Background: Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this disorder, however, are not well understood. Method: This review aims to define spasticity, describe hypotheses explaining its development after a stroke, give an overview of related neuroimaging studies as well as a description of the most common scales used to quantify the degree of spasticity and finally explore which treatments are currently being used to treat this disorder.

Drawing on research in the psychology of judgment and decision making, I argue that individual economists acting as experts in matters of public policy are likely to be victims of significant overconfidence. The case is based on the pervasiveness of the phenomenon, the nature of the task facing economists?as?experts, and the character of the institutional constraints under which they operate. Moreover, I argue that economist overconfidence can have dramatic consequences. Finally, I explore how the negative consequences of overconfidence can be (...) mitigated, and how the phenomenon can be reduced or eliminated. As a case study, I discuss the involvement of Western experts in post?communist Russian economic reforms. (shrink)

This is an extended meditation on ethics in literature across the Senecan corpus. There are two chapters on the Moral Letters, asking how one is to read philosophy or how one can write about being. Moving from the Letters to the Natural Questions and Dialogues, Professor Gunderson explores how authorship works at the level both of the work and of the world, the ethics of seeing, and the question of how one can give up on the here and now and (...) behold instead some other, better ethical sphere. Seneca's tragedies offer words of caution: desire might well subvert reason at its most profound level, or humanity's painful separation from the sublime might be part of some cruel divine plan. The book concludes by considering what, if anything, we are to make of Seneca's efforts to enlighten us. (shrink)

The ongoing ‘enhancement’ debate pits critics of new self-shaping technologies against enthusiasts. One important thread of that debate concerns medicalization, the process whereby ‘non-medical’ problems become framed as ‘medical’ problems.In this paper I consider the charge of medicalization, which critics often level at new forms of technological self-shaping, and explain how that charge can illuminate – and obfuscate. Then, more briefly, I examine the charge of pharmacological Calvinism, which enthusiasts, in their support of technological self-shaping, often level at critics. And (...) I suggest how that charge, too, can illuminate and obfuscate.Exploring the broad charge of medicalization and the narrower counter charge of pharmacological Calvinism leads me to conclude that, as satisfying as it can be to level one of those charges at our intellectual opponents, and as tempting as it is to lie down and rest with our favorite insight, we need to gather the energy to have a conversation about the difference between good and bad forms of medicalization. Specifically, I suggest that if we consider the ‘medicalization of love,’ we can see why critics of and enthusiasts about technological self-shaping should want (and in some cases have already begun) to distinguish between good and bad forms of such medicalization. (shrink)

We address some frequently encountered criticisms of Radical Embodied/Enactive Cognition. Contrary to the claims that the position is too radical, or not sufficiently so, we claim REC is just radical enough.

A measure of coherence is said to be truth conducive if and only if a higher degree of coherence (as measured) results in a higher likelihood of truth. Recent impossibility results strongly indicate that there are no (non-trivial) probabilistic coherence measures that are truth conducive. Indeed, this holds even if truth conduciveness is understood in a weak ceteris paribus sense (Bovens & Hartmann, 2003, Bayesian epistemology. New York, Oxford: Oxford University Press; Olsson, 2005, Against coherence: Truth probability and justification. Oxford: (...) Oxford University Press). This raises the problem of how coherence could nonetheless be an epistemically important property. Our proposal is that coherence may be linked in a certain way to reliability. We define a measure of coherence to be reliability conducive if and only if a higher degree of coherence (as measured) results in a higher probability that the information sources are reliable. Restricting ourselves to the most basic case, we investigate which coherence measures in the literature are reliability conducive. It turns out that, while a number of measures fail to be reliability conducive, except possibly in a trivial and uninteresting sense, Shogenji’s measure and several measures generated by Douven and Meijs’s recipe are notable exceptions to this rule. (shrink)

