Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of patients, but often at lower titers. The symptoms of ataxia may be mild at the onset but lead to permanent damage if remain untreated. It is characterized by damage to the cerebellum however, the pathophysiology of the disease is not clearly understood. The present study investigated the neurochemical profile of vermis and (...) right cerebellum and structural changes in various brain regions of patients with gluten ataxia and compared it with healthy controls. Volumetric 3-D T1 and T1-weighted magnetic resonance imaging in the three planes of the whole brain and single-voxel 1H- magnetic resonance spectroscopy of the vermis and right cerebellum were acquired on 3 T human MR scanner. The metabolite concentrations were estimated using LC Model while brain volumes were estimated using the online tool volBrain pipeline and CERES and corrected for partial volumes. The levels of neuro-metabolites were found to be significantly lower in vermis, while N-acetyl aspartate + N-acetyl aspartate glutamate and glycerophosphocholine + phosphocholine was lower in cerebellum regions in the patients with gluten ataxia compared to healthy controls. A significant reduction in the white matter of ; reduction in the volumes of cerebellum lobe and thalamus while lateral ventricles were increased in the patients with gluten ataxia compared to healthy controls. The reduced neuronal metabolites along with structural changes in the brain suggested neuronal degeneration in the patients with gluten ataxia. Our preliminary findings may be useful in understanding the gluten-induced cerebral damage and indicated that MRI and MRS may serve as a non-invasive useful tool in the early diagnosis, thereby enabling better management of these patients. (shrink)

The idea of human freedom is essentially rooted in the concept of human development, according to Nobel Laureate Amartya Sen's 'Development as Freedom' thesis. And the idea of human progress is a construct that is designed around the axis offreedom. What is freedom? Is it only lack ofsocietal constraint, withdrawal of discipline and punish, willing suspension of the panoptic super ego that they address as the 'mainstream'? Or is freedom a concept much more fundamental, to be read into the texts (...) of Rabindranath Tagore, Romain Rolland or Walden? Sociologists claim that civilization is what we are and culture is merely an arrangement of artifacts that we happen to use during the course of our politics of everyday life. Civilization, however, is also a system of values that is handed down generations as a movement of socialization that laymen identify as 'progress'. (shrink)

A major contradiction of globalisation lies in the universalisation of the imperatives of international finance-capital. The ascendancy of international finance has kept inter-imperialist rivalry under check since the past few decades, and imperialist nation-states under its imperatives have displayed greater unity under the leadership of the US. But the dominance of speculative finance and the deflationary impact it generates, threatens to precipitate worldwide recession. The US is trying to pre-empt any potential competition in this milieu, by pursuing an aggressive and (...) unilateralist military policy of endless war. However, the capacity of the US to sustain such high levels of military expenditure and debt-induced consumer spending is circumscribed by the fragility of the dollar hegemony in the backdrop of the growing indebtedness of the US vis-à-vis the rest of the world. Re-appearance of recessionary conditions in the US would be set the stage for inter-imperialist contradictions as well as the contradiction between imperialism and the Third World to play themselves out and create possible ruptures in the present world order. (shrink)

The temporality of historical flows can be understood through the paradigm of oceanic circulations of water. Historical processes are not linear and tunneled but circulatory and global, like oceanic currents. The argument of distributed agency deriving from the ‘ontological turn’ dovetails with the oceanic paradigm of circulatory histories. The latter allows us to grasp modes of both natural and historical inter-temporal communication through the medium of the natural and built environment. Yet the inclination in these new studies to deny any (...) particular privilege to human will or design risks neglecting the changing role of human agency. Analytically I distinguish historiographical time from historical time. Historiographical time may be seen as the purposive capture of historical processes for various goals whereas historical time is more continuous with natural flows. More than origins and causes, the paradigm emphasizes the ramifying con-sequences of purposive actions. The gap in our understanding of the two temporalities has had a devastating impact on the planet. (shrink)

