Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered “developing” countries. Safeguarding the rights and welfare of individuals participating as (...) research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process. (shrink)

The paper is a critical discussion of scholarship on the "Critique of Pure Reason" published during the past ten years. The emphasis is on Anglo-American authors. I identify and discuss three main trends in the field: a shift from the general discussion of transcendental arguments to the analysis and evaluation of particular proofs in Kant; a renewed interest in the doctrine of transcendental idealism and the distinction between things in themselves and appearances; and the emergence of an entire body of (...) literature on Kant's philosophy of mind, centered around the idea of a "transcendental psychology." The main body of the text is supplemented by extensive bibliographical information provided in the notes. (shrink)

The topic of synchronicity has long intrigued philosophers, scientists, and the general public. However, to date very little empirical research has explored the underlying mechanisms of synchronicity. In other words, why do synchronicities occur? Are synchronicities random, or do they hold clues about the ultimate nature of reality? Drawing on theoretical and empirical research, the current paper explores the idea that synchronicity might be one way that the fundamental (i.e. ontologically primary) nature of consciousness reveals itself to us in everyday (...) life, and that contemplative practices such as meditation might be capable of invoking synchronicity. In addition, this paper aims to summarize theoretical perspectives on synchronicity in an attempt to spark a renewed interest in conducting empirical research on this topic, arguing for a thoughtful consideration of post-materialist perspectives in an attempt to innovate within the field of consciousness studies and shed light on the ontological questions raised by synchronicity. (shrink)

As Husserl already noticed, artworks themselves have a phenomenological character. This means, however, that to experience artworks as phenomena no “epoché” and no “phenomenological reduction” is necessary. The leading question of my essay is whether, and possibly how, this observation can be methodologically generalized for understanding phenomena. I discuss if, and possibly how, a phenomenological reflection on art allows and even demands a general conception of phenomenology that nevertheless does not confuse artworks with phenomena in general. My intention is to (...) show that and how phenomenality can be clarified with reference to its spatial character. Accordingly, works of architecture that are artworks will play a decisive role in my argument. (shrink)

Scientific exploration and thus our knowledge about the outside world is subject to the conditions of our experience.These conditions are condensed here into an interface model which,besides being physical,has an additional interface structure not reducible to physics. We suggest that this structure can dynamically be characterized by separate modes.Their selection and operation presupposes free will and a rudimentary concept of time and space. Based on some analogies with quantum networks it is argued that the 'observed' gets 'dressed'as a consequence of (...) the observing. Interface dynamics and system dynamics supplement each other without over- determination. (shrink)

I offer an account of perceptual warrant according to which one’s basic perceptual beliefs are immediately and defeasibly warranted if they are formed on the basis of experiences produced by a competent perceptual system. I claim that sub-personal features of one’s perceptual systems can render one competent to perceptually represent a particular environment. When these conditions are met, one is warranted in forming beliefs on the basis of one’s perceptual experiences. I develop my account of perceptual warrant in the context (...) of a Bayesian theory of perceptual processing. (shrink)

I criticize an account of perceptual warrant proposed by [Burge, Tyler. 2003. “Perceptual Entitlement.” Philosophy and Phenomenological Research 67 (3): 503–548]. Burge contends that a subject's beliefs are entitled only if that subject's perceptual system represents its normal environment in a reliably veridical manner. The normal environment, according to Burge, is the environment in which the contents of the subject's perceptual experiences were fixed. I present a case that shows that the contents of a subject's perceptual experiences can remain fixed (...) while features of its perceptual system relevant to its representational reliability change. This leads to problematic consequences for Burge's view. (shrink)