In this paper I develop a novel challenge for sceptical theists. I present a line of reasoning that appeals to sceptical theism to support scepticism about divine assertions. I claim that this reasoning is at least as plausible as one popular sceptical theistic strategy for responding to evidential arguments from evil. Thus, I seek to impale sceptical theists on the horns of a dilemma: concede that either (a) sceptical theism implies scepticism about divine assertions, or (b) the sceptical theistic strategy (...) for responding to evidential arguments from evil fails. An implication of (a) is that sceptical theism is at odds with any religious tradition according to which there are certain claims that we can know to be true solely in virtue of the fact that God has told us that they are true. This result will render conceding (a) unattractive to many sceptical theists. (shrink)

The empty set of course contains no computable point. On the other hand, surprising results due to Zaslavskiĭ, Tseĭtin, Kreisel, and Lacombe have asserted the existence of non-empty co-r. e. closed sets devoid of computable points: sets which are even “large” in the sense of positive Lebesgue measure.This leads us to investigate for various classes of computable real subsets whether they always contain a computable point.

Jonathan Cohen has claimed that in cases of witness agreement there is an inverse relationship between the prior probability and the posterior probability of what is being agreed: the posterior rises as the prior falls. As is demonstrated in this paper, this contention is not generally valid. In fact, in the most straightforward case exactly the opposite is true: a lower prior also means a lower posterior. This notwithstanding, there is a grain of truth to what Cohen is saying, as (...) there are special circumstances under which a thesis similar to his holds good. What characterises these circumstances is that they allow for the fact of agreement to be surprising. In making this precise, I draw on Paul Horwich's probabilistic analysis of surprise. I also consider a related claim made by Cohen concerning the effect of lowering the prior on the strength of corroboration. 1 Introduction 2 Cohen's claim 3 A counterexample 4 A weaker claim 5 A counterexample to the weaker claim 6 The grain of truth in Cohen's claim 7 Prior probability and strength of corroboration 8 Conclusion. (shrink)

What are the semantic representations that underlie language production? We use structural priming to distinguish between two competing theories. Thematic roles define semantic structure in terms of atomic units that specify event participants and are ordered with respect to each other through a hierarchy of roles. Event structures instead instantiate semantic structure as embedded sub‐predicates that impose an order on verbal arguments based on their relative positioning in these embeddings. Across two experiments, we found that priming for datives depended on (...) the degree of overlap in event structures. Specifically, while all dative structures showed priming, due to common syntax, there was a boost for compositional datives priming other compositional datives. Here, the two syntactic forms have distinct event structures. In contrast, there was no boost in priming for dative light verbs, where the two forms map onto a single event representation. On the thematic roles hypothesis, we would have expected a similar degree of priming for the two cases. Thus, our results support event structural approaches to semantic representation and not thematic roles. (shrink)

I advance a novel challenge for Divine Command Theory based on the existence of psychopaths. The challenge, in a nutshell, is that Divine Command Theory has the implausible implication that psychopaths have no moral obligations and hence their evil acts, no matter how evil, are morally permissible. After explaining this argument, I respond to three objections to it and then critically examine the prospect that Divine Command Theorists might bite the bullet and accept that psychopaths can do no wrong. I (...) conclude that the Psychopathy Objection constitutes a serious and novel challenge for Divine Command Theory. (shrink)

