The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

There are generally two controversial issues over Kant's solution to the free will problem. One is over whether he is a compatibilist or an incompatibilist and the other is over whether his solution is a success. In this paper, I will argue, regarding the first controversy, that “compatibilist” and “incompatibilist” are not the right terms to describe Kant for his unique views on freedom and determinism; but that of the two, incompatibilist is the more accurate description. Regarding the second controversy, (...) I will argue that Kant's solution to the free will problem is not a success because his effort in making the effects of freedom part of the field of appearance has made his solution incoherent and ambiguous. Despite this, I argue that Kant's attempt to solve the free will problem is groundbreaking because he at least has separated freedom from the dominance of determinism. (shrink)

This article offers a comparative study of the views of Alexis de Tocqueville and those of several Chinese thinkers of the late Ming dynasty (1368–1644)—primarily Gu Yanwu, Huang Zongxi, Wang Fuzhi—on the socio-political processes of centralization. My central claim is that their views of political centralization and of the decentralized polycentric society that preceded it in their respective countries exhibit a remarkable array of analogous structural features. More specifically, both Tocqueville and his Chinese counterparts perceive in centralization an inherent unsustainability (...) driven by its self-destructive nature: since the foundation and strength of statism depends on its social resources, the centralization of power inevitably results in the weakening of its own basis. I conclude that through their nuanced reinterpretation of self-interest, both parties advocate a “small-community-oriented communitarianism” instead of the increasingly centralized modern state. (shrink)

Irresponsible research practices damaging the value of science has been an increasing concern among researchers, but previous work failed to estimate the prevalence of all forms of irresponsible research behavior. Additionally, these analyses have not included articles published in the last decade from 2011 to 2020. This meta-analysis provides an updated meta-analysis that calculates the pooled estimates of research misconduct and questionable research practices, and explores the factors associated with the prevalence of these issues. The estimates, committing RM concern at (...) least 1 of FFP and QRPs concern 1 or more QRPs, were 2.9% and 12.5%, respectively. In addition, 15.5% of researchers witnessed others who had committed at least 1 RM, while 39.7% were aware of others who had used at least 1 QRP. The results document that response proportion, limited recall period, career level, disciplinary background and locations all affect significantly the prevalence of these issues. This meta-analysis addresses a gap in existing meta-analyses and estimates the prevalence of all forms of RM and QRPs, thus providing a better understanding of irresponsible research behaviors. (shrink)

As the main literature of socio-economic history, local gazetteers display the dynamic process of local socio-economic structuring and reflect local conflicts among various interest groups. Focusing on local gazetteers in Wanzai County of Jiangxi Province from the Qing to the Republic, this essay shows how local literati played an active role in constructing their local community. These gazetteers reflected the complicated power relations, especially the conflict between the natives and immigrants, and they themselves became the important part of the process (...) of local power reproduction and culture construction. (shrink)

This essay tries to analyze the contention, conversation and conjunction between Confucian and Buddhism through debates on loyalty and filial piety from the Three Kingdoms to the Tang Dynasty, and to explain the influence on Buddhist loyalty and filial piety by the Confucian thoughts.

The impact of bilingual education and bilingual experience on working memory has been an important and controversial issue in the field of psycholinguistics. Taking Chinese-English bilinguals as an example, this study aims to investigate the differences in emotional working memory between proficient and non-proficient bilinguals by using delayed matching-to-sample task paradigm and more complex n-back task in the context of emotion. The results show that proficient bilinguals have better performance on both of the two working memory tasks than non-proficient bilinguals, (...) and the advantage effects were more apparent under high memory load conditions. Besides, the negative emotion context has a positive impact on complex n-back tasks. This study supports the notion that bilingual experience can promote the development of an individual’s cognitive ability and enable individuals to possess more advantages in working memory even in the presence of emotional distractions. (shrink)

[232 pages] This first book in the series 霍耐特选集 [Selected Works of Axel Honneth] is a Chinese translation of Axel Honneth’s Pathologien der Vernunft: Geschichte und Gegenwart der Kritischen Theorie directly from the German.

