Telomerase is a cellular reverse transcriptase responsible for telomere maintenance in most organisms. It does so by adding telomere repeats onto pre‐existing ends using an integral RNA component as template. Compared to “prototypical” reverse transcriptases, telomerase is unique in being able to repetitively copy a short templating RNA segment, thus adding multiple copies of the repeat to the DNA substrate following a single binding event. This uniquely processive property hints at the intricate conformational alterations that the enzyme must choreograph during (...) its reaction cycles. Recent studies have identified distinct structural elements within both the RNA and protein components of telomerase that modulate enzyme processivity. Pharmacological and genetic analysis suggest that telomerase processivity is a significant determinant of telomere length. Because telomere maintenance and the lack thereof have been linked to tumor progression and aging, further investigation of telomerase processivity may lead to novel medical intervention strategies. BioEssays 26:955–962, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

El presente artículo analiza las primeras consideraciones de Ludwig Wittgenstein respecto de la percepción de figuras ambiguas, lo que posteriormente fue englobado por la más amplia noción de “percepción de aspectos”. El objetivo consiste en poner de manifiesto algunas las consideraciones del Tractatus Logico-Philosophicus respecto al carácter intrínsecamente representacional de la percepción en el caso del Cubo de Necker, para establecer de qué manera y en qué medida sus primeras observaciones críticas de la percepción de propiedades que admiten grados en (...) Some Remarks on Logical Form, en 1929, puede impactar análogamente sobre su propia descripción de esta clase particular de experiencias bajo consideración. (shrink)

This study explores the impact of government informatization construction on corporate digital technology innovation. It uses the integration of informatization and industrialization pilot zones in China as a quasi-natural experiment of government informatization construction, and construct a difference-in-differences model. Based on a sample of Chinese A-share corporations from 2007 to 2021, the empirical findings reveal that government informatization construction significantly promotes corporate digital technology innovation by enhancing corporate attention to digital technologies and reducing transaction costs. Furthermore, the positive impact is (...) more pronounced in the southern regions and regions with stronger intellectual property protection and high-tech and digital economy industries, as well as mature-stage corporations and corporations with higher levels of digital technology innovation. These findings provide valuable insights for implementing informatization policies and facilitating corporate digital technology innovation. (shrink)

Augustine’s theory of first movements has provoked many controversies over the years. When discussing Augustine’s position in preliminary passions, some scholars maintain that he misunderstands the Stoics, whereas some others argue that he grasps their works rather well and his accounts are consistent with Stoic teaching. This article examines how Augustine transforms his predecessors’ conception of first movements into his own theory, with particular focus on whether Augustine misinterprets his predecessor’s doctrine in his approach. The first section introduces the recent (...) disputations on Augustine’s misunderstanding of the Stoic concept of the first movements. The second section compares Augustine’s opinions in his early, middle, and late writings to determine whether changes occur in his interpretation. Based on the above observations, this essay argues that Augustine is familiar with the Stoic doctrines, but in his later works, he ‘deliberately’ deviates from their concept of the first movements in order to refute their ‘pride’ and to defend his Christian position on the psychology of preliminary passions. These deliberate new changes of terms by Augustine do not derive from a misunderstanding, but rather follow from his attempt at constructing a new dynamic theological framework of addressing passions during his later thought. The article concludes with a third section that revisits the modern critiques and responds with a consideration of the significance of Augustine’s views on preliminary passions. (shrink)

本书简要地阐明了文学本文的创造过程,文学作品的构成及其实现过程,文学的审美价值系统及其实现过程,文学的历史发展过程。.

