed vision of human life, and then turning these towards the brain death criteria exposed to the criticism. The overall critique of the “neuro‐self” has scope to offer alternative perspectives to the contested issues in brain‐death criteria. Specifically, the paper examines two major shortcomings of a narrow brain view of life and culture. First, it considers the reduction of the individual to the brain: this is the crux of the neurological way of determining death, and is a way that is seemingly context‐independent and culturally neutral. Second, it considers how dimensions of society and culture for humans are detached from the brain and have little impact on clinical practice and thinking in brain‐death criteria; however, a deeper exploration reveals that they actually have direct relevance and that social and cultural factors have greater contributions to make to the current debates. (shrink)

In recent years, a number of prominent scientists have argued that free will is an illusion, appealing to evidence demonstrating that information about brain activity can be used to predict behavior before people are aware of having made a decision. These scientists claim that the possibility of perfect prediction based on neural information challenges the ordinary understanding of free will. In this paper we provide evidence suggesting that most people do not view the possibility of neuro-prediction as a threat (...) to free will unless it also raises concerns about manipulation of the agent’s behavior. In Experiment 1 two scenarios described future brain imaging technology that allows perfect prediction of decisions and actions based on earlier neural activity, and this possibility did not undermine most people’s attributions of free will or responsibility, except in the scenario that also allowed manipulation. In Experiment 2 the scenarios increased the salience of the physicalist implications of neuro-prediction, while in Experiment 3 the scenarios suggested dualism, with perfect prediction by mindreaders. The patterns of results for these two experiments were similar to the results in Experiment 1, suggesting that participants do not understand free will to require specific metaphysical conditions regarding the mind–body relation. Most people seem to understand free will in a way that is not threatened by perfect prediction based on neural information, suggesting that they believe that just because “my brain made me do it,” that does not mean that I didn’t do it of my own free will. (shrink)

1. I want to discuss a new area of scientific research called neuro-aesthetics, which is the study of art by neuroscientists. The most prominent champions of neuroaesthetics are V.S. Ramachandran and Semir Zeki, both of whom have both made ambitious claims about their work. Ramachandran says boldly that he has discovered “the key to understanding what art really is”, and that his theory of art can be tested by brain imaging experiments, although he does not describe these experiments, (...) or explain what results the theory predicts (Ramachandran and Hirstein 1999, 17). Zeki, who originally coined the term “neuro-aesthetics”, claims to have laid the foundations for understanding “the biological basis of aesthetic experience”, and to have formulated a “neurobiological definition of art” (Zeki 1999, 2, 22). If these claims are true, we are at the dawn of a new age in the study of art. Up to now, most of the people studying art have been historians, some of whom can read Latin, but hardly any of whom have mastered even the rudiments of brain science. And aesthetics has been in the hands of philosophers, who still disagree among themselves about ideas that were stated in the fourth century BC. Neuroaesthetics is different. As Ramachandran (2000, 19) says: “These ideas have the advantage that, unlike the vague notions of philosophers and art historians, they can be tested experimentally”. So, is neuro-aesthetics the next big thing? I want to assess its prospects, starting with Ramachandran. (shrink)

The article deals with the following: Three brain imaging studies on athletes are evaluated. What do these neuroscientific studies tell us about the brain and mind of the athlete? Empirical investigations will need a neuro-theory of mind if they are to make the leap from neural activity to the mental. The article looks at such a theory, Gerald Edelman's?Neural Darwinism?. What are the implications of such a theory for sport science and philosophy of sport? The article appreciates some (...) of the neurosciences applications, but questions the hope of giving a complete theory of mind. (shrink)

Consciousness, subjectivity, and the history of the organism -- Subjectivity considered as the first-person perspective -- Subjectivity and reference -- Unconscious subjectivity -- What subjectivity is not -- Subjectivity in the neurobiological image -- Subjectivity in the neurobiological image -- The science of subjectivity -- Putting the neuro in neurophenomenology -- Neural correlates of consciousness reconsidered -- Neurophilosophy, Darwinian naturalism, and subjectivity.

