RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize the (...) signaling pathways that activate ATF-2, as well as its downstream targets. We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. (shrink)

In this article I consider the normative and axiological dimension of Simmel’s thought. Building on previous interpretations, I argue that although Simmel cannot be interpreted as a systematic normative theorist, the issue of values and the normative standpoint can nevertheless be traced in various aspects of his multifarious work. This interpretive turn attempts to link Simmel’s obscure theory of value with his epistemological relationism. Relationism may offer a counterweight to Simmel’s value-pluralism, since it points to normative elements (e.g. internal teleology, (...) justice) that can contribute to the reconciliation between incommensurablity of forms and totality. Axiological and normative concerns (of a Hegelian source) survive also in his metaphysics of life, pointing beyond a merely Bergsonian and conservative Lebensphilosophie. I conclude with some thoughts on how this normative rethinking of Simmel’s thought can contribute towards more adequate appreciations of Simmel’s overall theory. (shrink)

ExcerptVassilios Paipais, ed. Theology and World Politics: Metaphysics, Genealogies, Political Theologies. Cham: Palgrave Macmillan, 2020. Pp. xiv + 349. Political theology represents one of the most fundamental subfields of contemporary political theory and international political theory. Since the 1920s, when Carl Schmitt introduced the respective terminology in the broader field of social and political sciences, political theology has developed in a dynamic way, composing, one way or another, a broader interdisciplinary field in which philosophy, theology, and politics are fruitfully interconnected.

Based on A. P. D. Mourelatos's "Events, Processes, and States", an overview of the literature on „verb types‟ is provided in this paper;the basic conceptual, logical and grammatical tests for the identification of different verb types are also briefly reviewed.Such tests, it is argued, reveal variations in a verb’s grammatical and/or lexical aspect; accordingly, verb types should be viewed as regularities governing aspectual variation within and across sentences. Verb types are not associated with particular verbs, predicates or sentences; rather, a (...) verb type is the sum of ways in which a verb‟s aspect may vary. In other words, verb types describe the possibilities for a verb to appear in one or another of a series of interrelated constructions. Verb types are verbal possibilities or, to use B. L. Whorf‟s apt term, fashions of speaking which cut across typical grammatical classifications. It is further argued that verb types, as “mere” fashions of speaking, cannot provide a firm basis for any metaphysics of „situation types‟; i.e., the metaphysics of verb types cannot be founded on their linguistics. (shrink)

Nel 1589 Hercole Filogenio scrisse un discorso che intitolò _Dell’eccellenza della donna_, con l’intento di allinearsi “all’opinione di coloro che si sforzano scoprire l’errore di molti, quali tanto si affannano in avilire il feminil sesso” e dedicò il suo scritto a Flavia Peretti Orsina, donna distinta e dallo spirito inquieto, che con i suoi interessi contribuì allo sviluppo della società dell’epoca. Nel suo tentativo di preservare le donne dal biasimo manifestato dal maschilismo egemone e, allo stesso tempo, elogiare le loro (...) virtù, Filogenio propone due conclusioni, l’analisi e l’approfondimento delle quali, per mezzo di un’argomentazione valida, costituiscono il nucleo testuale della sua opera. L’articolo presenta e analizza i ragionamenti che Filogenio sviluppa nella seconda parte del suo discorso sui quali intende imperniare la dimostrazione della seconda conclusione: che la Donna non è superiore né inferiore all’Uomo, ma simile e uguale per nobiltà, eccellenza e perfezione. (shrink)

Addison and Steele’s legacy on polite manners has been widely acknowledged as a hallmark of the Scottish Enlightenment’s tradition. On the other hand the place of courtly, ‘French’ politeness within the Scottish Enlightenment is much less debated. Conceiving the European Enlightenment as a status quo built on ‘French manners and English liberty’, as Pocock perfectly synthesizes1, points out to the restrictions imposed on religious fanaticism and warfare by the ‘jus gentium’ and European civility. In my paper I aim to shift (...) the attention to the seemingly obvious fact that manners, the backbone of European civility, originate in court, and Versailles was the court par excellence. In this context I explore Adam Smith’s struggle to strip politeness and civility of its aristocratic components. In the heart of the matter lies the strange idea of courtoisie without a court, of propriety that should overcome formal politeness i.e. imitation of aristocratic manners. (shrink)

Sophie de Grouchy, marquise de Condorcet, réinterprète la doctrine de la sympathie propre à la tradition moraliste écossaise dans le sens d’une réévaluation de ses origines physiologiques, ce qui affecte profondément ses dimensions morales et sociales. Dans le cadre d’un rousseauisme compassionnel, elle transforme Adam Smith en un républicain sentimentaliste modéré, précurseur des Idéologues. Elle s’emploie pour cela à montrer que la déférence envers le pouvoir établi, surtout la royauté, érigée par Adam Smith en servilité quasi fétichiste envers les puissants (...) et les rois, doit être réexaminée dans le cadre d’une économie affective post-révolutionnaire. Malgré le risque d’un mimétisme affectif enflammé par une rhétorique démagogique, Sophie de Grouchy mise sur la moralisation de l’identification avec la souffrance humaine, et sur sa régulation par des lois et institutions réformées pour tenir compte d’une nature humaine profondément sympathique. L’institutionnalisation de la sympathie morale est censée porter remède aux tragédies dues à la ségrégation sociale. En revanche, Adam Smith souligne à la fois la corruption morale due à l’adulation des puissants, et l’illusion socialement utile d’un imaginaire collectif cultivé par la tragédie classique et peuplé d’idéalisations du statut social. Adam Smith explore en outre d’une façon originale une dimension quasi psychanalytique de l’idéal social du moi qui anticipe la problématisation du culte du chef, là où la marquise se contente de critiquer le meneur de foule. (shrink)

