Molecular tumour boards (MTBs) offer recommendations for potentially effective, but potentially burdensome, molecularly targeted treatments to a patient's treating physician. In this paper, we discuss the question of who is responsible for ensuring that there is an adequate evidence base for any treatments recommended to a patient. We argue that, given that treating oncologists cannot usually offer a robust evaluation of the evidence underlying an MTB's recommendation, members of the MTB are responsible for ensuring that the evidence level is adequate. (...) We explore two models for how to share responsibility between MTB members. According to the first model, each MTB member, as well as the treating physician, should be held maximally and equally responsible for the recommendations. We argue that this insufficiently accounts for differences in roles and expertise of MTB members. We propose instead that responsibility is delegated via relationships of trust. We argue if these relationships of trust are to be instances of reasonable trust, (a) MTBs should offer a clinical representative to whom a treating physician may delegate the responsibility of ensuring there is sufficient evidence for treatment recommendations, (b) the relationships of trust between the representative and the other MTB members should be clearly defined, and (c) MTB members should be carefully selected. Treating oncologists retain a responsibility to consider general limitations of the evidence for targeted treatments in assessing whether the treatment recommendation offered by an MTB's representative is adequate for a given clinical situation. (shrink)

Is there a link between how a firm manages its internal and external stakeholders? More specifically, are firms that give employees stock ownership and more say in running the enterprise more likely to engage with external stakeholders? This study seeks to answer these questions by elaborating on mechanisms that link employees to external stakeholders, such as the community, suppliers, and the environment. It tests these relationships using a sample of 347 private, mostly small-to-medium size firms, which completed a stakeholder impact (...) assessment organized by the non-profit B Lab. The results support the hypotheses that both employee ownership and employee involvement are positively associated with external stakeholder engagement. Further, we found that certification plays a role, as employee ownership contributes to external stakeholder engagement only in certified B Corporations, and not in firms that merely completed the B Lab Impact assessment. Our findings have import for stakeholder engagement frameworks, as we show that there is interplay between internal employee stakeholders and external stakeholders that may be important to overall firm–stakeholder management. (shrink)

Outbreaks of epidemics like Ebola trigger difficult ethical challenges for civilian and military health care personnel. This book offers theoretical reflections combined with reports from recent military and NGO missions in the field. The authors of this volume focus on military medical ethics adding a distinct voice to the topic of epidemics and infectious diseases. While military health care personnel are always crucially involved during disaster relief operations and large-scale public health emergencies, most of the current literature treats ethical issues (...) during epidemics from a more general perspective without taking into account the specifics of the military context. The contributions in this volume provide first-hand insights into some of the ethical issues encountered by military health care personnel in missions during the Ebola outbreak in 2014/2015. This practical perspective is complimented by academic analyses and theoretical reflections on ethical issues associated with epidemics. (shrink)

We welcome Soltis' use of evolutionary signaling theory, but question his interpretations of colic as a signal of vigor and his explanation of abnormal high-pitched crying as a signal of poor infant quality. Instead, we suggest that these phenomena may be suboptimal by-products of a generally adaptive learning process by which infants adjust their crying levels in relation to parental responsiveness.

This book sheds light on various ethical challenges military and humanitarian health care personnel face while working in adverse conditions. Contexts of armed conflict, hybrid wars or other forms of violence short of war, as well as natural disasters, all have in common that ordinary circumstances can no longer be taken for granted. Hence, the provision of health care has to adapt, for example, to a different level of risk, to scarce resources, or uncommon approaches due to external incentives or (...) requirements. This affects the practice of health care as well as its ethics. This book offers a panoramic overview on various challenges healthcare faces in extraordinary situations and provides new insights from practitioners’ as well as from academic scholars’ perspectives. (shrink)

This chapter introduces to the main topic of the volume, namely the influence of the changing nature of warfare on the provision of medical care and the ethical challenges that occur. It presents the main ideas of relevant concepts such as asymmetrical warfare, hybrid warfare, and complex emergencies before illustrating the ethical challenges that new forms of warfare create for military and humanitarian health care providers. Examples of ethical challenges include embedding medical personnel in combating forces, questions regarding the treatment (...) of detainees, the need to uphold medical neutrality, and pitfalls of using medicine to non-medical ends. The chapter concludes with a synopsis of the volume. (shrink)

