The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

In what does the sense of a sentential connective consist? Like many others, I hold that its sense lies in rules that govern deductions. In the present paper, however, I argue that a classical logician should take the relevant deductions to be arguments involving affirmative or negative answers to yes-or-no questions that contain the connective. An intuitionistic logician will differ in concentrating exclusively upon affirmative answers. I conclude by arguing that a well known intuitionistic criticism of classical logic fails if (...) the answer "No" is accorded parity with the answer "Yes". (shrink)

Certain information-seeking yes/no (yn)-questions –e.g. Did Jorge really bring a present? and Doesn’t John drink?– convey an epistemic bias of the speaker. Two main approaches to biased yn-questions are compared: the VERUM approach and the Decision Theory approach. It is argued that, while Decision Theory can formally characterize the notion of “intent” of a question, VERUM is needed to derive the data.

Were we designed by an intelligent creation? Not likely: living organisms are designed, yes, but not intelligently...

_Yes, But How Do You Know?_ is an invitation to think philosophically through the use of sceptical ideas. Hetherington challenges our complacency and asks us to reconsider what we think we know. How much can we discover about our surroundings? What sort of beings are we? Can we trust our own reasoning? Is science all it is cracked up to be? Can we acquire knowledge of God? Are even the contents of our own minds transparent? In inviting, lucid prose, Hetherington (...) addresses these questions and more, using scepticism to illuminate many perennial philosophical puzzles. (shrink)

Yes, relative to the status quo. But the role of health policy experts is not to say what policies we personally favor, but rather to make policy consequences clear to the public. Once we tell the public that such a policy would not much harm the health of the non-low-income, then it is up to them to decide if they want to use the savings to subsidize low-income coverage.

In an essay recently published in this journal (“Is Safety in Danger?”), Fernando Broncano-Berrocal defends the safety condition on knowledge from a counterexample proposed by Tomas Bogardus (Philosophy and Phenomenological Research, 2012). In this paper, we will define the safety condition, briefly explain the proposed counterexample, and outline Broncano-Berrocal’s defense of the safety condition. We will then raise four objections to Broncano-Berrocal’s defense, four implausible implications of his central claim. In the end, we conclude that Broncano-Berrocal’s defense of the safety (...) condition is unsuccessful, and that the safety condition on knowledge should be rejected. (shrink)

Leading cultural, political and religious leaders offer witness to a new global awareness and to new ethical consensus, showing how we can move into the 21st Century with integrity. This collection reveals why the world, if it is to survive, needs a fundamental consensus concerning binding values, irrecoverable standards and personal attitudes.

In this article, we examine the empirical association between firm value and CSR engagement for firms in sinful industries, such as tobacco, gambling, and alcohol, as well as industries involved with emerging environmental, social, or ethical issues, i.e., weapon, oil, cement, and biotech. We develop and test three hypotheses, the window-dressing hypothesis, the value-enhancement hypothesis, and the value-irrelevance hypothesis. Using an extesive US sample from 1995 to 2009, we find that CSR engagement of firms in controversial industries positively affects firm (...) value after controlling for various firm characteristics. To address the potential endogeneity problem, we further estimate a system of equations and change regression and continue to find a positive relation between CSR engagement and firm value. Our findings support the value-enhancement hypothesis and are consistent with the premise that the top management of US firms in controversial industries, in general, considers social responsibility important even though their products are harmful to human being, society, or environment. (shrink)

O ye Gentlemen explores two permanent and vital strands in Arabic culture: the Greek tradition in science and philosophy and the literary tradition. More than thirty essays demonstrate that the strands freely interweave within the broader scope of Schrifttum.

