Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)
The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)
Based on its productionguideline, organic agriculture has set foritself the goals of minimizing all forms ofpollution and maintaining sustainability of thefarming system. By striving for these goals,organic farming meets the demands of anincreasing number of consumers who are criticalof conventional production methods. This papergives an overview of the present state of theart in the different issues. Possibilities ofand limitations in performing the self-aimedgoals under the basic standards of organicagriculture are discussed. Concerningenvironmental protection, in general, the riskof adverse environmental effects is (...) lower withorganic than with conventional farming methods,though not necessarily so; with reference tosoil fertility and nutrient management, organicfarming is suited to improve soil fertility andnutrient management markedly on the farm level;regarding biodiversity, comparison studies showthat organic farming has more positive effectson biodiversity conservation; in relation toproduct quality, under the basic standards oforganic farming, there is no sufficientevidence for a system-related effect on productquality due to the production method. (shrink)
While the conversations surrounding moral cultivation in Confucianism often focus on the debate regarding the starting point of moral learning (and corresponding features of the learning process) that is inspired by the disagreements between the _Mengzi_ 孟子 and the _Xunzi_ 荀子, there is another group of scholarship on moral cultivation which tends to the experiential qualities felt by the learning agents. This essay participates in the latter group of scholarship. The majority of discussions regarding the learning experience center around mental (...) states such as _an_ 安 (tranquility or equanimity) and _le_ 樂 (happiness, joy, or pleasure) of a special kind. There is, nonetheless, a minor trend that emphasizes the significance of _you_ 憂 (worry or distress). In this essay, I raise attention to the significance of _you_ and argue that in the _Analects_, an indispensable and significant part of Confucian moral cultivation is to learn to worry well, which involves learning to worry broadly about society in general, and to worry deeply about particular individuals standing in important relationship to us_._. (shrink)
As the main literature of socio-economic history, local gazetteers display the dynamic process of local socio-economic structuring and reflect local conflicts among various interest groups. Focusing on local gazetteers in Wanzai County of Jiangxi Province from the Qing to the Republic, this essay shows how local literati played an active role in constructing their local community. These gazetteers reflected the complicated power relations, especially the conflict between the natives and immigrants, and they themselves became the important part of the process (...) of local power reproduction and culture construction. (shrink)
This essay tries to analyze the contention, conversation and conjunction between Confucian and Buddhism through debates on loyalty and filial piety from the Three Kingdoms to the Tang Dynasty, and to explain the influence on Buddhist loyalty and filial piety by the Confucian thoughts.
This essay attempts to compare Kant’s better man and the Confucian junzi in the Zhongyong, and argues that Kant’s idea of the better man, which expresses human self-improvement in ultimate freedom, is in fact a conception very similar to that of the Confucian junzi, which denotes an ideal human being in cheng. Kant attributes the lack of emphasis on self-improvement in Western culture to the Christian conception of grace, and demonstrates the possibility of self-improvement on the ground of ultimate freedom. (...) We may call this treatment “the Confucian solution” in Kant’s thought. My intention is to explicate the conceptual commonality between the better man and the junzi and demonstrate the Confucian element in Kant’s religious thought. (shrink)
[The statement] A ^ Ā is doubtlessly a logical contradiction in terms of formal logic. However, according to dialectics this is a state which the contradiction in the essence of a thing experiences in the process of development — a state of qualitative change of being "at once this and that." A contradiction under such circumstances is an important object of dialectical studies. And such a state of affairs actually exists in real life; a thing tends to experience such a (...) state when it changes into its opposite. The contradictory aspects experiencing such a state both conform to reality. Therefore A ^ Ā is a logical contradiction and a dialectical contradiction as well. The two types of contradictions are actually the two manifestations of the same contradiction in different contexts. Or, in other words, they are the different points of view and approaches of two kinds of logic toward the same contradiction. Obviously, in distinguishing problems we must first make clear the two different kinds of logic, or, the two different methods in approaching contradictions, rather than distinguishing between two types of contradictions. That is to say, what we must distinguish first is logic and not contradiction. In different categories of logic, contradiction takes on different character. (shrink)