Minors are increasingly reaching countries far from their homes as migrants, and their ages are often unknown. In Europe, up to 1500 people per country annually have medical examinations and procedures to estimate their chronological age.1 These procedures can cause considerable harm to individuals, particularly if performed without appropriate safeguards. Inappropriate age estimation may deter minors from applying for asylum in specific countries, and doctors may find themselves exploited in the service of migration policy. During missions, military doctors face demands (...) to estimate the age of child soldiers destined for potentially unlawful detention or interrogation. Doctors therefore need to be aware of the limitations of medically estimating age and the associated ethical problems. (shrink)

In the cocktail party situation, people with normal hearing usually follow a single speaker among multiple concurrent ones. However, there is no agreement in the literature as to whether the background is segregated into multiple streams/speakers. The current study varied the number of concurrent speech streams and investigated target detection and memory for the contents of a target stream as well as the processing of distractors. A male-voiced target stream was either presented alone (single-speech), together with one male-voiced distractor (one-distractor), (...) or a male- and a female-voiced distractor (two-distractor). Behavioral measures of target detection and content tracking performance as well as target- and distractor detection related event-related brain potentials (ERPs) were assessed. We found that the N2 amplitude decreased whereas the P3 amplitude increased from the single-speech to the concurrent speech streams conditions. Importantly, the behavioral effect of distractors differed between the conditions with one vs. two distractor speech streams and the non-zero voltages in the N2 time window for distractor numerals and in the P3 time window for syntactic violations appearing in the non-target speech stream significantly differed between the one- and two-distractor conditions for the same (male) speaker. These results support the notion that the two background speech streams are segregated, as they show that distractors and syntactic violations appearing in the non-target streams are processed even when two speech non-target speech streams are delivered together with the target stream. (shrink)

David Hume wrote that Berkeley's arguments `admit of no answer but produce no conviction'. This book aims at the kind of understanding of Berkeley's philosophy that comes from seeing how we ourselves might be brought to embrace it. Berkeley held that matter does not exist, and that the sensations we take to be caused by an indifferent and independent world are instead caused directly by God. Nature becomes a text, with no existence apart from the spirits who transmit and (...) receive it. Kenneth P. Winkler presents these conclusions as natural consequences of Berkeley's reflections on such topics as representation, abstraction, necessary truth, and cause and effect. In the closing chapters Proefssor Winkler offers new interpretations of Berkeley's view on unperceived objects, corpuscularian science, and our knowledge of God and other minds. (shrink)

This collection of essays on themes in the work of John Locke , George Berkeley , and David Hume , provides a deepened understanding of major issues raised in the Empiricist tradition. In exploring their shared belief in the experiential nature of mental constructs, The Empiricists illuminates the different methodologies of these great Enlightenment philosophers and introduces students to important metaphysical and epistemological issues including the theory of ideas, personal identity, and skepticism. It will be especially useful in courses (...) devoted to the history of modern philosophy. (shrink)

For Hume, one task of logic is “to explain the principles and operations of our reasoning faculties”; this chapter is a study of his logic of inductive reasoning, as presented in Book I of his Treatise and in the Enquiry Concerning Human Understanding. Like other early modern logics—especially those composed, as Hume’s was, under the influence of Locke—Hume’s logic is descriptive, explanatory, and normative. It also aspires to be revelatory. It is descriptive in documenting how our reasoning actually proceeds, explanatory (...) in telling us why it so proceeds, normative in telling us how it should proceed, and revelatory in using those findings to arrive at larger truths about human nature and human life. Hume formulates rules of inductive reasoning and ranks inductive arguments as better and worse. He also advocates the reform of intellectual disciplines. Yet his logic, it is argued, is at the same time deeply skeptical. (shrink)

