The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)
Sandra Field, Jeffrey Flynn, Stephen Macedo, Longxi Zhang, and Martin Powers discussed Powers’ book China and England: The Preindustrial Struggle for Social Justice in Word and Image at the American Philosophical Association’s 2020 Eastern Division meeting in Philadelphia. The panel was sponsored by the APA’s “Committee on Asian and Asian-American Philosophers and Philosophies” and organized by Brian Bruya.
Scientists normally earn less money than many other professions which require a similar amount of training and qualification. The economic theory of marginal utility and cost-benefit analysis can be applied to explain this phenomenon. Although scientists make less money than entertainment stars, the scientists do research work out of their interest and they also enjoy a much higher reputation and social status in some countries.
Qi is one of the most important concepts in Chinese philosophy and culture, and neo-Confucian Zhang Zai plays a pivotal role in developing the notion. This book provides a thorough and proper understanding of his thoughts.
In this selective overview of scholarship generated by _The Hunger Games_—the young adult dystopian fiction and film series which has won popular and critical acclaim—Zhange Ni showcases various investigations into the entanglement of religion and the arts in the new millennium.
This essay seeks to demonstrate the following: 1. the value of metaphysical cosmology to our relationship with nature, and to making policy about the environment; 2. the mistaken nature and harmful consequences of the hegemonic cosmology of anthropocentrism; and, 3. the possibility of Zhang Zai's Qi/qi Great Harmony cosmology as both the refutation of and replacement for anthropocentrism. The essay concludes that ultimate moral progress of expanding the self from the narrow and exclusionary views of anthropocentrism consists in cosmocentrism, (...) or the transformation of thought to a cosmological perspective as exemplified by Zhang Zai's Great Harmony continual cyclical process of Qi/qi. It is argued that positive metaphysical visions such as Zhang Zai's can negate anthropocentric cosmology and inspire us to view our relationship with the environment in a fundamentally enlightened and more respectful way, which is not arrogantly self-centred, disconnected and supremacist. (shrink)