Leitkonzepte wie Nachhaltigkeit bedürfen, sollen sie erfahrbar werden, der konkreten Umsetzung. Nachhaltiges Denken in Form von Gedankenentwürfen muss demnach in nachhaltiges Handeln in Form entsprechender Initiativen überführt werden. Dabei geht nachhaltiges Denken weit über Unternehmensgrenzen hinaus und ragt in alle gesellschaftlichen Systeme hinein. Eine besonders wichtige "Keimzelle" des komplementären nachhaltigen Denkens und Handelns sind die Kommunen. Sie sind zum einen als Handlungseinheiten klein genug, um Nachhaltigkeit mit konkreten Initiativen ein Gesicht zu geben. Zum anderen sind sie aber auch groß genug, (...) um Nachhaltigkeit in einen übergeordneten Zusammenhang zu stellen und entsprechende Aktivitäten zu koordinieren und zu fördern. Mit dem inhaltlichen Fokuspunkt Wirtschaft und dem kommunalen Fokuspunkt Hannover wird mit diesem Werk ein konkreter und praxisnaher Forschungsbereich näher beleuchtet. Die kombinierte Forschungs- und Praxisperspektive des Werkes wurde ausgewählt, um sowohl den theoretischen Diskussionsstand widerzuspiegeln und mit dem integrativen Ansatz anzureichern als auch exemplarisch den praxisnahen Anwendungs- und Ausprägungsstand abzubilden. Das Buch richtet sich an Experten*innen im Bereich Kommunales Management aber auch an Wissenschaftler*innen und Studierende in Studiengängen zum Thema Nachhaltigkeitsmanagement und Regionale Entwicklung. Der Inhalt Konzeptionelle Grundlagenbeiträge Schnittstelle Kommune - Wirtschaft: Triebfeder für lokale und regionale Nachhaltigkeit Referenzbeispiele für (integriertes) kommunales Nachhaltigkeitsmanagement Die Herausgeber*innen Prof. Dr. Kristin Butzer-Strothmann ist Professorin für Allgemeine BWL, insbesondere Marketing und Empirische Sozialforschung an der Leibniz-Fachhochschule in Hannover. Prof. Dr. Friedel Ahlers ist Professor für Allgemeine BWL, insbesondere Unternehmensführung und Personalwirtschaft an der Leibniz-Fachhochschule in Hannover. (shrink)

Fichte's System of Ethics, published in 1798, is at once the most accessible presentation of its author's comprehensive philosophical project, The Science of Knowledge or Wissenschaftslehre, and the most important work in moral philosophy written between Kant and Hegel. Fichte's ethics integrates the discussion of our moral duties into the systematic framework of a transcendental theory of the human subject. Its major philosophical themes include the practical nature of self-consciousness, the relation between reason and volition, the essential role of the (...) drives in human willing, the possibility of changing the natural world, the reality of one's own body, the reality of other human beings, and the practical necessity of social relations between human beings. This volume offers a translation of the work together with an introduction that sets it in its philosophical and historical contexts. (shrink)

Exceptional human experiences (EHEs) have garnered increasing research attention, particularly with regard to the characteristics and potential functional aspects of these experiences. The current study sought to replicate and expand upon previous research on EHEs by using a mixed-methods approach to examine the characteristics of EHEs in a large adult sample. The participants were 869 healthy adults who completed a survey that allowed participants to share both quantitative ratings and qualitative descriptions of EHEs. The results revealed that 96.7% of respondents (...) had experienced at least one EHE, and EHEs were generally rated as having a positive impact on the participants' lives. Participants reported a variety of EHEs, with two primary themes emerging in the qualitative analysis: perception and function of EHEs. The results suggest that EHEs may serve a positive, functional purpose in the lives of those who experience them. (shrink)