At present, ‘naturalism’ is arguably the dominant trend in both Anglo-American and European philosophy. Owing to the influence of the works of W.V.O. Quine, Wilfred Sellars, and Hillary Putnam, among others, naturalism both as a methodological and ontological position has become one of the mainstays of contemporary analytic approaches to knowledge, mind and ethics. From the early 1990s onward, European philosophy in the English-speaking world has been witnessing a turn from the philosophies of the subjects of phenomenology, hermeneutics and existentialism (...) and a revival of a certain kind of vitalism, whether Bergsonian or Nietzschean, and also of a certain kind of materialism that is close in spirit to Spinoza’s _Ethics_ and to the naturalism and monism of the early Ionian thinkers. This book comprises essays written by experts in both the European and the Anglo-American traditions such as John Sallis, David Papineau, David Cerbone, Dan Zahavi, Paul Patton, Bernhard Weiss, Jack Reynolds and Benedict Smith, who explore the limit of naturalism and the debate between naturalism and phenomenology. This book also considers the relation between Deleuze’s philosophy and naturalism as well as the critique of phenomenology by speculative realism. This book was originally published as a special issue of the _International Journal of Philosophical Studies. _. (shrink)

In response to kenneth winkler's criticism of my suggestion (found in my "david hume: common sense moralist, sceptical metaphysician") that frances hutcheson embraced an interesting form of moral realism. i show important differences between hutcheson and locke, amplify my previous account of hutcheson's notion of concomitant ideas, and provide evidence that hutcheson's contemporaries, including his student adam smith, believed him to have maintained "that there is a real and essential distinction between vice and virtue". ("theory of moral sentiments").

Sur une suggestion de David Halperin, John Winkler, professeur à Yale puis à Stanford, rassembla, l’année de sa mort (1990), des études datées de 1981/1989, pour la plupart inédites. Leur convergence autorisait un livre sur l’éthique sexuelle grecque dans une approche sémiotique et anthropologique des pratiques sociales, se démarquant de l’histoire intellectuelle, comme de celles des idées et des mentalités, et du New Historicism des années 1980. À partir d’« observations informelles du compo...

When John Winkler died in 1990, he was working on a book that aimed at a wide-ranging reinterpretation of Greek tragedy as a pedagogical exercise aimed primarily at the city’s young men (“ephebes,”...

Here the philosopher and physicist David Z Albert argues, among other things, that the difference between past and future can be understood as a mechanical phenomenon of nature and that quantum mechanics makes it impossible to present the entirety of what can be said about the world as a narrative of “befores” and “afters.”.

In this monograph I propose to interpret John Locke's view of central metaphysical notions such as substance, essence and identity to the backdrop of his distinction between distinct and confused ideas. I show that Locke draws this traditional distinction in a novel way—as a distinction pertaining only to the way ideas are related to our use of language. This distinction, I argue, allows him to radically rethink traditional questions of metaphysics and to mount a linguistic criticism of traditional metaphysical views (...) about substance, essence and identity. Furthermore, I propose that taking into account the linguistic dimension of Locke's metaphysical thought helps recognize the coherence of his overall picture of substance, essence and identity. (shrink)

Longtermism is the thesis that in a large class of decision situations, the best thing we can do is what is best for the long-term future. The scope question for longtermism asks: how large is the class of decision situations for which this is true? In this paper, I suggest that the scope of longtermism may be narrower than many longtermists suppose. I identify a restricted version of longtermism: swamping axiological strong longtermism (swamping ASL). I identify three scope-limiting factors - (...) probabilistic and decision-theoretic phenomena which, when present, tend to reduce the prospects for swamping ASL. I argue that these scope-limiting factors are often present in human decision problems, then use two case studies from recent discussions of longtermism to show how the scope-limiting factors lead to a restricted, if perhaps nonempty, scope for swamping ASL. (shrink)

Once upon a time, the twentieth-century investigations of the behaviors of sub-atomic particles were thought to have established that there can be no such thing as an objective, observer-independent, scientifically realist, empirically adequate picture of the physical world.

Diese Abhandlung von 1748 fand unter den Zeitgenossen endlich die große und ungeteilte Beachtung, die Hume für seine kritischen Untersuchungen zur dogmatischen und empirischen Erkenntnis erwarten durfte. Seit Kants Bekenntnis, er sei durch diesen Text aus einem "dogmatischen Schlummer" erweckt und zu seinen eigenen kritischen Untersuchungen bewegt worden, gilt das Buch als Humes bedeutendstes Hauptwerk.