During antiquity, the astronomical questions of the day and the methods used to formulate and answer them were clearly within the realm of philosophy. That changed most notably in the sixteenth century when Tycho Brahe turned astronomy into a modern empirical science by formulating (in principle) testable hypotheses, figuring out how to test them, building the proper instruments, and making – for that time – very accurate and systematic observations of the sky. These observations eventually led to the modern view (...) of the solar system and ultimately the rejection of the classical Aristotelian worldview. Since then, the exploration of space has been located clearly in the realm of natural science – and, to an increasing extent, technology. In parallel to that, space has – at least since World War II –to a high degree been a place for military and political ambitions and activities. The scientists that have been involved in space exploration have mainly been physicists, together with some chemists and geologists. Lately, the exploration of space has engaged more and more biologists in the search for extraterrestrial life. The international space station, along with plans to send humans to Mars, has led to an increased involvement of medical science. If present speculations about space tourism and mining on planets, moons, and asteroids hold true, in the future we will probably see many new professions dealing not just with exploration, but also exploitation of space. Philosophy has never totally left the realm of space exploration. As space exploration and exploitation become more and more interdisciplinary, and as space becomes a bigger part of our lives, it will be time once more for philosophy to turn its attention towards space. The mission for philosophers is not to indulge in speculations over questions that are better dealt with by empirical methods. Ther are, however, several questions connected to the exploration and exploitation of space that are of a philosophical nature and that deserve to be examined seriously from a philosophical perspective. I believe that philosophical scrutiny of these questions will be to the benefit of both space exploration and philosophy. Interesting and, indeed, important philosophical questions arise in many areas of space exploration. Some of the most interesting and important ones relate to the search for extraterrestrial life, of which some will be presented here. I will not attempt to answer these questions here. Instead, this chapter should be seen as an introduction to some of the philosophical questions raised by astrobiology. (shrink)

I draw on the literature on skeptical theism to develop an argument against Christian theism based on the widespread existence of suffering that appears to its sufferer to be gratuitous and is combined with the sense that God has abandoned one or never existed in the first place. While the core idea of the argument is hardly novel, key elements of the argument are importantly different from other influential arguments against Christian theism. After explaining that argument, I make the case (...) that the argument is untouched by traditional skeptical theism. I then consider positive skeptical theism, arguing that while DePoe’s view might provide a response to my argument, it entangles the theist in worries about divine deception. Because traditional skeptical theism and DePoe’s positive skeptical theism constitute the most promising extant strategies for answering my argument, the argument constitutes a serious challenge for the Christian theist. My overall aim, then, is to draw on various strands of the skeptical theism literature to present a challenge for all Christian theists, not just those in the skeptical theist camp, while at the same time revealing some important limitations of skeptical theism. (shrink)

In this article, we review the intrinsic democratic flaws in electoral representation, lay out a set of principles that should guide the construction of a sortition chamber, and argue for the virtue of a bicameral system that combines sortition and elections. We show how sortition could prove inclusive, give citizens greater control of the political agenda, and make their participation more deliberative and influential. We consider various design challenges, such as the sampling method, legislative training, and deliberative procedures. We explain (...) why pairing sortition with an elected chamber could enhance its virtues while dampening its potential vices. In our conclusion, we identify ideal settings for experimenting with sortition. (shrink)

While color realism is endorsed, Byrne & Hilbert's (B&H's) case for it stretches the notion of “physical property” beyond acceptable bounds. It is argued that a satisfactory account of color should do much more to respond to antirealist intuitions that flow from the specificity of color experience, and a pointer to an approach that does so is provided.

According to the so?called swamping problem, reliabilist knowledge is no more valuable than mere true belief. In a paper called ?Reliabilism and the value of knowledge? (in Epistemic value, edited by A. Haddock, A. Millar, and D. H. Pritchard, pp. 19?41. Oxford: Oxford University Press, 2009), Alvin I. Goldman and myself proposed, among other things, a solution based on conditional probabilities. This approach, however, is heavily criticized by Jonathan L. Kvanvig in his paper ?The swamping problem redux: Pith and gist? (...) (in Social Epistemology, edited by A. Haddock, A. Millar, and D. H. Pritchard, pp. 89?111. Oxford: Oxford University Press, 2010). In the present article, I defend the conditional probability solution against Kvanvig?s objections. (shrink)

To give priority to the young over the elderly has been labelled ‘ageism’. People who express ‘ageist’ preferences may feel that, all else equal, an individual has greater right to enjoy additional life years the fewer life years he or she has already had. We shall refer to this as egalitarian ageism. They may also emphasise the greater expected duration of health benefits in young people that derives from their greater life expectancy. We may call this utilitarian ageism. Both these (...) forms of ageism were observed in an empirical study of social preferences in Australia. The study lends some support to the assumptions in the QALY approach that duration of benefits, and hence old age, should count in prioritising at the budget level in health care. (shrink)