I argue that racially biased perception can be incompetent in a way that undermines perceptual warrant. This can occur even when the subject is unaware of the influence of the bias upon their beliefs or when they possess no defeating evidence that makes it rational for them to doubt the accuracy of their perceptual experiences. When a subject’s racial bias causes their perceptual system to encode inaccurate information about their environment, or to process information in an epistemically incompetent manner, this (...) can reduce their perceptual competence, and thus their perceptual warrant. I discuss a series of cases that illustrate how my proposals treat various instances of racially biased perception. I then distinguish my view from a competing proposal from Jessie Munton (2019) which claims that racially biased priors are epistemically incompetent because they are gerrymandered. A gerrymandered prior is one whose accuracy depends on ongoing manipulations of the environment. I argue that the kinds of manipulations that Munton cites do not necessarily impact perceptual competence and that my account better explains how racist institutions and societal structures can impact the epistemic competence of perceivers. (shrink)

This article compares Kant and Fichte from the double stand- point of identity and difference with regard to two thinkers who were at first united by a master-student relation but who later on drifted apart from each other due to mutual defamation. At the center of the present discussion stands the relationship between spirit of freedom and system’s form which binds Kant and Fichte beyond methodological divergences and doctrinal differ- ences. The critical comparison between Kant and Fichte will be developed (...) in four steps: it will start with the general positioning of Kant within German Idealism, and then move on to Kant’s double critical enterprise of grounding an aprioristic doctrine of principles of nature and freedom; it will later on address the conception championed by Fichte of having pre- sented the “first system of freedom”, and from there it will focus on the manifestations of freedom within Fichte’s philosophical system, with Kant’s position as contrast. (shrink)

El presente artículo compara a Kant y a Fichte en la perspectiva doble de identidad y diferencia referida a dos pensadores a quienes une una primera relación de maestro y alumno y a quienes separa una posterior difamación mutua. En el centro de la presentación se encuentra la relación entre espíritu de libertad y forma del sistema que une a Kant y a Fichte más allá de divergencias metódicas y de diferencias doctrinales. La comparación crítica entre Kant y Fichte se (...) desarrollará en cuatro etapas: partirá de la ubicación general de Kant dentro del idealismo alemán y se extenderá a la empresa doble de Kant, expresada de forma crítica, de una doctrina de los principios apriorística de naturaleza y libertad, para después ir a la concepción enfáticamente reclamada por Fichte de un “primer sistema de la libertad”,[1] y de ahí a las manifestaciones de la libertad en el sistema filosófico de Fichte, teniendo como punto de vista rector el contraste con Kant.[2] Palabras clave: [1] En la forma de citación de la Gesamtausgabe de Fichte se señalará el tomo y el volumen con números romanos y arábigos respectivamente, y después el número de página en cuestión. [2] El presente artículo es parte de un proyecto de carácter más amplio, cuyo tema es la dilucidación del aporte filosófico de Kant y de Fichte; de ahí que se haga continua referencia a publicaciones particulares de mi autoría. (shrink)

Dogmatists claim that having a perceptual experience as of p can provide one with immediate and defeasible warrant to believe that p. A persistent complaint against this position is that it sanctions an intuitively illicit form of reasoning: bootstrapping. I argue that dogmatism has no such commitments. Dogmatism is compatible with a principle that disallows the final non-deductive inference in the bootstrapping procedure. However, some authors have maintained that such strategy is doomed to failure because earlier stages of in the (...) bootstrapping inference are already problematic. I argue that insofar as these inferences appear problematic, the dogmatist is not committed to sanctioning them. I conclude that the bootstrapping argument presents no significant objection to the claim that perceptual experiences can provide immediate and defeasible warrant to believe their contents. (shrink)

In spite of the importance of point mutations for evolution and human diseases, their natural spectrum of incidence in different species is not known. Here I propose to determine these spectra by comparing consecutive sequence periods in stretches of repetitive DNA. The article presents the analysis of more than 51,000 such point mutations identified by this approach in the genomes of human, chimpanzee, rat, mouse, pufferfish, zebrafish, and sea squirt. I propose to explain the observed spectra by auto‐mutagenic mechanisms of (...) genome variation involving the inter‐conversions of nucleotides, single base‐pair inversions and their combinations. (shrink)