This book argues that Josiah Royce bequeathed to philosophy a novel idealism based on an ethico-religious insight.This insight became the basis for an idealistic personalism, wherein the Real is the personal and a metaphysics of community is the most appropriate approach to metaphysics for personal beings, especially in an often impersonal and technological intellectual climate. -/- The first part of the book traces how Royce constructed his idealistic personalism in response to criticisms made by George Holmes Howison. That personalism is (...) interpreted as an ethical and panentheistic one, somewhat akin to Charles Hartshorne's process philosophy. The second part investigates Royce's idealistic metaphysics in general and his ethico-religious insight in particular. In the course of these investigations, the author examines how Royce's ethico-religious insight could be strengthened by incorporating the philosophical theology of Dr. Reverend Martin Luther King, Jr., and Emmanuel Levinas's ethical metaphysics. The author concludes by briefly exploring the possibility that Royce's progressive racial anti-essentialism is, in fact, a form of cultural, antiblack racism and asks whether his cultural, antiblack racism taints his ethico-religious insight. (shrink)

It’s a truism of philosophy that Realists must not postulate more than we could reasonably hope to know, while Anti-Realists must not leave us with so little that all knowledge is impossible. But balance is not easily come by—and even less in philosophy than in life. So philosophy continues to struggle over the hard cases, with neither the Realist nor the Anti-Realist able to score an easy victory.

The Mind Doesn’t Work That Way is an expose of certain theoretical problems in cognitive science, and in particular, problems that concern the Classical Computational Theory of Mind (CTM). The problems that Fodor worries plague CTM divide into two kinds, and both purport to show that the success of cognitive science will likely be limited to the modules. The first sort of problem concerns what Fodor has called “global properties”; features that a mental sentence has which depend on how the (...) sentence interacts with a larger plan (i.e., set of sentences), rather than the type identity of the sentence alone. The second problem concerns what many have called, “The Relevance Problem”: the problem of whether and how humans determine what is relevant in a computational manner. However, I argue that the problem that Fodor believes global properties pose for CTM is a non-problem, and that further, while the relevance problem is a serious research issue, it does not justify the grim view that cognitive science, and CTM in particular, will likely fail to explain cognition. (shrink)

Preposed negation yes/no (yn)-questions like Doesn''t Johndrink? necessarily carry the implicature that the speaker thinks Johndrinks, whereas non-preposed negation yn-questions like DoesJohn not drink? do not necessarily trigger this implicature. Furthermore,preposed negation yn-questions have a reading ``double-checking'''' pand a reading ``double-checking'''' p, as in Isn''t Jane comingtoo? and in Isn''t Jane coming either? respectively. We present otheryn-questions that raise parallel implicatures and argue that, in allthe cases, the presence of an epistemic conversational operator VERUMderives the existence and content of the (...) implicature as well as thep/ p-ambiguity. (shrink)

In this paper I examine Daniel M. Wegner's line of argument against the causal efficacy of conscious will, as presented in Wegner's book "The Illusion of Conscious Will" (Cambridge, MA: The MIT Press, 2002). I argue that most of the evidence adduced in the book can be interpreted in ways that do not threaten the efficacy of conscious will. Also, I argue that Wegner's view of conscious will is not an empirical thesis, and that certain views of consciousness and the (...) self are immune to Wegner's line of argument. (shrink)

In this paper I investigate responses to sentence (“yes-no”) questions in Greek dialogue which are neither a clear-cut ‘yes’ nor a ‘no’. I describe, classify, and discuss a range of patterns for expressing this strategy of indirectness, beginning with an example termed μέση ἀπόκρισις in the commentary of Olympiodorus to Plato Gorgias. Ancient rhetorical sources also discuss strategies for evading clear-cut non-polar responses to sentence questions in sections on the notion of ἀπόκρισις (and ἐρώτησις) without a fixed terminology. The fabricated (...) and quoted examples which these ancient sources give, serve as a point of departure for my classification of patterns in occurrences collected from literary dialogues (selections from Plato, and a corpus study of the Greek comedies of Aristophanes and Menander). The analysis of mechanisms for these non-polar responses draws on philological as well as linguistic scholarship from Greek antiquity through contemporary dialogue analysis, and refers also to contexts and conventions of characterization in Ancient Greek sources. (shrink)

This panel discussion took place on June 26, 2021, as part of the programming for an exhibition by critical art collaborative Cesar & Lois at experimental art and research project space Yes We Cannibal (Baton Rouge, LA). The exhibition was entitled Eat the Anthropocene with Cesar & Lois, mycelia and friend entities and ran for six weeks. The panel discussion collected scholars from art, anthropology, literature, landscape architecture, and amateur Mycology to elucidate themes relevant to the artwork, which features a (...) variety of experimental collaborations between codices and fungal life. (shrink)