Are demands for equality motivated by envy? Nietzsche, Freud, Hayek, and Nozick all thought so. Call this the Envy Objection. For egalitarians, the Envy Objection is meant to sting. Many egalitarians have tried to evade the Envy Objection.. But should egalitarians be worried about envy? In this paper, I argue that egalitarians should stop worrying and learn to love envy. I argue that the persistent unwillingness to embrace the Envy Objection is rooted in a common misunderstanding of the nature of (...) the charge, what it reveals, and what can be said in response to it. I develop what Bernard Williams might call a vindicatory genealogy of envy, thereby allowing us to see that envy, rather than undermining egalitarian intuitions, can in fact play a distinct justificatory role (when it is fitting), which undermines the Envy Objection. (shrink)

This volume addresses whether, how, and where laws (variously defined) teach values and shape moral character in late modern liberal societies. Each author recognizes the essential value of state law in fostering peace, security, health, education, charity, trade, democracy, constitutionalism, justice, and human rights, among many other moral goods. Each author also recognizes, however, the grave betrayals of law in supporting fascism, slavery, apartheid, genocide, persecution, violence, racism, and other forms of immorality and injustice. They thus call for state laws (...) that set a basic civil morality of duty for society and for robust freedoms that protect private individuals and private groups to cultivate a higher morality of aspiration"--Back cover. (shrink)

