BackgroundConcurrent with efforts to establish national and regional biorepositories in Africa is widespread endorsement of ethics committees as stewards of the interests of individual donors and their communities. To date, ethics training programs for IRB members in Botswana have focused on ethical principles and international guidelines rather than on the ethical dimensions of specific medical technologies and research methodologies. Little is known about the knowledge and concerns of current and prospective IRB members in Botswana with respect to export, reuse, storage, (...) and benefit-sharing of biospecimens.MethodsThis qualitative study examined perspectives of IRB members in Botswana about the collection and use of biospecimens in research. Forty-one IRB members representing five committees in Botswana participated in discussions groups in March 2013. Transcriptions of audiotapes and field notes were analyzed to identify issues of concern that might be alleviated through education and capacity-building, and areas that required ongoing discussion or additional regulatory guidance.ResultsAreas of concern included lack of understanding among patients and providers about the use of biospecimens in clinical care and research; reuse of biospecimens, particularly issues of consent, ownership and decision-making; export of specimens and loss of control over reuse and potential benefits; and felt need for regulatory guidance and IRB-member training. Local belief systems about bodily integrity and strong national identity in the construct of benefits may be at odds with initiatives that involve foreign biorepositories or consider such collections to be global public goods.ConclusionEducation is needed to strengthen IRB-member capacity to review and monitor protocols calling for the collection and use of biospecimens, guided by clear national policy on priority-setting, partnerships, review, and oversight. Engagement with local stakeholders is needed to harmonize fundamentally different ways of understanding the human body and community identity with the aims of contemporary biomedicine. (shrink)

This article presents a review of the literature, summarizes current initiatives, and provides a heuristic for assessing the effectiveness of a range of institutional review board collaborative strategies that can reduce the regulatory burden of ethics review while ensuring protection of human subjects, with a particular focus on international research. Broad adoption of IRB collaborative strategies will reduce regulatory burdens posed by overlapping oversight mechanisms and has the potential to enhance human subjects protections.

Although the notion of physician value neutrality in medicine may be traced back to the writings of Sir William Osler, it is relatively new to medicine and medical ethics. We argue in this paper that how physician value neutrality has been cashed out is often obscure and its defense not persuasive. In addition, we argue that the social/political implementation of neutrality, Political Liberalism, fails, and thus, PVN's case is weakened, for PVN's justification relies largely on the reasoning undergirding PL. For (...) these reasons, we conclude that PVN has no philosophical or ethical warrant and thus should be abandoned. We suggest that the physician present to her patients some type of statement or creed that would give them an idea of where she stands on important axiological issues and how these stands are cashed out clinically. (shrink)

Background: Family sense of coherence can be defined as the cognitive map of a family that enables the family to deal with stress during their lifetime. FSOC is the degree to which a family perceives family life as comprehensible, manageable, and meaningful. To the best of our knowledge, few studies have used this scale, and very few have evaluated FSOC Scale psychometric properties.Objective: This study aimed to evaluate the psychometric properties of the original FSOC Scale in a sample of Portuguese (...) caregivers of children aged between 10 and 15 years.Methods: A total of 329 caregivers completed a sociodemographic questionnaire and the FSOC Scale. Analyses were performed to evaluate the factor structure of the FSOC Scale with 26 items as well as composite reliability, internal consistency, convergent-related validity, and discriminant-related validity of the scale scores.Results: The findings supported a three-factor solution for a 13-item version that maintains the original FSOC Scale structure. The three FSOC dimensions presented a good fit to the data. Cronbach’s alpha, composite reliability, and convergent-related validity were considered very good for the FSOC Scale. No evidence of discriminant-related validity was found for the dimensions of FSOC.Conclusion: The findings support the use of the Portuguese FSOC Scale for research and clinical purposes with Portuguese caregivers. Future research is necessary to further develop a European Portuguese version of the FSOC Scale.Implications: This study provides a psychometric evaluation of FSOC Scale characteristics in a Portuguese sample. The results are helpful for clinicians and family therapists who work with families since it could help them to assess the resources of families and their ability to cope with adversity and enhance their strengths. (shrink)

Psalm 73 is a challenging Psalm in which the Psalmist draws on rich imagery to juxtapose doctrine and experience and to juxtapose the goodness of God with divine retribution. Drawing on data provided by 15 theological educators within the Anglican Diocese of Cyprus and the Gulf, this study tests the thesis that the imagery of Psalm 73 will be perceived differently by sensing types and by intuitive types and that the issue ‘Is God really good to the upright?’ will be (...) judged differently by feeling types and by thinking types. The findings from this study are consistent with the broader hermeneutical theory that the psychological type profile of the reader, in terms of perceiving preference and judging preference, plays a formative part in shaping the interpretation of biblical material.Contribution: Situated within the reader-perspective approach to biblical hermeneutics, the SIFT method is concerned with identifying the influence of the psychological type of the reader in shaping the interpretation of text. The present study demonstrates that this theory holds true for the way in which theological educators read Psalm 73. (shrink)

The subjective delight associated with the creative arts poses a well-known challenge to an integrated causal analysis of human psychology. Here we examine the distal causes of art in terms of an irreducibly risky search in a vast phase space of cognition and behavior. To explore means to engage in an activity that may result in a zero or negative payoff. Moreover, you may be unable to assess the risks with any certainty; the costs might spiral out of control. At (...) the same time, the known alternatives may simply not be viable; natural selection has no problems acting on the failure to locate new habitable subspaces. This represents the hard problem of evolution: there is no recurring procedure that will reliably deliver the benefits of a successful exploration. We propose to locate the emergence of play and art in the tension between the irreducible risks of exploration and its potential benefits and examine the complex suite of adaptations that has emerged to solve, however, imperfectly, the hard problem of evolution. This includes adaptations for lowering the cost of exploration and strategies for open-ended yet loosely targeted searches. We argue that the ability to become aware of possible actions, to evaluate their respective merits, and to explore and develop new strategies of perception, thinking, and action have had a major impact on human survival and reproduction and have been subject to persistent natural selection. The arts, we suggest, represent a distinct cognitive mode of pushing the boundaries of what is familiar and known into new areas of perceptual, emotional, and agentive exploration and discovery, characterized by a proximal motivation of intrinsic enjoyment. (shrink)

This book helps us to not only feel the full range of emotions, but to feel the emotions appropriate to the actual situations in which we find ourselves. Anger, fea r, sorrow - all take on a new meaning. '.

