The evolutionary origins of several vertebrate organs are still controversial. The thyroid is classically thought to derive directly from the endostyle (a pharyngeal organ found in urochordates, cephalochordates and lampreys). Several molecular and biochemical lines of evidence agree with this scenario. However, a recent paper,1 describing the expression of a FoxE ortholog in amphioxus, suggests that some molecular pathways might actually have been recruited from an adjacent region of the pharynx. Although additional data from urochordates and lamprey are needed to (...) confirm this hypothesis; these results propose an interesting new scenario for thyroid evolution that involved the reorganisation of genetical and morphological features in the pharyngeal endoderm in order to give rise to a entirely new organ. They also give an indication that the ancestral role of the FoxE gene family was probably limited to the differentiation of part of the pharynx. BioEssays 24:696–699, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

In January 2008, the Human Fertilisation and Embryology Authority issued two 1-year licenses for cytoplasmic hybrid embryo research. This article situates the HFEA's decision in its wider scientific and political context in which, until quite recently, the debate about human embryonic stem cell research has focused narrowly on the moral status of the developing human embryo. Next, ethical arguments against crossing species boundaries with humans are canvassed. Finally, a new argument about the risks of harm to women egg providers resulting (...) from research involving the creation of humanesque cytoplasmic hybrid embryos is elaborated. Taken together these ethical concerns about the moral status of the human embryo, about the ethics of crossing species boundaries with humans, and about the potential harms to women, provide good reason to eschew humanesque cytoplasmic hybrid embryo research in favor of less ethically controversial means to the laudable end of successful regenerative medicine. (shrink)

: Françoise Dastur describes her efforts to practice history of philosophy in a (paradoxically) non-historical fashion. She discusses her concept of the historical, and argues that the only true way to be of one's time is to be against one's time.

Françoise Dastur describes her efforts to practice history of philosophy in a non-historical fashion. She discusses her concept of the historical, and argues that the only true way to be of one's time is to be against one's time.

Françoise Dastur describes her efforts to practice history of philosophy in a (paradoxically) non-historical fashion. She discusses her concept of the historical, and argues that the only true way to be of one's time is to be against one's time.

Françoise Dastur describes her efforts to practice history of philosophy in a non-historical fashion. She discusses her concept of the historical, and argues that the only true way to be of one's time is to be against one's time.

A foreign juridicial databank inquiry gives to difficulties not only with the linguistic problem of the translation but also with the comparison of the different law systems. So, it’s necessary to create a device able to resolve the collation of different juridicial systems specially when the files data retrieval is realised by a foreign user. These interfaces use specific connexion which allow an efficient documentary research and protect the integrity and the specificity of each national law systems.

Dans un passage de Physique iii (7, 207b15-21), Aristote s’exprime d’une manière qui suppose valide l’implication suivante : « Si une grandeur peut être infinie en puissance, une telle grandeur peut aussi être infinie en acte ». Cette implication a intrigué les commentateurs tant anciens et médiévaux que modernes. Ces derniers se sont en général bornés à constater que l’implication n’est pas logiquement valide, sans expliquer comment et en quel sens Aristote avait pu la tenir pour telle. En rapprochant le (...) passage précité d’un autre passage de Physique iii (6, 206b16-27), le présent article en propose une interprétation qui semble lever toutes les difficultés. Au Moyen Age, le sens de l’implication a été très discuté, et l’interprétation proposée ici a été vue et soutenue par plusieurs commentateurs : on l’étudie chez quelques-uns de ceux-ci en situant leur position dans le cadre du débat médiéval sur la question, notamment en référence aux deux interprétations alors fameuses proposées par Averroès. (shrink)

Most philosophers adopt an etiological conception of functions, but not one that uniformly explains the functions attributed to material entities irrespective of whether they are natural or man-made. Here, I investigate the widespread idea that a combination of the two current etiological theories, SEL and INT, can offer a satisfactory account of the proper functions of both organisms and artifacts.. Making explicit what a realist theory of function supposes, I first show that SEL offers a realist theory of biological functions (...) in which these are objective properties of a peculiar sort. I argue next that an artifact function demonstrates the same objective nature as a biological function when it is accounted for by SEL, but not when it is accounted for by INT. I explain why a dual theory of artifact functions admitting both INT and SEL functions is to be dismissed. I establish that neither INT nor SEL alone can account for all artifact functions. Drawing the conclusion that we need a new etiological theory of function, I show how one can overcome the apparent inevitability of INT for some artifact functions. Finally, I outline a new etiological theory of functions that applies equally to biological entities and to artifacts. (shrink)

