SummaryThe present analysis compares the distribution of surnames by means of spatial autocorrelation analysis in the Spain–Portugal border region. The Spanish National Institute of Statistics provides a database of surnames of residents in the western Spanish provinces of Zamora, Salamanca, Cáceres, Badajoz and Huelva. The Spanish and Portuguese patterns of surname distribution were established according to various geographic axes. The results obtained show a low diversity of surnames in this region – especially in the centre – which can be explained (...) by the absence of any major geographic barriers, with the exception of the mountain ranges between hydrographic basins, and by the presence of traditional roads that have existed since Roman times. The latter have resulted in a constant migratory flow over short–median distances, which, as can be deduced from the surnames, fits two north/south territorial axes running parallel to the border between Spain and Portugal. The distribution patterns of Portuguese and Spanish surnames differ with regard to their frequencies in the five provinces studied, which can be attributed to their respective historical, economic and social conditions. It is concluded that the border delimiting these two countries has affected the migratory flow, thereby conditioning the demographic and genetic structure of the western Spanish regions. (shrink)

Prior research has found attributions to mediate the relationship between the elements of corporate social responsibility activities and consumer responses to firms; however, the question of what variables determine consumer attributions of CSR remains partially unaddressed. This article analyzes why consumers make attributions of CSR that are either positive, or negative. The results obtained from two empirical studies indicate that company–cause fit, corporate ability, and interpersonal trust have a positive influence on the motives that consumers attribute to CSR, whereas corporate (...) hypocrisy has a negative effect. This research contributes to our understanding of the psychological mechanisms underlying impactful consumer judgments and provides guidance for organizations in responding to such evaluations. (shrink)

Ethical concerns of Internet users continue to rise. Accordingly, several scholars have called for systematic empirical research to address these issues. This study examines the conceptualization and measurement of consumers' perceptions regarding the ethics of online retailers. Also, this research represents a first step into the analysis of the relationship between CPEOR, consumers' general Internet expertise and reported positive word of mouth. Results, from a convenience sample of 357 online shoppers, suggest that CPEOR can be operationalized as a second-order construct (...) composed of four dimensions: security, privacy, fulfillment, and non-deception. Our findings also indicate that consumers' general Internet expertise significantly improves CPEOR and CPEOR are strongly predictive of consumers' WOM. Managerial and research implications are offered. (shrink)

El ensayo pretende mostrar como la obra de García Lorca traspasa la barrera de lo puramente estético, para prefigurarse como un emblema de los problemas sociales que aquejaban a la España de su época, es decir lo social llevado al plano estético de una manera singular; así, el poeta granadino logra trascender a la muerte, tema recurrente en toda su obra, forjando un estilo y modelo de vida que se convertirán en paradigmas dentro del escenario literario hispanoamericano.

In this article, the manuscript of Codex Madrid I, Leonardo da Vinci's workshop drawings collection, is reviewed and the main mechanisms that appear in the aforesaid codex are analysed. It begins with a short reference to Leonardo da Vinci works and, subsequently, Leonardo's manuscripts and Codex Madrid I, in particular, are placed in their historical context. After analysing the historical scope of Codex Madrid I, a compilation of the 100 main drawings of the manuscript is made, composing nine Mechanisms Drawings (...) Boxes. Each Mechanisms Drawings Box is a collage made up of 10 to 14 drawings of mechanical elements that appear in Codex Madrid I, with a brief description of each drawing. This compilation illustrates the wide range of mechanical elements and simple mechanisms of Codex Madrid I, forming, as a whole, a complete treatise on mechanisms, understanding mechanisms as basic elements of machines. (shrink)

Although scholarship in philosophy of action has grown in recent years, there has been little work explicitly dealing with the role of time in agency, a role with great significance for the study of action. As the articles in this collection demonstrate, virtually every fundamental issue in the philosophy of action involves considerations of time. The four sections of this volume address the metaphysics of action, diachronic practical rationality, the relation between deliberation and action, and the phenomenology of agency, providing (...) an overview of the central developments in each area with an emphasis on the role of temporality. Including contributions by established, rising, and new voices in the field, _Time and the Philosophy of Action _brings analytic work in philosophy of action together with contributions from continental philosophy and cognitive science to elaborate the central thesis that agency not only develops in time but is shaped by it at every level. (shrink)

The problem of how the brain produces consciousness, subjectivity and "something it is like to be" remains one of the greatest challenges to a complete science of the natural world. While various scientists and philosophers approach the problem from their own unique perspectives and in the terms of their own respective fields, Biophysics of Consciousness: A Foundational Approach attempts a consilience across disparate disciplines to explain how it is possible that an objective brain produces subjective experience. This volume unites the (...) cr me de la cr me of physicists, neuroscientists, and psychiatrists in the attempt to understand consciousness through a foundational approach encompassing ontological, evolutionary, neurobiological, and Freudian interpretations with the focus on conscious phenomena occurring in the brain. By integrating the perspectives of these diverse disciplines with the latest research and theories on the biophysics of the brain, the book tries to explain how what John Searle calls a "conscious field" can be an adaptive and causal element in the natural world. (shrink)