Working within the sensing, intuition, feeling, thinking (SIFT) approach to biblical hermeneutics, the present study focuses attention on the distinctive voices of introverted intuition and extraverted intuition, by analysing the way in which two small groups, one comprising dominant introverted intuitive types and the other comprising dominant extraverted intuitive types, explored and reflected on the Lucan narrative of the Good Samaritan, a passage rich in material to stimulate the perceiving process. Two distinctive voices emerged from these two groups. CONTRIBUTION: Situated (...) within the reader perspective approach to biblical hermeneutics, the SIFT method is concerned with identifying the influence of the psychological type of the reader in shaping the interpretation of text. The foundations of the SIFT approach distinguish among the four functions of sensing, intuition, feeling, and thinking. The present study builds on this foundation by developing the nuance of the orientation in which the function is expressed, in this case focusing specifically on the comparison between introverted intuition and extraverted intuition. (shrink)

Working within the reader perspective approach to biblical hermeneutics, a series of empirical studies have tested the theory that the readers' psychological type preference between sensing and intuition shapes distinctive readings of biblical narratives. More recently, closer attention has also been given to differentiation within these two perceiving functions of sensing and intuition with regard to their introverted and extraverted orientation. Against this background, the present study examines the distinctive reading of the Johannine narrative of the wedding at Cana, a (...) passage rich in materials to engage the perceiving functions, by two groups whose dominant or auxiliary functions were introverted sensing and introverted intuition.CONTRIBUTION: Situated within the reader perspective approach to biblical hermeneutics, the sensing, intuition, feeling, thinking method is concerned with identifying the influence of the psychological type of the reader in shaping the interpretation of text. The foundations of the SIFT approach distinguish amongst the four functions of sensing, intuition, feeling and thinking. The present study builds on this foundation by introducing the nuance of the orientation in which the function is expressed, in this case focusing specifically on introverted sensing and introverted intuition. (shrink)

Working within the reader perspective approach to biblical hermeneutics, a recent series of empirical studies has tested the theory that the readers’ psychological type preferences between sensing and intuition and between feeling and thinking shape distinctive readings of biblical texts. This study advances the debate by distinguishing between the two orientations within which the functions are expressed. The added clarity offered by this refinement is illustrated by the distinctive voices of introverted intuition and introverted sensing engaging with the Matthean Beatitudes, (...) eight verses rich in materials to engage the perceiving functions. (shrink)

Working within the reader perspective approach to biblical hermeneutics, a recent series of empirical studies has tested the theory that the readers’ psychological type preferences between sensing and intuition (perceiving functions) and between feeling and thinking (judging functions) shape distinctive readings of biblical texts. This study advances the debate by distinguishing between the two orientations within which the functions are expressed (introverted and extraverted). The added clarity offered by this refinement is illustrated by the distinctive voices of introverted intuition and (...) introverted sensing engaging with the Matthean Beatitudes, eight verses rich in materials to engage the perceiving functions. (shrink)

Since the 1950s, the cognitive revolution has been transforming work in psychology, linguistics, and anthropology. Literary scholars, however, have only recently begun to grapple with the significance of cognitive understandings of language, mind, and behavior for literary and cultural studies. This unique issue of Poetics Today brings the concerns of literary history and cultural studies for the first time into a sustained and productive dialogue with cognitive methods, findings, and paradigms.The introduction situates the collection in relation to previous work, defines (...) the issues, highlights the stakes. Articles by Mark Turner and Paul Hernadi propose a bold extension of notions of literary history to include not only preliterature oral forms but the entire history of the species, viewing literary activity as a crucial human adaptation. Ellen Spolsky's essay provides an unprecedented statement of common ground shared by cognitive-evolutionary approaches and poststructuralist theory. The final three essays examine works by Aphra Behn, A. L. Barbauld, and Jane Austen in terms of their contemporary cultural and political contexts as well as in light of paradigms drawn from cognitive neuroscience and evolutionary theory. A commentary by Tony Jackson surveys the entire issue from the viewpoint of an informed outsider. (shrink)

DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.

As the subtitle indicates, this book consists of a series of essays on Heidegger, followed by a lengthy bibliography of English translations of Heidegger’s works up to 1996. An appendix to one of the essays also contains a translation of Adalbert Stifter’s “Ice Tale”.

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

F. H. Bradley was the foremost philosopher of the British Idealist school, which came to prominence in the second half of the nineteenth century. Bradley, who was a life fellow of Merton College, Oxford, was influenced by Hegel, and also reacted against utilitarianism. He was recognised during his lifetime as one of the greatest intellectuals of his generation and was the first philosopher to receive the Order of Merit, in 1924. His work is considered to have been important to the (...) formation of analytic philosophy. In metaphysics, he rejected pluralism and realism, and believed that English philosophy needed to deal systematically with first principles. This work, first published in 1893, is divided into two parts: 'Appearance' deals with exposing the contradictions that Bradley believed are hidden in our everyday conceptions of the world; and in 'Reality', he builds his positive account of reality and considers possible objections to it. (shrink)