Libertarian or incompatibilist conceptions of free will (according to which free will is incompatible with determinism) have been under withering attack in the modern era of Western philosophy as obscure and unintelligible and have been dismissed as outdated by many twentieth century philosophers and scientists because of their supposed lack of fit with modern images of human beings in the natural and human sciences. In a recent book (The Significance of Free Will), I attempt to reconcile incompatibilist free will with (...) new images of human beings emerging in the physical, biological, behavioral, cognitive, and neuro-sciences—avoiding the usual libertarian appeals to obscure or mysterious forms of agency or causation. In this paper, I extend that effort with special attention to the relation of libertarian free will to recent research on neural networks and cognition and to recent philosophical debates about freedom, control, rationality and responsibility. (shrink)

This paper investigates a special kind of social meaning-making manifest in how we experience static objects and properties of our everyday world. This happens, for example, when we recognize objects like vacuum cleaners, sliced tomatoes, and sneakers as placed in special sites in the environment. Given the compositional features of such images, we see them as designed to accomplish communicative functions. It is argued that object configurations of this kind are recognized as externalized ostensive cues. They are seen as having (...) been created with the intention of setting off an intersubjective mode of perception. This significantly changes the perceiver’s semiotic exploration of the scene. From a ‘private’ mode of sense-making mostly structured by reference to episodic, autobiographical experiential content, the perceiver takes a language stance. In other words, the perceiver adopts a qualitatively different meaning-constructing strategy in dealing with such images. Defending this claim, we present evidence from an empirical investigation of 20 participants’ construals of photographic images depicting everyday static objects. We show that a subset of these object configurations evoke a special kind of socially responsive attitude as manifested in participants’ introspective reports. The importance of these findings is brought out by discussion of parallels in neuro-cognitive work and how ostensive cues influence infant behavior. (shrink)

This paper investigates a special kind of social meaning-making manifest in how we experience static objects and properties of our everyday world. This happens, for example, when we recognize objects like vacuum cleaners, sliced tomatoes, and sneakers as placed in special sites in the environment. Given the compositional features of such images, we see them as designed to accomplish communicative functions. It is argued that object configurations of this kind are recognized as externalized ostensive cues. They are seen as having (...) been created with the intention of setting off an intersubjective mode of perception. This significantly changes the perceiver's semiotic exploration of the scene. From a `private' mode of sense-making mostly structured by reference to episodic, autobiographical experiential content, the perceiver takes a language stance. In other words, the perceiver adopts a qualitatively different meaning-constructing strategy in dealing with such images. Defending this claim, we present evidence from an empirical investigation of 20 participants' construals of photographic images depicting everyday static objects. We show that a subset of these object configurations evoke a special kind of socially responsive attitude as manifested in participants' introspective reports. The importance of these findings is brought out by discussion of parallels in neuro-cognitive work and how ostensive cues influence infant behavior. (shrink)

Libertarian or incompatibilist conceptions of free will (according to which free will is incompatible with determinism) have been under withering attack in the modern era of Western philosophy as obscure and unintelligible and have been dismissed as outdated by many twentieth century philosophers and scientists because of their supposed lack of fit with modern images of human beings in the natural and human sciences. In a recent book (The Significance of Free Will), I attempt to reconcile incompatibilist free will with (...) new images of human beings emerging in the physical, biological, behavioral, cognitive, and neuro-sciences—avoiding the usual libertarian appeals to obscure or mysterious forms of agency or causation. In this paper, I extend that effort with special attention to the relation of libertarian free will to recent research on neural networks and cognition and to recent philosophical debates about freedom, control, rationality and responsibility. (shrink)

A number of those that have advocated for theoretical pluralism in epistemology suggest that naturalistic arguments from cognitive science can support their case. Yet these theorists have traditionally faced two pressing needs. First, they have needed a cognitive science adequate to the task. Second, they have needed a bridge between whatever scientific account of cognition they favor and the normative claims of a pluralistic epistemology. Both of these challenges are addressed below in an argument for theoretical pluralism that brings together (...) two recent prototype-activation approaches to cognition. The paper dovetails Paul Churchland's neuro-computational approach with George Lakoff and Mark Johnson's image schematic approach, and shows how they mutually support each other in an increasingly persuasive naturalistic case for theoretical pluralism in epistemology. (shrink)