We do things in time. Philosophy of action can capture this phenomenon in at least two ways. On one hand, it might focus on the way that temporal preferences and long-term temporal horizons affect the rationality of decisions in the present (see, e.g., Parfit 1984; Rawls 1971). Such work may focus on the way we discount the distant future, for example, or prioritize the future over the past. Approaches of this kind treat time as, in a sense, something external to (...) agency; it sets various constraints on what we may rationally intend, for example. But if temporal considerations can constrain agency, it follows that they can also structure it internally, and if they can do so, it seems likely that this is possible because agency is already temporally structured. This volume focuses on the way that agency is temporally structured from within, such that time is an ineliminable constituent of agency. (shrink)

Wittgenstein's conception of the general form of a truth function given in thesis 6 can be presented as a sort of a trade-off: the author of the Tractatus is unable to reconcile the simplicity of his original idea of a series of forms with the simplicity of his generalisation of Sheffer's stroke; therefore, he is forced to sacrifice one of them. As we argue in this paper, the choice he makes – to weaken the logical constraints put on the concept (...) of a series of forms, thus effectively metaphorising that concept for the sake of upholding the N-operation's role of generating the series – is unfortunate. An actual expansion of a series of truth functions as defined in 6 would require either making decisions at each step (Anscombe) or outwardly rejecting the concept of a series (Sundholm). However, neither is faithful to Wittgenstein's own fundamental intuitions regarding the nature of logic. For this reason, a different trade-off that prioritises upholding the basic features of a series of forms over the simplicity of the operation that generates that series seems to be much more reasonable. We offer such a trade-off by developing the schema already present in the Tractatus (5.101). The key element of our alternative solution is the construction of an operation that can perform the task of producing all consecutive truth functions of a given collection of atomic propositions as an invariant difference between any base and its successor throughout the series. We define it as a composition of three functions (in an algebraic sense): the first turns a symbol of a given truth function into a binary number, the second increments that number, the third turns the result back into a symbol of another truth function. We also show how the operation can be defined by means of a different notation without invoking binary arithmetic. (shrink)

Since their derivation, human embryonic stem (hES) cells have been used for a variety of applications including developmental biology, pathology, chemical biology, genomics, and proteomics. However, their most important potential application is the generation of cells and tissues, which can be used for cell‐based therapies. One of the main drawbacks of hES cell culture is that they are particularly sensitive to dissociation, which is required for passaging, expansion, cryopreservation, and other applications. Recently, it has been discovered that an inhibitor of (...) Rho kinase (ROCKi; Y‐27632) increases the survival rate of dissociated, single hES cells. This breakthrough has allowed new methods in hES cell culture to be developed, with the promise of increasing hES cell numbers into the realm of clinical relevance. In our studies demonstrating that ROCKi dramatically increases hES cell cryopreservation efficiency, we have observed that ROCKi treatment does not decrease hES cell's susceptibility to apoptosis. Rather, we hypothesize that ROCKi treatment desensitizes single hES cells to their environment reducing the odds that individual cells will undergo anoikis. (shrink)

Traces the development of recursive functions from their origins in the late nineteenth century to the mid-1930s, with particular emphasis on the work and influence of Kurt Gödel.

Ethical concerns of Internet users continue to rise. Accordingly, several scholars have called for systematic empirical research to address these issues. This study examines the conceptualization and measurement of consumers' perceptions regarding the ethics of online retailers (CPEOR). Also, this research represents a first step into the analysis of the relationship between CPEOR, consumers' general Internet expertise and reported positive word of mouth (WOM). Results, from a convenience sample of 357 online shoppers, suggest that CPEOR can be operationalized as a (...) second-order construct composed of four dimensions: security, privacy, fulfillment, and non-deception. Our findings also indicate that consumers' general Internet expertise significantly improves CPEOR and CPEOR are strongly predictive of consumers' WOM. Managerial and research implications are offered. (shrink)

