The main point of this paper is to underscore that tests with very low power will be significant only if the observations are deviant under both H0 and H1. Therefore, the results of those significant tests will generate misleadingly high severity scores for differences between H0 and H1 that are excessively overestimated. In other words, that measure of evidence is bound to fail in those cases. It will inevitably fail to adequately measure the strength of the evidence provided by tests (...) with low power. (shrink)

The success of fecal microbiota transplantation as a treatment for Clostrioides difficile infection has stirred excitement about the potential for microbiota transplantation as a therapy for a wide range of diseases and conditions. In this article, we discuss vaginal microbiota transplantation as “the next frontier” in microbiota transplantation and identify the medical, regulatory, and ethical challenges related to this nascent field. We further discuss what we anticipate will be the first context for testing VMT in clinical trials, prevention of the (...) recurrence of a condition referred to as bacterial vaginosis. We also compare clinical aspects of VMT with FMT and comment on how VMT may be similar to or different from FMT in ways that may affect research design and regulatory decisions. (shrink)

Souvent abordée par sa « micropolitique du désir », l’œuvre commune de Deleuze et Guattari est rarement sollicitée lorsqu’on s’interroge sur les problèmes classiques ou contemporains de la pensée politique : la forme-État, la souveraineté, le rapport de la violence et du droit, la guerre, le paradigme de la Nation et les recombinaisons qu’il a entraînées entre les idées de peuple, de citoyenneté et de minorité. En suivant la trajectoire conduisant du premier tome de Capitalisme et schizophrénie (1972) au second (...) (1980), ce sont pourtant tous ces problèmes qui se trouvent réélaborés, au fil d’une conjoncture de transition historique marquée par la fin des guerres de décolonisation, la transformation du capitalisme mondial, les recompositions aussi profondes qu’incertaines des forces de résistance collective. Encore faut-il, pour mesurer les prises de la pensée guattaro-deleuzienne sur les bouleversements de son temps, la confronter à ce qui fut son interlocuteur principal, le marxisme, à son champ épistémique (le matérialisme historique), à son programme critique (la critique de l’économie politique) et à sa grammaire politique (la lutte des classes). De ces pourparlers, trois hypothèses nouvelles se dégagent : celle d’un « Urstaat », incarnant un excès de la violence souveraine sur l’appareil d’État et sur ses investissements politiques ; celle d’une puissance de « machine de guerre », que les États ne peuvent jamais s’approprier que partiellement, et à laquelle ils peuvent eux-mêmes se subordonner ; celle d’un excès du « destructivisme » de l’accumulation capitaliste sur son organisation productive. Dans ce triple excès, la pensée politique de Deleuze et Guattari trahit le spectre de l’entre-deux-guerres qui la hante, mais qui la fait aussi communiquer avec les penseurs actuels de l’impolitique. S’y donnent à lire non seulement une nouvelle théorie politique, mais aussi un tableau de la pluralité des voies d’ascension à l’extrême-violence susceptibles de détruire la politique même et auxquelles les luttes contemporaines ne peuvent s’épargner de faire face. (shrink)

Recent developments in generalized probability theory have renewed a debate about whether regularity (i.e., the constraint that only logical contradictions get assigned probability 0) should be a necessary feature of both chances and credences. Crucial to this debate, however, are some mathematical facts regarding the interplay between the existence of regular generalized probability measures and various cardinality assumptions. We improve on several known results in the literature regarding the existence of regular generalized probability measures. In particular, we give necessary and (...) sufficient conditions for the existence of regular generalized probability measures defined on the whole powerset of any sample space. (shrink)

The model companion of the theory of fields with valuation and automorphism exists. A counterexample shows that the theory of models of ACFA equipped with valuation is not this model companion.