[The statement] A ^ Ā is doubtlessly a logical contradiction in terms of formal logic. However, according to dialectics this is a state which the contradiction in the essence of a thing experiences in the process of development — a state of qualitative change of being "at once this and that." A contradiction under such circumstances is an important object of dialectical studies. And such a state of affairs actually exists in real life; a thing tends to experience such a (...) state when it changes into its opposite. The contradictory aspects experiencing such a state both conform to reality. Therefore A ^ Ā is a logical contradiction and a dialectical contradiction as well. The two types of contradictions are actually the two manifestations of the same contradiction in different contexts. Or, in other words, they are the different points of view and approaches of two kinds of logic toward the same contradiction. Obviously, in distinguishing problems we must first make clear the two different kinds of logic, or, the two different methods in approaching contradictions, rather than distinguishing between two types of contradictions. That is to say, what we must distinguish first is logic and not contradiction. In different categories of logic, contradiction takes on different character. (shrink)

[174 pages] This third book in the series 霍耐特选集 [Selected Works of Axel Honneth] is a Chinese translation of Axel Honneth’s and Jacques Rancière’s Anerkennung oder Unvernehmen? Eine Debatte directly from the German.

[232 pages] This second book in the series 霍耐特选集 [Selected Works of Axel Honneth] is a Chinese translation of Axel Honneth’s Vivisektionen eines Zeitalters: Porträts zur Ideengeschichte des 20. Jahrhunderts directly from the German.

China has a longstanding tradition of stressing the values of harmony and coherence, and Chinese society has often been portrayed as a culture in which conflict avoidance is viewed more positively than direct confrontation and argumentation. In order to evaluate the validity of this claim, this paper sketches Chinese people’s feelings and understandings about interpersonal arguing by reporting results of a data collection in China, using measures of argumentativeness, verbal aggressiveness, argument frames, and personalization of conflict. These results were compared (...) to those from a US sample. Chinese and US data differed in complex ways, but did not show Chinese respondents to be more avoidant. The Chinese correlations among variables were a reasonable match to expectations based on Western argumentation theories, although they did not replicate the US results precisely. The paper offers evidence that Chinese respondents had a more sophisticated understanding of interpersonal arguing than their US counterparts, and were more sensitive to the constructive possibilities of face-to-face disagreement. (shrink)

Based on its productionguideline, organic agriculture has set foritself the goals of minimizing all forms ofpollution and maintaining sustainability of thefarming system. By striving for these goals,organic farming meets the demands of anincreasing number of consumers who are criticalof conventional production methods. This papergives an overview of the present state of theart in the different issues. Possibilities ofand limitations in performing the self-aimedgoals under the basic standards of organicagriculture are discussed. Concerningenvironmental protection, in general, the riskof adverse environmental effects is (...) lower withorganic than with conventional farming methods,though not necessarily so; with reference tosoil fertility and nutrient management, organicfarming is suited to improve soil fertility andnutrient management markedly on the farm level;regarding biodiversity, comparison studies showthat organic farming has more positive effectson biodiversity conservation; in relation toproduct quality, under the basic standards oforganic farming, there is no sufficientevidence for a system-related effect on productquality due to the production method. (shrink)

Deception is common in the marketplace where individuals pursue self-interests from their perspectives. Extant research suggests that perspective-taking, a cognitive process of putting oneself in other’s situation, increases consumers’ ethical tolerance for marketers’ deceptive behaviors. By contrast, the current research demonstrates that consumers who take the dishonest marketers’ perspective become less tolerant of deception when consumers’ moral self-awareness is high. This effect is driven by moral self-other differentiation as consumers contemplate deception from the marketers’ perspective: high awareness of the “moral (...) self” motivates consumers to distance themselves from the “immoral other.” The findings shed new light on how self-morality can vicariously shape social consideration in ethical judgments. (shrink)

The cause of Chinese philosophy has made significant progress since it began to reform three decades ago. However, Chinese philosophy also faces many problems. Shaken by current market economic forces, it now confronts a huge challenge in taking on its mission of raising questions, both theoretical and practical, and responding to them using the methods of philosophy. This article analyzes developments and problems in the three sub-disciplines of philosophy: Marxist philosophy, the history of Chinese philosophy and foreign philosophies. Using this (...) framework, it will purposefully address the great historical responsibility facing Chinese philosophers. (shrink)