Voilà un ouvrage d’une grande originalité, si grande qu’un spécialiste aussi consommé de la biologie aristotélicienne que Pierre Pellegrin – qui préface le livre – peut écrire (p. 10) : « Mes années d’études ne me donnent pas plus de compétence que n’en a n’importe quel lecteur nouveau du corpus biologique aristotélicien pour apprécier un travail aussi neuf ». Quant à moi, je ne saurais mieux faire, pour en donner une première idée, que d’emprunter quelques phrases à cette préface : (...) « […] l.. (shrink)

On se souvient peut-être de la parution au début de l’année 2008 du livre de Sylvain Gougenheim, Aristote au Mont Saint-Michel – Les racines grecques de l’Europe chrétienne (Le Seuil, Paris, 2008), des recensions laudatives dont cet ouvrage fit l’objet dans de grands quotidiens (le Monde, le Figaro), et de la polémique qui s’ensuivit. Cette polémique et l’ouvrage qui l’a suscitée semblent aujourd’hui déjà oubliés, les projecteurs de l’actualité, comme on dit, s’étant braqués sur d’autres obje..

oise Baylis, 1234 Le Marchant Street, Halifax, Nova Scotia, Canada B3H 3P7. Tel.: (902)-494–2873; Fax: (902)-494-2924; Email: francoise.baylis{at}dal.ca ' + u + '@' + d + ' '//--> . Abstract Recently, there has been a growing interest in public health and public health ethics. Much of this interest has been tied to efforts to draw up national and international plans to deal with a global pandemic. It is common for these plans to state the importance of drawing upon a well-developed (...) ethics framework and we argue that this framework should reflect the values and insights of feminist relational theory. More specifically, we argue that pandemic planning must be squarely situated in the larger realm of public health and that an ethics framework for public health will be one that recognizes the need to pay particular attention to the vulnerability of subpopulations lacking in social and economic power. We propose an ethics framework for public health that builds on the notions of relational personhood (including relational autonomy and social justice) and relational solidarity. In this way, we aim for a public health ethics that, as appropriate, promotes the public interest and the common good. CiteULike Connotea Del.icio.us What's this? (shrink)

Chronique/critique de Françoise Favretto parue dans la revue L'intranquille. Revue de littérature, n° 20, St-Quentin-de-Caplong, L'Atelier de l'Agneau, 2021, p. 83. - Recensions.

How, asks Françoise Dastur, can philosophy account for the sudden happening and the factuality of the event? Dastur asks how phenomenology, in particular the work of Heidegger, Husserl, and Merleau-Ponty, may be interpreted as offering such an account. She argues that the "paradoxical capacity of expecting surprise is always in question in phenomenology," and for this reason, she concludes, "We should not oppose phenomenology and the thinking of the event. We should connect them; openness to phenomena must be identified (...) with openness to unpredictability." The article offers reflections in these terms on a phenomenology of birth. (shrink)

How, asks Françoise Dastur, can philosophy account for the sudden happening and the factuality of the event? Dastur asks how phenomenology, in particular the work of Heidegger, Husserl, and Merleau-Ponty, may be interpreted as offering such an account. She argues that the “paradoxical capacity of expecting surprise is always in question in phenomenology,” and for this reason, she concludes, “We should not oppose phenomenology and the thinking of the event. We should connect them; openness to phenomena must be identified (...) with openness to unpredictability.” The article offers reflections in these terms on a phenomenology of birth. (shrink)

We study extensions of Presburger arithmetic with a unary predicate R and we show that under certain conditions on R, R is sparse and the theory of $\langle\mathbb{N}, +, R\rangle$ is decidable. We axiomatize this theory and we show that in a reasonable language, it admits quantifier elimination. We obtain similar results for the structure $\langle\mathbb{Q},+, R\rangle$.