Un navire humain fait naufrage sur l'ile du roi des djinns ou l'entente regne entre toutes les especes. Les naufrages pretendent qu'ils sont les seigneurs, que les animaux sont leurs serviteurs. S'engage alors un proces dans lequel les representants des nations humaines se succedent pour prouver leur superiorite. Les familles animales se relaient pour les refuter. Telle est l'epitre sur les animaux des Freres en Purete. Une fable-fleuve, un joyau inespere de la litterature arabe intercale entre un traite de botanique (...) et un traite d'anatomie. Tout a la fois divertissement et oeuvre de mobilisation politique, miroir tendu au prince aussi bien qu'aux peuples, hymne de louange au Createur, dispute theologique autour du privilege de l'homme dans la Creation, allegorie du systeme philosophique des Freres en Purete, le Proces animal de la domination humaine, qui connut un grand retentissement depuis les Mille et une nuits jusqu'a la Ferme des animaux d'Orwell, n'a pas fini de nous donner a penser et a debattre. Pour restituer l'oeuvre dans sa forme authentique et en offrir les clefs de lecture, il aura fallu se confronter a des manuscrits aux versions contradictoires, realiser l'enquete historique replacant le texte dans son contexte, et operer l'interpretation philosophique de la fable. Car cette epopee judiciaire est aux Freres en Purete ce qu'est la Caverne pour Platon, a savoir l'allegorie du systeme. (shrink)

La philosophie morale des stoïques -- Le manuel d'Épictète -- Les responses d'Épictète aux demandes de l'empereur Adrian -- L'exhortation à la vie civile -- De la constance et consolation ès calamitez publiques.

Free riding involves benefiting from common resources or services while avoiding contributing to their production and maintenance. Few studies have adequately investigated the propensity to overestimate the prevalence of free riding. This is a significant omission, as exaggeration of the phenomenon is often used to justify control and coercion systems. To address this gap, we investigate how the common good approach may mitigate the flaws of a system excessively focused on free-riding risk. In this conceptual paper featuring illustrative vignettes, we (...) argue that the common good perspective is realistic and effective in preventing this excessive attention by promoting trust as an unconditional gift and a response to vulnerability. We discuss the common good perspective’s originality over the dominant approaches and propose a set of ethical and managerial recommendations that may be the best protection against this excessive focus and maybe even against free riding itself. (shrink)

Malgré l’important renouveau que connaît la théologie naturelle depuis environ un demi-siècle dans le champ de la philosophie de la religion, Charles Taylor soutient que celle-ci appartient à une époque désormais révolue. Cette étude propose de restituer de manière aussi fidèle et précise que possible les raisons de ce verdict. Une telle analyse vise à combler une lacune importante dans la littérature secondaire. Cette lacune tient, d’une part, au fait que Taylor lui-même ne développe jamais ces raisons de façon systématique (...) ; d’autre part, elle tient également au fait que plusieurs commentateurs semblent présupposer qu’un tel argument n’existe pas : Taylor récuserait la théologie naturelle simplement parce qu’elle ne correspond pas à la manière dont il est enclin à justifier ses propres convictions religieuses. (shrink)

Este texto é uma tradução a partir do original em latim, com uma introdução e comentários, da Dissertação sobre o estilo filosófico de Nizólio, obra escrita em 1669 pelo jovem Leibniz. Nessa obra Leibniz se ocupa com o estilo que deve ter a exposição filosófica. A introdução tem duas partes: na primeira parte se examina o contexto da aparição daquela obra de Leibniz em uma época em que não há uma distinção clara entre os limites entre a Lógica, a Retórica (...) e a Dialética. Na segunda parte é feita uma exposição do conteúdo do texto de Leibniz. (shrink)

This comment expands on Hooks et al.’s criticism of the problematic and overly general uses of “stress” within the microbiota-gut-brain field. The comment concludes that, for the microbiota-gut-brain field, much work is yet to be done in terms of how we explore and understand biology vis-à-vis psychology.