While there is much writing on the nation as the subject of linear history, considerably less attention has been paid to the dimension of the nation as the always identifiable, unchanging subject of history. This unchanging subject is necessitated by the ascendancy of the conception of linear time in capitalism in which change is viewed not only as accelerating, but can no longer be framed by an ultimate source of meaning such as God. Ostensibly, linear history is the falling of (...) events into the "river of time," but national history also posits a continuous subject to gather these changes. Such a subject is recognizable only by the spiritual qualities of authenticity, purity, and sacrality. The nation-state and nationalists stake their claim to sovereign authority, in part, as custodians of this authenticity.A range of figures, human and non-human, come to symbolize a regime of authenticity manipulable to some extent by nationalists and state-builders. This essay focuses on the instance of women in early twentieth-century China. Nationalists and cultural essentialists tended to depict women as embodying the eternal Chinese civilizational virtues of self-sacrifice and loyalty and to elevate them as national exemplars. The essay also examines cases of how women themselves may have perceived this role as exemplars and concludes that while there was considerable subversion in their enunciation of this role , there was sufficient reference to the prescriptive code of authenticity in their self-formation to sustain the regime of authenticity. The essay ends with some thoughts about the changing relationship between authenticity and intensifying globalization in the contemporary world. (shrink)

Journal of Social Philosophy, EarlyView.

Dāvarī, Riz̤ā -- Interviews ; Islamic philosophy - Iran.

Por ocasião do centenário de nascimento de Paul Ricoeur, a Universidade de Coimbra juntou num mesmo volume um conjunto de estudos académicos em tributo a este pensador. Reuniram-se deste modo comunicações de professores, de novos investigadores e de estudantes de doutoramento em redor de temas que marcaram a receção da obra e do filósofo francês em Coimbra. Cada capítulo do presente livro demonstra a fecundidade de um pensamento que, enraizado na “tradição reflexiva”, assumindo a mensagem das “filosofias da existência”, articulando (...) Fenomenologia e Hermenêutica, adquire, hoje, crescente impacto e relevância. Esta é uma filosofia que promove o diálogo entre disciplinas, autores e culturas e supera divisões teóricas em ordem a enfrentar as exigências da praxis. O desafio da praxis fez assim emergir um pensamento exigente e, simultaneamente, capaz de dialogar com diversas áreas do saber como: a psicoterapia, a história, as neurociências, a bioética, as ciências sociais e os estudos literários. At the occasion of the Paul Ricoeur’s centenary this volume joined in tribute several scholars, young researchers, and Ph.D students around the main themes that marked the reception of the philosopher’s work in Portugal and, especially in the University of Coimbra. Each chapter demonstrates the vigour Ricoeur’s thought as it is rooted in the "reflexive tradition", as it assumed the "existentialist" horizon, as it articulated Phenomenology and Hermeneutics. This philosophical project as, today, an enormous range of influence. This is a project that promotes dialogue between disciplines, authors, and cultures, overcoming theoretical divisions in face the demands of praxis. From this rich and plural inspiration comes the ability to meet with other fields of thought, namely psychotherapy, history, neuroscience, bioethics, social sciences, and literary studies. (shrink)

This article intends to explore the philosophical potency in the work of the black writer Carolina Maria de Jesus (1914-1977). Carolina de Jesus is best known for her work Quarto de Despejo, diary of a favelada (1960), our approach, however, focuses specifically on her short story “Socrates Africano”, in which she deals with her experience with her grandfather Benedito and the relationship between her wisdom and that of the Greek philosopher Sócrates (5th century BC). Her reflection starts from the attempt (...) to understand the reason why her grandfather was compared to Socrates and called “African Socrates”. In this sense, we intend to expand the idea of an African Socrates and the origins of one of the African philosophical matrices, the Yoruba tradition, dialoguing with the thought of the Nigerian philosopher Sophie Oluwole (1935-2018) and her approximation between Socrates and Orunmilá, as a motto to think about the philosophical potentialities of Carolina's work and the traits of an Afro-Brazilian philosophy. (shrink)

