I present a reconstruction of F.H.C. Crick's two 1957 hypotheses "Sequence Hypothesis" and "Central Dogma" in terms of a contemporary philosophical theory of causation. Analyzing in particular the experimental evidence that Crick cited, I argue that these hypotheses can be understood as claims about the actual difference-making cause in protein synthesis. As these hypotheses are only true if restricted to certain nucleic acids in certain organisms, I then examine the concept of causal specificity and its potential to counter claims about (...) causal parity of DNA and other cellular components. I first show that causal specificity is a special kind of invariance under interventions, namely invariance of generalizations that range over finite sets of discrete variables. Then, I show that this notion allows the articulation of a middle ground in the debate over causal parity. (shrink)

When scientist investigate why things happen, they aim at giving an explanation. But what does a scientific explanation look like? In the first chapter (Theories of Scientific Explanation) of this book, the milestones in the debate on how to characterize scientific explanations are exposed. The second chapter (How to Study Scientific Explanation?) scrutinizes the working-method of three important philosophers of explanation, Carl Hempel, Philip Kitcher and Wesley Salmon and shows what went wrong. Next, it is the responsibility of current philosophers (...) of explanation to go on where Hempel, Kitcher and Salmon failed. However, we should go on in a clever way. We call this clever way the pragmatic approach to scientific explanation and clarify briefly what this approach consists in. The third chapter (A Toolbox for Describing and Evaluating Explanatory Practices) elaborates the pragmatic approach by presenting a toolbox for analysing scientific explanation. In the last chapter (Examples of Descriptions and Evaluations of Explanatory Practices) the approach is illustrated with real-life examples of scientists aiming at explaining. (shrink)

The autocell proposal for the emergence of life and natural selection through the interaction of two reciprocally coupled self-organizing processes specifically provides a protein-first model for the origin of life that can be explored by computer simulations and experiment. Beyond the specific proposal it can be considered more generally as a thought experiment in which the principles deduced for the autocell could apply to other possible detailed chemical scenarios of catalytic polymers and protometabolism, including living systems emerging within membranelike barriers. (...) The autocell model allows for the analysis of the emergence of not only agency and purpose but also of interpretation and semiosis as true living systems arise. (shrink)

In this chapter I propose to understand the current paradigm shift in biology as the origination of a biology of subjects. A description of living beings as experiencing selves has the potential to transform the current mechanistic approach of biology into an embodied-hermeneutic one, culminating in a poetics of nature. We are at the right moment for that: The findings of complex systems research, autopoiesis theory, and evolutionary developmental biology are converging into a picture where the living can not longer (...) be described in terms of causal mechanisms (as is, e. g., the Watson-Crick “central dogma”). Instead, organisms bring forth themselves physically and thereby generate a hermeneutic standpoint, interpreting external and internal stimuli interfering with their auto-creation according to embodied values. This can be observed empirically during embryonic develoment, where genetic instructions do not act as orders, but rather as perturbations being interpreted by an auto-maintaining developmental centre. The notion of organic subjectivity opens the living realm to a hermeneutic perspective. Since any encounter has a meaning and is interpreted accordingly, it creates a perspective of innerness or self. This self experiences all external and internal stimuli as values. The innerness is coextensive with the material dimensions of biochemical processes as their other, or symbolic, side. By this process the subjective perspective of organisms is open to other’s experience. Meaning and value become visible, as they are generated in material, embodied form. Instead of being separate from nature as pure “mind” or “language”, man shares with any other being the same “conditio vitae” of experienced meaning and expressive feeling. (shrink)

Several authors have used the notion of causal specificity in order to defend non-parity about genetic causes (Waters 2007, Woodward 2010, Weber 2017, forthcoming). Non-parity in this context is the idea that DNA and some other biomolecules that are often described as information-bearers by biologists play a unique role in life processes, an idea that has been challenged by Developmental Systems Theory (e.g., Oyama 2000). Indeed, it has proven to be quite difficult to state clearly what the alleged special (...) role of genetic causes consists in. In this paper, I show that the set of biomolecules that are normally considered to be information-bearers (DNA, mRNA) can be shown to be the most specific causes of protein primary structure, provided that causal specificity is measured over a relevant space of biological possibilities, disregarding physical as well as logically possible states of the causal variables. (shrink)

We consider a confidence parametrization of binary information sources in terms of appropriate likelihood ratios. This parametrization is used for Bayesian belief updates and for the equivalent comparison of binary experiments. In contrast to the standard parametrization of a binary information source in terms of its specificity and its sensitivity, one of the two confidence parameters is sufficient for a Bayesian belief update conditional on a signal realization. We introduce a confidence-augmented receiver operating characteristic for comparisons of binary experiments for (...) a class of “balanced” decision problems, relative to which the confidence order offers a higher resolution than Blackwell’s informativeness order. Where observation is concerned, Chance favors only the prepared mind.—Louis Pasteur (1822–1895). (shrink)

Le thlicien d'identittique d'Averrotudie par les penseurs latins du XIIIe siveloppe avec exigence en vue de sauvegarder le caractritcessaire qu'identifie la pens personnelle de l'optre latin du XIIIe si le discernement d'Averrotique et l'a confirmre rigoureusement personnel de 1'intellection humaine.

I present a persistent religious moral theory, known as divine command theory, which conflicts with liberal political thought. John Rawls's notion of public reason offers a framework for thinking about this conflict, but it has been criticized for demanding great restrictions on religious considerations in public deliberation. I argue that although Paul Kurtz is critical of organized religion, his epistemological suggestions and ethical theory offer a feasible way to build common moral ground between atheists, secularists, and theists, so long as (...) each maintains the important democratic value of toleration in the form of either fallibilism or skepticism. (shrink)

In this discussion note I clarify the motivation behind my original paper "Social Mechanisms, Causal Inference and the Policy Relevance of Social Science." I argue that one of the tasks of philosophers of social science is to draw attention to methodological problems that are often forgotten or overlooked. Then I show that my original paper does not make the mistake or fallacy that Daniel Steel suggests in his comment on it. Key Words: social mechanisms • causal inference • social policy.

Bioethicist Peter Singer got a respectful reception Friday as he told advocates for the disabled it is morally acceptable to kill severely disabled newborns. The Governor's Commission on Disability was harshly criticized for inviting Singer to Friday's conference because of that stance, first enunciated in a 1979 book.

'Sense perception in current process thought' was the topic of a workshop organized by the 'Whitehead Psychology Nexus' (for more information see below) at Fontareches in spring 2003. This and earlier Fontareches meetings can be characterized by just a few elements: non-dogmatism, interdisciplinarity and overlapping approaches. Although the convergence point is Whitehead's philosophy, this is intended in the sense of an 'eschaton' rather than a 'telos'. The vivid discussions, occurring in a very thoughtful, yet relaxed, atmosphere in the small village (...) of Fontareches in Southern France, have amply testified for the promising paths and synergies that can emerge in such an environment. This year, the core intention was to examine relations between Whitehead's theory of perception and contemporary psychology. The individual contributions can be sorted into the three areas of philosophy, cognitive science, and mental health/psychoanalysis. Unsurprisingly, the question of temporality was addressed -- explicitly or implicitly -- in most of the papers. (shrink)