In response to the Covid-19 pandemic, online learning has been carried out in many countries with different types of online learning models being promoted and implemented. In the global pandemic continues, the education environment is forced to change from traditional classroom or blended teaching mode to online learning teaching model. With the outbreak of COVID-19, China was the first to announce that online courses are to be implemented in February 2020. In China, whether online learning can replace traditional offline teaching (...) has become a topic worth discussing. Therefore, this study investigates university students in China by questionnaires and discussions of this topic. The study is based on the Push–Pull Mooring model. Based on 854 valid responses collected from an online survey questionnaire, structural equation modeling was employed to examine the research model. The results show that push effects, pull effects, and mooring effects all significantly influence users' switching intentions from offline to online learning platform. Finally, this study explores whether push–pull–mooring can be a reference for promoting and implementing online learning courses in Chinese colleges and universities in the future after the pandemic. (shrink)

Background Based on the principle of informed consent, doctors are required to fully inform patients and respect their medical decisions. In China, however, family members usually play a special role in the patient’s informed consent, which creates a unique “doctor-family-patient” model of the physician-patient relationship. Our study targets young doctors to investigate the ethical dilemmas they may encounter in such a model, as well as their attitudes to the family roles in informed consent. Methods A questionnaire was developed including general (...) demographic characteristics, the fulfillment of the obligation to fully inform, who will be informed, and the ethical dilemmas in decision-making. We recruited a total of 421 doctors to complete this questionnaire, of which 368 met the age requirements for this study. Cross tabulation and Pearson’s chi-squared test were used to analyze the differences between types of patients for categorical variables, and a p-value < 0.05 was considered statistically significant. Results Our data shows that only 20 doctors (5.40%) stated “informing the patient alone is sufficient” when it comes to informing patients of their serious conditions. The rest of the participants would ensure that the family was informed. When facing elderly patients with decision-making capacity, the data was statistically different (3.8%; P < 0.001) The primary reason for ensuring that family members be informed differs among the participants. In addition, when family members asked doctors to conceal the patient’s medical condition for the best interests of patients, 270 doctors (73.4%) would agree and cooperate with the family. A similar proportion (79.6%) would do so when it comes to elderly patients. Conclusions (1) Chinese doctors pay extra attention to informing the patient’s family, which may not be in the patient’s best interests. (2) Chinese doctors treat adult (but not elderly) patients and elderly patients differently when it comes to informing family members. (3) When family members request that doctors withhold information from patients “in the best interest of the patient,” the majority choose to comply with the request, although this may cause them distress. (shrink)

The Legalist school, which played a progressive role in the history of our country, was a school of thought in direct opposition to the Confucian school. It appeared in the Spring and Autumn and Warring States periods and had its own particular economic basis and political conditions. The school which through the ages has worshiped Confucius and the chieftains of the opportunist line within our own Party have proceeded from their reactionary political needs to fabricate lies regarding the question of (...) the appearance of the Legalists and to cover over the basic differences between the two classes and lines represented by the Confucians and the Legalists. Therefore, we must uphold the Marxist theory of historical materialism and correctly analyze the economic and political sources of the Legalist school. (shrink)

本书以文化交流的一般理论为基本出发点,从中美文化交流的广阔的社会文化背景着眼,通过杜威五四时期的中国之行的典型个案研究,较为准确地深入探讨了杜威学说与中国文化的辩证关系。.

Corporate citizenship represents various organizational activities and status related to the organization's societal and stakeholder obligations. This study develops five different dimensions of corporate citizenship and examines the relationship between the five dimensions and purchase intention by including two key mediators. In the proposed model of this study, purchase intention is indirectly affected by economic, legal, ethical, general philanthropic, and strategic philanthropic citizenship via the mediation of corporate identification and brand trust. Empirical testing using a survey of 353 consumers from (...) various industries confirms most of our hypothesized effects. Last, managerial implications for corporate leaders and limitations of our findings are discussed in depth. (shrink)

Ever since the ancient Chinese paradox "white horse is not horse" was brought into the context of Western philosophy, various interpretations have been proposed by modern scholars based on different theoretical considerations, although no satisfactory consensus has been reached. Controversy focuses especially on whether the paradox implies a realist or nominalist ontology.The controversy starts from Fung Yu-lan's realist reading of Gongsun Long. Fung read "white horse is not horse" as "white-horseness is different from horseness." "The universal, horseness, is the essential (...) attribute of all horses. … Such 'horseness' is distinct from 'white-horseness'". He ascribes to Gongsun Long a Platonic realism... (shrink)

