A wide range of biological processes, in all eukaryotes and in some prokaryotes, are controlled by rhythms with a period close to 24 hours. The circadian oscillator, which is responsible for generating these rhythms, is controlled by light signals that maintain its synchrony with the environmental day/night cycle. Higher plants exhibit many circadian rhythms, including rhythms in the transcription of specific genes. Molecular tools derived from such clock‐controlled genes have led to the identification of several circadian rhythm mutants in the (...) genetic model, Arabidopsis thaliana. The extensive understanding of photoperception in this species will make it a powerful system with which to investigate the light regulation of circadian rhythms. We compare Arabidopsis rhythms to the results from other systems, and discuss these data with respect to the current phototransduction models. (shrink)

ABSTRACTThis article addresses the question of whether certain experiences that originate in causes other than bereavement are properly termed ‘grief’. To do so, we focus on widespread experiences of grief that have been reported during the Covid-19 pandemic. We consider two potential objections to a more permissive use of the term: grief is, by definition, a response to a death; grief is subject to certain norms that apply only to the case of bereavement. Having shown that these objections are unconvincing, (...) we sketch a positive case for a conception of grief that is not specific to bereavement, by noting some features that grief following bereavement shares with other experiences of loss. (shrink)

How we understand the nature and role of grief depends on what we take its object to be and vice versa. This paper focuses on recent claims by philosophers that grief is frequently or even inherently irrational or inappropriate in one or another respect, all of which hinge on assumptions concerning the proper object of grief. By emphasizing the temporally extended structure of grief, we offer an alternative account of its object that undermines these assumptions and dissolves the apparent problems. (...) The principal object of grief, we suggest, is a loss of life possibilities, which is experienced, understood, and engaged with over a prolonged period. Other descriptions of grief's object identify more specific aspects of this loss in ways that do not respect a straightforward distinction between concrete and formal objects. (shrink)

Recent epistemology has reflected a growing interest in issues about the value of knowledge and the values informing epistemic appraisal. Is knowledge more valuable that merely true belief or even justified true belief? Is truth the central value informing epistemic appraisal or do other values enter the picture? Epistemic Value is a collection of previously unpublished articles on such issues by leading philosophers in the field. It will stimulate discussion of the nature of knowledge and of directions that might be (...) taken by the theory of knowledge. The contributors are Jason Baehr, Michael Brady, Berit Brogaard, Michael DePaul, Pascal Engel, Catherine Elgin, Alvin Goldman, John Greco, Stephen Grimm, Ward Jones, Martin Kusch, Jonathan Kvanvig, Michael Lynch, Erik Olsson, Wayne Riggs and Matthew Weiner. (shrink)

This paper argues that the dominance of linear models has led many sociologists to construe the social world in terms of a "general linear reality." This reality assumes (1) that the social world consists of fixed entities with variable attributes, (2) that cause cannot flow from "small" to "large" attributes/events, (3) that causal attributes have only one causal pattern at once, (4) that the sequence of events does not influence their outcome, (5) that the "careers" of entities are largely independent, (...) and (6) that causal attributes are generally independent of each other. The paper discusses examples of these assumptions in empirical work, consider standard and new methods addressing them, and briefly explores alternative models for reality that employ demographic, sequential, and network perspectives. (shrink)

Recently two developments have had a major impact on the field of ancient DNA (aDNA). First, new advances in DNA sequencing, in combination with improved capture/enrichment methods, have resulted in the recovery of orders of magnitude more DNA sequence data from ancient animals. Second, there has been an increase in the range of tissue types employed in aDNA. Hair in particular has proven to be very successful as a source of DNA because of its low levels of contamination and high (...) level of ancient endogenous DNA. These developments have resulted in significant advances in our understanding of recently extinct animals: namely their evolutionary relationships, physiology, and even behaviour. Hair has been used to recover the first complete ancient nuclear genome, that of the extinct woolly mammoth, which then facilitated the expression and functional analysis of haemoglobins. Finally, we speculate on the consequences of these developments for the possibility of recreating extinct animals. (shrink)

The paper explains what disjunctivism is and explores its implications for skepticism. Following an account of Paul Snowdon’s conception of a disjunctivist account of perceptual experience the the focus is on how disjunctivism has figured in the epistemological work of John McDowell. A conception of recognitional abilities is deployed to expand on McDowell’s position. Finally, there is consideration of whether McDowell offers a satisfactory response to skepticism, taking account of criticism’s made by Crispin Wright.