Is there a substantial difference between a portrait depicting the sitter’s face made by an artist and an image captured by a machine able to simulate the neuro-physiology of facial perception? Drawing on the later Wittgenstein, this paper answers this question by reference to the relation between seeing a visual pattern as (i) a series of shapes and colours, and (ii) a face with expressions. In the case of the artist, and not of the machine, the portrait’s creative process (...) involves the ability to see both aspects. From the perspective of the image’s viewer, the distinction is more difficult to draw. I address this difficulty by further distinguishing between two attributes of portraits: their representational accuracy, and their ability to convey the artist’s reflection on her experience of seeing the sitter face-to-face. While artificial intelligence can mimic this latter reflective ability, it cannot exactly reproduce it. (shrink)

The article offers an analysis of the topic of negotiations, from the most concreto area to the most abstract, and then an analysis of the many meanings of the term profit, which in negotiations has three areas: mine, yours, or shared. Yet the estimation of profit requires a comparison with the idealsituation expectations or with other empirically available kinds of goods. In all these, it is possible to modify the vision of a situation through tinkering or even systemic deception via (...) the image of an anchor point, the extreme value. The concept of neuro-linguistic programming in particular includes a rich set of verbal manipulations, which may reflect the hidden intentions of a negotiating party. Even in an individual’s cognitive system, there exist tendencies for tinkering with the image of truth in order to protect the person’s good opinion of themselves. In the other part of the article, the authors discussed seven strategies of manipulation which are used in Polish business practice. (shrink)

Real-time computer graphics and complex sensory input challenge past assumptions of highly constrained metaphors based on static imagery. Access to research and gaming interfaces have popularized the understanding of tracking technologies that tailor interaction to ambulatory displacement and dexterous handling of objects, expanding the realm of metaphors from visual to physical phenomena. But behaviour and the mind have been studied far before there were real-time computer graphics or digitally created synthetic environments. Dynamic relationships between environment, body and thought are being (...) dissected today by neuro-scientific research, and, conversely, synthetic environments are being utilized to address psychological disorders. This article examines research on scientific and philosophical fields that advance the definition of representation, from an image-based realm as limited by previous popular media to an understanding of action and immersion, where attention is activated by change, and rooted in the body. From this perspective, the advent of embodied representation may not be as much of a change of medium, but the perceptual relation with the medium, the medium being a created Umwelt, where the virtual world builds the mind through the body. (shrink)