Que reste-t-il du "sujet", en littérature, après le retrait du structuralisme? C'est la question que pose ce livre, qui, dans le compte tenu de l'héritage théorique des années 1960-1970, cherche à préciser le statut d'un sujet qui insiste dans les discours critiques contemporains (Compagnon, Clément, Macé) aussi bien que dans les tentatives littéraires récentes (Beck, Deguy, Michon). Trois études articulées, qui sont autant d'expériences de lecture, tentent ici de répondre à cette interrogation : la première, "L'exception du sujet", se propose (...) de relire les psychanalyses existentielles de Sartre ; la seconde, "Poétique et vérité", entre en dialogue avec la lecture d'A la recherche du temps perdu par Gérard Genette ; la troisième, "Prose de soi", s'essaie à décrire la singularité de l'autofiction rimbaldienne, telle qu'elle s'avive dans Une Saison en enfer, et notamment dans sa section prosimétrique, "Alchimie du verbe". Au terme du parcours, une hypothèse : c'est dans l'articulation critique entre la littérature et son commentaire que la forme restante du sujet trouve son lieu paradoxal. (shrink)

La réflexion de Canguilhem est précieuse car elle nous rend attentif au fait qu’il n’existe pas de science de la santé mais seulement un savoir des patho­logies. La santé relève d’abord d’une évaluation existentielle qui vient de l’épreuve de la maladie. Si tel est le cas, elle ne saurait s’identifier avec un sens univoque de la normalité mais doit toujours être rapportée à la perception d’un individu, y compris quand elle est l’objet d’une rationalité économique ou politique exogène. Deux sens (...) de la santé entrent dès lors en conflit qui traversent les différentes analyses de l’Essai sur quelques problèmes concernant le normal et le pathologique, la santé comme abus et la santé comme régulation. Il semble bien que l’enjeu d’une philosophie de la vie soit de parvenir à les articuler. (shrink)

À travers la mise en scène des fantasmes héroïques et les controverses sur le sens de la loi quand c’est sur la scène de l’histoire que les individus doivent faire leur devoir, Le Prince de Hombourg prend la forme d’une série d’échecs à établir un langage où s’exprimeraient clairement les décisions, les responsabilités, et la loi. Sous le regard de Kleist, l’histoire invalide les postulats de la dramaturgie aristotélicienne, elle suspend la capacité à juger éthiquement des identités, des actes et (...) des intentions. Elle confronte le langage de la loi à sa limite indépassable : celle d’un discours performatif qui déclare la loi, mais ne maîtrise pas les conditions de sa performativité. (shrink)

Qu’est-ce qui relie Le Prince de Machiavel et Que faire? de Lénine, que près de quatre cents ans séparent? Le premier est un recueil de formulations sur ce que doit être un prince, les pièges rencontrés sur le chemin de sa réussite, la manière de gouverner, les indices de son pouvoir et ce qui est nécessaire pour inciter le peuple à contribuer à la gloire d’un royaume princier. Le second, écrit à l’époque de la Révolution russe, traite de la construction (...) d’un parti révolutionnaire, de l’union d’une idéologie et d’une classe, et de la manière dont un parti politique peut devenir un tribun du peuple. Les contextes comme les situations sont très différents. Pourtant, il existe un lien étrange entre les deux. Tous deux ont la qualité énigmatique d’être intemporels tout en étant entièrement axés sur les problèmes de l’époque. Tous deux résonnent avec des préoccupations qui partagent des bases similaires. Tous deux touchent la grande question de la contingence et de l’incertitude. Ils semblent ne pas avoir de filiation. Comme s’ils étaient sortis du vide. (shrink)