High-tech industries often regard workers as their main source of value creation. In order to stimulate their employees' willingness to innovate and their innovative behavior and reduce the turnover intention, companies are now seeking to establish employer–employee relationships in which their employee's willingness to stay is not simply driven by extrinsic motivations. Therefore, it is an important topic in human resources for companies to implement measures that encourage employees to willingly devote themselves to their jobs and consider organizational growth as (...) a component of their career development. This study aimed to investigate the effect of person–organization fit and person–job fit on employees' innovative behavior and turnover intention via the mediators including job satisfaction and organizational commitment. Six hundred ninety-seven employees from China's eight major high-tech industries were examined in this study, and the empirical results were analyzed using partial least squares. Based on the results, it is suggested that the person–organization fit and person–job fit are both crucial factors affecting employees' job satisfaction and organizational commitment, which, in turn, increase employees' willingness to innovate in their jobs and reduce their turnover intentions. Furthermore, this study could serve as a reference for companies in selecting employees, promoting job satisfaction, and developing strategies for sustainable development. (shrink)

The Dao Companion to Chinese Philosophy of Logic is the first general overview of Chinese logical philosophy in English, presumably providing students and researchers of Chinese thought in the Engl...

Industrial investment funds are a new financing innovation mode that can build an effective financing channel for enterprises.Based on the panel data of Chinese Listed Companies in 2008–2017, this manuscript constructed a static panel model between industrial investment funds, government R&D subsidies, and technological innovation to empirically analyze the effects of industrial investment fund involvement and government R&D subsidies on companies’ technological innovation. The research shows that industrial investment fund involvement can increase the company’s R&D investment by providing financial funds (...) for the company, which can effectively solve the company’s lack of funds in the process of technological innovation and guarantee the smooth running of the company’s innovation activities. Secondly, government R&D subsidies can alleviate the pressure of R&D investment to a certain extent, which is conducive to promote a higher level of technological innovation in the company. Thirdly, for companies with industrial investment fund involvement, government R&D subsidies are conducive to promote technological innovation. In contrast, for companies without industrial investment fund involvement, government R&D subsidies have no significant impact on technological innovation to a certain extent or even have a “crowding out effect.”. (shrink)

Volatile compounds, such as nitric oxide and ethylene gas, play a vital role as signaling molecules in organisms. Ethylene is a plant hormone that regulates a wide range of plant growth, development, and responses to stress and is perceived by a family of ethylene receptors that localize in the endoplasmic reticulum. Constitutive Triple Response 1 (CTR1), a Raf‐like protein kinase and a key negative regulator for ethylene responses, tethers to the ethylene receptors, but undergoes nuclear translocation upon activation of ethylene (...) signaling. This ER‐to‐nucleus trafficking transforms CTR1 into a positive regulator for ethylene responses, significantly enhancing stress resilience to drought and salinity. The nuclear trafficking of CTR1 demonstrates that the spatiotemporal control of ethylene signaling is essential for stress adaptation. Understanding the mechanisms governing the spatiotemporal control of ethylene signaling elements is crucial for unraveling the system‐level regulatory mechanisms that collectively fine‐tune ethylene responses to optimize plant growth, development, and stress adaptation. (shrink)

RESUMEN Los casos de "ver-como", presentados por Wittgenstein en la Segunda Parte de Philosophical Investigations, muestran que el concepto de "ver" se encuentra cercano al de "interpretar" y resiste su separación. El presente artículo propone un argumento para aclarar la noción de "interpretación" presente en estos casos, a partir de su comparación con los usos presentes en el Tractatus y en la Primera Parte de Philosophical Investigations. Se sostiene que dicha noción cumple el rol de determinar el sentido de lo (...) visualmente experimentado. Además, "ver" e "interpretar" mantienen un tipo de relación interna y "ver-como" puede considerarse como una "representación elástica". ABSTRACT The "seeing-as" cases, presented by Wittgenstein in the Second Part of Philosophical Investigations, show that the concept of 'seeing' is close to that of 'interpretation' and resists its separation. This article proposes an argument to clarify the notion of 'interpretation' present in these cases, from its comparison with the uses present in the Tractatus and in the First Part of Philosophical Investigations. It is argued that this notion fulfills the role of determining the sense of the visually experienced. In addition, 'to see' and 'to interpret' maintain a type of internal relationship and 'seeing-as' can be considered an "elastic representation". (shrink)