This paper starts from qualitative research on volunteering and citizenship, with a special focus on volunteering within a setting of restorative justice and mediation. In a first stage, the author reconstructs two models of meaningfulness as hermeneutical lenses to better understand how volunteers see their engagement and experiences as a source of meaningfulness. The paper argues that a biographical model of meaningfulness is in need of a complementary approach to meaningfulness, which focuses on transformational experiences with a strong existential depth. (...) In a second stage, the paper dialogues with the experiences and narratives of the volunteers, and shows how their understanding of citizenship informs, and transforms their ideas of meaningfulness. Both the biographical and the existential approach to meaningfulness appear to be deeply influenced by the volunteers’ civic imaginaries. (shrink)

We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to (...) promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon.Also watch the Video Abstract. (shrink)

ABSTRACTUnquestionably, philosophy has acquired a somewhat new register lately. First, I discuss the appearance of the theological virtues in contemporary philosophy. This appearance is heralded in Nietzsche’s famous preface to The Gay Science. The event remains at this point curious and without explanation. In a second step, I explore current French philosophy and culture as the frame and/or the effect of this appearance. At this point, I still cannot find the philosophical meaning of the virtues, only the condition of possibility (...) of their ‘extra-theological’ relevance. At most, I can reopen the religious nature, element or register of thought, of philosophy. I will do that by introducing eschatology and desecularisation, implying that modern rationalist allegedly areligious atheism is actually a hyper-religious theism. Desecularisation can only be understood within the frame of an ‘open world’, within a world-as-opening. World then becomes the event of meaning and the thought that thinks the opening, open thought as it were, is philosophical charity or philosophy-as-charity. The effect of all this is precisely philosophy turning into virtuous thought. Philosophy becomes, in ‘fact’, hope, faith and charity. (shrink)

This paper is a reaction to ‘Styles of Thought on the Continental Drift Debate’ by Pablo Pellegrini, published in this journal. The author argues that rationalist accounts of the continental drift debate fail because they overlook important issues. In this discussion we distinguish various forms of rationalism. Then we present a sophisticated rationalist account of the continental drift debate and argue that it is satisfactory because it explains all the central developments in that debate. Finally, we point to a problematic (...) tension in Pellegrini’s paper and unravel an underlying ambiguity. (shrink)

In this article we criticize two recent articles that examinethe relation between explanation and unification. Halonen and Hintikka (1999), on the one hand,claim that no unification is explanation. Schurz (1999), on the other hand, claims that all explanationis unification. We give counterexamples to both claims. We propose a pluralistic approach to the problem:explanation sometimes consists in unification, but in other cases different kinds of explanation(e.g., causal explanation) are required; and none of these kinds is more fundamental.

We argue that two well-known examples (strawberry distribution and Konigsberg bridges) generally considered genuine cases of distinctively _mathematical_ explanation can also be understood as cases of distinctively _generic_ explanation. The latter answer resemblance questions (e.g., why did neither person A nor B manage to cross all bridges) by appealing to ‘generic task laws’ instead of mathematical necessity (as is done in distinctively mathematical explanations). We submit that distinctively generic explanations derive their explanatory force from their role in ontological unification. Additionally, (...) we argue that distinctively generic explanations are better seen as standardly mathematical instead of distinctively mathematical. Finally, we compare and contrast our proposal with the work of Christopher Pincock on abstract explanations in science and the views of Michael Strevens on abstract causal event explanations. (shrink)