Articles in the popular media and testimonies collected in empirical work suggest that many people who have not been bereaved have nevertheless grieved over pandemic-related losses of various kinds. There is a philosophical question about whether any experience of a non-death loss ought to count as grief, hinging upon how the object of grief is construed. However, even if one accepts that certain significant non-death losses are possible targets of grief, many reported cases of putative pandemic-related grief may appear less (...) plausible. For instance, it might be argued that many of these losses are temporary or minor and therefore unlikely to be grieved, and that the associated experiences are phenomenologically dissimilar to grief. In this article, as well as discussing the more general question about the coherence of the idea of non-bereavement grief, we address these obstacles to taking reports of pandemic non-bereavement grief to be literal and true. In particular, we argue that some may have experienced grief over even apparently minor losses during the pandemic. This is generally so, we suggest, only insofar as experiences of such losses form part of an overarching grief process directed at some broader significant loss. Thus, we cast light on both the nature of non-bereavement grief and the kinds of disruption and loss experienced during the pandemic. (shrink)

Recent epistemology has reflected a growing interest in the social dimension of the subject. This volume presents new work by leading philosophers on a wide range of topics in social epistemology, such as the nature of testimony, the epistemology of disagreement, and the social genealogy of the concept of knowledge.

Recent epistemology has reflected a growing interest in issues about the value of knowledge and the values informing epistemic appraisal. Is knowledge more valuable that merely true belief or even justified true belief? Is truth the central value informing epistemic appraisal or do other values enter the picture? Epistemic Value is a collection of previously unpublished articles on such issues by leading philosophers in the field. It will stimulate discussion of the nature of knowledge and of directions that might be (...) taken by the theory of knowledge. The contributors are Jason Baehr, Michael Brady, Berit Brogaard, Michael DePaul, Pascal Engel, Catherine Elgin, Alvin Goldman, John Greco, Stephen Grimm, Ward Jones, Martin Kusch, Jonathan Kvanvig, Michael Lynch, Erik Olsson, Wayne Riggs and Matthew Weiner. (shrink)

Ownership rights influence thought and behavior in relation to the physical world and in relation to other people. We review recent research examining the nature of ownership rights, and how young children and adults conceive of them. This research examines issues such as the rights ownership is assumed to confer; whether ownership rights reflect principles specific to ownership or instead depend on more general moral principles; and whether ownership rights are inventions of law and culture, or whether they have a (...) more natural basis. (shrink)

The mechanistic model depicts scientific explanations as involving the discovery of multi-level, organized components that constitute a target phenomenon. Meanwhile, sensorimotor enactivism purports to offer a scientifically informed account of perceptual experience as a skill-laden interactive relationship, constitutively involving both perceiver and world, rather than as an agent-bound representation of the world. Insofar as sensorimotor enactivism identifies an empirically tractable phenomenon – skillful agent-world interaction – and mechanistic explanation establishes the subpersonal components of this phenomenon, the two approaches allow for (...) a fruitful division of labor in investigating perceptual experience. On closer inspection, however, two challenges arise. First, the “representation challenge” arises because promising attempts to set out implementational details of our sensorimotor interaction with the world implicate cognitive representations, creating tension with sensorimotor enactivism’s nonrepresentational commitments. Second, the “reconstitution challenge” arises when mechanistic explanation not only uncovers the components of some established phenomenon but plays a role in “reconstituting” this phenomenon. This means that, through investigating mechanisms, perceptual experience may be reconceived such that its constituents are wholly organism-bound. We explore both challenges to the compatibility of mechanism and sensorimotor enactivism and examine possible solutions. The result is a clearer understanding of the tensions and opportunities for learning between the frameworks. (shrink)