The cause of Chinese philosophy has made significant progress since it began to reform three decades ago. However, Chinese philosophy also faces many problems. Shaken by current market economic forces, it now confronts a huge challenge in taking on its mission of raising questions, both theoretical and practical, and responding to them using the methods of philosophy. This article analyzes developments and problems in the three sub-disciplines of philosophy: Marxist philosophy, the history of Chinese philosophy and foreign philosophies. Using this (...) framework, it will purposefully address the great historical responsibility facing Chinese philosophers. (shrink)
Green consumption values have been shown to motivate consumers to engage in green consumption practices. However, surprisingly little research has examined how green consumption values develop in young people. In the current study, we employed ecological socialization theory as a framework to investigate the process by which parents’ green consumption values shape similar values in their young adolescents. In Study 1, data from 722 Chinese families that included an early adolescent showed that both mothers’ and fathers’ green consumption values were (...) positively associated with early adolescents’ green consumption values, and this association was mediated by each parent’s environmentally responsible consumption behavior. Study 2 replicated the results of Study 1 using two waves of matched parent-adolescent data collected a month apart from another group of 477 Chinese families. Furthermore, Study 2 showed that the mediation process identified in Study 1 was evident only when there was a close parent–child relationship. These findings have implications for cultivating the green consumption values of today’s youth. The results also have heuristic value for future research on the ecological socialization and inter-generational transmission of pro-environmental values. (shrink)
Extensive conflicts of interest at both individual and institutional levels are identifiable in scientific research and healthcare in China, as in many other parts of the world. A prominent new case from China is He Jiankui’s experiment that produced the world’s first gene-edited babies and that raises numerous ethical, political, socio-cultural, and transnational questions. Serious financial and other COI were involved in He’s genetic adventure. Using He’s infamous experiment as a case study, this paper explores the wider issue of financial (...) and other COI in scientific research and healthcare in China, especially institutional conflict of interest and policy-related COI. Taking a socio-ethical perspective, it examines China’s state policies and its massive efforts to transform and commercialize scientific research, the lack of policies and oversight mechanisms for regulating COI, as well as major ethical issues arising from COI including the undermining of public trust. Some practical suggestions are offered for institutional reform and institutional development so that COI, particularly ICOI, can be avoided or more effectively managed in scientific research in China. (shrink)
Every scientific or intellectual movement is founded upon basic assumptions and hypotheses that shape its specifically formulated philosophy. This study seeks to explore and explicate the basic philosophical underpinnings of grey systems theory, as well as the paradigm governing its postulates. The study, more specifically, scrutinizes the underlying principles of GST from the perspective of postmodern philosophy. To accomplish this, the epistemology, ontology, human nature, and methodology of GST are substantially investigated in the light of postmodern philosophy. The study draws (...) on Burrell and Morgan’s framework to reveal the paradigm underlying the philosophy of GST. Results demonstrate that GST is an anti-realistic, anti-positivistic, and non-deterministic theory which is inherently pluralistic and ideographic. Based on the principles of GST, change is an indispensable dimension of human speculation about the world and systems, and knowledge is ceaselessly reproduced as new information is collected. As a result, knowledge, narratives, theories and scientific laws are dynamically changed. GST, then, is remarkably compatible with the foundations of postmodern thought and it could be regarded as a postmodern theory governed by a humanistic paradigm. (shrink)
The impact of bilingual education and bilingual experience on working memory has been an important and controversial issue in the field of psycholinguistics. Taking Chinese-English bilinguals as an example, this study aims to investigate the differences in emotional working memory between proficient and non-proficient bilinguals by using delayed matching-to-sample task paradigm and more complex n-back task in the context of emotion. The results show that proficient bilinguals have better performance on both of the two working memory tasks than non-proficient bilinguals, (...) and the advantage effects were more apparent under high memory load conditions. Besides, the negative emotion context has a positive impact on complex n-back tasks. This study supports the notion that bilingual experience can promote the development of an individual’s cognitive ability and enable individuals to possess more advantages in working memory even in the presence of emotional distractions. (shrink)