Objectives Older adults are considered one of the most vulnerable groups to COVID-19. However, previous studies on emotion and aging have found that older adults report better well-being than younger adults in global survey and daily report. To better understand older adults’ well-being during the COVID-19 outbreak, we examined age differences in daily affective experiences in this study. Method Two hundred and thirty-one participants from mainland China aged 18 to 85 were recruited to participate in the 14-day daily diary study, (...) after a pretest. Their trait affect and demographic information were measured in the pretest. Their daily affect and stress levels were measured in the daily assessments. Results We found that older adults reported lower perceived stress related to COVID-19 in daily life, compared to younger adults. The negative relationship between daily perceived stress and high arousal positive affect and the positive relationship between daily perceived stress and high arousal negative affect was weaker in older than younger adults. Discussion These results provide initial evidence of daily affective well-being across different age groups in adulthood during the COVID-19 outbreak. Such information is important for developing interventions to promote better well-being during the COVID-19 outbreak. (shrink)

© The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved.Cell walls of grasses, including cereal crops and biofuel grasses, comprise the majority of plant biomass and intimately influence plant growth, development and physiology. However, the functions of many cell wall synthesis genes, and the relationships among and the functions of cell wall components remain obscure. To better understand the patterns of cell wall accumulation and identify genes that act in grass (...) cell wall biosynthesis, we characterized 30 samples from aerial organs of rice at 10 developmental time points, 3-100 d post-germination. Within these samples, we measured 15 cell wall chemical components, enzymatic digestibility and 18 cell wall polysaccharide epitopes/ligands. We also used quantitative reverse transcription-PCR to measure expression of 50 glycosyltransferases, 15 acyltransferases and eight phenylpropanoid genes, many of which had previously been identified as being highly expressed in rice. Most cell wall components vary significantly during development, and correlations among them support current understanding of cell walls. We identified 92 significant correlations between cell wall components and gene expression and establish nine strong hypotheses for genes that synthesize xylans, mixed linkage glucan and pectin components. This work provides an extensive analysis of cell wall composition throughout rice development, identifies genes likely to synthesize grass cell walls, and provides a framework for development of genetically improved grasses for use in lignocellulosic biofuel production and agriculture. (shrink)

This book is an essential guide for veterinarians, veterinary faculty and policymakers for understanding the core competencies of a fresh veterinarian. The book briefly covers competencies in preclinical, paraclinical, and clinical subjects including anatomy, physiology, biochemistry, veterinary jurisprudence, animal management & welfare including nutrition and breeding, infectious and non-infectious diseases, disease epidemiology, diagnosis, and treatment, prevention, control and zoonoses, surgical and other clinical interventions. The book further includes other competencies, including biologicals, anti-mortem, and post-mortem inspection, certifications, applied one health aspects, (...) review and analysis of scientific evidence, international trade and regulations, and organization of veterinary services. It also highlights the importance of effective communication, interpersonal skills, record keeping and management of a small veterinary hospital, health informatics, etc. The book breakdowns the must-have competencies of a global veterinarian into different topics and subtopics for easy comprehension and further learning. It enables the professional standard-setting & regulatory bodies and academicians in improved curricula designing and implementation and more importantly tries to bring uniformity in day one veterinary graduates’ competencies globally, enhancing the movement and employability of veterinarians across the world. (shrink)

Considerações acerca da emenda da sociologia das religiões -- Conceito da sociologia da arte.

In a recent opinion paper, it was argued that individuals with multiple retractions or a record of academic misconduct should not serve as editors, including as editors-in-chief, on the editorial boards of scholarly or academic journals. As a first step towards appreciating how such a policy could be applied in practice, the presence of 30 individuals listed on the Retraction Watch Leaderboard on editorial boards was screened. Six cases are highlighted to gain an appreciation of the potential reputational risks that (...) journals and publishers might incur by including individuals with a tainted academic record on editorial boards. Given the reputational, legal and other risks associated with this type of assessment and decision, more formal positioning and guidance are needed by global ethics policy-related bodies such as COPE, the ICMJE, and the CSE, even more so in journals that claim to follow these organizations’ ethical guidelines. (shrink)

Em 2016 comemoram-se os 200 anos de publicação da “Enciclopédia das Ciências Filosóficas” de Hegel. Esta parece ser uma ocasião especial para se poder avaliar a pertinência da “Enciclopédia” para o Brasil. Essa avaliação, aqui elaborada, conduz à percepção de que se a filosofia é pensar o presente, então a “Enciclopédia” não pode ser compreendida como contendo problemas e soluções para o Brasil, mas apenas para a velha Europa. Portanto, nessa ocasião se torna especialmente perceptível a necessidade de se abandonarem (...) as velhas categorias da Europa como instrumentos para se pensar o Brasil. (shrink)

Livros -- Opúsculos, ensaios prefaciais e artigos -- Agostiniana -- Palavras posfaciais, cronologia, Onomástica.