In the last decades, the rapid growth of functional brain imaging methodologies allowed cognitive neuroscience to address open questions in philosophy and the social sciences. At the same time, novel insights from cognitive neuroscience research have begun to influence various disciplines, leading to a turn to cognition and emotion in the fields of planning and architectural design. Since 2003, the Academy of Neuroscience for Architecture has been supporting ‘neuro-architecture’ as a way to connect neuroscience and the study of (...) behavioral responses to the built environment. Among the many topics related to multisensory perceptual integration and embodiment, the concept of hapticity was recently introduced, suggesting a pivotal role of touch and haptic imagery in architectural appraisal. Arguments have thus risen in favor of the existence of shared cognitive foundations between hapticity and the supramodal functional architecture of the human brain. Precisely, supramodality refers to the functional feature of defined brain regions to process and represent specific information content in a more abstract way, independently of the sensory modality conveying such information to the brain. Here we highlight some commonalities and differences between the concepts of hapticity and supramodality according to the distinctive perspectives of architecture and cognitive neuroscience. This comparison and connection between these two different approaches may lead to novel observations in regard to people-environment relationships, and even provide empirical foundations for a renewed evidence-based design theory. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:An Encounter with the Art and Science of MedicineAnonymous Five“Let Nothing Upset YouLet Nothing Frighten YouEverything is ChangingOnly God is Changeless”—St. Theresa of AvilaSt. Teresa’s prayer is on the front cover of each of four binders dedicated to storing insurance authorizations, studies, references, and reports about our daughter’s brain tumor treatment. They represent our experience, what we learned, the information we were given, and the information we sought out. (...) I kept them in case our daughter ever wanted to understand how my husband and I arrived at a decision for her treatment that was in direct opposition to the strong recommendation of her primary treatment team of physicians.On December 10, 2003, I received an urgent call from our daughter’s neurologist requesting that we meet with the doctor late that afternoon. For six months prior to that appointment, our daughter had been telling us about odd sensations with breathing, nausea, and balance. Sometimes she would seem extremely distressed for a short period of time or report that her friends told her about doing or saying things that didn’t make sense and that she didn’t remember. We consulted a series of physicians as her symptoms became steadily more intense and more prevalent. Our family practice physician referred us to an allergy specialist and a pulmonologist. There were a number of tests for allergies and lung problems. As the tests and treatments did not help, our daughter became increasingly unwilling to go to doctor’s appointments. My husband and I were confused and deeply concerned about the lack of progress. The next series of referrals included a gastroenterologist and a neurologist. The gastroenterologist suggested our daughter had partial–complex epilepsy, concurred with our plan to see a neurologist, and mentioned she should have an MRI.I remember the neurologist putting the MRI scans up, pointing to the large dark spot which he called a “large mass” (5 cm), that could be either a cluster of blood vessels or a neoplasm. He said his office had arranged for us to meet a neurosurgeon the following day. We all remember the same thing about that visit—the image of the large dark mass on the scan—and the neurologists flat, brisk tone. We met with the neuro-surgeon the next day. Her team was kind and sympathetic—she was positive, up beat and direct. She did not think this mass was blood vessels. She thought it was a large tumor that needed to be removed right away. Our daughters surgery was scheduled for the following Friday—December 19, 2003. She had turned 15 on November 5.Four and a half hours after our daughter was wheeled into the operating room, her surgeon told us they had removed 98% of the tumor. She said there was no cure, but there was a good prognosis based on the surgical outcome. Several days later, she called us and said she had more data, and it looked like the resection was closer to 90%. The first pathology report, a “first impression” directly after surgery, described our daughter’s tumor as an astrocytoma, probably high grade. Three weeks after surgery, we met with a panel of doctors—two oncologists and radiologist—who explained that based on the final pathology report, our daughter’s tumor was classified as an ependymoma, grade 2. We were dismayed. First, there had been the change in the estimated success of the resection and now a complete shift in both grade and tumor type.The team recommended radiation to follow her surgery, which they said was standard treatment. We began to try to inform ourselves about her tumor. Her father, an agronomist, did an extensive search in PubMed to evaluate and sort through the literature on low–grade gliomas and radiation. What he could find was inconclusive and grim. Most reports in the literature suggested at best delayed mortality at five years after radiation. [End Page E7] Meanwhile, our daughter went through a spinal MRI and the preparatory “fitting” of the mask to immobilize her head during radiation.E7I consulted with a friend who had worked as an EKG tech. She urged... (shrink)

This paper investigates a special kind of social meaning-making manifest in how we experience static objects and properties of our everyday world. This happens, for example, when we recognize objects like vacuum cleaners, sliced tomatoes, and sneakers as placed in special sites in the environment. Given the compositional features of such images, we see them as designed to accomplish communicative functions. It is argued that object configurations of this kind are recognized as externalized ostensive cues. They are seen as having (...) been created with the intention of setting off an intersubjective mode of perception. This significantly changes the perceiver's semiotic exploration of the scene. From a `private' mode of sense-making mostly structured by reference to episodic, autobiographical experiential content, the perceiver takes a language stance. In other words, the perceiver adopts a qualitatively different meaning-constructing strategy in dealing with such images. Defending this claim, we present evidence from an empirical investigation of 20 participants' construals of photographic images depicting everyday static objects. We show that a subset of these object configurations evoke a special kind of socially responsive attitude as manifested in participants' introspective reports. The importance of these findings is brought out by discussion of parallels in neuro-cognitive work and how ostensive cues influence infant behavior. (shrink)

Over 100 million Americans suffer from chronic pain, which causes more disability than any other medical condition in the United States at a cost of $560–$635 billion per year. Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy can (...) be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, including attainment of personal goals and the psychological flexibility to choose responses to pain. Acceptance and Commitment Therapy has been recognized as an effective, non-pharmacologic treatment for a variety of CP conditions. However, little is known about the neurologic mechanisms underlying ACT. We conducted an ACT intervention in women with chronic musculoskeletal pain. Functional magnetic resonance imaging data were collected pre- and post-ACT, and changes in functional connectivity were measured using Network-Based Statistics. Behavioral outcomes were measured using validated assessments such as the Acceptance and Action Questionnaire, the Chronic Pain Acceptance Questionnaire, the Center for Epidemiologic Studies Depression Scale, and the NIH Toolbox Neuro-QoLTM scales. Results suggest that, following the 4-week ACT intervention, participants exhibited reductions in brain activation within and between key networks including self-reflection, emotion, and cognitive control. These changes in connectivity strength were correlated with changes in behavioral outcomes including decreased depression and pain interference, and increased participation in social roles. This study is one of the first to demonstrate that improved function across the DMN, SN, and FPN may drive the positive outcomes associated with ACT. This study contributes to the emerging evidence supporting the use of neurophysiological indices to characterize treatment effects of alternative and complementary mind-body therapies. (shrink)

