Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific (...) and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections. (shrink)

This paper examines Lesia Ukrainka’s two lyrical cycles about Crimea, Krymski spohady and Krymski vidhuky, as examples of a poetic dialogue with Adam Mickiewicz’s Sonety krymskie. I begin my analysis by highlighting the diff erent sensibilities of Mickiewicz’s Sonety krymskie and Lesia Ukrainka’s Krymski spohady, and underscore their formal and thematic peculiarities. The paper continues with an examination of Lesia Ukrainka’s second cycle, Krymski vidhuky, as an experiment in drama – a genre that is absent from her fi rst cycle (...) – before situating a dramatic scene, “Ifi heniia v Tavridi,” this cycle’s only text about Crimea’s Hellenic history, within the cultural contexts of Lesia Ukrainka’s oeuvre. In doing so, I argue that Iphigenia’s lament echoes the voice of an exiled poet from Mickiewicz’s sonnets and conclude my analysis by probing reasons behind Lesia Ukrainka’s choice of a Greek heroine. (shrink)

Im vorliegenden Buch stellt Klaus Oehler die Lehre vom noetischen und dianoetischen Denken bei Platon und Aristoteles dar und begründet damit erstmals die These, dass das für die neuzeitliche Philosophie zentrale Problem der Reflexion und des Selbstbewusstseins schon, wenn auch nicht in gleicher Weise, in der antiken Philosophie eine Rolle gespielt hat.

In this book, linguists and philosophers combine to offer a unique insight not only into Grice's contribution to philosophy of language, but on his theories of natural and non-natural meaning, implicatures and the semantic-pragmatic distinction.

Attention is automatically allocated to stimuli that are opposite in valence to the current motivational focus (Rothermund, 2003; Rothermund, Voss, & Wentura, 2008). We tested whether this incongruency effect is due to affective–motivational counter-regulation or to an increased salience of stimuli that mismatch with cognitively activated information. Affective processing biases were assessed with a search task in which participants had to detect the spatial position at which a positive or negative stimulus was presented. In the motivational condition, positive or negative (...) affective–motivational states were induced by performance feedback after each trial. In the cognitive activation condition, participants memorised the word “good” or “bad” during the search task. The affective incongruency effect was replicated in the motivational condition, whereas an affective congruency effect obtained in the cognitive activation condition. These findings support an explanation of affective incongruency effects in terms of automatic counter-regulation that is motivational in nature. (shrink)

Historical Justice and Memory highlights the global movement for historical justice—acknowledging and redressing historic wrongs—as one of the most significant moral and social developments of our times. Such historic wrongs include acts of genocide, slavery, systems of apartheid, the systematic persecution of presumed enemies of the state, colonialism, and the oppression of or discrimination against ethnic or religious minorities. The historical justice movement has inspired the spread of truth and reconciliation processes around the world and has pushed governments to make (...) reparations and apologies for past wrongs. It has changed the public understanding of justice and the role of memory. In this book, leading scholars in philosophy, history, political science, and semiotics offer new essays that discuss and assess these momentous global developments. They evaluate the strength and weaknesses of the movement, its accomplishments and failings, its philosophical assumptions and social preconditions, and its prospects for the future. (shrink)

The achievement of unity and perfection in human action begins with a struggle for these ideals in human thought. Dr. Klaus Vondung in his collection of essays that span four decades explores examples of this in different fields of human inquiry: striving for harmonious existential unity of talents and morals, intellect and emotion; seeking to make natural sciences consonant with the humanities and thereby moving toward a more universal, "perfect" science; and establishing unity in political structures and cultivating in (...) this unity a homogenous society. Vondung has given special devotion to National Socialism as a context wherein he revisits its perverted motivation and the consequences of this despite noble ideals. Particular focus in following the thread of unity and perfection in human intellectual and practical ambitions ultimately hones in on the combination of religion and politics. Vondung in these essays unpacks the ways in which this continues to fascinate and disturb us, and in his expertise he uses National Socialism to connect this pursuit of unity and perfection to what he calls one of the signature marks of modernity--namely, secular apocalypticism. This claim stands in opposition to Eric Voegelin's remark that Gnosticism, rather, is "the nature of modernity." Vondung, who studied and wrote his dissertation under Voegelin, grapples with the contrast of these positions. Vondung is willing to challenge Voegelin, but ultimately his treatment of the latter bears the quality of tribute to this great scholar. Vondung also explores the points of contact between apocalypticism and Hermetic speculation. Despite the independence of the religious and philosophical doctrines of Hermeticism, there are parallels to be found. Apocalypticism and Hermeticism originated in antiquity and yet each represents a tradition that still holds footing today. Vondung furthermore leads the reader to see the project of salvation found in both even as each operates with a different scope. This collection of essays centers itself on a perspective of the human pursuit of unity and perfection, directly or indirectly, as objectives of intellectual endeavors, existential ideals, as social or political outcomes, and in the case of National Socialism even as perverse aberrations. Vondung's particular treatment of Voegelin's work likewise establishes what the former identifies as a stand-out question of this study: Does the search of order in history show us the unity of the history of humankind? (shrink)

In the age of digitization, the world seems to be reducible to a digital computer. However, mathematically, modern quantum field theories do not only depend on discrete, but also continuous concepts. Ancient debates in natural philosophy on atomism versus the continuum are deeply involved in modern research on digital and computational physics. This example underlines that modern physics, in the tradition of Newton’s Principia Mathematica Philosophiae Naturalis, is a further development of natural philosophy with the rigorous methods of mathematics, measuring, (...) and computing. We consider fundamental concepts of natural philosophy with mathematical and computational methods and ask for their ontological and epistemic status. The following article refers to the author’s book, “The Digital and the Real World. Computational Foundations of Mathematics, Science, Technology, and Philosophy.”. (shrink)

