The formation of blood vessels within the vascular system entails a variety of cellular processes, including proliferation, migration and differentiation. In many cases, these diverse processes need to be finely coordinated among neighbouring endothelial cells in order to establish a functional vascular network. For instance, during angiogenic sprouting specialized endothelial tip cells follow guidance cues and migrate extensively into avascular tissues while trailing stalk cells must stay connected to the patent blood vessel. The vascular endothelial growth factor (VEGF) and Notch (...) signalling pathways have emerged as the major players in governing these different cellular behaviours. In particular, recent work indicates an important role for Notch signalling in determining how an endothelial cell responds to VEGF. In this review, we provide an overview of these biochemically distinct pathways and discuss how they may interact during endothelial cell differentiation and angiogenesis. BioEssays 30:303–313, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

1 Knowledge and Justification This book is an investigation of one central problem which arises in the attempt to give a philosophical account of empirical ...

In this incisive new book one of Britain's most eminent philosophers explores the often overlooked tension between voluntariness and involuntariness in human cognition. He seeks to counter the widespread tendency for analytic epistemology to be dominated by the concept of belief. Is scientific knowledge properly conceived as being embodied, at its best, in a passive feeling of belief or in an active policy of acceptance? Should a jury's verdict declare what its members involuntarily believe or what they voluntarily accept? And (...) should statements and assertions be presumed to express what their authors believe or what they accept? Does such a distinction between belief and acceptance help to resolve the paradoxes of self-deception and akrasia? Must people be taken to believe everything entailed by what they believe, or merely to accept everything entailed by what they accept? Through a systematic examination of these problems, the author sheds new light on issues of crucial importance in contemporary epistemology, philosophy of mind, and cognitive science. (shrink)

My aim in this paper is to explore the dispute between foundationalism and coherentism and attempt a resolution. I will begin by considering the origin of the issue in the famous epistemic regress problem. Next I will explore the central foundationalist idea and the most central objections that have been raised against foundationalist views. This will lead to a consideration of the main contours of the coherentist alternative, and eventually to a discussion of objections to coherentism – including several specific (...) ones that I now judge to be clearly fatal, especially when taken together. This will motivate, finally, a reconsideration of foundationalism. I will argue that the dialectically most serious objection to foundationalism can be successfully answered. While the answer that I will suggest admittedly carries with it the price of aggravating certain other difficulties, especially the venerable problem of showing how belief in an external world of physical objects can be justified, it still seems to me to leave foundationalism as by far the more defensible and promising of the two alternatives. (shrink)

A syntactically correct number-specification may fail to specify any number due to underspecification. For similar reasons, although each sentence in the Yablo sequence is syntactically perfect, none yields a statement with any truth-value. As is true of all members of the Liar family, the sentences in the Yablo sequence are so constructed that the specification of their truth-conditions is vacuous; the Yablo sentences fail to yield statements. The ‘revenge’ problem is easily defused. The solution to the semantical paradoxes offered here (...) revives the mediaeval cassatio approach, one that largely disappeared due to its incomprehending rejection by influential contemporary writers such as William Shyreswood and Thomas Bradwardine. The diagnosis readily extends to the set-theoretic paradoxes. (shrink)

The Russell class does not exist because the conditions purporting to specify that class are contradictory, and hence fail to specify any class. Equally, the conditions purporting to specify the Liar statement are contradictory and hence, although the Liar sentence is grammatically in order, it fails to yield a statement. Thus the common source of these and related paradoxes is contradictory (or tautologous) specifying conditions-for such conditions fail to specify. This is the diagnosis. The cure consists of seeking and destroying (...) the deep-seated preconceptions that make almost irresistible our belief in the existence of items which provably do not exist. (shrink)

Outlines a tenable version of a traditional foundationalist account\nof empirical justification and its implications for the justification\nof beliefs about physical or material objects. Presupposing the acceptability\nof other beliefs about physical objects; Concept of a basic belief;\nMetabeliefs about one's own occurrent beliefs; Beliefs about sensory\nexperience.