The Islamic Republic of Pakistan has been a mere victim of climate change in recent years. The country needs emergency measures at every level to mitigate environmental dilapidation. The role of enterprises in the country’s environmental efforts is critical. In this regard, the hotel sector is known for its outsized carbon footprint. Knowing this, the current study aims to improve a hotel enterprise’s environmental performance as an outcome of corporate social responsibility. The study also considers the mediating role of pro-environmental (...) behavior of employees and the moderating role of altruistic values. A hypothesized model was developed, which was validated by employing the structural equation modeling technique. The empirical results confirmed that CSR, directly and indirectly, positively induces the ENP of a hotel enterprise. Whereas the conditional indirect role of ALT was also found significant. The study offers different implications for theory and practice, among which one important takeaway for the hotel sector is to realize the importance of employees to spur ENP of a hotel enterprise through their eco-friendly behavior. At the same time, the current work also advances the theory by highlighting the moderating role of ALT between the indirect relationship of CSR and ENP. (shrink)
In transitional economies, the governing central authorities impose heavy regulatory burdens on firms, which results in great costs for business in terms of time, resources, and other constraints. However, quality assurance through decentralized institutions is rapidly becoming more prevalent. This study examines the contingent implications that such decentralized institutions have for centralized regulation by focusing on the relationship between international certifications and regulatory burdens. As two prominent features of the institutional environment in emerging economies, the threat of competition from the (...) informal sector and corruption may influence the relationship between international certifications and regulatory burdens. These features are therefore examined in terms of their moderating roles. The study draws on institutional and signaling theories to interpret data from a survey conducted by the World Bank in China in 2012. The empirical results show that international certification is negatively associated with regulatory burdens. This relationship is strengthened by the threat of competition from the informal sector, but mitigated by a corrupt business environment. Our study contributes to the institutional literature and to research on international certifications, and it has implications for both business management and governmental policy. (shrink)
To investigate the universality and cultural specificity of emotion processing in children from different ethnic groups (Han, Jingpo and Dai), we conducted three questionnaires, including emotional contagion scale, emotion regulation scale and the Chinese mood adjective check list (CMACL), among 1,362 ethnic Han, Dai and Jingpo participants (Mage = 13.78 years). We found emotion regulation (reappraisal and suppression) mediated the relations between emotional contagion and mood state, relation: (1) emotional contagion (positive and negative) increased positive mood state and decreased negative (...) mood state by reappraisal, and (2) Negative contagion finally increased negative mood state by weaken effect of reappraisal and enhance effect of suppression. Importantly, we found both universality and ethnic cultural specificity in the relations among emotional contagion, emotion regulation, and state mood. Firstly, the cultural specificity: (1) For Dai and Jingpo participants, negative contagion positively predicted reappraisal, while Han participants did not; (2) Jingpo participants demonstrated a weaker negative relation between reappraisal and negative mood state, and a stronger positive relation between negative contagion and suppression; and (3) Dai participants was the only ethnic group that showed a negative connection between negative contagion and positive mood state. Secondly, the emotion universality: Three ethnics both showed positive relations between negative contagion and negative mood, between suppression and negative mood; For all of them, positive contagion positively predicted positive mood state, mediated by reappraisal. In this paper, we discuss universal emotion processes and ethnic cultural differences in these emotion processes. (shrink)
This study seeks to explicate the philosophical foundations and theoretical outlines of grey systems theory by focusing on human perception, cognition, and understanding processes and by considering their functions in the process of producing knowledge. Primarily, the study investigates the processes of perception, cognition, and understanding, as well as their dynamicity. Then, it is explained how knowledge is produced through the interpretation/understanding of information and data and through the dynamicity governing this process. The findings reveal that human perception, cognition, and (...) understanding perpetually remain grey and imperfect, while lost sensatory data mark the very first aspect of greyness in such human capabilities. Furthermore, any piece of data, as a discrete and single entity, represents a determinate fact, symbol or signal from the world, while any set of data, no matter how large, remains incomplete and imperfect, and human beings always interpret inadequate sets of data in the world. Therefore, information and knowledge always remain grey and uncertain because they deeply rely on subjective understandings/interpretations and work with imperfect inputs and sets of data. The impact of knowledge on action and interaction and their effects on the world are some factors adding to the dynamicity of the world. Constant change in world data, outdated knowledge, defects in datasets, and human biases in understanding all confirm the infinitely grey nature of human knowledge of the world. (shrink)
We discuss the relationships between effect algebras with the Riesz Decomposition Property and partially ordered groups with interpolation. We show that any σ-orthocomplete atomic effect algebra with the Riesz Decomposition Property is an MV-effect algebras, and we apply this result for pseudo-effect algebras and for states.