History of ideas "duality" is Mr. Li Jinquan the focus of attention problems. Articles by examining his case studies the history of thought, school of analysis, the overall concept through the three levels of detailed analysis, to explore his object throughout the study in the "philosophy of integrating" approach orientation and the "heritage and innovation" cultural standpoint, and shows that he contemplation of the modern practice of traditional character, the close integration of academic learning and social spirit of the people. (...) Mr. Jin-quan Li pay close attention to a focal question which is "dual nature" of history of thinking. The article will review the detailed analyse about three arrangments of ideals which consists of individual research, analyse on school of thought and the whole history of thought. And will search for the method of the fusion of philosoghy and history, the successive arid innovative cultural stand which ran through his research. And will delineate his practical character of using tradition take care of modernization and the scholcal spirit of combining study with life and society. (shrink)

This study examines the role of responsible entrepreneurship among female entrepreneurs by examining how and when responsible entrepreneurship may exert a positive influence on female entrepreneurial success. Using the data collected from 337 Chinese female entrepreneurs, and by integrating responsible entrepreneurship research with a dynamic capability framework, our findings show, firstly, that responsible entrepreneurship is positively correlated to female entrepreneurial success; secondly, this relationship is mediated by female entrepreneurs’ opportunity recognition; and thirdly, the indirect effect of responsible entrepreneurship on female (...) entrepreneurial success through opportunity recognition is weaker when women entrepreneurs perceive more gender discrimination. Furthermore, using a post hoc analysis, we find that responsible entrepreneurship has a positive impact on entrepreneurial success for both male and female entrepreneurs, but that this impact is more significant for female entrepreneurs than for their male counterparts. With the contextual factor of traditional female social stereotypes inadvertently contributing to greater gender discrimination in the field of entrepreneurship, our results underscore the importance of both responsible entrepreneurship and opportunity recognition in promoting female entrepreneurial success. (shrink)

The extent to which we generalize a novel property from a sample of familiar instances to novel instances depends on the sample composition. Previous property induction experiments have only used samples consisting of novel types (unique entities). Because real‐world evidence samples often contain redundant tokens (repetitions of the same entity), we studied the effects on property induction of adding types and tokens to an observed sample. In Experiments 1–3, we presented participants with a sample of birds or flowers known to (...) have a novel property and probed whether this property generalized to novel items varying in similarity to the initial sample. Increasing the number of novel types (e.g., new birds with the target property) in a sample produced tightening, promoting property generalization to highly similar stimuli but decreasing generalization to less similar stimuli. On the other hand, increasing the number of tokens (e.g., repeated presentations of the same bird with the target property) had little effect on generalization. Experiment 4 showed that repeated tokens are encoded and can benefit recognition, but appear to be given little weight when inferring property generalization. We modified an existing Bayesian model of induction (Navarro, Dry, & Lee, 2012) to account for both the information added by new types and the discounting of information conveyed by tokens. (shrink)

An enormous challenge facing China is how to provide sustainable care for its rapidly-increasing elderly population. Its recent policy directives include three medical forms—the institution-cooperation-form, the institution-medical-form, and the family-physician-form—to integrate medical care into ordinary care for the elderly. This essay indicates that China will not be able to maintain sustainable elderly care unless it places emphasis on the family-physician-form that focuses on family physicians and the use of primary care services. The essay constructs arguments for this policy suggestion based (...) on China’s long-standing Confucian ethical resources of filial piety and family-based concerns for elderly care. (shrink)

本书根据“人是文化(符号)的动物”、人是政治(城邦)的动物”等四种法哲学作了细致入微的分析。.

本书从逻辑与历史相结合的思维原则出发,对人类历史上几种主要自然观的特征进行了深入的剖析,对“天人合一”的自然观提出了自己的看法,重点展示了产生这些迥异自然观的文化基因。.

Despite advancements in human research ethics and the growing significance of Research Ethics Board (REB) members, educational opportunities specifically tailored to their needs remain lacking in many countries. In response to this gap, our research aims to understand the demographics, needs, and preferences for educational opportunities of REB members in Canada. We conducted a survey that found REB demographics to be diverse and have different perceptions of their roles on topics such as the evaluation of the scientific merit of studies (...) and responsibilities to stakeholders. We found that REB members in general prefer online tutorials and webinars for their education. Educators interested in facilitating the development of future training programs should consider the needs and preferences of REB members outlined in this publication. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.