How, asks Françoise Dastur, can philosophy account for the sudden happening and the factuality of the event? Dastur asks how phenomenology, in particular the work of Heidegger, Husserl, and Merleau-Ponty, may be interpreted as offering such an account. She argues that the “paradoxical capacity of expecting surprise is always in question in phenomenology,” and for this reason, she concludes, “We should not oppose phenomenology and the thinking of the event. We should connect them; openness to phenomena must be identified (...) with openness to unpredictability.” The article offers reflections in these terms on a phenomenology of birth. (shrink)

Suddenly, COVID-19 has changed the world and the way people work. Companies had to accelerate something they knew was imminent in the future, but not immediate and extremely humongous. This situation poses a huge challenge for companies to survive and thrive in this complex business environment and for employees, who must adapt to this new way of working. An effective e-leadership, which promotes companies’ adaptability, is needed. This study investigates the existing knowledge on teleworking and e-leadership; and analyzes the supposed (...) challenges. The literature review shows that companies with effective e-leadership can view teleworking as an opportunity. It is advantageous for not only companies’ productivity but also the environment and people who work remotely. However, a traditional or no leadership can result in some risks. Thriving in remote work environments implies that managers must adjust the companies’ structure, making them less hierarchical, and developing new abilities to establish a strong and trustworthy relationship with their employees to maintain their competitiveness, while retaining a genuine concern for their employees’ well-being. Similarly, successful e-leadership must be able to consolidate and lead effective virtual teams to accomplish organizational goals. This study contributes to the literature and leaders during the pandemic. (shrink)

We outline a number of ethical objections to genetic technologies aimed at enhancing human capacities and traits. We then argue that, despite the persuasiveness of some of these objections, they are insufficient to stop the development and use of genetic enhancement technologies. We contend that the inevitability of the technologies results from a particular guiding worldview of humans as masters of the human evolutionary future, and conclude that recognising this worldview points to new directions for ethical thinking about genetic enhancement (...) technologies. (shrink)

The prominence and peculiarity of color in French symbolist verse have often been noted. Yet the dominance of color in symbolism is not the result of aesthetic preference or mere poetic technique, as has been previously argued; rather, color functions, with the synaesthetic poetic context of which it is an integral part, as the direct manifestation of a particular metaphysical stance. Color leads to the heart of what symbolism is, for it is the paradigmatic literary expression of a general spiritual (...) crisis—a crisis in epistemology. The nineteenth century extended seventeenth-century empiricism—an empiricism which had invented mathematical measurement as the gauge of reality and which resulted in a predilection to see most authentic knowledge as quantifiable. The logical corollary of such a predilection is that all sensory experience is regarded as suspect. Newtonian physics had rationalized the laws of the universe in reducing its properties to atomical structures and laws of motion. Nothing, it seemed, was left unexplained. Those areas of perception which remained unquantifiable were dispelled as illusion or attributed to the necessary limitations of the human mind. The theories of John Locke act as a kind of historical watershed in this regard: they are the classic philosophic expression of the disjunction between sensory experience and knowledge which, in its nineteenth-century versions, would lead to the symbolist revolt. Françoise Meltzer is a professor of French literature and of comparative literature at the University of Chicago. Her previous contribution to Critical Inquiry is the translation of Christian Metz's "Trucage and the Film" . She is the author of The Trial of Psychoanalysis, Salome and the Dance of Writing, and Hot Property: The Stakes and Claims of Literary Originality. (shrink)