This study describes the results of experiments motivated by an attempt to understand spectral processing in the cerebral cortex (DeValois and DeValois, 1988; Pribram, 1971, 1991). This level of inquiry concerns processing within a restricted cortical area rather than that by which spatially separate circuits become synchronized during certain behavioral and experiential processes. We recorded neural responses for 55 locations in the somatosensory (barrel) cortex of the rat to various combinations of spatial frequency (texture) and temporal frequency stimulation of their (...) vibrissae. The recordings obtained from single and multi-unit bursts of spikes were mapped as surface distributions of local dendritic potentials. The distributions showed a variety of patterns that are asymmetric with respect to the spatial and temporal parameters of stimulation, and were, therefore, not simply reflecting whisker flick rate. Next, a simulation of our results showed that these surface distributions of local dendritic potentials can be described by Gabor-like functions much as in the visual system. The results provide support for a model of distributed cortical processing that imposes a physiologically derived frame (the limited extent of a dendritic patch) and an anatomically derived (axonal) sampling of the distributed process. This combination provides a complex Gabor wavelet that encodes phase, which is necessary to processing such details as edges and texture in a scene. The synchronization across cortical areas that make the Gabor wavelet processes within restricted cortical areas available to one another (the binding problem) proceed at a ''higher order'' level of integration. Both levels of distributed processing accomplish computation in the conjoint spacetime and spectral domain. (shrink)
This research examines the relationship between physical exercise and subjective well-being via the mediation of body image and self-esteem, thereby providing some suggestions on the improvement of subjective well-being in college students. A total of 671 college students from three universities of science and engineering in Sichuan, China voluntarily participated in the survey. Descriptive statistics, Pearson’s product-moment correlation, and mediation model analysis were conducted using the SPSS statistics 19.0. The results showed that the physical exercise level was positively and significantly (...) correlated with the subjective well-being level in each dimension college students with the medium and high level of exercise have higher subjective well-being than those with the low level of exercise, and body image and self-esteem played a complete mediation role between physical exercise and subjective well-being. The mediation analysis revealed two paths: first, the single mediating path via self-esteem [indirect effect = 0.087, 95% CI: ] and second, the serial mediating path via body image and self-esteem [indirect effect = 0.038, 95% CI: ]. Some practical implications have been discussed on the physical exercise intervention for promoting the subjective well-being level in college students. (shrink)
Employees' knowledge hiding behavior has an essential inhibitory impact on organizational innovation and employee knowledge sharing. Accordingly, studying the antecedents and influencing mechanisms of employees' knowledge hiding behavior is quite necessary. In the perspective of leader–member exchange theory and resource conservation theory, the leaders' bias tendency will lead to the workplace marginalization perception of some employees and promote the generation of employees' knowledge hiding behavior. Thus, this research is intended to discuss the influence of leaders' bias tendency toward employees' knowledge (...) hiding behavior, and to analyze the mediating effects of employees' perception of workplace marginalization and the moderating role of emotional commitment to the organization. The sample of this study covered 500 Chinese full-time corporate employees. The conclusions of the research indicate that the following: Leaders' bias tendency is vitally and absolutely correlated with employees' knowledge hiding behavior; Workplace marginalization perception plays an intermediary role between leaders' bias tendency and employees' knowledge hiding behavior; Emotional commitment to the organization plays a negative moderating role between leaders' bias tendency and employees' knowledge hiding behavior; Emotional commitment to the organization plays a negative moderating role between workplace marginalization perception and employees' knowledge hiding behavior. These findings will help organizations and managers to recognize the harm of bias tendency, regulate their own behaviors, and effectively reduce the generation of employees' knowledge hiding behaviors, thereby promoting knowledge sharing and innovative behaviors in organizations. (shrink)