Confrontée à la question de la « production de la société », la « sociologie des transitions » doit rechercher de nouvelles méthodes qui se distinguent du positivisme instrumental. L’ « Intervention sociologique », fondée sur la « sociologie de l’action », représente un choix possible. Cependant, face aux logiques pratiques de la transition sociale chinoise, cette méthode, développée par l’ « École de Touraine », doit être perfectionnée tant dans ses principes que dans ses techniques. S’inspirant de la « (...) sociologie de la libération » et de la « sociologie publique », les deux types d’intervention que nous distinguons, « forte » et « faible », constituent une tentative féconde. En présentant deux recherches menées sur les paysans migrants et les mouvements urbains, cet article tente d’expliquer les caractéristiques des « interventions forte et faible ».Having to address the issue of « producing society », the « sociology of transformation » must use new methods of research distinct from instrumental positivism. Based on the « sociology of action », the method of « sociological intervention » may be one of it. However, facing the practical logics of social transition in China, this method, Touraine’s school’s method, must be improved both in its principles and techniques. Bringing together the principles of the « sociology of liberation », and of the « public sociology », we distinguish two types of intervention, namely « strong » and « weak », which represent a very rich attempt. Through two research projects about migrant workers and urban movements, this articles tries to present the features of « strong and weak interventions ». (shrink)

The evaluation index system of ecological security of marine ranching is based on the assumption that there is independence among evaluation indexes in the existing studies, which ignores the complex interactive paths of marine ranching as an artificial ecosystem. In this study, the MRES evaluation network model that includes interdependent relationships is established based on the Driver-Pressure-State-Impact-Response model and the analytic network process method. Then, the probabilistic linguistic term sets and analytic network process methods are used to calculate the weights (...) of the evaluation indexes of MRES. The overall evaluation value and the contribution rate of clusters are consequently defined and analyzed to reflect the performance of MRES. Finally, a case study is carried out for evaluating the MRES of marine ranches in Rongcheng by means of the proposed method. The conclusions are summarized as follows: The weights of clusters are ranked as Responses > Impact > Driver > State > Pressure, and “scientific management of fishery resources” is the most important index; the MRES performance of marine ranches in the city of Rongcheng is at the medium security grade on the whole, and all 11 samples are driven by the response. (shrink)

This study investigates the efficacy of three corporate social responsibility (CSR) initiatives—sponsorship, cause-related marketing (CRM), and philanthropy—on consumer–company identification (C–C identification) and brand attitude and, in turn, consumer citizenship behaviors. CSR reputation is proposed as the moderating variable that affects the relationship between CSR initiatives, C–C identification, and brand attitude. A conceptual model that integrates the hypothesized relationships and the moderating effect of CSR reputation is used to frame the study. Using a between-subjects factorial designed experiment, the results showed that (...) all three CSR initiatives have a significant effect on C–C identification and brand attitude. The level of that influence, however, varied according to a firm’s CSR reputation. Managerial implications of these findings are also discussed. (shrink)

This comparative study of the ethics of care and the Confucian concept of jen argue against two assumptions made by Chenyang Li in his own study of these two traditions. Against him, I argue that a "feminine" morality is not adequate to address human equality, and that care-orientated theories like jen and care seem incompatible with the feminist commitment to oppose the subjection of women.

What is time? Is time real, or a mere illusion? We seem to feel the passage of time in our consciousness but are doomed to encounter great difficulty when trying to get a deeper grip on the nature of time. As Augustine famously remarked, "if no one asks me about what time is, I know what it is, but if I wish to explain it to him who asks, I do not know". The present essay does not aim so much (...) at giving a complete answer to this intricate and difficult question as to focus on Zhuangzi to excavate the idea of time inherent in his philosophical writings. A second aim is to show how it relates to some of the contemporary concerns about time. More specifically, our concern is not about... (shrink)