The role of the reader is central to the epistolary genre because the letters anticipate a reader within the novel's framework. There is the letter's intended recipient , the occasional interceptor, the invented publisher and/or editor who organize the collected correspondence, and the extrafictional reader who reads the collection in its entirety, including the disclaiming or condemning prefaces which precede it. The epistolary form, however, with so many layers of readers, considerably complicates the issue of reader response. If we share, (...) for example, Stanley Fish's assumption that "literature is in the reader," the epistolary novel apparently reverses the formula: the reader is in the literature.And yet it is in the novel of letters that the reader, the fictional reader, most clearly creates the text. Let us return to Merteuil's admonishment to Cécile: "Voyez donc à soigner davantage votre style…. Vous voyez bien que, quand vous écrivez à quelqu'un, c'est pur lui et non pas pour vous: vous devez donc moins chercher à lui dire ce que vous pensez, que ce qui lui plaît davantage."2 If a reader's response to a given sentence is colored by the previous one, the epistolary novel achieves the same effect within a larger unit: each letter is determined by the one which precedes it. In this sense the letter is a grammatical unit, a larger sentence. Moreover, a letter-novel presents the possibility of an architectural as well as conceptual interruption. That is, whereas insufficiencies in a first-or third-person narrative must consist of circumlocutions, repetitions, and exclusions of information, the letter-novel can create a concrete insufficiency by a lost, suppressed, stolen, or interrupted letter. In such cases the letter must function without its precedent since the destinataire remains empty-handed. Thus, the epistolary novel has a great capacity for mise en abîme.Both inside and outside the narrative, there always is a destinataire; and even if he is the wrong one in the context of the récit he is the intended one for the histoire.3 In any case, the extrafictional reader is the final destinataire and holds a privileged position. And yet, he too is subject to interruptions: here the editor rears his head by claiming in footnotes that a letter is lost, too damaged to decipher, or so boring or obscene that he has seen fit to exclude it; these footnotes are the only "letters" addressed to and meant for us. At this point the editor removes his mask but remains on stage. Apart from such tricks, however, we do read every letter available, each of which is addressed to another reader, a system of the once removed or of the "letter in suffrance." Or, loosely interpreting Jacques Lacan, a purloined letter means that a letter always arrives at its destination.42. Choderlos de Laclos, Les Liasons dangereuses , letter 105, p. 247; all subsequent quotations are taken from this edition and will be identified by letter and page number in the text. "Therefore attend more to your style....You must well know that, when you write to someone, it is for him and not for you: you must therefore seek less to tell him what you think, than what pleases him more"; here and elsewhere my translation.3. I am using the French terms of Gérard Genette to avoid confusion caused by English equivalents. "Récit is often translated as discourse, plot, narrative, subject, narration; histoire as story, events, myth, and so forth.4. See Jacques Lacan, "Seminar on'The Purloined Letter,'" trans. Jeffrey Mehlman, Yale French Studies 48 : 38-72; all further references to this work, abbreviated as "SPL," will be included in the text. The final sentence reads as follows: "Thus it is that what the 'purloined letter,' nay, the 'letter in suffrance' means is that a letter always arrives at its destination." What Lacan means by this statement has to do with the language of the unconscious, or of unconscious Desire. Each individual sends his own message of "truth" of identity. Earlier in this passage Lacan says: "The sender, we tell you , receives from the receiver his own message in reverse form." Françoise Meltzer is an associate professor of Romance language and literatures and of comparative literature at the University of Chicago. Her previous contributions to Critical Inquiry are "Color as Cognition in Symbolist Verse" and the translation of Christian Metz's "Trucage and the Film" . She is presently working on the relationship between rhetoric and psychoanalytic terminology. (shrink)

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually (...) very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination. -/- . (shrink)

This work was supported, in part, by a Stem Cell Network grant to Françoise Baylis and Jason Scott Robert and a CIHR grant to Françoise Baylis. We sincerely thank Alan Fine, Rich Campbell, Cynthia Cohen, and Tim Krahn for helpful comments on an earlier draft of this paper. Thanks are also owed to Tim Krahn for his research assistance. An earlier version of this paper was presented to the Department of Bioethics and the Novel Tech Ethics research team. (...) We thank the participants at each of these meetings for their helpful comments. (shrink)

En partant de la définition des rituels, et notamment du rôle de la parole, qu'elle soit verbale ou non-verbale, cet article interroge la façon dont la ritualisation peut contribuer à l'éducation, notamment en milieu scolaire. Après un tour d'horizon des principaux aspects rituels de l'enseignement et de l'école, l'auteur questionne plus particulièrement les rituels d'apprentissage, c'est-à-dire ceux qui structurent la relation enseignant/enseigné au sein de la classe. En s'appuyant sur une théorisation psychanalytique elle montre alors comment les rituels peuvent ou (...) non, notamment en fonction de leur degré « d'ouverture », contribuer à faire exister les élèves dans leur singularité et, ce faisant, les aider à se construire dans leur rapport au savoir.Starting from the definition of rituals, including the role of speech, either verbal or non-verbal, this article examines how ritual can contribute to education, particularly in schools. After an overview of the main aspects of teaching and rituals of the school, especially the author questions the rituals of learning, that is to say those that structure the relationship teacher / learner in the class. Based on psychoanalytic theorizing it then shows how rituals may or may not, depending on their particular degree of "openness" to help students exist in their singularity, thereby helping to build in their relation to knowledge. (shrink)

La loi dite loi Taubira fut votée le 10 mai 2001 par les élus de la République. L’article 1 de cette loi précisait : « La République française reconnaît que la traite négrière transatlantique et l’ esclavage perpétrés à partir du XVe siècle contre les populations africaines déportées en Europe, aux Amériques et dans l’océan Indien constituent un crime contre l’humanité.