Over the past thirty-five years, there has been an explosive increase in scientists' ability to explain the structure and functioning of the human brain. While psychology has advanced our understanding of human behavior, various other sciences, such as anatomy, physiology, and biology, have determined the critical importance of synapses and, through the use of advanced technology, made it possible actually to see brain cells at work within the skull's walls. Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, (...) taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our understanding in the twentieth century. (shrink)

The concept of medicine as a profession in the English-language literature of medical ethics is of recent vintage, invented by the Scottish physician and medical ethicist, John Gregory (1724-1773). Gregory wrote the first secular, philosophical, clinical, and feminine medical ethics and bioethics in the English language and did so on the basis of Hume's principle of sympathy. This paper provides a brief account of Gregory's invention and the role that Humean sympathy plays in that invention, with reference to key texts (...) in Gregory's work. The paper also considers two interesting and perhaps provocative ways in which Hume can be read through Gregory: first, sympathy as a principle of scientific discovery in Hume's science of man and moral physiology; and sympathy as gendered feminine in Hume's moral philosophy. Hume's principle of sympathy is at the core of Gregory's medical ethics and the histories of Western medical ethics and bioethics pivot on Gregory - and, therefore, on Hume - as it does on few other figures. (shrink)

Managed care employs two business tools of managed practice that raise important ethical issues: paying physicians in ways that impose conflicts of interest on them; and regulating physicians' clinical judgment, decision making, and behavior. The literature on the clinical ethics of managed care has begun to develop rapidly in the past several years. Professional organizations of physicians have made important contributions to this literature. The statements on ethical issues in managed care of four such organizations are considered here, the American (...) Medical Association, the American College of Physicians, the American College of Obstetricians and Gynecologists, and the American Academy of Pediatrics. Three themes common to these statements are identified and critically assessed: the primacy of meeting the medical needs of each individual patient; disclosure of conflicts of interest in how physicians are paid; and opposition to gag orders. The paper concludes with an argument for a basic concept in the clinical ethics of managed care: physicians and institutions as economically disciplined moral co-fiduciaries of populations of patients. (shrink)

Several approaches to clinical ethics consultation (CEC) exist in medical practice and are widely discussed in the clinical ethics literature; different models of CECs are classified according to their methods, goals, and consultant’s attitude. Although the “facilitation” model has been endorsed by the American Society for Bioethics and Humanities (ASBH) and is described in an influential manual, alternative approaches, such as advocacy, moral expertise, mediation, and engagement are practiced and defended in the clinical ethics field. Our Clinical Ethics Center in (...) Paris was founded in 2002 in the wake of the Patients’ Rights Act, and to date it is the largest center that provides consultation services in France. In this article we shall describe and defend our own approach to clinical ethics consultation, which we call the “Commitment Model,” in comparison with other existing models. Indeed commitment implies, among other meanings, continuity through time, a series of coherent actions, and the realization of important social goals. By drawing on a recent consultation case, we shall describe the main steps of our consultation procedure: interviews with major stakeholders, including patients and proxies; case conferences; and follow up. We shall show why we have chosen the term “commitment” to represent our approach at three different but interrelated levels: commitment towards patients, within the case conference group, and towards society as a whole. (shrink)

This paper focuses on how Soldiers make hard choices between competing options. To understand the psychological processes behind these types of decisions, we present qualitative data collected from...

Nancy Jecker (2013) mounts a sustained and formidable critique of Norman Daniels's prudential lifespan account (PLA) as a reliable basis for justice between age groups in the responsible allocation...

A Sceptical Theory of Scientific Inquiry: Problems and Their Progress presents a distinctive re-interpretation of Popper's 'critical rationalism', displaying the kind of spirit found at the L.S.E. before Popper's retirement. It offers an alternative to interpretations of critical rationalism which have emphasised the significance of research programmes or metaphysics (Lakatos; Nicholas Maxwell), and is closer to the approach of Jagdish Hattiangadi. Briskman gives priority to methodological argument rather than logical formalisms, and takes further his own work on creativity. In addition (...) to offering an important contribution to the understanding of critical rationalism, the book contains interesting engagements with Michael Polanyi and the Meno Paradox. This volume also contains an introduction by the editor, which situates Briskman's work in the history of the interpretation of 'critical rationalism'. (shrink)

Buson, Nardy, Muller & Chevrot (2018) report two experiments ‐ a repetition task and a judgment task ‐ based on the phenomenon of sociolinguistic restoration. When people repeat utterances mixing standard and non‐standard variants, they make them homogeneous. The results suggest that coherent cognitive representation of the sociolinguistic varieties influences the reconstruction of the mixed heard utterance during the repetition. Using the repetition task could help understanding how sociolinguistic cues are organized in memory.