Roald Hoffmann's contributions to chemistry are well known; this Nobel laureate has published more than 500 articles and two books. As an "applied theoretical chemist," he has made significant contributions to our understanding of chemical bonding and reactivity, and taught two generations of chemists how to use molecular orbitals for real chemistry. Less well known, however, are Hoffmann's important and insightful contributions to the areas of scholarship surrounding chemistry. Over a career that spans nearly fifty years, Roald (...) class='Hi'>Hoffmann has thought and written copiously about the broader context of chemistry and its relationship to the arts and poetry. This book contains Hoffmann's essays and is organized around several major themes: chemical reasoning and explanation, writing and communicating in science, ethics, art and science, and chemical education. A few are unpublished lectures that are valuable additions to the volume. The editors have the full cooperation of Roald Hoffmann in this project. Most of the published work will be reprinted verbatim, but a few of the essays will be revised to eliminate redundancy. The unpublished lectures will also be edited since they were originally intended to be delivered orally at specific occasions. The editors will provide an introduction to the book, and some introductory material for each section. In introducing the material, they will highlight the intrinsic importance and interest of the ideas, as well as the places where Hoffmann's thought makes novel contributions to cognate areas. (shrink)

Several authors have recently claimed that the notorious causal exclusion problem, according to which higher-level causes are threatened with causal pre-emption by lower-level causes, can be avoided if causal relevance is understood in terms of Woodward's interventionist account of causation. They argue that if causal relevance is defined in interventionist terms, there are cases where only higher-level properties, but not the lower-level properties underlying them, qualify as causes of a certain effect. In this article, I show that the line of (...) reasoning supposed to establish this claim does not succeed and that interventionism is not better capable of dealing with higher-level causal claims than other accounts of causation. According to Woodward, higher-level causal claims are nonetheless more adequate than lower-level ones if they describe a realization-independent dependency relationship and, hence, meet the requirement that causes should be proportional to their effects. I argue, however, that combining interventionism with proportionality considerations raises difficulties and that, therefore, Woodward's account does not vindicate higher-level causation. (shrink)

Author: Thomas Sören Hoffmann. Translated by Pedro Sepúlveda Zambrano.

Abductive reasoning takes place in forming``hypotheses'''' in order to explain ``facts.'''' Thus, theconcept of abduction promises an understanding ofcreativity in science and learning. It raises,however, also a lot of problems. Some of them will bediscussed in this paper. After analyzing thedifference between induction and abduction (1), Ishall discuss Peirce''s claim that there is a ``logic''''of abduction (2). The thesis is that this claim can beunderstood, if we make a clear distinction between inferential elements and perceptive elements of abductive reasoning. For (...) Peirce, the creative act offorming explanatory hypotheses and the emergence of``new ideas'''' belongs exclusively to the perceptive side of abduction. Thus, it is necessary to study the roleof perception in abductive reasoning (3). A furtherproblem is the question whether there is arelationship between abduction and Peirce''s concept of``theorematic reasoning'''' in mathematics (4). Both forms of reasoning could be connected, because both arebased on perception. The last problem concerns therole of instincts in explaining the success ofabductive reasoning in science, and the question whether the concept of instinct might be replaced bymethods of inquiry (5). (shrink)

This introductory chapter gives a general survey of the research context, along with brief descriptions of the chapters collected here, indicating how they contribute to the three-year project which provided that context. Focusing on absolute notions of necessity and possibility, the project's principal aims were to explore the most fundamental questions and issues centred on them — ranging from scepticism about modal notions themselves, anti-realist view such as non-cognitivism, and the tenability of any sort of realism about modal facts, through (...) to questions about the metaphysics, logic, and epistemology of modality which any broadly realist view must answer. (shrink)

How do we individuate the senses, what exactly do we do when we do so, and why does it matter? In the following article, I propose a general answer to these related questions based on Franz Brentano's views on the senses. After a short survey of various answers offered in the recent literature on the senses, I distinguish between two major ways of answering this question, causally and descriptively, arguing that only answers giving priority to description and to the classification (...) involved in it are on the right track for a general answer to the related questions. In the second part of the article, I argue that Brentano's descriptive psychology is an attractive candidate for such an answer. His descriptive psychology provides a plausible account of the classification involved in description, in particular regarding the classification of sensory qualities. I close the article by briefly explaining how Brentano spells out the priority of descriptive answers over causal ones. (shrink)