Decisions to use antibiotics require that patient interests are balanced against the public good, that is, control of antibiotic resistance. Patients carry the risks of suboptimal antibiotic treatment and many physicians are reluctant to impose even small avoidable risks on patients. At the same time, antibiotics are overused and antibiotic-resistant microbes are contributing an increasing burden of adverse patient outcomes. It is the criteria that we can use to reject the use of antibiotics that is the focus of this paper. (...) Scanlon's contractualism explains why antibiotics should not be used to gain small benefits, even when the direct costs of antibiotics are low. We know that some individuals now (and probably more in the future will) carry a burden of irretrievable harm as a consequence of treatment- (antibiotic-) resistant infection. If we accept that the dominant justification for use of antibiotics is to prevent irretrievable harm to an individual or contact, then the use of antibiotics for self-limiting conditions, or for the treatment of individuals with conditions for which antibiotics do not substantially impact on outcomes (eg, in the latter stages of terminal illness), or for access based on preference or willingness to pay (internet or over-the-counter access), or the use of antibiotics as animal growth promoters can be rejected. Scanlon's approach also suggests that, with few new antibiotics in the pipeline and an increasing burden of disease attributable to resistant microbes, control of the spread of antibiotic-resistant microbes should be given increasing priority. (shrink)

This paper develops a theory of analog representation. We first argue that the mark of the analog is to be found in the nature of a representational system’s interpretation function, rather than in its vehicles or contents alone. We then develop the rulebound structure theory of analog representation, according to which analog systems are those that use interpretive rules to map syntactic structural features onto semantic structural features. The theory involves three degree-theoretic measures that capture three independent ways in which (...) a system can be more or less analog. We explain how our theory improves upon prior accounts of analog representation, provides plausible diagnoses for novel challenge cases, extends to hybrid systems that are partially analog and partially symbolic, and accounts for some of the advantages and disadvantages of representing analogically versus symbolically. (shrink)

An explanation is given of why it is in the nature of inquiry into whether or not p that its aim is fully achieved only if one comes to know that p or to know that not-p and, further, comes to know how one knows, either way. In the absence of the latter one is in no position to take the inquiry to be successfully completed or to vouch for the truth of the matter in hand. An upshot is that (...) although knowledge matters because truth matters this should not be understood to mean that knowledge matters because true belief matters. (shrink)

This paper posits that differences in corporate governance structure partly result from differences in institutional arrangements linked to business systems. We developed a new international triad of business systems: the Anglo-American, the Communitarian and the Emerging system, building on the frameworks of Choi et al. (British Academy of Management (Kynoch Birmingham) 1996, Management International Review 39, 257–279, 1999). A common factor determining the success of a corporate governance structure is the extent to which it is transparent to market forces. Such (...) transparency is more than pure financial transparency; as it can also be based on factors such as governmental, banking and other types of institutional transparency mechanism. There may also be a choice for firms to adopt voluntary corporate disclosure in situations where mandatory disclosure is not established. The Asian financial crisis of 1997–1999 and the more recent corporate governance scandals such as Enron, Andersen and Worldcom in the United States and Ahold and Parmalat in Europe show that corporate governance and business ethics issues exist throughout the world. As an illustration we focus on Asia’s emerging1 markets, as, both in view of the pressure of globalization and taking into account the institutional arrangements peculiar to the emerging business system, these issues are important there. Particularly for those who have to find an accommodation between the corporate governance structures and disclosure standards of the Emerging system and those of the Anglo-American and Communitarian systems. (shrink)