The primary objective of The Health Care Ethics Con sultant is to focus attention on an immediate practical problem: the role and responsibilities, the education and training, and the certification and accreditation of health care ethics consultants. The principal questions addressed in this book include: Who should be considered health care ethics consultants? Whom should they advise? What should be their responsi bilities and what kind of training should they have? Should there be some kind of accreditation or certification program (...) to ensure that those who call themselves ethics consultants are in fact qualified to advise, consult, research, and write in health care ethics? The distinguished authors ofthese articles are persons with diverse backgrounds, interests, presumptions, and val ues. Not surprisingly, therefore, diverse responses have emerged to the questions posed. Though the book's chapters are individually authored, they are informed by the group discussions that went on during active workshop sessions, and by knowledge of the contributions of others. All of the chapters meaningfully represent their consensus. This is not to say that there were no disagreements regarding specific details, but rather that there were no fundamental objections on the book's basic content among a panel of authors who share basic premises regarding the role, responsibilities, education, and certifica tion of health care ethics consultants. (shrink)

Les premières mythographies de l’Europe néo-latine, depuis la Genealogia deorum de Boccace, considèrent l’histoire des dieux sur le modèle des généalogies humaines, en cherchant à recomposer « la lignée de Saturne ». Les premiers historiens de la Grèce, comme les poètes, inventèrent des généalogies mythiques pour inscrire l’origine des hommes dans l’histoire de leur relation aux dieux. Que fondent les généalogies divines ? Non seulement des structures religieuses, non seulement la raison même des sociétés humaines, mais encore la préhistoire de (...) l’humanité. Mais si les engendrements divins donnent sens aux relations entre les hommes et les dieux, c’est l’histoire des commencements du monde que les mythographes cherchent à comprendre en interrogeant l’articulation des généalogies divines et humaines. Depuis que, dans le Timée, Platon a associé mythologia et genealogia comme deux modes de discours « archéologiques », les mythographes ont ouvertement revendiqué un savoir sur le monde qui se définit comme une synthèse des « sciences de la nature ».Mythologia, Genealogia, Archaiologia:A Paleontological Scope for Mythography. The first European mythographical treatises in the Middle Ages and Renaissance, since Boccaccio’s Genealogia deorum, were determined by a genealogical method, looking at the history of the gods with human patterns and seeking the reconstruction of “Saturn’s lineage”. The early Greek mythographers, like the poets, imagined various genealogies for seeking out the origins of humanity through their relationships with gods. What is founded on divine genealogies? Not only religious structures, nor only the true ratio of human sociability, but a human paleon­tology too. By interpreting filiations as a system of connexions between gods and humans, the mythographers aimed at understanding the protohistory of the universe. Since Plato’s Timaeus associated mythologia and genealogia as two modes of “archaeological” discourse, mythographers have wanted to assert their own “physical science” as a whole synthetic perception of the natural world. (shrink)

C’est à l’aide de la distinction de L. Wittgenstein entre critères et symptômes dans une théorie, et de l’affirmation chez Freud de la conscience (Bewusstheit) comme symptôme pour la Métapsychologie, que nous posons la question de l’existence de symptômes dans la théorie lacanienne. Ne serait-ce pas alors sur la question du réel que nous retrouvons Lacan et Wittgenstein dans leur dialogue fictif ? La question du réel sera posée chez eux en lien avec celle de la nature mentale du corps, (...) puis d’une question commune sur l’objet du désir. Les apories rencontrées dans les tentatives de la pensée du réel mènent Wittgenstein à trouver une solution, la forme (logicalform). Pour Lacan la réponse sera dans l’introduction des n’uds pour la théorie analytique, y ajoutant, pour l’usage, une catégorie : celle du semblant. (shrink)