Meaning (Philosophy) ; Civilization, Modern ; Postcolonialism.

This chapter contains sections titled: Introduction Paraconsistent Logic and Latin America Thinking about Logic The Nature of Paraconsistent Logic A History of Paraconsistent Logic Philosophical Aspects of Paraconsistent Logic References Further Reading.

This monograph offers a fresh perspective on the applicability of mathematics in science. It explores what mathematics must be so that its applications to the empirical world do not constitute a mystery. In the process, readers are presented with a new version of mathematical structuralism. The author details a philosophy of mathematics in which the problem of its applicability, particularly in physics, in all its forms can be explained and justified. Chapters cover: mathematics as a formal science, mathematical ontology: what (...) does it mean to exist, mathematical structures: what are they and how do we know them, how different layers of mathematical structuring relate to each other and to perceptual structures, and how to use mathematics to find out how the world is. The book simultaneously develops along two lines, both inspired and enlightened by Edmund Husserl’s phenomenological philosophy. One line leads to the establishment of a particular version of mathematical structuralism, free of “naturalist” and empiricist bias. The other leads to a logical-epistemological explanation and justification of the applicability of mathematics carried out within a unique structuralist perspective. This second line points to the “unreasonable” effectiveness of mathematics in physics as a means of representation, a tool, and a source of not always logically justified but useful and effective heuristic strategies. (shrink)

Textures of the Ordinary shows how anthropology finds a companionship with philosophy in the exploration of everyday life. Based on two decades of ethnographic work among low-income urban families in India, Das shows how the notion of texture aligns ethnography with the anthropological tone in Wittgenstein and Cavell, as well as in literary texts. The book shows different routes of return to the everyday as it is corroded not only by catastrophic events but also by repetitive and routine violence within (...) everyday life itself. As an alternative to normative ethics, this book develops ordinary ethics as attentiveness to the other and as the ability of small acts of care to stand up to horrific violence. Textures of the Ordinary offers a model of thinking in which concepts and experience are shown to be mutually vulnerable. The book is an intellectually intimate invitation into the ordinary, that which is most simple yet most difficult to perceive in our lives. (shrink)

O significado hermenêutico da experiência da obra de arte -- A pertinência hermenêutica da ética aristotélica -- Para uma hermenêutica do cuidado: do mistério da saúde de H.-G. Gadamer aos novos fins da medicina -- A hermenêutica como pensamento de fronteira -- Hermenêutica filosófica e mobilidade cultural: conceitos fundamentais -- A Europa e o destino das ciências humanas -- Para uma hermenêutica da memória -- Tradição, linguagem e jogo -- A missão hermenêutica da filosofia -- Problemas da hermenêutica prática -- (...) O reconhecimento como núcleo da aplicação: de Gadamer a Ricoeur -- A linguagem da polis -- Retórica e hermenêutica. (shrink)

This chapter presents findings on a study of neuropsychological aspects of visual hallucinations with a focus on hallucinations in Parkinson's disease. The results of the study suggest that VHs in PD are a complex multifactor effect of different risk factors, primarily the dysfunctions of the visual system and the system that regulates rapid eye movement sleep and arousal. The study reported here also investigated whether the same risk factors are implicated in proneness to VHs as they are in VHs in (...) PD. The results suggest that the predisposition to VHs in the healthy young population is a multifactor effect of strikingly similar risk factors to those found in PD. However, in addition to the dysfunctions of the visual and arousal system, proneness to hallucinations in the normal population is also predicted by a specific personality profile. (shrink)