Stuart White argues that egalitarians need a diverse toolkit of policy proposals in order to move closer to a just economic system. In particular he argues that a policy of Basic Capital grants should be included in this toolkit along with a variety of other more familiar instruments such as unconditional Basic Income, welfare state services and income supports, and support for worker cooperatives. The various policies in the egalitarian toolkit, however, have implications for issues other than contributing to a (...) more just economic system. In particular, they have implications for the long term stability, transformation, or even transcendence, of capitalism as an economic system. In this article I will argue that unconditional Basic Income has a greater potential to erode capitalism than does Basic Capital. While both of these policies in the egalitarian toolkit may make the economic system statically more just, over time Basic Capital grants are likely to strengthen capitalism as the core structure of the economic system, whereas unconditional Basic Income has the potential to erode the dominance of capitalism. As part of a long-term project of human emancipation, therefore, unconditional Basic Income should have priority over Basic Capital. (shrink)

The general-case glass ceiling hypothesis states that not only is it more difficult for women than for men to be promoted up levels of authority hierarchies within workplaces but also that the obstacles women face relative to men become greater as they move up the hierarchy. Gender-based discrimination in promotions is not simply present across levels of hierarchy but is more intense at higher levels. Empirically, this implies that the relative rates of women being promoted to higher levels compared to (...) men should decline with the level of the hierarchy. This article explores this hypothesis with data from three countries: the United States, Australia, and Sweden. The basic conclusion is that while there is strong evidence for a general gender gap in authority—the odds of women having authority are less than those of men—there is no evidence for systematic glass ceiling effects in the United States and only weak evidence for such effects in the other two countries. (shrink)

Isaac Levi has claimed that our reliance on the testimony of others, and on the testimony of the senses, commonly produces inconsistency in our set of full beliefs. This happens if what is reported is inconsistent with what we believe to be the case. Drawing on a conception of the role of beliefs in inquiry going back to Dewey, Levi has maintained that the inconsistent belief corpus is a state of ``epistemic hell'': it is useless as a basis for inquiry (...) and deliberation. As he has also noticed, the compatibility of these two elements of his pragmatist epistemology could be called into question. For if inconsistency means hell, how can it ever be rational to enter that state, and on what basis could we attempt to regain consistency? Levi, nonetheless, has tried to show that the conflict is only apparent and that no changes of his theory are necessary. In the main part of the paper I argue, by contrast, that his attempts to reconcile these components of his view are unsuccessful.The conflict is real andthus presents a genuine threat to Deweyan pragmatism, as understood by Levi. After an attempt to pinpoint exactly where the source of the problem lies, I explore some possibilities for how to come to grips with it. I conclude that Levi can keep his fundamental thesis concerning the role of beliefs in inquiry and deliberation, provided that he (i) gives up the view that the agent can legitimately escape from inconsistency, and (ii) modifies his account of prediction alias deliberate expansion by acknowledging a third desideratum, besides probability and informational value, namely, not to cause permanent breakdown further down the line of inquiry. The result is a position which is more similar to Peter Gärdenfors's than is Levi's original theory, while retaining the basic insights of the latter. (shrink)

Gerald Harrison identifies two Euthyphro-related concerns for divine command theories and makes the case that to the extent that these concerns make trouble for divine command theories they also make trouble for non-naturalistic moral realism and naturalistic moral realism. He also offers responses to the two concerns on behalf of divine command theorists. I show here that the parity thesis does not hold for the most commonly discussed version of divine command theory. I further argue that his responses to the (...) two concerns fail. Finally, I draw on some of Harrison’s ideas to identify an advantage that non-naturalistic moral realism has over divine command theories and naturalistic moral realism. (shrink)

In Robust Ethics, I defend a nontheistic version of moral realism according to which moral properties are sui generis, not reducible to other kinds of properties (e.g., natural properties or supernatural properties) and objective morality requires no foundation external to itself. I seek to provide a plausible account of the metaphysics and epistemology of the robust brand of moral realism I favor that draws on both analytic philosophy and contemporary empirical moral psychology. In this paper, I respond to some objections (...) to my view advanced by William Craig, Mark Murphy, Tyler McNabb, and Adam Johnson. (shrink)