Empirische Wissenschaft und Philosophie, von T. Litt.--Die Erscheinung der lebendigen Gestalten im Lichtfelde, von A. Portmann.--Der Geschmack, von F. J. J. Buytendijk.--Natur und Humanität des Menschen, von K. Löwith.--Die Vernunft und die Mächte des Irrationalen, von O. F. Bollnow.--Existenz und System bei Sören Kierkegaard, von W. Schulz.--Kants Zum ewigen Frieden, von K. Jaspers.--Geschichte und teleologisches System bei Karl Marx, von R. E. Schulz.--Staat und Gewissen im Zeitalter des Säkularismus, von H. Barth.--Über den Konservativismus als historische Kategorie, ein Versuch, von J. (...) Romein.--Soziologie und empirische Forschung, von T. W. Adorno.--Zum Begriff des Menschen heute, von M. Horkheimer.--Die Natur der ästhetischen Wirkung, von J. König.--Bemerkungen zu Theorien des Stils, von B. Snell.--Objektivität, Subjektivität und Erzählkunst: zur Romantheorie Friedrich Spielhagens, von W. Hellmann.--Bibliographie Helmuth Plessner, zusammengestellt von L. Stern (p.[398]-403). (shrink)

The present volume collects novel approaches to two classical topics within verbal semantics, namely argument structure and the treatment of time and aspect.

In der 1970 gegründeten Reihe erscheinen Arbeiten, die philosophiehistorische Studien mit einem systematischen Ansatz oder systematische Studien mit philosophiehistorischen Rekonstruktionen verbinden. Neben deutschsprachigen werden auch englischsprachige Monographien veröffentlicht. Gründungsherausgeber sind: Erhard Scheibe (Herausgeber bis 1991), Günther Patzig (bis 1999) und Wolfgang Wieland (bis 2003). Von 1990 bis 2007 wurde die Reihe von Jürgen Mittelstraß mitherausgegeben.

Unter der Perspektive von Big Data werden ethische Grundfragen fokussiert, die sich aus der Entwicklung und Anwendung fortgeschrittener Informationstechnologien ergeben. Allen fortgeschrittenen informatischen Werkzeugen ist gemeinsam, dass sie mit großen Datenmengen umgehen müssen, diese zu analysieren, zu verarbeiten und möglichst selbständig auf die Analysate regulierend und steuernd zu reagieren haben. Im Fokus steht erstens die Anschließbarkeit eines speziellen Diskurses über fortgeschrittene Informationstechnologien innerhalb der Technikethik, zweitens die Verortbarkeit spezifischer Handlungsprobleme in Prozessen, die die gesamte Gesellschaft und den ethischen Status des (...) Individuums betreffen, und drittens die Aufweisung metaphysischer Voraussetzungen gegenwärtiger Einstellungen im Umgang mit Analysaten, die aus großen, insbesondere fließenden Datenmengen gewonnen werden. Es wird versucht die Kontinuität bestimmter ethischer Grundkonflikte im informationstechnologischen Diskurs aufzuweisen. Schlüsselthemen sind u.a. die Dialektik von Ermächtigung und Entmündigung im Umgang mit modernen Informationstechnologien sowie, damit verbunden, der Verlust von Widerständigkeitserfahrungen, der mit einem Wirklichkeitsverlust einhergeht. Die Studie versteht sich als Orientierungshilfe und als Beitrag zur philosophischen Verortung und Einschätzung einer Bereichsethik. Der Autor Prof. Dr. Klaus Wiegerling arbeitete bis zur Pensionierung am Institut für Technikfolgenabschätzung und Systemanalyse (ITAS) des KIT Karlsruhe. Er ist Lehrbeauftragter an verschiedenen deutschen und ausländischen Universitäten. (shrink)

What makes a good teacher? In 1991 Hartmut von Hentig attempted to answer this when he first formulated a "Socratic oath" for the profession and it is a question which remains relevant today. In The Socratic Oath for Teachers Klaus Zierer revisits and reframes the concept of a teacher's oath while also addressing challenges currently facing our society developments in recent didactic-methodological research, and fresh perspectives on the goals of the teaching profession. Referencing Socrates throughout, this short think piece (...) proposes a professional oath for teachers that at its core is fully committed to the successful education and well-being of students. Drawing upon key research and his own experiences within education, Zierer answers the following questions, establishing how a professional oath may support teachers. For example, What is a professional oath, and what can it do? What characterises teacher professionalism? What can be understood by teacher attitudes? Why are they crucial for a successful professional oath? Why is Socrates suitable as a guarantor for a professional oath of teachers? Why is a renewal of the Socratic Oath necessary? For whom is an oath necessary, and what must it contain? In this fascinating work, Klaus Zierer explores the principles and goals of the teaching profession and formulates theoretically sound and empirically validated principles of successful teaching. This is an essential read for any teacher, senior leader, policy maker, educationalist or researcher who wants to learn more about what makes a good teacher. (shrink)

This anthology illustrates how law and economics is developing in Europe and what opportunities and problems - both in general and specific legal fields - are associated with this approach within the legal traditions of European countries. The first part illuminates the differences in the development and reception of the economic analysis of law in the American Common Law system and in the continental European Civil Law system. The second part focuses on the different ways of thinking of lawyers and (...) economists, which clash in economic analysis of law. The third part is devoted to legal transplants, which often accompany the reception of law and economics from the United States. Finally, the fourth part focuses on the role economic analysis plays in the law of the European Union. This anthology with its 14 essays from young European legal scholars is an important milestone in establishing a European law and economics culture and tradition. (shrink)