Although a fascination with language is a familiar feature of 20th-century empiricism, its origins reach back at least to the early modern period empiricists. John Locke offers a detailed (if sometimes puzzling) treatment of language and uses it to illuminate key regions of the philosophical topography, particularly natural kinds and essences. Locke's main conceptual tool for dealing with language is 'signification'. Locke's central linguistic thesis is this: words signify nothing but ideas. This on its face seems absurd. Don't we need (...) words to signify things as well? But its very absurdity – our inclination to dismiss Locke as a 'linguistic idealist'– should signal to us that we have not yet understood Locke. Doing so must begin with an analysis of signification. Each of the three main interpretations on offer allows Locke to escape the charge of linguistic idealism, although they do so in very different ways. Locke's text also offers an influential account of linguistic particles, words like 'is', 'and' and 'if'. These signify, not ideas, but acts of the mind. These acts can either take place within a proposition, uniting its constituent ideas into a thought that admits of a truth-value, or they can take propositions as their objects, in which case they express attitudes like doubt, assertion and so on. Even this seemingly innocuous sketch of Locke's view is controversial, and many writers, from J.S. Mill onwards, have argued that Locke cannot make sense of propositional attitudes. Apart from the intrinsic interest of these questions, understanding how Locke thinks language works is a prerequisite for understanding his arguments against scholastic essentialism. It also illuminates later discussions of language in Berkeley, Hume and Mill. Author Recommends: 1. Losonsky, Michael. 'Language, Meaning, and Mind in Locke's Essay. ' The Cambridge Companion to Locke's Essay . Ed. Lex Newman. Cambridge: Cambridge UP, 2007. 286–313. In addition to making some original points, Losonsky provides an excellent overview of the three main competing positions on Lockean signification: the Fregean reading, the Scholastic reading and the Indicator theory (see entries 2–5 in the following). 2. Kretzmann, Norman. 'The Main Thesis of Locke's Semantic Theory.' Locke on Human Understanding . Ed. I. C. Tipton. Oxford: Oxford UP, 1975. 123–40. Kretzmann's influential paper offers a broadly Fregean analysis, according to which primary signification is sense and secondary, reference. Locke can then avoid the charge of linguistic idealism, as it is not the case that words signify only ideas. 3. Ashworth, E. J. 'Do Words Signify Ideas or Things?' Journal of the History of Philosophy 19 (1981): 299–326. Ashworth rejects Kretzmann's view, partly on the grounds of anachronism, and sets Locke in his historical context. As she reads Locke, he holds a scholastic position, according to which signification amounts to 'making known' or 'expressing'. This preserves the portmanteau analysis of Kretzmann: words can primarily signify or express ideas, while secondarily signifying things. 4. Lowe, E. J. 'Language and Meaning,' chapter 4. Locke . London: Routledge, 2005. This is a spirited defense of Locke's claim that words signify ideas against contemporary prejudices. Like Ian Hacking (see entry 7 in the following), Lowe argues that Locke is not offering a semantic theory in anything like the contemporary sense; rather, he is concerned with explaining human communication. 5. Ott, Walter. Locke's Philosophy of Language . Cambridge: Cambridge UP, 2004. On the interpretation offered in chapter 1, Lockean signification is indication: words signify ideas in the same sense in which clouds signify rain. If this view is correct, Locke is departing from the particular scholastic tradition Ashworth focuses on, and embracing instead a tradition running from the Stoics through Thomas Hobbes. http://www.springerlink.com/content/xv362655719101n3/ 6. Winkler, Kenneth. 'Signification, Intention, Projection.' Forthcoming, Philosophia . http://www.springerlink.com/content/xv362655719101n3 Although previous commentators acknowledge the role of intentions in Locke's view (see especially Kretzmann's argument from the uses of words), Winkler claims that they are far more central to Locke's view than has been supposed. In particular, Winkler uses these considerations to criticize the indicator interpretation. 7. Hacking, Ian. Why Does Language Matter to Philosophy? Cambridge: Cambridge UP, 1975. Much broader in focus than these other works, Hacking's classic text has much to say about early modern views on language. Hacking argues that Hobbes and Locke do not, properly speaking, even have theories of meaning. Online Materials The Stanford Encyclopedia of Philosophy's entry on Locke, by William Uzgalis: http://plato.stanford.edu/entries/locke/ > The Internet Encyclopedia of Philosophy's entry on Locke, author unknown: http://www.utm.edu/research/iep/l/locke.htm > Sample Syllabus Weeks 1–2: What is Locke's linguistic thesis? Is it a semantic thesis at all? Ashworth, E. J. 'Do Words Signify Ideas or Things?' Journal of the History of Philosophy 19 (1981): 299–326. Kretzmann, Norman. 'The Main Thesis of Locke's Semantic Theory.' Locke on Human Understanding . Ed. I. C. Tipton. Oxford: Oxford UP, 1975. 123–40. Locke, Essay III. i–iii. Lowe, E. J. 'Language and Meaning,' chapter 4. Locke . London: Routledge, 2005. Week 3: Propositions and attitudes Locke, Essay III. vii. Ott, Walter. 'Propositional Attitudes in Modern Philosophy.' Dialogue 41 (2002): 1–18. Owen, David. 'Locke on Judgment.' The Cambridge Companion to Locke's Essay . Ed. Lex Newman. Cambridge: Cambridge UP, 2007. 406–35. If one wanted to explore whether and how Locke applies his semiotic theory in his anti-essentialist argument, one might add (or perhaps replace Week 3 with): Week 4: Applications Bolton, Martha. 'The Relevance of Locke's Theory of Ideas to his Doctrine of Nominal Essence and Anti-Essentialist Semantic Theory.' Locke . Ed. Vere Chappell. Oxford: OUP, 1998. pp. 214–225 Locke, Essay III. vi; III.xi. 4–22. Ott, Walter. 'Locke's Argument from Signification.' Locke Studies 2 (2002): 145–76. Focus Questions 1. What is a semantic theory? What do we want out of such a theory, and does Locke even purport to provide one? 2. What are the differences among the three main competing readings of Locke? What is at stake here? What, if anything, turns on which of them accurately captures Locke's view? 3. How does Locke think his linguistic thesis tells against competing views, such as those of the scholastics? 4. What is the difference between a proposition and a list? Can Locke account for this difference? 5. There is clearly a difference between merely thinking that the cat is on the mat and asserting that it is. Can Locke account for this difference? (shrink)

Presentists, who believe that only present objects exist, face a problem concerning truths about the past. Presentists should (but cannot) locate truth-makers for truths about the past. What can presentists say in response? We identify two rival factions ‘upstanding’ and ‘nefarious’ presentists. Upstanding presentists aim to meet the challenge, positing presently existing truth-makers for truths about the past; nefarious presentists aim to shirk their responsibilities, using the language of truth-maker theory but without paying any ontological price. We argue that presentists (...) should be nefarious presentists. (shrink)