ObjectiveTo elucidate the clinical, radiologic characteristics of Leber’s hereditary optic neuropathy (LHON) associated with the other diseases.Materials and methodsClinical data were retrospectively collected from hospitalized patients with LHON associated with the other diseases at the Neuro-Ophthalmology Department at the Chinese People’s Liberation Army General Hospital (PLAGH) from December 2014 to October 2018.ResultsA total of 13 patients, 24 eyes (10 men and 3 women; mean age, 30.69 ± 12.76 years) with LHON mitochondrial DNA (mtDNA) mutations, were included in the cohort. (...) 14502(5)11778(4)11778 &11696(1)12811(1)11696(1)3460(1). One patient was positive for aquaporin-4 antibody (AQP4-Ab), and two were positive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab). Three patients were associated with idiopathic optic neuritis (ON). Two patients were with compression optic neuropathy. Three patients were with the central nervous system (CNS) diseases. One patient was with proliferative diabetic retinopathy (PDR) and one with idiopathic orbital inflammatory syndrome (IOIS). At the onset, visual acuity (VA) in eighteen eyes was below 0.1, one eye was 0.5, five eyes were above 0.5, while VA in sixteen eyes was below a 0.1 outcome, three eyes experienced moderate vision loss. MRI images showed T2 lesions and enhancement in nine patients who received corticosteroids treatment; additional immune modulators treatment was performed on two patients. None of the patients had relapse during the follow-up time.ConclusionLeber’s hereditary optic neuropathy can be accompanied with multiple-related diseases, especially different subtypes of ON, which were also exhibited with IOIS and compression optic neuropathy for the first time in this cohort. This condition may be a distinct entity with an unusual clinical and therapeutic profile. (shrink)

Background: Maximum safe resection of infiltrative brain tumors in eloquent area is the primary objective in surgical neuro-oncology. This goal can be achieved with direct electrical stimulation to perform a functional mapping of the brain in patients awake intraoperatively. When awake surgery is not possible, we propose a pipeline procedure that combines advanced techniques aiming at performing a dissection that respects the anatomo-functional connectivity of the peritumoral region. This procedure can benefit from intraoperative monitoring with computerized tomography scan and (...) brain shift correction. Associated with this intraoperative monitoring, the additional value of preoperative investigation combining brain mapping by navigated transcranial magnetic stimulation with various neuroimaging modalities has not yet been reported.Case Report: A 42-year-old left-handed man had increased intracranial pressure, left hand muscle deficit, and dysarthria, related to an infiltrative tumor of the right frontal lobe with large mass effect and circumscribed contrast enhancement in motor and premotor cortical areas. Spectroscopy profile and intratumoral calcifications on CT-scan suggested an WHO grade III glioma, later confirmed by histology. The aforementioned surgical procedure was considered, since standard awake surgery was not appropriate for this patient. In preoperative time, nTMS mapping of motor function was performed, combined with magnetic resonance imaging -based tractography reconstruction of 6 neural tracts and resting-state functional MRI connectivity of sensorimotor and language networks. In intraoperative time, DES mapping was performed with motor evoked response recording and tumor resection was optimized using non-rigid image transformation of the preoperative data to iCT data. Image guidance was updated with correction for brain shift and tissue deformation using biomechanical modeling taking into account brain elastic properties. This correction was done at crucial surgical steps, i.e., when tumor bulged through the craniotomy after dura mater opening and when approaching the presumed eloquent brain regions. This procedure allowed a total resection of the tumor region with contrast enhancement as well as a complete regression of IICP and dysarthria. Hand paresis remained stable with no additional deficit. Postoperative nTMS mapping confirmed the good functional outcome.Conclusion: This case report and technical note highlights the value of preoperative functional evaluation by nTMS updated intraoperatively with correction of brain deformation by iCT. This multimodal approach may become the optimized technique of reference for patients with brain tumors in eloquent areas that are unsuitable for awake brain surgery. (shrink)