In this paper, we examine Sextus Empiricus' treatise Against the geometers . We first set this treatise in the overall context of the sceptic's polemics against the liberal arts. After a discussion of Sextus' attitude to the quadrivium , we discuss the structure, the sources and the target of the Against the geometers . It appears that Euclid is not Sextus' source, and neither he, nor the professional geometers, seem to be Sextus' main targets. Of course, Sextus never really makes (...) clear his precise target, but his attacks are rather directed against geometry as a means of modelling the physical world, thus ruining the support geometry was intended to bring to the physical part of dogmatic philosophy. (shrink)

Several authors have recently claimed that the distinction between intrinsic and extrinsic properties is hyperintensional, i.e., that there are cointensional properties P and Q, such that P is intrinsic, while Q is extrinsic. In this paper, I aim to defend the classical view that whenever P and Q are cointensional properties, then P and Q are either both intrinsic or both extrinsic. I first argue that the standard characterization of the intrinsic/extrinsic distinction involves dependence claims: intrinsic properties are those properties (...) whose instantiation by x only depends on what x is like in itself, whereas extrinsic properties are those properties whose instantiation by x may also depend on what other individuals are like. I then consider a number of examples supposed to show that the intrinsic/extrinsic distinction is hyperintensional and argue that none of them succeeds if the dependence characterization of the distinction is taken seriously. (shrink)

La réflexion philosophique, dont l'ouverture à l'univers dans lequel nous nous découvrons - avec une acuité proportionnelle à un étonnement renouvelé - n'a pas de limites, n'en est que plus tributaire des sciences et des techniques, des arts et de multiples activités qui régissent plus ou moins fructueusement notre expérience. Or, au sein des sciences humaines, privilégiées pour éclairer une condition que nous ne saurions cesser d'interpréter, peu d'oeuvres du dernier siècle auront enrichi en le précisant notre être-au-monde, comme la (...) théorie linguistique de Gustave Guillaume, assez solitaire, et les recherches multiformes de Jean Piaget - où la psychologie de l'enfant a souvent occulté la visée épistémologique et son enracinement biologique (cf Biologie et connaissance, 1967) et ses prolongements pédagogiques, voire éthiques. Le Cinquantenaire et le Trentenaire de leur disparition appelaient un hommage d'autant plus impératif qu'ils sont restés marginaux ou ignorés dans les milieux philosophiques, malgré la centralité de leurs élucidations. Leur commune orientation génétique et structurale n'ayant suscité aucun échange, pendant la contemporanéité de publications d'un tiers de siècle (1923-1960), mesurer leur complémentarité s'impose d'autant plus. S'ils peuvent aider à repenser la condition humaine, c'est qu'ils auront contribué à dissiper le "mystère de la pensée". L'un cherchant à habiliter les caractères systématique et cinétique des langues, irremplaçables moyens de penser ; l'autre dans un vis-à-vis cognitif et opératoire de Freud, en relavant sur les plans épistémologique et logique, notamment, l'élan révolutionnaire de la seconde modernité, autour de l'évolutionnisme. Mais les thèmes majeurs du constructivisme, du schème et de la symbolisation - et plus largement du temps et du langage - auront sans doute aidé à spécifier les mutations autorisées par la révolution critique. Entre l'Instant du je parle et un décentrement exigible pratiquement (éthique) comme théoriquement (épistémique), c'est bien la condition humaine dans son ensemble qui est concernée. Si repenser cette Condition s'impose en permanence, il importe de ne pas manquer des oeuvres qui, par-delà toute mode, proposent à notre expérience des fondations résistant à d'inéluctables vicissitudes. (shrink)