According to some commentators, Wittgenstein’s Tractatus is all one big joke: we plough through the text trying to extract the sense out of each spare and heroic proposition, only to be told at the end, that anyone who understands the author will realize that all of his propositions are nonsensical and so are not even propositions. The whole work is a kind of hoax; the readers are ridiculed, but, with luck, will eventually have to laugh when they come to recognize (...) that what they had taken for deep philosophy was all so much gibberish. As a result of this revelation, they will be cured for ever of the urge to philosophize. (shrink)

Summary The article discusses the decline of Aristotelian physics at the University of Paris in the seventeenth and early eighteenth centuries. A course of physics remained essentially Aristotelian until the final decade of the seventeenth century, when it came under the influence of Descartes. But the history of physics teaching over this period cannot be properly appreciated if it is simply seen in terms of the replacement of one physical philosophy by another. Long before the 1690s, the traditional Aristotelianism of (...) the Schools had been forced to come to terms with the New Science to some degree, while the Cartesianism of the early eighteenth century was always alive to the challenges to Descartes's particular physical theories. Except in the early seventeenth century the physics course at Paris was always in a state of change. The replacement of Aristotelian by Cartesian physics too involved the development of a novel epistemology. Although both Aristotelian and Cartesian professors believed that natural philosophy was a science of causes based upon a priori principles, the latter had a far more probabilist conception of physics. (shrink)

There has recently been revived logical interest, particularly in the context of attempts to solve the logico-semantical paradoxes, of the idea that there are true contracistions, and of semantics accomodating the glut value both true and false. By considering some generally accepted claims about assertion. I attempt to show that this dialetheist idea is untenable.

Our interpretation of the "parmenides" 132a1 - 132b2 has the following features. (i) it stresses that the third man argument is an infinite regress and (ii) notes its epistemological thrust. (iii) a faithful translation of the last line of the argument reads "and no longer will each of the forms be for you one but each is infinite in multitude." parmenides' point is that each form, which socrates believed to be complete (one), turns out to be an unbounded, incompletable series (...) of subforms useless for comprehending the unity of many particulars. (iv) related problems are seen to occupy plato in the "philebus" and in the "sophist". (shrink)

Wittgenstein likened himself to a soil distinctive only in that once implanted with the seeds of great thinkers, interesting flora grew. This chapter examines the influence on him of authors he regarded as truly original, such as Bolzmann, Hertz, Schopenhauer, Frege and Russell.

The author recommends an involved study of logical fallacies in order to provide a database of testable hypotheses for error reasoning. The purpose of the study is to make the study of logical fallacies accessible to a wider audience. Following a recent study conducted by Ludwig Schlecht, the author presents a diagnostic method to illustrate how an argument can be fallacious from the breach of particular rational principles. The diagnosis method also serves as investigation into other forms of argumentative fallacies (...) and the author suggests it could later be the basis for training programs for undergraduate students in logic courses. (shrink)

Letting is a common practice in mathematics. For example, we let x be the sum of the first n integers and, after a short proof, conclude that x = n(n+1)/2; we let J be the point where the bisectors of two of the angles of a triangle intersect and prove that this coincides with H, the point at which another pair of bisectors of the angles of that triangle intersect. Karl Weierstrass's colleagues, in an attempt to solve optimization problems, stipulated (...) that the minimum area for a triangle with a given perimeter be a straight line segment conceived as a triangle with zero altitude. (Weierstrass complained that this obscured the insight that some problems have no solutions.) In mathematics applied to physics, we let x be the temperature in Fahrenheit corresponding to 30° Centigrade; we let v be the velocity of the Earth through the luminiferous ether. Before the error was spotted, the official rules for Little League Baseball made an inconsistent stipulation about the dimensions of home plate (Bradley 1996). (shrink)