As a social issue of widespread concern, work-to-family conflict has been found to adversely affect employees’ work and family lives. The current research linked employees’ work-to-family conflict to disruptions in parenting and in turn to adolescents’ materialism. In Study 1, two-wave data from 207 Chinese dual-career families that included an adolescent in junior high school showed that both men’s and women’s work-to-family conflict was positively correlated with material rewards parenting, and this positive relationship was stronger when parenting daughters than sons. (...) Study 2 replicated the results of Study 1 in a sample of 284 Chinese dual-career families that included an adolescent of the same age group. Furthermore, Study 2 showed that employees’ work-to-family conflict was indirectly related to their adolescent offspring’s materialism through increased material rewards parenting, and this mediating effect was stronger for daughters. The results are discussed in terms of the spillover and crossover processes that affect employees and their families in the context of work-to-family conflict. (shrink)
At Shantou University in 2008, a stand-alone engineering ethics course was first included within a Conceive–Design–Implement–Operate curriculum to address the scarcity of engineering ethics education in China. The philosophy of the course design is to help students to develop an in-depth understanding of social sustainability and to fulfill the obligations of engineers in the twenty-first century within the context of CDIO engineering practices. To guarantee the necessary cooperation of the relevant parties, we have taken advantage of the top-down support from (...) the STU administration. Three themes corresponding to contemporary issues in China were chosen as the course content: engineers’ social obligations, intellectual property and engineering safety criteria. Some popular pedagogies are used for ethics instruction such as case studies and group discussions through role-playing. To impart the diverse expertise of the practical professional practice, team teaching is adopted by interdisciplinary instructors with strong qualifications and industrial backgrounds. Although the assessment of the effectiveness of the course in enhancing students’ sense of ethics is limited to assignment reports and class discussions, our endeavor is seen as positive and will continue to sustain the CDIO reform initiatives of STU. (shrink)
In recent years, precise high flow oxygen therapy as a new type of oxygen therapy machine has gradually attracted people’s attention and has been widely used in hospital emergency and clinical treatment of respiratory diseases; especially in recent years, severe coronavirus disease has played an important role in the treatment of patients. This paper presents a new type of precise high flow oxygen therapy machine with electromagnetic pneumatic flow valve as the core control element. A sliding mode control strategy based (...) on the system is proposed to realize the accurate control of oxygen concentration and output flow of oxygen therapy mixture. The physical equipment of the precision high flow system is established, and its working performance is verified through the test platform. The optimization design goal of the precision high flow equipment is achieved. (shrink)
As a social issue of widespread concern, work-to-family conflict has been found to adversely affect employees’ work and family lives. The current research linked employees’ work-to-family conflict to disruptions in parenting and in turn to adolescents’ materialism. In Study 1, two-wave data from 207 Chinese dual-career families that included an adolescent in junior high school showed that both men’s and women’s work-to-family conflict was positively correlated with material rewards parenting, and this positive relationship was stronger when parenting daughters than sons. (...) Study 2 replicated the results of Study 1 in a sample of 284 Chinese dual-career families that included an adolescent of the same age group. Furthermore, Study 2 showed that employees’ work-to-family conflict was indirectly related to their adolescent offspring’s materialism through increased material rewards parenting, and this mediating effect was stronger for daughters. The results are discussed in terms of the spillover and crossover processes that affect employees and their families in the context of work-to-family conflict. (shrink)