A number of EU institutions and government committees across Europe have expressed interest in developing methods and decision-support tools to facilitate consideration of the ethical dimensions of biotechnology assessment. As part of the work conducted in the EC supported project on ethical tools (Ethical Bio-TA Tools), a number of ethical frameworks with the potential to support the work of public policy decision-makers has been characterized and evaluated. One of these potential tools is the Delphi method. The Delphi method was originally (...) developed to assess variables that are intangible and/or shrouded in uncertainty by drawing on the knowledge and abilities of a diverse group of experts through a form of anonymous and iterative consultation. The method has hitherto been used by a diversity of practitioners to explore issues such as technology assessment, environmental planning, and public health measures. From the original (classical) Delphi, a family of Delphi-related processes has emerged. As a result of the evaluation of the various Delphi processes, it is proposed that the classical method can be further developed and applied as a form of ethical framework to assist policy-makers. Through a series of exercises and trials, an Ethical Delphi has been developed as a potential approach for characterizing ethical issues raised by the use of novel biotechnologies. Advantages and disadvantages of the method are discussed. Further work is needed to develop the procedural aspects of the Ethical Delphi method and to test its use in different cultural contexts. However, utilizing an ethical framework of this type combines the advantages of a methodical approach to capture ethical aspects with the democratic virtues of transparency and openness to criticism. Ethical frameworks such as the Ethical Delphi should contribute to better understanding of and decision-making on issues that involve decisive ethical dimensions. (shrink)

We analyse the contention that privacy is an alien concept within Japanese society, put forward in various presentations of Japanese cultural norms at least as far back as Benedict in The chrysanthemum and the sword: patterns of Japanese culture. Houghton Mifflin, Boston, 1946. In this paper we distinguish between information privacy and physical privacy. As we show, there is good evidence for social norms of limits on the sharing and use of personal information (i.e. information privacy) from traditional interactions in (...) Japanese society, as well as constitutional evidence from the late 19th century (in the Meiji Constitution of 1889). In this context the growing awareness of the Japanese public about problems with networked information processing by public sector and commercial organisations from the 1980s (when a law governing public sector use of personal information was first passed) to recent years (when that law was updated and a first law governing commercial use of personal information was adopted) are not the imposition or adoption of foreign practices nor solely an attempt to lead Japanese society into coherence with the rest of the OECD. Instead they are drawing on the experience of the rest of the developed world in developing legal responses to the breakdown of social norms governing interchange and use of personal information, stressed by the architectural changes wrought by networked information processing capabilities. This claim is supported by consideration of standard models of Japanese social interactions as well as of Supreme Court judgements declaring reasonable expectations of protection of privacy to hold in Japan. (shrink)

The received view on the contributions of the physics community to the birth of molecular biology tends to present the physics community as sharing a basic level consensus on how physics should be brought to bear on biology. I argue, however, that a close examination of the views of three leading physicists involved in the birth of molecular biology, Bohr, Delbrück, and Schrödinger, suggests that there existed fundamental disagreements on how physics should be employed to solve problems in biology even (...) within the physics community. In particular, I focus on how these three figures differed sharply in their assessment of the relevance of complementarity, the potential of chemical methods, and the relative importance of classical physics. In addition, I assess and develop Roll-Hansen’s attempt to conceptualize this history in terms of models of scientific change advanced by Kuhn and Lakatos. Though neither model is fully successful in explaining the divergence of views among these three physicists, I argue that the extent and quality of difference in their views help elucidate and extend some themes that are left opaque in Kuhn’s model. (shrink)

All representationalists maintain that there is a necessary connection between an experience’s phenomenal character and intentional content; but there is a disagreement amongst representationalists regarding the nature of those intentional contents that are necessarily connected to phenomenal character. Russellian representationalists maintain that the relevant contents are composed of objects and/or properties, while Fregean representationalists maintain that the relevant contents are composed of modes of presentation of objects and properties. According to Fregean representationalists such as David Chalmers and Brad Thompson, the (...) Fregean variety of the view is preferable to the Russellian variety because the former can accommodate purported counterexamples involving spectrum inversion without illusion and colour constancy while the latter cannot. I maintain that colour constancy poses a special problem for the Fregean theory in that the features of the theory that enable it handle spectrum inversion without illusion cannot be extended to handle colour constancy. I consider the two most plausible proposals regarding how the Fregean view might be developed in order to handle colour constancy—one of which has recently been defended by Thompson —and argue that neither is adequate. I conclude that Fregean representationalism is no more able to accommodate colour constancy than is Russellian representationalism and, as such, ought to be rejected. (shrink)