This book aims to develop a philosophical theory of extrinsic properties – of properties whose instantiation by an object does not only depend on what the object itself is like, but also on features of its environment. Various accounts of the intrinsic/extrinsic distinction are analysed in detail, and it is argued that the most promising approach to defining this distinction is to consider extrinsic properties as a particular type of relational property. Moreover, it is shown that two key notions in (...) the metaphysics of properties, the supervenience relation and the dispositional/categorical distinction, whose scope is usually restricted to intrinsic properties, can fruitfully be applied to extrinsic properties as well. (shrink)

Guillaume Collett questions to what extent we can locate Deleuze within the Lacanian School during the late-1960s, prior to Guattari. In so doing, he offers a new, integrated reading of Deleuze's The Logic of Sense by understanding it as a 'psychoanalysis of sense', and gives a new interpretation of Deleuze's conception of philosophy itself. The Psychoanalysis of Sense shows that Deleuze was not merely aware of the debates animating the Lacanian School during the 1960s: he sought to contribute to (...) them. Emphasising his appropriation of the work of post-Lacanian Serge Leclaire, Collett explains how Deleuze constructed a more singular and immanent theory of the linguistic structure of the unconscious - granting the erogenous body a larger structuring role. (shrink)

To the woman, God said, “I will greatly multiply your pain in child bearing; in pain you shall bring forth children, yet your desire shall be for your husband, and he shall rule over you.”Genesis 3:16There is now a well-established body of literature documenting the pervasive inadequate treatment of pain in this country. There have also been allegations, and some data, supporting the notion that women are more likely than men to be undertreated or inappropriately diagnosed and treated for their (...) pain.One particularly troublesome study indicated that women are more likely to be given sedatives for their pain and men to be given pain medication. Speculation as to why this difference might exist has included the following: Women complain more than men; women are not accurate reporters of their pain; men are more stoic so that when they do complain of pain, “it's real”; and women are better able to tolerate pain or have better coping skills than men. (shrink)

Chemical structures are among the trademarks of our profession, as surely chemical as flasks, beakers and distillation columns. When someone sees one of us busily scribbling formulas or structures, he or she has no trouble identifying a chemist. Yet these familiar objects, which accompany our work from start to end, from the initial doodlings (Fig. I) to the final polished artwork in a publication (Fig. II), are deceptively simple. They raise interesting and difficult questions about representation. It is the intent (...) of this article to reflect upon molecular graphics. (shrink)

The article studies the reception of Aristotle’s treatments of voluntariness and decision (EN 3.1–5) in the first three Latin commentaries (two by Albert the Great, one by Thomas Aquinas) that are based on the integral text of the Nicomachean Ethics. In particular, my goal is to examine how Albert’s and Thomas’s non-Aristotelian concepts of the will as a faculty distinct from reason influences their explanations of the Aristotelian account. It is argued that the Dominican commentators emphasize the idea of freedom (...) more than Aristotle did. (shrink)

Highlighting Hegel's conceptual realism Hoffmann focuses on an undervalued move in his dialectic: inversion (μεταβολή). Easily proving completeness for Kant's table of categories, Hoffmann shows how metabolic dialectic substantiates Hegel's claim for his _Logic_: it is indeed the science of absolute form!

The Grand Challenges literature brings under its umbrella a wide variety of disjointed phenomena but runs the risk of reinventing the wheel as well as overlooking incremental progress and past work. To avert this, scholars need to (dis)connect (dis)similar issues, build on past research on these issues, and create opportunities for generalizability through theoretical examinations.

Representing an epistemic situation involving several agents obviously depends on the modeling point of view one takes. We start by identifying the types of modeling points of view which are logically possible. We call the one traditionally followed by epistemic logic the perfect external approach, because there the modeler is assumed to be an omniscient and external observer of the epistemic situation. In the rest of the paper we focus on what we call the internal approach, where the modeler is (...) one of the agents involved in the situation. For this approach we propose and axiomatize a logical formalism based on epistemic logic. This leads us to formalize some intuitions about the internal approach and about its connections with the external ones. Finally, we show that our internal logic is decidable and PSPACE-complete. (shrink)