The effects of time and the longitudinal course of the children’s internalizing symptoms following Intimate Partner Violence Exposure are still of great interest today. This study aimed to analyze the effect of the frequency of IPVE, adverse experiences after the cessation of the IPVE and the time elapsed since the termination of the violent relation on the prevalence of anxiety and depression among children. Participants were 107 children and their mothers who had been victims of IPV and had existing judicial (...) protection and restraining orders. Hierarchical logistic regression models were estimated to analyze children’s adjustment, considering the effect of the time elapsed since the termination, frequency of IPVE, experiences of revictimization, maternal pathology, and anxious anticipation of the mother at the prospect of future harm. Exposure to multiple events of violence at the hands of multiple ex-partners and higher scores in the mother’s anxious anticipation were significant predictors of children’s pathological depression and anxiety. Our results emphasize the need for early psychological evaluation of women and children’s victims of IPV to provide timely interventions that avoid symptoms from becoming chronic. Strategies to bring support and emotional security to the victims after the end of the violent relationship are desirable. (shrink)

Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific (...) and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections. (shrink)

According to J=K, only beliefs that qualify as knowledge are epistemically justified. Traditionalists about justification have objected to this view that it predicts that radically deceived subjects do not have justified beliefs, which they take to be counter-intuitive. In response, proponents of J=K have argued that traditionalists mistake being justified with being excused in the relevant cases. To make this response work, Timothy Williamson has offered a dispositional account of excuse which has recently been challenged by Jessica Brown. She has (...) presented cases in which Williamson’s account excuses subjects believing things in an epistemically reckless fashion. To steer clear of Brown’s counterexamples, I argue for a modification of Williamson’s account that employs a more fine-grained notion of the dispositions involved. (shrink)

“What is the structure of thought?” is as central a question as any in cognitive science. A classic answer to this question has appealed to a Language of Thought (LoT). We point to emerging research from disparate branches of the field that supports the LoT hypothesis, but also uncovers diversity in LoTs across cognitive systems, stages of development, and species. Our letter formulates open research questions for cognitive science concerning the varieties of rules and representations that underwrite various LoT-based systems (...) and how these variations can help researchers taxonomize cognitive systems. (shrink)

Editorial: the second phenomenology, by A. T. Tymieniecka.--Roman Ingarden, critique de Bergson, par J. M. Fataud.--Some remarks on the ego in the phenomenology of Husserl, by C. van Peursen.--The empirical and transcendental ego, by M. Natanson.--Rencontre et dialogue, par E. Minkowski.--Quelques thèmes d'une phénoménologie de rêve, par J. Héring.--Man and his life-world, by J. Wild.--Die Verwirklichung des Wesens in der Sprache der Dichtung: Gustave Flaubert, von F. Kaufmann.--Le langage de la poésie, par J. F. Mora.--L'analyse de l'idée et la participation, (...) par A. T. Tymieniecka. (shrink)

Plagiarism and other transgressions of the norms of academic integrity appear to be a persistent problem among upper secondary students. Numerous surveys have revealed high levels of infringement of what appear to be clearly stated rules. Less attention has been given to students’ understanding of academic integrity, and to the potential misconceptions and false beliefs that may make it difficult for them to comply with existing rules and handle complex real-life situations.In this paper we report findings from a survey of (...) European upper secondary students’ views on issues relating to academic integrity. We relate these findings to the students’ training about academic integrity, self-reported level of questionable behavior and country of study.A total of 1654 students at 51 institutions located in 6 European countries participated in the study. The participants generally believed they had a good understanding of the rules applying to them and knew how to behave in compliance with norms of academic integrity. The results indicate, however, that often, in practice, this belief was mistaken. Many students had an inadequate understanding of core elements of academic integrity. They were uncertain about how to act, and they struggled in the handling of complex situations that require context-sensitive judgement. While some differences between countries were identified, they were modest and exhibited no clear pattern. Our results also suggest that reducing students’ level of uncertainty and, to a lesser degree, improving their level of knowledge could lead them to engage less in certain types of questionable behaviours. Surprisingly, the effect of academic training is modest and ambiguous. The study also confirms that perception of peer behaviour has the strongest association with student engagement in questionable behaviours. Thus, academic integrity at the upper secondary level cannot be explained simply in terms of individual ethics or knowledge. (shrink)

Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion‐dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? (...) Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. If future studies can demonstrate that PRG4 is a potent inflammatory mediator, this will change current paradigms in the musculoskeletal and ophthalmological fields regarding the how the inflammatory microenvironment is regulated in these tissues and potentially others. (shrink)

Good academic practice is more than the avoidance of clear-cut cheating. It also involves navigation of the gray zones between cheating and good practice. The existing literature has left students’ understanding of gray zone practices largely unexplored. To begin filling in this gap, we present results from a questionnaire study involving N = 1639 undergraduate students from seven European countries representing all major disciplines. We show that large numbers of these students are unable to identify gray area issues and lack (...) sensitivity to the context dependence of these. We also show that a considerable proportion of students have a poor understanding of concepts like plagiarism and falsification, not only in gray zone scenarios, but also in cases of relatively clear-cut cheating. Our results are similar across the faculties and countries of study, and even for students who have attended academic integrity training. We discuss the implications of this for academic integrity training. (shrink)