Healthcare workers carry a substantial risk of harm from infectious disease, particularly, but not exclusively, during outbreaks. More can be done by healthcare institutions to identify risks, quantify the current burden of preventable infectious disease amongst HCWs and identify opportunities for prevention. We suggest that institutional obligations should be clarified with respect to the mitigation of infectious disease risks to staff, and question the duty of HCWs to care while healthcare institutions persist with a reactive rather than proactive attitude to (...) infectious disease threats. (shrink)

Conscious experiences are characterized by mental qualities, such as those involved in seeing red, feeling pain, or smelling cinnamon. The standard framework for modeling mental qualities represents them via points in geometrical spaces, where distances between points inversely correspond to degrees of phenomenal similarity. This paper argues that the standard framework is structurally inadequate and develops a new framework that is more powerful and flexible. The core problem for the standard framework is that it cannot capture precision structure: for example, (...) consider the phenomenal contrast between seeing an object as crimson in foveal vision versus merely as red in peripheral vision. The solution I favor is to model mental qualities using regions, rather than points. I explain how this seemingly simple formal innovation not only provides a natural way of modeling precision, but also yields a variety of further theoretical fruits: it enables us to formulate novel hypotheses about the space and structures of mental qualities, formally differentiate two dimensions of phenomenal similarity, generate a quantitative model of the phenomenal sorites, and define a measure of discriminatory grain. A noteworthy consequence is that the structure of the mental qualities of conscious experiences is fundamentally different from the structure of the perceptible qualities of external objects. (shrink)

Millar, A. 2017. Berkeley's Puzzle. Analysis 77: 232–242.

In this wide-ranging interview Andrew Sayer discusses how he became a realist and then the development of his work over the subsequent decades. He comments on his postdisciplinary approach, his early work on economy and its influences, how he came to write Method in Social Science and the transition in Realism and Social Science to normative critical social science and moral economy. The interview concludes with discussion of his three most recent books and the themes that connect them, not (...) least the ongoing problem of a ‘diabolical double crisis’ of capitalism: extreme inequality and climate change. (shrink)

Foucault never presented a systematic history of tragedy, but reflections on the relationship between tragedy and the will to truth are scattered throughout his writings. Given the Nietzschean inspiration of his work, this is not surprising. Yet Foucault rarely referenced The Birth of Tragedy, preferring to draw on Nietzsche’s later genealogical writings. In this paper I highlight the importance of The Birth of Tragedy for understanding Foucault’s entire corpus, suggesting that it can be read as a sustained consideration on the (...) political significance of the madness of Orestes from Aeschylus to Racine. (shrink)

For countable structure, "Scott rank" provides a measure of internal, model-theoretic complexity. For a computable structure, the Scott rank is at most [Formula: see text]. There are familiar examples of computable structures of various computable ranks, and there is an old example of rank [Formula: see text]. In the present paper, we show that there is a computable structure of Scott rank [Formula: see text]. We give two different constructions. The first starts with an arithmetical example due to Makkai, and (...) codes it into a computable structure. The second re-works Makkai's construction, incorporating an idea of Sacks. (shrink)

Alan Millar examines our understanding of why people think and act as they do. His key theme is that normative considerations form an indispensable part of the explanatory framework which we use to understand each other. Millar offers illuminating discussions of reasons for belief and reasons for action, the explanation of beliefs and actions in terms of the subject's reasons, the idea that simulation has a key role in understanding people, and the limits of explanation in terms of (...) propositional attitudes. (shrink)

For countable structure, "Scott rank" provides a measure of internal, model-theoretic complexity. For a computable structure, the Scott rank is at most [Formula: see text]. There are familiar examples of computable structures of various computable ranks, and there is an old example of rank [Formula: see text]. In the present paper, we show that there is a computable structure of Scott rank [Formula: see text]. We give two different constructions. The first starts with an arithmetical example due to Makkai, and (...) codes it into a computable structure. The second re-works Makkai's construction, incorporating an idea of Sacks. (shrink)