Adam Smith not only champions commerce, he also criticizes it. In this criticism Smith draws critically upon a long-standing concern in enlightenment’s culture about the proper basis of political and moral life. For the purposes of this chapter, we can identify two interrelated dimensions in Smith’s analysis of the relation between corruption and commerce. He focuses on atavistic remainders of pre-modern, feudal, or aristocratic aspects of behaviour within the heart of commercial society and considers obsequiousness as emblematic of dependent socio-economic (...) relationships while, simultaneously, he raises the issue of distinct socio-economic, moral and political forms of commercial corruption, endemic to the core of commercial polity. (shrink)

In his famous Der Nomos der Erde, while discussing the foundational role of Francisco de Vitoria’s work for the emergence of international law, especially with regard to the legal and political justifications of the territorial conquest of a new world, Carl Schmitt—quite well-known as an enemy of modern and contemporary humanism—offers the following reflection.

In The Birth of Tragedy Nietzsche expounds on the origins of Greek tragedy and its relevance to the German culture of its time. He declares it to be the expression of a culture which has achieved a delicate but powerful balance between Dionysian insight into the chaos and suffering which underlies all existence and the discipline and clarity of rational Apollonian form. In order to promote a return to these values, Nietzsche critiques the complacent rationalism of late nineteenth-century German culture (...) and makes an impassioned plea for the regenerative potential of the music of Wagner. A wide ranging discussion of the nature of art, science, and religion, The Birth of Tragedy's argument raises important questions about the problematic nature of cultural origins which are still valid today. (shrink)

Dieser Band umfasst 35 Texte des Wiener Philosophen und Wissenschaftstheoretikers Friedrich G. Wallner aus den 1980er Jahren. Sie setzen sich allesamt auseinander mit dem sprachphilosophischen Denken des fruhen wie spaten Wittgenstein. Die Auseinandersetzung erfolgt dabei in einer zweifachen Weise: In einem ersten Teil gilt es den Texten, Grundgedanken Wittgensteins zu analysieren, zu erhellen sowie deren Pragungen und Einflusse aufzuzeigen. Dabei werden der Ansatz seines Denkens sowie dessen Bedeutung fur Wissenschaftstheorie und Dichtung erortert. In einem zweiten Teil verfolgen die Texte (...) das Ziel, im Anschluss an Wittgenstein ein Konzept von Philosophie auszuarbeiten, welches Philosophie als Therapie begreift. Ein Konzept, welches im Horizont der Einzelwissenschaften mehrfach zur Anwendung kommt.". (shrink)

Selections from the books, notes, and letters of this 19th century philosopher.

This English translation—the first since 1909—restores Human, All Too Human to its proper central position in the Nietzsche canon. First published in 1878, the book marks the philosophical coming of age of Friedrich Nietzsche. In it he rejects the romanticism of his early work, influenced by Wagner and Schopenhauer, and looks to enlightened reason and science. The "Free Spirit" enters, untrammeled by all accepted conventions, a precursor of Zarathustra. The result is 638 stunning aphorisms about everything under and above (...) the sun. (shrink)

A misconception regarding the ultrastructural basis of myocardial failure has been observed in laboratory studies involving medical students and practicing physicians, in medical textbooks, and in clinical instruction of students. This misconception attributes heart failure to overextension of individual cardiac muscle fibres and their sarcomeres, resulting in a mechanically based decline in contractile force production. The basis of the misconception is a set of component misconceptions which interact in reciprocally supportive ways. The interlocking nature of the component misunderstandings strengthens the (...) overall misconception, making it difficult to undermine. A contributor to many aspects of the faulty account of heart failure is a tendency toward oversimplification of complex phenomena in learning, instruction, and scientific research. Implications for medical education are considered. Keywords: mental models, knowledge representation, reductionism, myocardium, heart failure, physiology CiteULike Connotea Del.icio.us What's this? (shrink)

Beyond Good and Evil is one of the most scathing and powerful critiques of philosophy, religion, science, politics and ethics ever written. In it, Nietzsche presents a set of problems, criticisms and philosophical challenges that continue both to inspire and to trouble contemporary thought. In addition, he offers his most subtle, detailed and sophisticated account of the virtues, ideas, and practices which will characterize philosophy and philosophers of the future. With his relentlessly energetic style and tirelessly probing manner, Nietzsche embodies (...) the type of thought he wants to foster, while defining its historical role and determining its agenda. This edition offers a new and readable translation, by Judith Norman, of one of the most influential texts in the history of philosophy, together with an introduction by Rolf-Peter Horstmann that sets it in its historical and philosophical context. (shrink)