In _Speech and Phenomena,_ Jacques Derrida situates the philosophy of language in relation to logic and rhetoric, which have often been seen as irreconcilable criteria for the use and interpretations of signs. His critique of Husserl attacks the position that language is founded on logic rather than on rhetoric; instead, he claims, meaningful language is limited to expression because expression alone conveys sense. Derrida's larger project is to confront phenomenology with the tradition it has so often renounced--the tradition of Western (...) metaphysics. (shrink)

Both utilitarian and deontological moral theories locate the source of our moral beliefs in the wrong sorts of considerations. One way this failure manifests itself, we argue, is in the ways these theories analyze the proper human relationship toward the non-human environment. Another, more notorious, manifestation of this failure is found in Derek Parfit's Repugnant Conclusion. Our goal is to explore the connection between these two failures, and to suggest that they are failures of act-centered moral theories in general. As (...) such, they cannot be fixed by simply developing a better version of such a theory. Virtue-based theories, we suggest, provide a more promising alternative. (shrink)

It is argued that certain recent advances in the construction of a theory of the collapses of Quantum Mechanical wave functions suggest the possibility of new and improved foundations for statistical mechanics, foundations in which epistemic considerations play no role.

This book uncovers the lost history of Christianity's encounters with Pythagorean ideas before the Renaissance. David Albertson skillfully examines ancient and medieval theologians, particularly Thierry of Chartres and Nicholas of Cusa, who successfully reconceived the Trinity and the Incarnation within the framework of Greek number theory. David Albertson challenges modern assumptions about the complex relationship between religion and science.

This paper argues that higher-order doubt generates an epistemic dilemma. One has a higher-order doubt with regards to P insofar as one justifiably withholds belief as to what attitude towards P is justified. That is, one justifiably withholds belief as to whether one is justified in believing, disbelieving, or withholding belief in P. Using the resources provided by Richard Feldman’s recent discussion of how to respect one’s evidence, I argue that if one has a higher-order doubt with regards to P, (...) then one is not justified in having any attitude towards P. Otherwise put: No attitude towards the doubted proposition respects one’s higher-order doubt. I argue that the most promising response to this problem is to hold that when one has a higher-order doubt about P, the best one can do to respect such a doubt is to simply have no attitude towards P. Higher-order doubt is thus much more rationally corrosive than non-higher-order doubt, as it undermines the possibility of justifiably having any attitude towards the doubted proposition. (shrink)

We discuss two recent attempts two solve Schrodinger's cat paradox. One is the modal interpretation developed by Kochen, Healey, Dieks, and van Fraassen. It allows for an observable which pertains to a system to possess a value even when the system is not in an eigenstate of that observable. The other is a recent theory of the collapse of the wave function due to Ghirardi, Rimini, and Weber. It posits a dynamics which has the effect of collapsing the state of (...) macroscopic systems. We argue that the modal interpretation cannot account for non-accurate measurements and that both accounts have the consequence that in ordinary measurement situations the observables that ends up well defined are not quite the ones that we want to be well defined. (shrink)

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other (...) more popular views of the nature of God and the nature of God's relationship with His creation. This book seeks to challenge that untested assumption. With clarity and rigor, this collection of essays seeks to fill a significant hole in the literature on the problem of evil. (shrink)

I distinguish between two conceptually different kinds of physical space: a space of ordinary material bodies, which is the space of points at which I could imaginably place the tip of my finger, or the center of a billiard-ball, and a space of elementary physical determinables, which is the smallest space of points such that stipulating what is happening at each one of those points, at every time, amounts to an exhaustive physical history of the universe. In all classical physical (...) theories, these two spaces happen to coincide – and what we mean by calling a theory “classical”, and all we mean by calling a theory “classical”, is precisely that these two spaces coincide. But once the distinction between these two spaces in on the table, it becomes clear that there is no logical or conceptual reason why they must coincide – and it turns out that a very simple way of pulling them apart from one another gives us quantum mechanics. (shrink)