What is the Bare Particular Theory? Is it committed, like the Bundle Theory, to a constituent ontology: according to which a substance’s qualities—and according to the Bare Particular Theory, its substratum also—are proper parts of the substance? I argue that Bare Particularists need not, should not, and—if a recent objection to ‘the Bare Particular Theory’ succeeds—cannot endorse a constituent ontology. There is nothing, I show, in the motivations for Bare Particularism or the principles that distinguish Bare Particularism from rival views (...) that entails a constituent ontology. I outline a version of Bare Particularism that in rejecting a constituent ontology avoids the New Objection. I argue against Theodore Sider that this really is a distinct theory to the version of Bare Particularism that endorses a constituent ontology, and not a mere terminological variant. I show that this, the best version of the Bare Particular Theory, is also defensible against the old objections. (shrink)

We empirically examine the impact of corporate social responsibility (CSR) on CEO compensation using a large sample of the US firms from 1996 to 2010. We develop and test two hypotheses, the overinvestment hypothesis based on agency theory and the conflict–resolution hypothesis based on stakeholder theory. We find that the lag of CSR adversely affects both total compensation and cash compensation, after controlling for various firm and board characteristics. Our estimates show that an interquartile increase in CSR is followed by (...) a 4.35% (2.78%) decrease in total (cash) compensation. We also find an inverse association between lagged employee relations and CEO compensation. Our results are robust to the correction for endogeneity using instrumental variable approach. Taken together, our results support the conflict–resolution hypothesis, but not the CSR overinvestment argument. (shrink)

Consumers are increasingly facing product evaluation and choice situations that include information about product sustainability, i.e., information about a product’s relative environmental and social impact. In many cases, consumers have to make decisions that involve a trade-off between product sustainability and other valued product attributes. Similarly, product and marketing managers need to make decisions that reflect how consumers will respond to different trade-off scenarios. In the current research, we study consumer responses across two different possible trade-off scenarios: one in which (...) consumers face a trade-off between product sustainability and hedonic value, and another in which they must trade-off between product sustainability and utilitarian value. Our results suggest that, overall, consumers are more likely to trade-off hedonic value for sustainability than to trade-off utilitarian value for sustainability. In Studies 1A and 1B, we presented participants with a product choice task and also measured their anticipatory emotions as they contemplated their options. The results suggest that given a trade-off, consumers are more likely to choose a sustainable product when they have to trade-off hedonic value than when they have to trade-off utilitarian value. Further, these studies provide some insight into the emotions underlying this effect. In Study 2, we use a different consumer response measure, relative purchase likelihood, and investigate the effect of trade-off type across categories that vary in the degree to which hedonic and utilitarian attributes are perceived to be important. Our results suggest that the effect of trade-off type still holds, yet is moderated by product type such that consumers’ greater willingness to trade-off hedonic value for sustainability is attenuated as the relative importance of hedonic attributes increases. In addition to building on our theoretical understanding of decision making given trade-offs with moral attributes, this research is also intended to support managers as they define and choose among various strategic, product development, and marketing promotion options. (shrink)

A popular but intelligent and readable examination of Marxist communism. The author holds that communism can best be seen as a religious response to the problem of evil; the many analogies he finds between communist and Christian doctrine bear him out.--A. C. P.

This paper argues that the much discussed issue between "scientific realism" and "instrumentalism" has not been clearly drawn. Particular attention is paid to the claim that only realism can "explain" the success of scientific theories and---more especially---the progressively increasing success of such theories in a coherent line of inquiry. This claim is used to attempt to reach a clearer conception of the content of the realist thesis that underlies it; but, it is here contended, that attempt fails, and the claim (...) itself hangs in the air. A series of increasingly sophisticated versions of the "instrumentalist" thesis is considered, and both these and the contentions of realism are placed in relation both to particular examples of scientific development and positions historically maintained by philosophers and by scientists. The author’s conclusion is that, when the positions are assessed against the background of the actual history of science, each of the contrary doctrines, interpreted with excessive simplicity, is inadequate as a theory of the dialectic of scientific development; each, so interpreted, has contributed in important instances to actual damage to investigations by great scientists ; whereas in both the theoretical statements and the actual practice of the most sophisticated philosophers/scientists, important aspects of realism and instrumentalism are present together in such a way that the alleged contradiction between them vanishes. (shrink)

In their recent book The Inessential Indexical Herman Cappelen and Josh Dever take issue with what has become close to philosophical orthodoxy – the view, most often associated with John Perry and David Lewis, that psychological explanations are essentially indexical. Cappelen and Dever claim that claims of essential indexicality are typically driven by intuitions rather than supported by arguments. They issue a challenge to supporters of essential indexicality: Produce an argument to back up the intuitions. This paper answers their challenge.

ABSTRACTThe idea that the crowd could ever be intelligent is a counterintuitive one. Our modern, Western faith in experts and bureaucracies is rooted in the notion that political competence is the purview of the select few. Here, as in my book Democratic Reason, I defend the opposite view: that the diverse many are often smarter than a group of select elites because of the different cognitive tools, perspectives, heuristics, and knowledge they bring to political problem solving and prediction. In this (...) essay I defend my epistemic argument against proceduralist democrats; the value of model thinking against empiricists; the bracketing of fundamental value diversity against critics who see such diversity as an essential feature of politics; the intelligence of the masses in the face of voter ignorance and systematic biases; and the normative priority of democracy over market mechanisms. I also consider challenges to my use of Hong and Page's formal results, the epistemically proper selection method for representatives, and the role of deliberation in problem solving. I finally chart three avenues for further research. (shrink)

Rather than assume—based on the contents of the Nachlass—that the Eternal Recurrence, in its initial formulation, coheres with the later theoretico-metaphysical sense (i.e., sharing abstract space with the Will to Power) I propose the inverse (contrary to Heidegger, Deleuze, and Nehamas (whose Proustian exegesis (Nietzsche: Life as Literature) I’m obliged to radically extend)); namely, that the rotary cosmology of recurrence, as a literal proposition, is a consequence of the poetic sense of the earlier parable (GS)–which, I find, ultimately prefigures the (...) design of his own virulent relapse into theoria (WP). (shrink)

Ford’s Helen Keller Was Never in a Chinese Room claims that my argument in How Helen Keller Used Syntactic Semantics to Escape from a Chinese Room fails because Searle and I use the terms ‘syntax’ and ‘semantics’ differently, hence are at cross purposes. Ford has misunderstood me; this reply clarifies my theory.

Open peer commentary on the article “A Computational Constructivist Model as an Anticipatory Learning Mechanism for Coupled Agent–Environment Systems” by Filipo Studzinski Perotto. Upshot: The CALM cognitive agent with its learning mechanism, as presented by the author, can be described as “trivially constructivist.” Probably, at best, it can be seen as a model of the empirical abstraction but not of the reflective abstraction. The “intrinsic motivations” in the simulated agent presented as “evaluative signals” sent from the agent’s “body” to its (...) “mind” can be seen as low-level physiological drives. They cannot account for far more sophisticated intrinsic motivations such as curiosity. (shrink)

B. H. Slater has argued that there cannot be any truly paraconsistent logics, because it's always more plausible to suppose whatever "negation" symbol is used in the language is not a real negation, than to accept the paraconsistent reading. In this paper I neither endorse nor dispute Slater's argument concerning negation; instead, my aim is to show that as an argument against paraconsistency, it misses (some of) the target. A important class of paraconsistent logics - the preservationist logics - are (...) not subject to this objection. In addition I show that if we identify logics by means of consequence relations, at least one dialetheic logic can be reinterpreted in preservationist (non-dialetheic) terms. Thus the interest of paraconsistent consequence relations - even those that emerge from dialetheic approaches - does not depend on the tenability of dialetheism. Of course, if dialetheism is defensible, then paraconsistent logic will be required to cope with it. But the existence (and interest) of paraconsistent logics does not depend on a defense of dialetheism. (shrink)

PETER SAINT-ANDRE explores the personal meaning of progressive rock music and Rand's fiction as both consistent with a world-view that values "joy and reason and meaning." This exploration leads him to ask whether Rand's novels and philosophical project are progressive, and to urge further cross-pollination between libertarian and progressive thinking and action in politics and the arts.